Carlos J. Orihuela - Publications, H-index & Citations

Carlos J. Orihuela

University of Alabama System

49H指数

165论文数

6.7K被引数

收录论文 64

发表时间

Transcriptional regulation of the pneumococcal capsule can dictate serotype-specific infection 肺炎球菌荚膜的转录调控可以决定血清型特异性感染

Nature Communications

IF15.7

2026-03-09

OAAI

Michela Marra; Ozcan Gazioglu; David G. Glanville; Victoria M. Harper-Cummings; Silvia Santana-Krimskaya; Abby R. Kroken; Adonis D’Mello; Feroze A. Ganaie; Moon H. Nahm; Hervé Tettelin; Carlos J. Orihuela; Hasan Yesilkaya; Andrew T. Ulijasz

The Oxylipin Dependent Quorum Sensing System enhances Pseudomonas aeruginosa dissemination during burn-associated infection 氧化脂质依赖的群体感应系统增强铜绿假单胞菌在烧伤相关感染期间的扩散

PLoS Pathogens

IF4.9

2026-01-20

PREAI

Martinez, Eriel; Im, Hansol; Mohasin, Mohammed; Wilson, Landon; Campos-Gomez, Javier; Orihuela, Carlos J.

Multispecies transcriptomics reveals influenza A virus modulation of Streptococcus pneumoniae EF3030 infection in human lung epithelium and murine lung 多组转录组学揭示流感A病毒对肺炎链球菌EF3030在人肺上皮和鼠肺中感染的影响

mSphere

IF3.1

2026-01-01

PREAI

D'Mello, Adonis; Earnhardt, Erin Y.; Lane, Jessica R.; Tipper, Jennifer L.; Martinez, Eriel; Prokopczuk, Federico I.; Im, Hansol; Roussey, Holly N.; Harrod, Kevin S.; Orihuela, Carlos J.; Tettelin, Herve

Allele-specific zinc metalloprotease B influences cardiac damage during invasive pneumococcal disease 等位基因特异性锌金属蛋白酶B影响侵袭性肺炎球菌疾病期间的心脏损伤

Cell Reports

IF6.9

2025-12-04

OAAI

Jennifer N. Luck; Adonis D’Mello; Vipin Chembilikandy; Jessica R. Lane; Katherine Kruckow; Eriel Martínez; Efrain Rodriguez; Mohammed Mohasin; Ian Berg; Katherine D. Porter; Palanappian Sethu; Hervé Tettelin; Carlos J. Orihuela

CXCR3 promotes development of heart failure following severe pneumococcal disease

JOURNAL OF IMMUNOLOGY

IF3.4

2025-11-01

PREAI

Minassian, Daniel; Tousif, Sultan; Sterndorf, Hannah P.; Wilson, Christopher Garrett; Weaver, Casey T.; Erdmann, Nathan; He, Chao; Xie, Min; Lal, Hind; Orihuela, Carlos J.

S100A8/9-NLRP3-mediated chronic unresolved inflammation drives cardiac pathologies following invasive pneumococcal disease S100A8/9-NLRP3介导的慢性难愈性炎症在侵袭性肺炎链球菌疾病后驱动心脏病理变化

Experimental & Molecular Medicine

IF12.9

2025-10-10

OAAI

Sultan Tousif; Daniel Minassian; Chao He; Baldeep Singh; Prachi Umbarkar; Arvind Singh Bhati; Mohammed Mohasin; Nathan Erdmann; Min Xie; Palaniappan Sethu; Carlos J. Orihuela; Hind Lal

Streamlining marker-less allelic replacement in Streptococcus pneumoniae through a single transformation step strategy: easyJanus

APPLIED AND ENVIRONMENTAL MICROBIOLOGY

IF3.7

2024-09-18

PREAI

Chembilikandy, Vipin; D'Mello, Adonis; Tettelin, Herve; Martinez, Eriel; Orihuela, Carlos J.

Characterization of Transcriptional Responses to Streptococcus pneumoniae Infection in the Heart versus Sterile Cardiac Injury

CIRCULATION RESEARCH

IF16.2

2024-08-02

PREAI

Minassian, Daniel; Wilson, Garrett; Weaver, Casey; Orihuela, Carlos

Chronic TNF exposure induces glucocorticoid-like immunosuppression in the alveolar macrophages of aged mice that enhances their susceptibility to pneumonia

AGING CELL

IF7.1

2024-03-08

OAAI

Kruckow, Katherine L.; Murray, Elizabeth; Shayhidin, Elnur; Rosenberg, Alexander F.; Bowdish, Dawn M. E.; Orihuela, Carlos J.

Community-acquired bacterial coinfections and COVID-19

PHYSIOLOGICAL REVIEWS

IF28.7

2024-01-01

PREAI

Patton, Michael John; Gaggar, Amit; Might, Matthew; Erdmann, Nathaniel; Orihuela, Carlos J.; Harrod, Kevin S.

PspA-mediated aggregation protects Streptococcus pneumoniae against desiccation on fomites PspA介导的聚集保护肺炎链球菌免受fomites干燥

MBIO

IF4.7

2023-12-19

OAAI

Lane, Jessica R.; Tata, Muralidhar; Yasmin, Rahena; Im, Hansol; Briles, David E.; Orihuela, Carlos J.

Mechanistic Insights Into Cardiac Dysfunction And Remodeling Associated With Invasive Pneumococcal Pathogenesis

CIRCULATION RESEARCH

IF16.2

2023-08-04

PREAI

Sultan, Tousif; Minassian, Daniel; Umbarkar, Prachi; He, Chao; Xie, Min; Sethu, Palaniappan; Orihuela, Carlos J.; Lal, Hind

Influenza A-induced cystic fibrosis transmembrane conductance regulator dysfunction increases susceptibility to Streptococcus pneumoniae

JCI INSIGHT

IF6.1

2023-07-24

OAAI

Earnhardt, Erin Y.; Tipper, Jennifer L.; D'Mello, Adonis; Jian, Ming -Yuan; Conway, Elijah S.; Mobley, James A.; Orihuela, Carlos J.; Tettelin, Herve; Harrod, Kevin S.

Engineered Superinfective Pf Phage Prevents Dissemination of Pseudomonas aeruginosa in a Mouse Burn Model

MBIO

IF4.7

2023-06-27

OAAI

Prokopczuk, Federico I. I.; Im, Hansol; Campos-Gomez, Javier; Orihuela, Carlos J. J.; Martinez, Eriel

Acute organ injury and long-term sequelae of severe pneumococcal infections

PNEUMONIA

IF6.2

2023-03-05

OAAI

Kruckow, Katherine L.; Zhao, Kevin; Bowdish, Dawn M. E.; Orihuela, Carlos J.

COVID-19 bacteremic co-infection is a major risk factor for mortality, ICU admission, and mechanical ventilation

CRITICAL CARE

IF9.3

2023-01-23

OAAI

Patton, Michael John; Orihuela, Carlos J.; Harrod, Kevin S.; Bhuiyan, Mohammad A. N.; Dominic, Paari; Kevil, Christopher G.; Fort, Daniel; Liu, Vincent X. X.; Farhat, Maha; Koff, Jonathan L.; Lal, Charitharth V.; Gaggar, Anuj; Richter, Robert P.; Erdmann, Nathaniel; Might, Matthew; Gaggar, Amit

Capsule Promotes Intracellular Survival and Vascular Endothelial Cell Translocation during Invasive Pneumococcal Disease

MBIO

IF4.7

2021-10-26

OAAI

Brissac, Terry; Martinez, Eriel; Kruckow, Katherine L.; Riegler, Ashleigh N.; Ganaie, Feroze; Im, Hansol; Bakshi, Sayan; Arroyo-Diaz, Nicole M.; Spencer, Brady L.; Saad, Jamil S.; Nahm, Moon H.; Orihuela, Carlos J.

Splenic macrophages as the source of bacteraemia during pneumococcal pneumonia

EBIOMEDICINE

IF10.8

2021-10-01

OAAI

Carreno, David; Wanford, Joseph J.; Jasiunaite, Zydrune; Hames, Ryan G.; Chung, Wen Y.; Dennison, Ashley R.; Straatman, Kornelis; Martinez-Pomares, Luisa; Pareek, Manish; Orihuela, Carlos J.; Restrepo, Marcos, I; Lim, Wei Shen; Andrew, Peter W.; Moxon, E. Richard; Oggioni, Marco R.

Streptococcus pneumoniae Binds to Host Lactate Dehydrogenase via PspA and PspC To Enhance Virulence 肺炎链球菌通过PspA和PspC与宿主乳酸脱氢酶结合增强毒力

MBIO

IF4.7

2021-06-29

OAAI

Park, Sang-Sang; Gonzalez-Juarbe, Norberto; Martinez, Eriel; Hale, Joanetha Yvette; Lin, Yi-Han; Huffines, Joshua T.; Kruckow, Katherine L.; Briles, David E.; Orihuela, Carlos J.

Streptococcus pneumoniae binds to host GAPDH on dying lung epithelial cells worsening secondary infection following influenza

CELL REPORTS

IF6.9

2021-06-01

OAAI

Park, Sang-Sang; Gonzalez-Juarbe, Norberto; Riegler, Ashleigh N.; Im, Hansol; Hale, Yvette; Platt, Maryann P.; Croney, Christina; Briles, David E.; Orihuela, Carlos J.

研究方向