未登录 Mapping the functional impact of non-coding regulatory elements in primary T cells through single-cell CRISPR screens 通过单细胞CRISPR筛选绘制原代T细胞中非编码调控元件的功能影响 Alda-Catalinas, Celia; Ibarra-Soria, Ximena; Flouri, Christina; Gordillo, Jorge Esparza; Cousminer, Diana; Hutchinson, Anna; Sun, Bin; Pembroke, William; Ullrich, Sebastian; Krejci, Adam; Cortes, Adrian; Acevedo, Alison; Malla, Sunir; Fishwick, Carl; Drewes, Gerard; Rapiteanu, Radu 分享 收藏
Inhibitors of Rho kinases (ROCK) induce multiple mitotic defects and synthetic lethality in BRCA2-deficient cells (vol 12, e80254, 2023) Martino, Julieta; Siri, Sebastian Omar; Calzetta, Nicolas Luis; Paviolo, Natalia Soledad; Garro, Cintia; Pansa, Maria F.; Carbajosa, Sofia; Brown, Aaron C.; Bocco, Jose Luis; Gloger, Israel; Drewes, Gerard; Madauss, Kevin P.; Soria, Gaston; Gottifredi, Vanesa 分享 收藏
Inhibitors of Rho kinases (ROCK) induce multiple mitotic defects and synthetic lethality in BRCA2-deficient cells Martino, Julieta; Omar Siri, Sebastian; Luis Calzetta, Nicolas; Soledad Paviolo, Natalia; Garro, Cintia; Pansa, Maria F.; Carbajosa, Sofia; Brown, Aaron C.; Luis Bocco, Jose; Gloger, Israel; Drewes, Gerard; Madauss, Kevin P.; Soria, Gaston; Gottifredi, Vanesa 分享 收藏
Deoxycytidine kinase (dCK) inhibition is synthetic lethal with BRCA2-deficiency Guantay, Maria L.; Garro, Cintia A.; Siri, Sebastian; Pansa, Maria; Ghidelli-Disse, Sonja; Paviolo, Natalia; Racca, Ana; Nicotra, Viviana; Radu, Caius; Bocco, Jose L.; Felice, Rosana; Gloger, Israel; Muelbaier, Marcel; Drewes, Gerard; Madauss, Kevin; Garcia, Manuela; Gottifredi, Vanesa; Soria, Gaston 分享 收藏
Deoxycytidine kinase (dCK) inhibition is synthetic lethal with BRCA2 deficiency Guantay, Laura; Garro, Cintia; Siri, Sebastian; Pansa, Maria Florencia; Ghidelli-Disse, Sonja; Paviolo, Natalia; Racca, Ana; Nicotra, Viviana; Radu, Caius; Bocco, Jose Luis; Felice, Rosana; Jansson, Keith H.; Remlinger, Katja; Amador, Alejandro; Stronach, Euan; Coleman, Kevin; Muelbaier, Marcel; Drewes, Gerard; Gloger, Isro; Madauss, Kevin; Garcia, Manuela; Gottifredi, Vanesa; Soria, Gaston 分享 收藏
1,3-Diarylpyrazolyl-acylsulfonamides Target HadAB/BC Complex in Mycobacterium tuberculosis 1，3-二芳基吡唑基酰基磺酰胺靶向结核分枝杆菌中的HadAB/BC复合物 Singh, Vinayak; Grzegorzewicz, Anna E.; Fienberg, Stephen; Muller, Rudolf; Khonde, Lutete Peguy; Sanz, Olalla; Alfonso, Salvatore; Urones, Beatriz; Drewes, Gerard; Bantscheff, Marcus; Ghidelli-Disse, Sonja; Ioerger, Thomas R.; Angala, Bhanupriya; Liu, Jiuyu; Lee, Richard E.; Sacchettini, James C.; Krieger, Inna, V; Jackson, Mary; Chibale, Kelly; Ghorpade, Sandeep R. 分享 收藏
The anticancer human mTOR inhibitor sapanisertib potently inhibits multiple Plasmodium kinases and life cycle stages Arendse, Lauren B.; Murithi, James M.; Qahash, Tarrick; Pasaje, Charisse Flerida A.; Godoy, Luiz C.; Dey, Sumanta; Gibhard, Liezl; Ghidelli-Disse, Sonja; Drewes, Gerard; Bantscheff, Marcus; Lafuente-Monasterio, Maria J.; Fienberg, Stephen; Wambua, Lynn; Gachuhi, Samuel; Coertzen, Dina; van der Watt, Mariette; Reader, Janette; Aswat, Ayesha S.; Erlank, Erica; Venter, Nelius; Mittal, Nimisha; Luth, Madeline R.; Ottilie, Sabine; Winzeler, Elizabeth A.; Koekemoer, Lizette L.; Birkholtz, Lyn-Marie; Niles, Jacquin C.; Llinas, Manuel; Fidock, David A.; Chibale, Kelly 分享 收藏
The small-molecule SMARt751 reverses Mycobacterium tuberculosis resistance to ethionamide in acute and chronic mouse models of tuberculosis 小分子SMARt751在急性和慢性结核病小鼠模型中逆转结核分枝杆菌对乙硫酰胺的耐药性 Flipo, Marion; Frita, Rosangela; Bourotte, Marilyne; Martinez-Martinez, Maria S.; Boesche, Markus; Boyle, Gary W.; Derimanov, Geo; Drewes, Gerard; Gamallo, Pablo; Ghidelli-Disse, Sonja; Gresham, Stephanie; Jimenez, Elena; de Mercado, Jaime; Perez-Herran, Esther; Porras-De Francisco, Esther; Rullas, Joaquin; Casado, Patricia; Leroux, Florence; Piveteau, Catherine; Kiass, Mehdi; Mathys, Vanessa; Soetaert, Karine; Megalizzi, Veronique; Tanina, Abdalkarim; Wintjens, Rene; Antoine, Rudy; Brodin, Priscille; Delorme, Vincent; Moune, Martin; Djaout, Kamel; Slupek, Stephanie; Kemmer, Christian; Gitzinger, Marc; Ballell, Lluis; Mendoza-Losana, Alfonso; Lociuro, Sergio; Deprez, Benoit; Barros-Aguirre, David; Remuinan, Modesto J.; Willand, Nicolas; Baulard, Alain R. 分享 收藏
Converging roles of PSENEN/PEN2 and CLN3 in the autophagy-lysosome system Klein, Marcel; Kaleem, Abuzar; Oetjen, Sandra; Wuenkhaus, Daniela; Binkle, Lars; Schilling, Sandra; Gjorgjieva, Milena; Scholz, Ralf; Gruber-Schoffnegger, Doris; Storch, Stephan; Kins, Stefan; Drewes, Gerard; Hoffmeister-Ullerich, Sabine; Kuhl, Dietmar; Hermey, Guido 分享 收藏
Direct Automated MALDI Mass Spectrometry Analysis of Cellular Transporter Function: Inhibition of OATP2B1 Uptake by 294 Drugs Unger, Melissa S.; Schumacher, Lena; Enzlein, Thomas; Weigt, David; Zamek-Gliszczynski, Maciej J.; Schwab, Matthias; Nies, Anne T.; Drewes, Gerard; Schulz, Sandra; Reinhard, Friedrich B. M.; Hopf, Carsten 分享 收藏
CDK12 inhibition reduces abnormalities in cells from patients with myotonic dystrophy and in a mouse model Ketley, Ami; Wojciechowska, Marzena; Ghidelli-Disse, Sonja; Bamborough, Paul; Ghosh, Tushar K.; Morato, Marta Lopez; Sedehizadeh, Saam; Malik, Naveed Altaf; Tang, Zhenzhi; Powalowska, Paulina; Tanner, Matthew; Billeter-Clark, Rudolf; Trueman, Rebecca C.; Geiszler, Philippine C.; Agostini, Alessandra; Othman, Othman; Bosche, Markus; Bantscheff, Marcus; Rudiger, Martin; Mossakowska, Danuta E.; Drewry, David H.; Zuercher, William J.; Thornton, Charles A.; Drewes, Gerard; Uings, Iain; Hayes, Christopher J.; Brook, J. David 分享 收藏
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Epigenetic reader complexes of the human malaria parasite, Plasmodium falciparum Hoeijmakers, Wieteke Anna Maria; Miao, Jun; Schmidt, Sabine; Toenhake, Christa Geeke; Shrestha, Sony; Venhuizen, Jeron; Henderson, Rob; Birnbaum, Jakob; Ghidelli-Disse, Sonja; Drewes, Gerard; Cui, Liwang; Stunnenberg, Hendrik Gerard; Spielmann, Tobias; Bartfai, Richard 分享 收藏
Biological plasticity rescues target activity in CRISPR knock outs Smits, Arne H.; Ziebell, Frederik; Joberty, Gerard; Zinn, Nico; Mueller, William F.; Clauder-Muenster, Sandra; Eberhard, Dirk; Savitski, Maria Falth; Grandi, Paola; Jakob, Petra; Michon, Anne-Marie; Sun, Hanice; Tessmer, Karen; Buerckstuemmer, Tilmann; Bantscheff, Marcus; Steinmetz, Lars M.; Drewes, Gerard; Huber, Wolfgang 分享 收藏
Chemical proteomics reveals target selectivity of clinical Jak inhibitors in human primary cells Eberl, H. Christian; Werner, Thilo; Reinhard, Friedrich B.; Lehmann, Stephanie; Thomson, Douglas; Chen, Peiling; Zhang, Cunyu; Rau, Christina; Muelbaier, Marcel; Drewes, Gerard; Drewry, David; Bantscheff, Marcus 分享 收藏
Development of Chemical Entities Endowed with Potent Fast-Killing Properties against Plasmodium falciparum Malaria Parasites Matralis, Alexios N.; Malik, Adnan; Penzo, Maria; Moreno, Inmaculada; Almela, Maria J.; Camino, Isabel; Crespo, Benigno; Saadeddin, Anas; Ghidelli-Disse, Sonja; Rueda, Lourdes; Calderon, Felix; Osborne, Simon A.; Drewes, Gerard; Boeesche, Markus; Fernandez-Alvaro, Elena; Martin Hernando, Jose Ignacio; Baker, David A. 分享 收藏
BRD4 bimodal binding at promoters and drug-induced displacement at Pol II pause sites associates with I-BET sensitivity Khoueiry, P.; Gahlawat, A. Ward; Petretich, M.; Michon, A. M.; Simola, D.; Lam, E.; Furlong, E. E.; Benes, V; Dawson, M. A.; Prinjha, R. K.; Drewes, G.; Grandi, P. 分享 收藏
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Identification of GSK3186899/DDD853651 as a Preclinical Development Candidate for the Treatment of Visceral Leishmaniasis Thomas, Michael G.; De Rycker, Manu; Ajakane, Myriam; Albrecht, Sebastian; Isabel Alvarez-Pedraglio, Ana; Boesche, Markus; Brand, Stephen; Campbell, Lorna; Cantizani-Perez, Juan; Cleghorn, Laura A. T.; Copley, Royston C. B.; Crouch, Sabrinia D.; Daugan, Alain; Drewes, Gerard; Ferrer, Santiago; Ghidelli-Disse, Sonja; Gonzalez, Silvia; Gresham, Stephanie L.; Hail, Alan P.; Hindley, Sean J.; Lowe, Rhiannon M.; MacKenzie, Claire J.; MacLean, Lorna; Manthri, Sujatha; Martin, Franck; Miguel-Siles, Juan; Van Loc Nguyen; Norval, Suzanne; Osuna-Cabello, Maria; Woodland, Andrew; Patterson, Stephen; Pena, Imanol; Teresa Quesada-Campos, Maria; Reid, Iain H.; Revill, Charlotte; Riley, Jennifer; Ramon Ruiz-Gomez, Jose; Shishikura, Yoko; Simeons, Frederick R. C.; Smith, Alasdair; Smith, Victoria C.; Spinks, Daniel; Stojanovski, Laste; Thomas, John; Thompson, Stephen; Underwood, Tim; Gray, David W.; Fiandor, Jose M.; Gilbert, Ian H.; Wyatt, Paul G.; Read, Keyin D.; Miles, Timothy J. 分享 收藏
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