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From image to insight: optimized multiplex staining panel for formalin-fixed, paraffin-embedded mouse bone marrow enables spatial profiling of the hematopoietic niche 从图像到见解：优化的多色染色方案用于甲醛固定、石蜡包埋的鼠骨髓，可实现造血微环境的空间表征 Zell, Franziska; Gellrich, Katharina; Grunder, Albert; Schulze, Jana; Muller, Anja; Eble, Philipp; Preiss, Fiona; Grafemeyer, Annika; Koellerer, Christoph; Staehle, Anne Marie; Kovacs, Sarolta Bojtine; Kovalchuk, Sofia; Erny, Elias; Orcinha, Catarina Reis; Illert, Lena; Pahl, Heike L.; Staehle, Hans Felix 分享 收藏
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CSF3RT6181 Is Stabilized By Calnexin and Induces Unfolded Protein Response (UPR) and ER-Phagy: A Pro-Survival Pathway for Oncogenic Misfolded CSF3R Proteins in Chronic Neutrophilic Leukemia (CNL) CSF3RT6181被Calnexin稳定，并诱导未折叠蛋白反应（UPR）和ER-Phagy：一种慢性中性粒细胞白血病（CNL）中致癌性错误折叠CSF3R蛋白的促生存通路。 Hartke, Alessandra; Klotz, Julia; Kuenstner, Axel; Faehnrich, Anke; Busch, Hauke; Gemoll, Timo; Osius, Jasmin; Koschmieder, Steffen; Brummendorf, Tim H. H.; Pahl, Heike L.; Heidel, Florian H.; Doehner, Konstanze; Griesshammer, Martin; Reiter, Andreas; Duyster, Justus; Bubnoff, Nikolas C. C. von; Gorantla, Sivahari P. 分享 收藏
Oncogene-induced TIM-3 ligand expression dictates susceptibility to anti-TIM-3 therapy in mice 癌基因诱导的TIM-3配体表达决定了小鼠对anti-TIM-3治疗的敏感性 Talvard-Balland, Nana; Braun, Lukas M.; Dixon, Karen O.; Zwick, Melissa; Engel, Helena; Hartmann, Alina; Duquesne, Sandra; Penter, Livius; Andrieux, Geoffroy; Rindlisbacher, Lukas; Acerbis, Andrea; Ehmann, Jule; Koellerer, Christoph; Ansuinelli, Michela; Rettig, Andres; Moschallski, Kevin; Apostolova, Petya; Brummer, Tilman; Illert, Anna L.; Schramm, Markus A.; Cheng, Yurong; Koettgen, Anna; Duyster, Justus; Menssen, Hans D.; Ritz, Jerome; Blazar, Bruce R.; Boerries, Melanie; Schmitt-Graeff, Annette; Sariipek, Nurefsan; Van Galen, Peter; Buescher, Joerg M.; Cabezas-Wallscheid, Nina; Pahl, Heike L.; Pearce, Erika L.; Soiffer, Robert J.; Wu, Catherine J.; Vago, Luca; Becher, Burkhard; Koehler, Natalie; Wertheimer, Tobias; Kuchroo, Vijay K.; Zeiser, Robert 分享 收藏
Oncogenic Calreticulin Induces Immune Escape by Stimulating TGFβ Expression and Regulatory T-cell Expansion in the Bone Marrow Microenvironment 致癌钙网蛋白通过刺激骨髓微环境中tgf β 表达和调节性T细胞扩增诱导免疫逃逸 Schmidt, Dominik; Endres, Cornelia; Hoefflin, Rouven; Andrieux, Geoffroy; Zwick, Melissa; Karantzelis, Nikolaos; Staehle, Hans F.; Vinnakota, Janaki Manoja; Duquesne, Sandra; Mozaffari Jovein, Miriam; Pfeifer, Dietmar; Becker, Heiko; Blazar, Bruce R.; Zaehringer, Alexander; Duyster, Justus; Brummer, Tilman; Boerries, Melanie; Baumeister, Julian; Shoumariyeh, Khalid; Li, Juan; Green, Anthony R.; Heidel, Florian H.; Tirosh, Itay; Pahl, Heike L.; Leimkuehler, Nils; Koehler, Natalie; de Toledo, Marcelo A. S.; Koschmieder, Steffen; Zeiser, Robert 分享 收藏
GPRC5C drives branched-chain amino acid metabolism in leukemogenesis Zhang, Yu Wei; Mess, Julian; Lalioti, Maria-Eleni; Romero-Mulero, Mari Carmen; Velasco-Hernandez, Talia; Obier, Nadine; Karantzelis, Nikolaos; Rettkowski, Jasmin; Schoenberger, Katharina; Karabacz, Noemie; Jaecklein, Karin; Morishima, Tatsuya; Trincado, Juan Luis; Romecin, Paola; Martinez, Alba; Takizawa, Hitoshi; Shoumariyeh, Khalid; Renders, Simon; Zeiser, Robert; Pahl, Heike L.; Beliveau, Francois; Hebert, Josee; Lehnertz, Bernhard; Sauvageau, Guy; Menendez, Pablo; Cabezas-Wallscheid, Nina 分享 收藏
Real-world analysis of ruxolitinib in myelofibrosis: interim results focusing on patients who were naive to JAK inhibitor therapy treated within the JAKoMo non-interventional, phase IV trial Koschmieder, Steffen; Isfort, Susanne; Schulte, Clemens; Jacobasch, Lutz; Geer, Thomas; Reiser, Marcel; Koenigsmann, Michael; Heinrich, Bernhard; Wehmeyer, Jurgen; von der Heyde, Eyck; Tesch, Hans; Groeschl, Benedikt; Bachhuber, Petra; Grosser, Susanne; Pahl, Heike L. 分享 收藏
The histone demethylase JMJD2C constitutes a novel NFE2 target gene that is required for the survival of JAK2V617F mutated cells Staehle, Anne Marie; Peeken, Jan Caspar; Vladimirov, Georg; Hoeness, Mirjam Elisabeth; Kovacs, Sarolta Bojtine; Karantzelis, Nikolaos; Gruender, Albert; Koellerer, Christoph; Jutzi, Jonas Samuel; Pahl, Heike Luise; Staehle, Hans Felix 分享 收藏
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Enhanced expression of the sphingosine-1-phosphate-receptor-3 causes acute myelogenous leukemia in mice Vorbach, Samuel; Gruender, Albert; Zhou, Fengbiao; Koellerer, Christoph; Jutzi, Jonas S.; Simoni, Manuela; Riccetti, Laura; Valk, Peter J.; Sanders, Mathijs A.; Mueller-Tidow, Carsten; Nofer, Jerzy-Roch; Pahl, Heike L.; Poti, Francesco 分享 收藏
Gab2 is Essential for Transformation by FLT3-ITD in Acute Myeloid Leukemia Sies, Katharina; Spohr, Corinna; Gruender, Albert; Todorova, Rumyana; Uhl, Franziska Maria; Huber, Julia; Zeiser, Robert; Pahl, Heike Luise; Becker, Heiko; Aumann, Konrad; Brummer, Tilman; Halbach, Sebastian 分享 收藏
Oncogenic JAK2V617F causes PD-L1 expression, mediating immune escape in myeloproliferative neoplasms 致瘤性JAK2V617F引起PD-L1表达，介导骨髓增殖性肿瘤的免疫逃逸 Prestipino, Alessandro; Emhardt, Alica J.; Aumann, Konrad; O'Sullivan, David; Gorantla, Sivahari P.; Duquesne, Sandra; Melchinger, Wolfgang; Braun, Lukas; Vuckovic, Slavica; Boerries, Melanie; Busch, Hauke; Halbach, Sebastian; Pennisi, Sandra; Poggio, Teresa; Apostolova, Petya; Veratti, Pia; Hettich, Michael; Niedermann, Gabriele; Bartholomae, Mark; Shoumariyeh, Khalid; Jutzi, Jonas S.; Wehrle, Julius; Dierks, Christine; Becker, Heiko; Schmitt-Graeff, Annette; Follo, Marie; Pfeifer, Dietmar; Rohr, Jan; Fuchs, Sebastian; Ehl, Stephan; Hartl, Frederike A.; Minguet, Susana; Miething, Cornelius; Heidel, Florian H.; Kroeger, Nicolaus; Triviai, Ioanna; Brummer, Tilman; Finke, Jurgen; Illert, Anna L.; Ruggiero, Eliana; Bonini, Chiara; Duyster, Justus; Pahl, Heike L.; Lane, Steven W.; Hill, Geoffrey R.; Blazar, Bruce R.; von Bubnoff, Nikolas; Pearce, Erika L.; Zeiser, Robert 分享 收藏
Associations between gender, disease features and symptom burden in patients with myeloproliferative neoplasms: an analysis by the MPN QOL International Working Group Geyer, Holly L.; Kosiorek, Heidi; Dueck, Amylou C.; Scherber, Robyn; Slot, Stefanie; Zweegman, Sonja; te Boekhorst, Peter A. W.; Senyak, Zhenya; Schouten, Harry C.; Sackmann, Federico; Kerguelen Fuentes, Ana; Hernandez-Maraver, Dolores; Pahl, Heike L.; Griesshammer, Martin; Stegelmann, Frank; Doehner, Konstanze; Lehmann, Thomas; Bonatz, Karin; Reiter, Andreas; Boyer, Francoise; Etienne, Gabriel; Ianotto, Jean-Christophe; Ranta, Dana; Roy, Lydia; Cahn, Jean-Yves; Harrison, Claire N.; Radia, Deepti; Muxi, Pablo; Maldonado, Norman; Besses, Carlos; Cervantes, Francisco; Johansson, Peter L.; Barbui, Tiziano; Barosi, Giovanni; Vannucchi, Alessandro M.; Paoli, Chiara; Passamonti, Francesco; Andreasson, Bjorn; Ferrari, Maria L.; Rambaldi, Alessandro; Samuelsson, Jan; Cannon, Keith; Birgegard, Gunnar; Xiao, Zhijian; Xu, Zefeng; Zhang, Yue; Sun, Xiujuan; Xu, Junqing; Kiladjian, Jean-Jacques; Zhang, Peihong; Gale, Robert Peter; Mesa, Ruben A. 分享 收藏
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Myeloproliferative neoplasms and inflammation: whether to target the malignant clone or the inflammatory process or both Koschmieder, S.; Mughal, T. I.; Hasselbalch, H. C.; Barosi, G.; Valent, P.; Kiladjian, J-J; Jeryczynski, G.; Gisslinger, H.; Jutzi, J. S.; Pahl, H. L.; Hehlmann, R.; Vannucchi, A. Maria; Cervantes, F.; Silver, R. T.; Barbui, T. 分享 收藏
Ptch2 loss drives myeloproliferation and myeloproliferative neoplasm progression Klein, Claudius; Zwick, Anabel; Kissel, Sandra; Forster, Christine Ulrike; Pfeifer, Dietmar; Follo, Marie; Illert, Anna Lena; Decker, Sarah; Benkler, Thomas; Pahl, Heike; Oostendorp, Robert A. J.; Aumann, Konrad; Duyster, Justus; Dierks, Christine 分享 收藏
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