logo
科言猫学术研究的AI总结
language
手机端手机端
  • Phone Feature微信小程序
简体中文简体中文
notice消息通知
博客博客
delete
arrow
返回
T

Thomas J. Gardella

massachusetts general hospital

56H指数
204论文数
9.5K被引数
收录论文 89
发表时间
logo
Spatial control of parathyroid hormone receptor-1 signaling dictates ligand-specific biological outcomes甲状旁腺激素受体-1信号的空间调控决定了配体特异性生物学结果
errSignal Transduction and Targeted Therapy
IF52.7
err2026-09-11
err0
errOAAI
errJakob Höppner; Harald Jüppner; Monica Reyes; Prem Swaroop Yadav; Dian Wang; Thomas Dean; Patrick Hanna; Roberto Civitelli; Asuka Inoue; Ernestina Schipani; Ignacio Portales-Castillo; Thomas J. Gardella
err分享
err收藏
Hypoparathyroidism: translating science from the laboratory to the clinic甲状旁腺功能减退症：从实验室到临床的科学转化
errLancet Diabetes & Endocrinology
IF41.8
err2026-09-07
err0
PREAI
errMaria Luisa Brandi; Hajar AbuAlrob; Wenhan Chang; Bart L Clarke; Michael T Collins; Richard DiMarchi; Thomas J Gardella; Caroline Gorvin; Diane Krause; Michael A Levine; Michael Mannstadt; Francesca Marini; Kelly Roszko; Heide Siggelkow; Karen K Winer; Hao Zuo; Aliya A Khan
err分享
err收藏
Regulation of cAMP levels in osteocytes by mechano-sensitive focal adhesion kinase and phosphodiesterase 8A机械敏感性 focal adhesion kinase 和 phosphodiesterase 8A 对成骨细胞中 cAMP 水平的调控
erriScience
IF4.1
err2026-05-22
err0
errOAAI
errGaryfallia Papaioannou; Tadatoshi Sato; Caroline Houghton; Chuanqing Yan; Parthena E. Kotsalidis; Katelyn E. Strauss; Thomas Dean; Courtney M. Mazur; Alissa J. Nelson; Matthew P. Stokes; Thomas J. Gardella; Marc N. Wein
err分享
err收藏
Altered Intracellular Trafficking as a Mechanism for Prolonged Duration of G Protein-Coupled Receptor Activation细胞内转运改变作为延长G蛋白偶联受体激活持续时间的机制
errJournal of the American Chemical Society
IF15.6
err2026-05-20
err0
errOAAI
errTae Wook Kim; Elliot J. Gerrard; Jeeeun Shin; Thomas J. Gardella; Denise Wootten; Patrick M. Sexton; Brian P. Cary; Samuel H. Gellman
err分享
err收藏
How ligands tune the parathyroid hormone receptor's grip on β-arrestin配体如何调节甲状旁腺激素受体对β-抑制蛋白的抓握力
errNATURE STRUCTURAL & MOLECULAR BIOLOGY
IF10.1
err2026-05-01
err0
PREAI
errHoppner, Jakob; Gardella, Thomas J.
err分享
err收藏
A novel brachydactyly type E syndrome caused by variants in helix 8 of the PTH1R由PTH1R螺旋8的变异引起的一种新型E型短指(趾)畸形综合征
errJOURNAL OF BONE AND MINERAL RESEARCH
IF5.9
err2025-12-01
err0
PREAI
errMonahan, Gavin; Hoppner, Jakob; Juppner, Harald; Rick, Audrey; McNamara, Elyshia; Tee, William; Lay-Son, Guillermo; Contreras, Andy; Martinez, Alejandro; Garcia, Cristian; Vildoso, Javiera; Gardella, Thomas J.; Kamien, Benjamin; Ravenscroft, Gianina
err分享
err收藏
Human diseases caused by homozygous PTH1R mutations由纯合PTH1R基因突变引起的人类疾病
errFrontiers in Endocrinology
IF4.6
err2025-08-20
err0
errOAAI
errIgnacio Portales-Castillo; Jakob Höppner; Harald Jüppner; Thomas J. Gardella
err分享
err收藏
Prolonging parathyroid hormone analog action in vitro and in vivo through peptide lipidation通过肽脂化在体外和体内延长甲状旁腺激素类似物的药效
errNATURE COMMUNICATIONS
IF15.7
err2025-05-14
err0
errOAAI
errHoppner, Jakob; Noda, Hiroshi; Anitha, Anju Krishnan; Cheloha, Ross W.; Dean, Thomas; Bruce, Michael; Brooks, Daniel J.; Mannstadt, Michael; Bouxsein, Mary L.; Gellman, Samuel H.; Khatri, Ashok; Juppner, Harald; Gardella, Thomas J.
err分享
err收藏
Eiken syndrome with parathyroid hormone resistance due to a novel parathyroid hormone receptor type 1 mutation: clinical features and functional analysis
errJOURNAL OF BONE AND MINERAL RESEARCH
IF5.9
err2024-09-14
err0
PREAI
errCalder, Alistair D.; Allgrove, Jeremy; Hoppner, Jakob; Cheung, Moira; Alexander, Saji; Garagnani, Lorenzo; Thakker, Rajesh; Juppner, Harald; Gardella, Thomas J.; Holder-Espinasse, Muriel
err分享
err收藏
Highly biased agonism for GPCR ligands via nanobody tethering
errNATURE COMMUNICATIONS
IF15.7
err2024-06-01
err2
errOAAI
errSachdev, Shivani; Creemer, Brendan A.; Gardella, Thomas J.; Cheloha, Ross W.
err分享
err收藏
Backbone Modification Provides a Long-Acting Inverse Agonist of Pathogenic, Constitutively Active PTH1R Variants
errJOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
err2024-02-28
err1
PREAI
errLiu, Shi; Daley, Eileen J.; Tran, Lauren My-Linh; Yu, Zhen; Reyes, Monica; Dean, Thomas; Khatri, Ashok; Levine, Paul M.; Balana, Aaron T.; Pratt, Matthew R.; Juppner, Harald; Gellman, Samuel H.; Gardella, Thomas J.
err分享
err收藏
Substantially Delayed Maturation of Growth Plate Chondrocytes in Humanized PTH1R Mice with the H223R Mutation of Jansen's Disease具有Jansen病H223R突变的人源化PTH1R小鼠的生长板软骨细胞的成熟大大延迟
errJBMR PLUS
IF2.4
err2023-08-15
err4
errOAAI
errReyes, Monica; Firat, Damla; Hanna, Patrick; Khan, Mohd; Bruce, Michael; Shvedova, Maria; Kobayashi, Tatsuya; Schipani, Ernestina; Gardella, Thomas J.; Juppner, Harald
err分享
err收藏
Altered Signaling and Desensitization Responses in PTH1R Mutants Associated with Eiken Syndrome
errCOMMUNICATIONS BIOLOGY
IF5.1
err2023-06-02
err5
errOAAI
errPortales-Castillo, Ignacio; Dean, Thomas; Cheloha, Ross W.; Creemer, Brendan A.; Vilardaga, Jean-Pierre; Savransky, Sofya; Khatri, Ashok; Juppner, Harald; Gardella, Thomas J.
err分享
err收藏
Homozygous Ser-1 to Pro-1 mutation in parathyroid hormone identified in hypocalcemic patients results in secretion of a biologically inactive pro-hormone
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2023-02-16
err3
errOAAI
errHanna, Patrick; Khatri, Ashok; Choi, Shawn; Brabant, Severine; Gild, Matti L.; Piketty, Marie L.; Francou, Bruno; Prie, Dominique; Potts Jr, John T.; Clifton-Bligh, Roderick J.; Linglart, Agnes; Gardella, Thomas J.; Juppner, Harald
err分享
err收藏
Altered signaling at the PTH receptor via modified agonist contacts with the extracellular domain provides a path to prolonged agonism in vivo
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2022-11-21
err4
errOAAI
errLiu, Shi; Yu, Zhen; Daley, Eileen J.; Bingman, Craig A.; Bruchs, Austin T.; Gardella, Thomas J.; Gellman, Samuel H.
err分享
err收藏
Kinetic and Thermodynamic Insights into Agonist Interactions with the Parathyroid Hormone Receptor-1 from a New NanoBRET Assay
errACS CHEMICAL BIOLOGY
IF3.8
err2022-10-25
err9
errOAAI
errYu, Zhen; Cary, Brian P.; Kim, Tae Wook; Nguyen, Kevin D.; Gardella, Thomas J.; Gellman, Samuel H.
err分享
err收藏
Biased GPCR signaling by the native parathyroid hormone-related protein 1 to 141 relative to its N-terminal fragment 1 to 36
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2022-09-01
err12
errOAAI
errPena, Karina A.; White, Alex D.; Savransky, Sofya; Castillo, Ignacio Portales; Jean-Alphonse, Frederic G.; Gardella, Thomas J.; Sutkeviciute, Ieva; Vilardaga, Jean-Pierre
err分享
err收藏
Actions of Parathyroid Hormone Ligand Analogues in Humanized PTH1R Knockin Mice
errENDOCRINOLOGY
IF3.3
err2022-04-23
err5
errOAAI
errDaley, Eileen J.; Yoon, Sung-Hee; Reyes, Monica; Bruce, Michael; Brooks, Daniel J.; Bouxsein, Mary; Potts, John T.; Kronenberg, Henry M.; Wein, Marc N.; Lanske, Beate; Juppner, Harald; Gardella, Thomas J.
err分享
err收藏
Functional Properties of Two Distinct PTH1R Mutants Associated With Either Skeletal Defects or Pseudohypoparathyroidism
errJBMR PLUS
IF2.4
err2022-04-14
err4
errOAAI
errPortales-Castillo, Ignacio; Dean, Thomas; Khatri, Ashok; Juppner, Harald; Gardella, Thomas J.
err分享
err收藏
Activity-based, bioorthogonal imaging of phospholipase D reveals spatiotemporal dynamics of GPCR-Gq signaling
errCELL CHEMICAL BIOLOGY
IF7.2
err2022-01-01
err15
errOAAI
errLiang, Dongjun; Cheloha, Ross W.; Watanabe, Tomoyuki; Gardella, Thomas J.; Baskin, Jeremy M.
err分享
err收藏

研究方向

暂时未获取到该数据
合作学者
合作期刊
R
Ramnik J. Xavier
H 指数: 186 · 论文数: 1.0K
H
Hidde L. Ploegh
H 指数: 148 · 论文数: 927
N
Nathanael S. Gray
H 指数: 145 · 论文数: 1.5K
M
Maria Luisa Brandi
H 指数: 114 · 论文数: 1.7K
S
Samuel J. Danishefsky
H 指数: 111 · 论文数: 1.3K
查看更多