David A. Scott - Publications, H-index & Citations

David A. Scott

Sanford Burnham Prebys Medical Discovery Institute

47H指数

174论文数

1.1W被引数

收录论文 76

发表时间

PI5P4Kα promotes glucose and iron acquisition to support metabolic fitness in pancreatic cancer PI5P4Kα促进葡萄糖和铁的获取以支持胰腺癌的代谢适应性

Cell Reports

IF6.9

2025-08-29

PREAI

Gurpreet K. Arora; Ryan M. Loughran; Kyanh Ly; Cheska Marie Galapate; Alicia Llorente; Taylor R. Anderson; Cynthia Y. Zhang; Shea F. Grenier; Li Ling; Sophia Crabtree; Guillem Lambies; Chantal Pauli; David A. Scott; Yoav Altman; Benji Portillo; Rabi Murad; Cosimo Commisso; Brooke M. Emerling

Macropinocytosis maintains CAF subtype identity under metabolic stress in pancreatic cancer 巨胞饮作用在代谢应激条件下维持胰腺癌中CAF亚型特性

Cancer Cell

IF44.5

2025-07-24

OAAI

Yijuan Zhang; Li Ling; Rabi Murad; Swetha Maganti; Ambroise Manceau; Hannah A. Hetrick; Madelaine Neff; Cheska Marie Galapate; Shea F. Grenier; Florent Carrette; Karen Duong-Polk; Anindya Bagchi; David A. Scott; Yoav Altman; Jennifer L. Hope; Andrew M. Lowy; Linda M. Bradley; Cosimo Commisso

Self-amplifying NRF2–EZH2 epigenetic loop converts KRAS-initiated progenitors to invasive pancreatic cancer 自扩增NRF2-EZH2表观遗传环将KRAS启动的祖细胞转化为侵袭性胰腺癌

Nature Cancer

IF28.5

2025-06-30

PREAI

Laura Antonucci; Na Li; Angeles Duran; Isidoro Cobo; Chiara Nicoletti; Kosuke Watari; Shuvro Prokash Nandi; Feng Zhu; Yongmei Zhao; Irene Riahi; Motoyuki Tsuda; Vidhi M. Shah; Terry Morgan; Trent Waugh; Luca Caputo; Yuan Liu; Alexandra Rundberg Nilsson; Hongxu Xian; Jelena Todoric; Li Gu; Elsa Sanchez-Lopez; Guido Eibl; Emily A. Vucic; Michal Krawczyk; Qianlan Xu; Andrew M. Lowy; Georgia Hatzivassiliou; Merone Roose-Girma; Dorota Skowronska-Krawczyk; David A. Scott; Dafna Bar-Sagi; Pablo Tamayo; Ying Wu; Rosalie C. Sears; Christopher K. Glass; Ludmil B. Alexandrov; Pier Lorenzo Puri; David W. Dawson; Yinling Hu; Maria T. Diaz-Meco; Jorge Moscat; Michael Karin

Metabolic deficiencies underlie reduced plasmacytoid dendritic cell IFN-I production following viral infection 病毒感染后，代谢缺陷是导致浆细胞样树突状细胞IFN-I产生减少的基础。

NATURE COMMUNICATIONS

IF15.7

2025-02-07

OAAI

Greene, Trever T.; Jo, Yeara; Chiale, Carolina; Macal, Monica; Fang, Ziyan; Khatri, Fawziyah S.; Codrington, Alicia L.; Kazane, Katelynn R.; Akbulut, Elizabeth; Swaminathan, Shobha; Fujita, Yu; Fitzgerald-Bocarsly, Patricia; Cordes, Thekla; Metallo, Christian; Scott, David A.; Zuniga, Elina I.

Cell polarity proteins promote macropinocytosis in response to metabolic stress

NATURE COMMUNICATIONS

IF15.7

2024-12-03

OAAI

Lambies, Guillem; Lee, Szu-Wei; Duong-Polk, Karen; Aza-Blanc, Pedro; Maganti, Swetha; Galapate, Cheska M.; Deshpande, Anagha; Deshpande, Aniruddha J.; Scott, David A.; Dawson, David W.; Commisso, Cosimo

Aberrant BCAT1 expression augments MTOR activity and accelerates disease progression in chronic lymphocytic leukemia (Oct, 10.1038/s41375-024-02448-8, 2024)

LEUKEMIA

IF13.4

2024-11-13

OAAI

Shao, Qiangqiang; Wykretowicz, Jedrzej; Hu, Nan; Bedi, Karan; Rizk, Mohamed; Malek, Isabella A.; Kumar, Surinder; Lombard, David B.; Shedden, Kerby; Scott, David; Malek, Sami N.

Aberrant BCAT1 expression augments MTOR activity and accelerates disease progression in chronic lymphocytic leukemia

LEUKEMIA

IF13.4

2024-10-25

OAAI

Shao, Qiangqiang; Wykretowicz, Jedrzej; Hu, Nan; Bedi, Karan; Rizk, Mohamed; Malek, Isabella A.; Kumar, Surinder; Lombard, David B.; Shedden, Kerby; Scott, David; Malek, Sami N.

PI5P4Kα regulates cell fitness through iron homeostasis in pancreatic cancer

CANCER RESEARCH

IF16.6

2024-09-15

PREAI

Arora, Gurpreet Kaur; Loughran, Ryan; Ly, Kyanh; Galapate, Cheska Marie; Llorente, Alicia; Anderson, Taylor R.; Pauli, Chantal; Scott, David A.; Altman, Yoav; Commisso, Cosimo; Emerling, Brooke M.

Control of melanoma development by B. rodentium in germ free mice

CANCER RESEARCH

IF16.6

2024-03-22

PREAI

Olea, Ximena Diaz; Beede, Kristin; Osterman, Andrei; Scott, David; Petucci, Christopher; Kelly, Daniel; Ramer-Tait, Amanda; Ronai, Ze'ev A.

Investigating the phenotypic changes in in vitro and in vivo cancer models expressing isocitrate dehydrogenase 1 (IDH1) mutations R132H and R132Q

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

IF3.4

2023-12-01

PREAI

Adam, Mowaffaq A. A.; Robinson, Mikella; Hoang, An; Wells, Grace A.; Scott, David A.; Zagnitko, Olga; House, Carrie; Sohl, Christal D.

Glutamine mimicry suppresses tumor progression through asparagine metabolism in pancreatic ductal adenocarcinoma 谷氨酰胺模拟通过天冬酰胺代谢抑制胰腺导管腺癌的肿瘤进展

NATURE CANCER

IF28.5

2023-10-09

OAAI

Recouvreux, Maria Victoria; Grenier, Shea F.; Zhang, Yijuan; Esparza, Edgar; Lambies, Guillem; Galapate, Cheska Marie; Maganti, Swetha; Duong-Polk, Karen; Bhullar, Deepika; Naeem, Razia; Scott, David A.; Lowy, Andrew M.; Tiriac, Herve; Commisso, Cosimo

Asparagine restriction enhances CD8+ T cell metabolic fitness and antitumoral functionality through an NRF2-dependent stress response 天冬酰胺限制通过NRF2-dependent应激反应增强CD8 T细胞代谢适应性和抗肿瘤功能

NATURE METABOLISM

IF20.8

2023-08-07

OAAI

Gnanaprakasam, J. N. Rashida; Kushwaha, Bhavana; Liu, Lingling; Chen, Xuyong; Kang, Siwen; Wang, Tingting; Cassel, Teresa A.; Adams, Christopher M.; Higashi, Richard M.; Scott, David A.; Xin, Gang; Li, Zihai; Yang, Jun; Lane, Andrew N.; Fan, Teresa W. -M.; Zhang, Ji; Wang, Ruoning

OGT controls mammalian cell viability by regulating the proteasome/mTOR/ mitochondrial axis

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2023-01-10

OAAI

Li, Xiang; Yue, Xiaojing; Sepulveda, Hugo; Burt, Rajan A.; Scott, David A.; Carr, Steven A.; Myers, Samuel A.; Rao, Anjana

GAB functions as a bioenergetic and signalling gatekeeper to control T cell inflammation

NATURE METABOLISM

IF20.8

2022-10-03

OAAI

Kang, Siwen; Liu, Lingling; Wang, Tingting; Cannon, Matthew; Lin, Penghui; Fan, Teresa W. -M.; Scott, David A.; Wu, Hsin-Jung Joyce; Lane, Andrew N.; Wang, Ruoning

Origin of cytoplasmic GDP-fucose determines its contribution to glycosylation reactions

JOURNAL OF CELL BIOLOGY

IF6.4

2022-09-02

OAAI

Sosicka, Paulina; Ng, Bobby G.; Pepi, Lauren E.; Shajahan, Asif; Wong, Maurice; Scott, David A.; Matsumoto, Kenjiroo; Xia, Zhi-Jie; Lebrilla, Carlito B.; Haltiwanger, Robert S.; Azadi, Parastoo; Freeze, Hudson H.

NRF2 mediates melanoma addiction to GCDH by modulating apoptotic signalling

NATURE CELL BIOLOGY

IF19.1

2022-09-01

OAAI

Verma, Sachin; Crawford, David; Khateb, Ali; Feng, Yongmei; Sergienko, Eduard; Pathria, Gaurav; Ma, Chen-Ting; Olson, Steven H.; Scott, David; Murad, Rabi; Ruppin, Eytan; Jackson, Michael; Ronai, Ze'ev A.

A stromal Integrated Stress Response activates perivascular cancer-associated fibroblasts to drive angiogenesis and tumour progression

NATURE CELL BIOLOGY

IF19.1

2022-06-02

OAAI

Verginadis, Ioannis I.; Avgousti, Harris; Monslow, James; Skoufos, Giorgos; Chinga, Frank; Kim, Kyle; Leli, Nektaria Maria; Karagounis, Ilias V.; Bell, Brett I.; Velalopoulou, Anastasia; Salinas, Carlo Salas; Wu, Victoria S.; Li, Yang; Ye, Jiangbin; Scott, David A.; Osterman, Andrei L.; Sengupta, Arjun; Weljie, Aalim; Huang, Menggui; Zhang, Duo; Fan, Yi; Radaelli, Enrico; Tobias, John W.; Rambow, Florian; Karras, Panagiotis; Marine, Jean-Christophe; Xu, Xiaowei; Hatzigeorgiou, Artemis G.; Ryeom, Sandra; Diehl, J. Alan; Fuchs, Serge Y.; Pure, Ellen; Koumenis, Constantinos

Succinate dehydrogenase/complex II is critical for metabolic and epigenetic regulation of T cell proliferation and inflammation 琥珀酸脱氢酶/复合物II对T细胞增殖和炎症的代谢和表观遗传调控至关重要

SCIENCE IMMUNOLOGY

IF16.3

2022-04-15

OAAI

Chen, Xuyong; Sunkel, Benjamin; Wang, Meng; Kang, Siwen; Wang, Tingting; Gnanaprakasam, J. N. Rashida; Liu, Lingling; Cassel, Teresa A.; Scott, David A.; Munoz-Cabello, Ana M.; Lopez-Barneo, Jose; Yang, Jun; Lane, Andrew N.; Xin, Gang; Stanton, Benjamin Z.; Fan, Teresa W. -M.; Wang, Ruoning

Experiments from unfinished Registered Reports in the Reproducibility Project: Cancer Biology

ELIFE

IF0

2021-12-07

OAAI

Errington, Timothy M.; Denis, Alexandria; Allison, Anne B.; Araiza, Renee; Aza-Blanc, Pedro; Bower, Lynette R.; Campos, Jessica; Chu, Heidi; Denson, Sarah; Donham, Cristine; Harr, Kaitlyn; Haven, Babette; Iorns, Elizabeth; Kwok, Jennie; McDonald, Elysia; Pelech, Steven; Perfito, Nicole; Pike, Amanda; Sampey, Darryl; Settles, Michael; Scott, David A.; Sharma, Vidhu; Tolentino, Todd; Trinh, Angela; Tsui, Rachel; Willis, Brandon; Wood, Joshua; Young, Lisa

The deacylase SIRT5 supports melanoma viability by influencing chromatin dynamics

JOURNAL OF CLINICAL INVESTIGATION

IF13.6

2021-06-15

OAAI

Giblin, William; Bringman-Rodenbarger, Lauren; Guo, Angela H.; Kumar, Surinder; Monovich, Alexander C.; Mostafa, Ahmed M.; Skinner, Mary E.; Azar, Michelle; Mady, Ahmed S. A.; Chung, Carolina H.; Kadambi, Namrata; Melong, Keith-Allen; Lee, Ho-Joon; Zhang, Li; Sajjakulnukit, Peter; Trefely, Sophie; Varner, Erika L.; Iyer, Sowmya; Wang, Min; Wilmott, James S.; Soyer, H. Peter; Sturm, Richard A.; Pritchard, Antonia L.; Andea, Aleodor A.; Scolyer, Richard A.; Stark, Mitchell S.; Scott, David A.; Fullen, Douglas R.; Bosenberg, Marcus W.; Chandrasekaran, Sriram; Nikolovska-Coleska, Zaneta; Verhaegen, Monique E.; Snyder, Nathaniel W.; Rivera, Miguel N.; Osterman, Andrei L.; Lyssiotis, Costas A.; Lombard, David B.

研究方向