未登录 分享 收藏
Arrayed CRISPR libraries for the genome-wide activation, deletion and silencing of human protein-coding genes Yin, Jiang-An; Frick, Lukas; Scheidmann, Manuel C.; Liu, Tingting; Trevisan, Chiara; Dhingra, Ashutosh; Spinelli, Anna; Wu, Yancheng; Yao, Longping; Vena, Dalila Laura; Knapp, Britta; Guo, Jingjing; De Cecco, Elena; Ging, Kathi; Armani, Andrea; Oakeley, Edward J.; Nigsch, Florian; Jenzer, Joel; Haegele, Jasmin; Pikusa, Michal; Taeger, Joachim; Rodriguez-Nieto, Salvador; Bouris, Vangelis; Ribeiro, Rafaela; Baroni, Federico; Bedi, Manmeet Sakshi; Berry, Scott; Losa, Marco; Hornemann, Simone; Kampmann, Martin; Pelkmans, Lucas; Hoepfner, Dominic; Heutink, Peter; Aguzzi, Adriano 分享 收藏
The ASC inflammasome adapter governs SAA-derived protein aggregation in inflammatory amyloidosis Losa, Marco; Emmenegger, Marc; De Rossi, Pierre; Schuerch, Patrick M.; Serdiuk, Tetiana; Pengo, Niccolo; Capron, Danaelle; Bieli, Dimitri; Bargenda, Niklas; Rupp, Niels J.; Carta, Manfredi C.; Frontzek, Karl J.; Lysenko, Veronika; Reimann, Regina R.; Schwarz, Petra; Nuvolone, Mario; Westermark, Gunilla T.; Nilsson, K. Peter R.; Polymenidou, Magdalini; Theocharides, Alexandre P. A.; Hornemann, Simone; Picotti, Paola; Aguzzi, Adriano 分享 收藏
An arrayed genome-wide perturbation screen identifies the ribonucleoprotein Hnrnpk as rate-limiting for prion propagation Avar, Merve; Heinzer, Daniel; Thackray, Alana M.; Liu, Yingjun; Hruska-Plochan, Marian; Sellitto, Stefano; Schaper, Elke; Pease, Daniel P.; Yin, Jiang-An; Lakkaraju, Asvin K. K.; Emmenegger, Marc; Losa, Marco; Chincisan, Andra; Hornemann, Simone; Polymenidou, Magdalini; Bujdoso, Raymond; Aguzzi, Adriano 分享 收藏
A conformational switch controlling the toxicity of the prion protein Frontzek, Karl; Bardelli, Marco; Senatore, Assunta; Henzi, Anna; Reimann, Regina R.; Bedir, Seden; Marino, Marika; Hussain, Rohanah; Jurt, Simon; Meisl, Georg; Pedotti, Mattia; Mazzola, Federica; Siligardi, Giuliano; Zerbe, Oliver; Losa, Marco; Knowles, Tuomas; Lakkaraju, Asvin; Zhu, Caihong; Schwarz, Petra; Hornemann, Simone; Holt, Matthew G.; Simonelli, Luca; Varani, Luca; Aguzzi, Adriano 分享 收藏
Ligands binding to the prion protein induce its proteolytic release with therapeutic potential in neurodegenerative proteinopathies 与病毒蛋白结合的配体诱导其蛋白水解释放，在神经退行性蛋白质病中具有治疗潜力 Linsenmeier, Luise; Mohammadi, Behnam; Shafiq, Mohsin; Frontzek, Karl; Bar, Julia; Shrivastava, Amulya N.; Damme, Markus; Song, Feizhi; Schwarz, Alexander; Da Vela, Stefano; Massignan, Tania; Jung, Sebastian; Correia, Angela; Schmitz, Matthias; Puig, Berta; Hornemann, Simone; Zerr, Inga; Tatzelt, Jorg; Biasini, Emiliano; Saftig, Paul; Schweizer, Michaela; Svergun, Dmitri; Amin, Ladan; Mazzola, Federica; Varani, Luca; Thapa, Simrika; Gilch, Sabine; Schatzl, Hermann; Harris, David A.; Triller, Antoine; Mikhaylova, Marina; Aguzzi, Adriano; Altmeppen, Hermann C.; Glatzel, Markus 分享 收藏
Novel regulators of PrP(C) biosynthesis revealed by genome-wide RNA interference Heinzer, Daniel; Avar, Merve; Pease, Daniel Patrick; Dhingra, Ashutosh; Yin, Jiang-An; Schaper, Elke; Dogancay, Berre; Emmenegger, Marc; Spinelli, Anna; Maggi, Kevin; Chincisan, Andra; Mead, Simon; Hornemann, Simone; Heutink, Peter; Aguzzi, Adriano 分享 收藏
LAG3 is not expressed in human and murine neurons and does not modulate α-synucleinopathies LAG3在人和鼠神经元中不表达，并且不调节 α-突触核蛋白病 Emmenegger, Marc; De Cecco, Elena; Hruska-Plochan, Marian; Eninger, Timo; Schneider, Matthias M.; Barth, Melanie; Tantardini, Elena; de Rossi, Pierre; Bacioglu, Mehtap; Langston, Rebekah G.; Kaganovich, Alice; Bengoa-Vergniory, Nora; Gonzalez-Guerra, Andres; Avar, Merve; Heinzer, Daniel; Reimann, Regina; Haesler, Lisa M.; Herling, Therese W.; Matharu, Naunehal S.; Landeck, Natalie; Luk, Kelvin; Melki, Ronald; Kahle, Philipp J.; Hornemann, Simone; Knowles, Tuomas P. J.; Cookson, Mark R.; Polymenidou, Magdalini; Jucker, Mathias; Aguzzi, Adriano 分享 收藏
The ultrastructure of infectious L-type bovine spongiform encephalopathy prions constrains molecular models Kamali-Jamil, Razieh; Vazquez-Fernandez, Ester; Tancowny, Brian; Rathod, Vineet; Amidian, Sara; Wang, Xiongyao; Tang, Xinli; Fang, Andrew; Senatore, Assunta; Hornemann, Simone; Dudas, Sandor; Aguzzi, Adriano; Young, Howard S.; Wille, Holger 分享 收藏
Scaling analysis reveals the mechanism and rates of prion replication in vivo 尺度分析揭示了朊病毒在体内复制的机制和速率 Meisl, Georg; Kurt, Timothy; Condado-Morales, Itzel; Bett, Cyrus; Sorce, Silvia; Nuvolone, Mario; Michaels, Thomas C. T.; Heinzer, Daniel; Avar, Merve; Cohen, Samuel I. A.; Hornemann, Simone; Aguzzi, Adriano; Dobson, Christopher M.; Sigurdson, Christina J.; Knowles, Tuomas P. J. 分享 收藏
分享 收藏
Autoantibodies against the prion protein in individuals with PRNP mutations Frontzek, Karl; Carta, Manfredi; Losa, Marco; Epskamp, Mirka; Meisl, Georg; Anane, Alice; Brandel, Jean-Philippe; Camenisch, Ulrike; Castilla, Joaquin; Haik, Stephane; Knowles, Tuomas; Lindner, Ewald; Lutterotti, Andreas; Minikel, Eric Vallabh; Roiter, Ignazio; Safar, Jiri G.; Sanchez-Valle, Raquel; Zakova, Dana; Hornemann, Simone; Aguzzi, Adriano 分享 收藏
Protective anti-prion antibodies in human immunoglobulin repertoires Senatore, Assunta; Frontzek, Karl; Emmenegger, Marc; Chincisan, Andra; Losa, Marco; Reimann, Regina; Horny, Geraldine; Guo, Jingjing; Fels, Sylvie; Sorce, Silvia; Zhu, Caihong; George, Nathalie; Ewert, Stefan; Pietzonka, Thomas; Hornemann, Simone; Aguzzi, Adriano 分享 收藏
Prion infection, transmission, and cytopathology modeled in a low-biohazard human cell line Avar, Merve; Heinzer, Daniel; Steinke, Nicolas; Dogancay, Berre; Moos, Rita; Lugan, Severine; Cosenza, Claudia; Hornemann, Simone; Andreoletti, Olivier; Aguzzi, Adriano 分享 收藏
Genome-wide transcriptomics identifies an early preclinical signature of prion infection Sorce, Silvia; Nuvolone, Mario; Russo, Giancarlo; Chincisan, Andra; Heinzer, Daniel; Avar, Merve; Pfammatter, Manuela; Schwarz, Petra; Delic, Mirzet; Muller, Micha; Hornemann, Simone; Sanoudou, Despina; Scheckel, Claudia; Aguzzi, Adriano 分享 收藏
Isolation of infectious, non-fibrillar and oligomeric prions from a genetic prion disease Vanni, Ilaria; Pirisinu, Laura; Acevedo-Morantes, Claudia; Kamali-Jamil, Razieh; Rathod, Vineet; Di Bari, Michele Angelo; D'Agostino, Claudia; Marcon, Stefano; Esposito, Elena; Riccardi, Geraldina; Hornemann, Simone; Senatore, Assunta; Aguzzi, Adriano; Agrimi, Umberto; Wille, Holger; Nonno, Romolo 分享 收藏
分享 收藏
Prion pathogenesis is unaltered in a mouse strain with a permeable blood-brain barrier Keller, Annika; Nuvolone, Mario; Abakumova, Irina; Chincisan, Andra; Reimann, Regina; Avar, Merve; Heinzer, Daniel; Hornemann, Simone; Wagner, Josephin; Kirschenbaum, Daniel; Voigt, Fabian F.; Zhu, Caihong; Regli, Luca; Helmchen, Fritjof; Aguzzi, Adriano 分享 收藏
A bispecific immunotweezer prevents soluble PrP oligomers and abolishes prion toxicity Bardelli, Marco; Frontzek, Karl; Simonelli, Luca; Hornemann, Simone; Pedotti, Mattia; Mazzola, Federica; Carta, Manfredi; Eckhardt, Valeria; D'Antuono, Rocco; Virgilio, Tommaso; Gonzalez, Santiago F.; Aguzzi, Adriano; Varani, Luca 分享 收藏
Inhibition of group-I metabotropic glutamate receptors protects against prion toxicity Goniotaki, Despoina; Lakkaraju, Asvin K. K.; Shrivastava, Amulya N.; Bakirci, Pamela; Sorce, Silvia; Senatore, Assunta; Marpakwar, Rajlakshmi; Hornemann, Simone; Gasparini, Fabrizio; Triller, Antoine; Aguzzi, Adriano 分享 收藏
.png){kind=icon}
未登录.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
