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R

Ruben van Boxtel

University Medical Center Utrecht
H指数:46
被引数:1.8万

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荣誉奖项

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Clonotypic characterization defines B-cell drivers of clonal expansion and intratumor heterogeneity in IgM monoclonal gammopathies

克隆表型特征分析定义了IgM单克隆丙种球蛋白病中B细胞克隆性扩增和肿瘤内异质性的驱动因素

HemaSphere
IF14.6
2026-09-130
OAAI
David F. Moreno; Ferran Nadeu; Marta Casado-Peláez; Caterina Mata; Ian Márquez-López; Marco A. Fernández; Sergi Vaqué; Elena Medina; Helena Llobregat; Marta Garrote; Joan Mañé; Oriol Cardús; Luis Gerardo Rodríguez-Lobato; Anna de Daniel; María Teresa Cibeira; Theo Gremen Oliveira; Elizaveta Kulaeva; Ester Lozano; Dolors Colomer; Laura Rosiñol; Ruben van Boxtel; Manel Esteller; Carlos Fernández de Larrea
High-resolution single-cell mapping of clonal hematopoiesis and structural variation in aplastic anemia

再生障碍性贫血中克隆造血和结构变异的高分辨率单细胞定位

Nature Genetics
IF29
2026-05-010
PRE
Masanori Yoshida; Sushree S. Sahoo; Paula Y. Arnold; Carmelo Gurnari; Anaïs J. C. N. van Leeuwen; Limeng Pu; Markus J. van Roosmalen; Ti-Cheng Chang; Charnise Goodings; Rashid Mehmood; Lucca L. M. Derks; Nathan Gray; Michelle Boals; Sara Lewis; Lili Kotmayer; Cristyn N. Branstetter; Swapna Thota; Joshua Leow; Wenchao Zhang; Yichao Li; Melanie R. Loyd; Granger Ridout; Emily V. Walker; Christy W. LaFlamme; Heather C. Mefford; Zachary Brady; Yash B. Shah; Rheanna G. Congdon; Miriam Erlacher; Brigitte Strahm; Ayami Yoshimi; Shinsuke Hirabayashi; Helen D. Reed; Akiko Shimamura; Guolian Kang; Xiang Chen; Jinghui Zhang; Charlotte M. Niemeyer; Joseph H. Oved; Timothy S. Olson; Ruben van Boxtel; Jaroslaw P. Maciejewski; Daria V. Babushok; Marcin W. Wlodarski
Small round cell sarcoma tumoroid biobank reveals CIC::DUX4 sarcoma vulnerability to MCL-1 inhibition

小型圆形细胞肉瘤类器官生物库揭示了CIC::DUX4肉瘤对MCL-1抑制的易感性

Nature Communications
IF15.7
2025-08-210
OAAI
Femke C. A. S. Ringnalda; Gijs J. F. van Son; Laurens H. G. Verweij; Seok-Young Kim; Vicky Amo-Addae; Uta E. Flucke; Laura S. Hiemcke–Jiwa; Karin P. S. Langenberg; Jos A. M. Bramer; Lotte Heimans; Michiel A. J. van de Sande; Winan J. van Houdt; Max M. van Noesel; Hinri H. D. Kerstens; Marcel Santoso; Georg Seifert; Olivier Delattre; Katia Scotlandi; Birgit Geoerger; Johannes H. M. Merks; Jan J. Molenaar; Ruben van Boxtel; Marc van de Wetering; Karin Sanders; Hans Clevers
Unraveling mutagenic processes influencing the tumor mutational patterns of individuals with constitutional mismatch repair deficiency

解析影响常染色体错配修复缺陷个体肿瘤突变模式的致突变过程

NATURE COMMUNICATIONS
IF15.7
2025-05-141
OA
Weijers, Dilys D.; Hinic, Snezana; Kroeze, Emma; Gorris, Mark A. J.; Schreibelt, Gerty; Middelkamp, Sjors; Mensenkamp, Arjen R.; Bladergroen, Reno; Verrijp, Kiek; Hoogerbrugge, Nicoline; Wesseling, Pieter; van der Post, Rachel S.; Loeffen, Jan L. C.; Gidding, Corrie E. M.; van Kouwen, Mariette C. A.; de Vries, I. Jolanda M.; van Boxtel, Ruben; de Voer, Richarda M.; Jongmans, Marjolijn C. J.; Kuiper, Roland P.
Recapitulating the adenoma-carcinoma sequence by selection of four spontaneous oncogenic mutations in mismatch-repair-deficient human colon organoids

通过选择错配修复缺陷型人类结肠类器官中的四个自发致癌突变来重述腺瘤-癌序列

NATURE CANCER
IF28.5
2024-11-010
OAAI
Mizutani, Tomohiro; Boretto, Matteo; Lim, Sangho; Drost, Jarno; Gonzalez, Diego Montiel; Oka, Rurika; Geurts, Maarten H.; Begthel, Harry; Korving, Jeroen; van Es, Johan H.; van Boxtel, Ruben; Clevers, Hans
Somatic genetic development of Wilms tumor via normal kidneys in predisposed children

易感儿童通过正常肾脏进行Wilms肿瘤的体细胞遗传发育

CANCER RESEARCH
IF16.6
2024-09-050
PRE
Treger, Taryn D.; Wegert, Jenny; Wenger, Anna; Coorens, Tim H. H.; Al-Saadi, Reem; Kemps, Paul; Kennedy, Jonathan; Parks, Conor; Anderson, Nathaniel D.; Hodder, Angus; Letunovska, Aleksandra; Jung, Hyunchul; Ogbonnah, Toochi; Mi Trinh; Lee-Six, Henry; Morcrette, Guillaume; van den Heuvel-Eibrink, Marry M.; Drost, Jarno; van Boxtel, Ruben; Bertrums, Eline; Goemans, Bianca; Jongmans, Marjolein; Kuiper, Roland; Antoniou, Evangelia; Reinhardt, Dirk; Bartram, Jack; Hutchinson, Ciaran; Vujanic, Gordan; Vokuhl, Christian; Chowdhury, Tanzina; Furtwangler, Rhoikos; Graf, Norbert; Gessler, Manfred; Behjati, Sam
Selective pressures of platinum compounds shape the evolution of therapy-related myeloid neoplasms

铂化合物的选择性压力影响了与治疗相关的髓系肿瘤的发展

NATURE COMMUNICATIONS
IF15.7
2024-07-171
OAAI
Bertrums, Eline J. M.; de Kanter, Jurrian K.; Derks, Lucca L. M.; Verheul, Mark; Trabut, Laurianne; van Roosmalen, Markus J.; Hasle, Henrik; Antoniou, Evangelia; Reinhardt, Dirk; Dworzak, Michael N.; Muehlegger, Nora; van den Heuvel-eibrink, Marry M.; Zwaan, C. Michel; Goemans, Bianca F.; van Boxtel, Ruben
Homopolymer switches mediate adaptive mutability in mismatch repair-deficient colorectal cancer

均聚物开关介导错配修复缺陷型结直肠癌的适应性可变性

NATURE GENETICS
IF31.8
2024-07-031
OAAI
Kayhanian, Hamzeh; Cross, William; van der Horst, Suzanne E. M.; Barmpoutis, Panagiotis; Lakatos, Eszter; Caravagna, Giulio; Zapata, Luis; Van Hoeck, Arne; Middelkamp, Sjors; Litchfield, Kevin; Steele, Christopher; Waddingham, William; Patel, Dominic; Milite, Salvatore; Jin, Chen; Baker, Ann-Marie; Alexander, Daniel C.; Khan, Khurum; Hochhauser, Daniel; Novelli, Marco; Werner, Benjamin; van Boxtel, Ruben; Hageman, Joris H.; Buissant des Amorie, Julian R.; Linares, Josep; Ligtenberg, Marjolijn J. L.; Nagtegaal, Iris D.; Lacle, Miangela M.; Moons, Leon M. G.; Brosens, Lodewijk A. A.; Pillay, Nischalan; Sottoriva, Andrea; Graham, Trevor A.; Rodriguez-Justo, Manuel; Shiu, Kai-Keen; Snippert, Hugo J. G.; Jansen, Marnix
Polyketide synthase positive Escherichia coli one-time measurement in stool is not informative of colorectal cancer risk in a screening setting

在筛查环境中，粪便中聚酮化合物合酶阳性大肠杆菌的一次性测量不能提供结直肠癌风险的信息

JOURNAL OF PATHOLOGY
IF5.2
2024-03-290
OA
de Klaver, Willemijn; de Wit, Meike; Bolijn, Anne; Tijssen, Marianne; Delis-van Diemen, Pien; Lemmens, Margriet; Spaander, Manon C. W.; Dekker, Evelien; van Leerdam, Monique E.; Coupe, Veerle M. H.; van Boxtel, Ruben; Clevers, Hans; Carvalho, Beatriz; Meijer, Gerrit A.
Comprehensive single-cell genome analysis at nucleotide resolution using the PTA Analysis Toolbox

使用PTA分析工具箱以核苷酸分辨率进行全面的单细胞基因组分析

CELL GENOMICS
IF9
2023-09-014
OAAI
Middelkamp, Sjors; Manders, Freek; Peci, Flavia; Roosmalen, Markus J. van; Gonzalez, Diego Montiel; Bertrums, Eline J. M.; Werf, Inge van der; Derks, Lucca L. M.; Groenen, Niels M.; Verheul, Mark; Trabut, Laurianne; Pleguezuelos-Manzano, Cayetano; Brandsma, Arianne M.; Antoniou, Evangelia; Reinhardt, Dirk; Bierings, Marc; Belderbos, Mirjam E.; van Boxtel, Ruben

研究方向

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Edwin Cuppen
H 指数:102论文数:534被引数:4.9万
H
Hans Clevers
H 指数:236论文数:1,340被引数:25.0万
R
Rurika Oka
H 指数:20论文数:90被引数:3,348
M
Markus J. van Roosmalen
H 指数:26论文数:113被引数:3,665
M
Mark Verheul
H 指数:20论文数:79被引数:2,374
J
Jarno Drost
H 指数:34论文数:187被引数:1.1万
N
Nicolle Besselink
H 指数:21论文数:72被引数:2,097
E
Ewart Kuijk
H 指数:27论文数:61被引数:5,099
J
Jurrian K. de Kanter
H 指数:9论文数:23被引数:744
M
Myrthe Jager
H 指数:13论文数:44被引数:3,884