Patrick D. Hsu - Publications, H-index & Citations

Patrick D. Hsu

University of California System

39H指数

125论文数

5.4W被引数

收录论文 26

发表时间

Predicting cellular responses to perturbation across diverse contexts with State 使用State预测不同背景下扰动引起的细胞反应

Cell

IF42.5

2026-09-01

PREAI

Adduri, Abhinav K.; Gautam, Dhruv; Bevilacqua, Beatrice; Naghipourfar, Mohsen; Imran, Alishba; Shah, Rohan; Teyssier, Noam; Verma, Rishi; Carpenter, Christopher; Eraslan, Basak; Chalissery, Francis; Ilango, Rajesh; Subramanyam, Vishvak; Ricci-Tam, Chiara; Nagaraj, Sanjay; Winters, Aidan; Dong, Mingze; Fellinger, Stefanie; Krejci, Adam; Burckstummer, Tilmann; Tirukkovular, Sravya; Sullivan, Jeremy; Plosky, Brian S.; Youngblut, Nicholas D.; Leskovec, Jure; Gilbert, Luke A.; Konermann, Silvana; Hsu, Patrick D.; Dobin, Alexander; Burke, Dave P.; Goodarzi, Hani; Roohani, Yusuf H.

scBaseCount: An AI agent-curated, standardized, auto-updated single-cell data repository scBaseCount: 一个由AI智能体筛选、标准化和自动更新的单细胞数据仓库

Cell

IF42.5

2026-09-01

PREAI

Youngblut, Nicholas D.; Carpenter, Christopher; Nayebnazar, Arshia; Adduri, Abhinav; Shah, Rohan; Ricci-Tam, Chiara; Prashar, Jaanak; Ilango, Rajesh; Teyssier, Noam; Konermann, Silvana; Hsu, Patrick D.; Dobin, Alexander; Burke, Dave P.; Goodarzi, Hani; Roohani, Yusuf H.

Structural mechanism governing the directionality of bridge recombination 桥重组方向性调控的结构机制

Nature

IF48.5

2026-08-12

OAAI

Masahiro Hiraizumi; Januka S. Athukoralage; Nicholas T. Perry; Eisuke Tsujimoto; Nami Shiojiri; Naoto Nagahata; Lauren Lee; Gwanggyu Sun; Matthew G. Durrant; Sita S. Chandrasekaran; Silvana Konermann; Keitaro Yamashita; Patrick D. Hsu; Hiroshi Nishimasu

Generalist biological artificial intelligence in modeling the language of life 通用生物人工智能在生命语言建模中的应用

Nature Biotechnology

IF41.7

2026-03-20

PREAI

Vishwanatha M. Rao; Serena Zhang; Brian S. Plosky; Patrick D. Hsu; Bo Wang; James Zou; Marinka Zitnik; Eric J. Topol; Pranav Rajpurkar

Genome modelling and design across all domains of life with Evo 2 使用Evo 2在生活的所有领域进行基因组建模和设计

Nature

IF48.5

2026-03-04

OAAI

Garyk Brixi; Matthew G. Durrant; Jerome Ku; Mohsen Naghipourfar; Michael Poli; Gwanggyu Sun; Greg Brockman; Daniel Chang; Alison Fanton; Gabriel A. Gonzalez; Samuel H. King; David B. Li; Aditi T. Merchant; Eric Nguyen; Chiara Ricci-Tam; David W. Romero; Jonathan C. Schmok; Ali Taghibakhshi; Anton Vorontsov; Brandon Yang; Myra Deng; Liv Gorton; Nam Nguyen; Nicholas K. Wang; Michael T. Pearce; Elana Simon; Etowah Adams; Zachary J. Amador; Euan A. Ashley; Stephen A. Baccus; Haoyu Dai; Steven Dillmann; Stefano Ermon; Daniel Guo; Michael H. Herschl; Rajesh Ilango; Ken Janik; Amy X. Lu; Reshma Mehta; Mohammad R. K. Mofrad; Madelena Y. Ng; Jaspreet Pannu; Christopher Ré; John St. John; Jeremy Sullivan; Joseph Tey; Ben Viggiano; Kevin Zhu; Greg Zynda; Daniel Balsam; Patrick Collison; Anthony B. Costa; Tina Hernandez-Boussard; Eric Ho; Ming-Yu Liu; Thomas McGrath; Kimberly Powell; Sudarshan Pinglay; Dave P. Burke; Hani Goodarzi; Patrick D. Hsu; Brian L. Hie

Rapid directed evolution guided by protein language models and epistatic interactions 蛋白质语言模型和上位性相互作用指导的快速定向进化

Science

IF45.8

2026-02-19

PREAI

Vincent Q. Tran; Matthew Nemeth; Liam J. Bartie; Sita S. Chandrasekaran; Alison Fanton; Hyungseok C. Moon; Brian L. Hie; Silvana Konermann; Patrick D. Hsu

Site-specific DNA insertion into the human genome with engineered recombinases 用工程重组酶将位点特异性DNA插入人类基因组

Nature Biotechnology

IF41.7

2025-11-06

OAAI

Alison Fanton; Liam J. Bartie; Juliana Q. Martins; Vincent Q. Tran; Laine Goudy; Courtney Kernick; Matthew G. Durrant; Jingyi Wei; Zev Armour-Garb; April Pawluk; Silvana Konermann; Alexander Marson; Luke A. Gilbert; Theodore L. Roth; Patrick D. Hsu

Megabase-scale human genome rearrangement with programmable bridge recombinases 兆碱基规模人类基因组重排与可编程桥联重组酶

Science

IF45.8

2025-09-25

PREAI

Nicholas T. Perry; Liam J. Bartie; Dhruva Katrekar; Gabriel A. Gonzalez; Matthew G. Durrant; James J. Pai; Alison Fanton; Juliana Q. Martins; Masahiro Hiraizumi; Chiara Ricci-Tam; Hiroshi Nishimasu; Silvana Konermann; Patrick D. Hsu

Deep learning and CRISPR-Cas13d ortholog discovery for optimized RNA targeting

CELL SYSTEMS

IF7.7

2023-12-01

OAAI

Wei, Jingyi; Lotfy, Peter; Faizi, Kian; Baungaard, Sara; Gibson, Emily; Wang, Eleanor; Slabodkin, Hannah; Kinnaman, Emily; Chandrasekaran, Sita; Kitano, Hugo; Durrant, Matthew G.; Duffy, Connor, V; Pawluk, April; Hsu, Patrick D.; Konermann, Silvana

The KDM6A-KMT2D-p300 axis regulates susceptibility to diverse coronaviruses by mediating viral receptor expression

PLOS PATHOGENS

IF4.9

2023-07-06

OAAI

Wei, Jin; Alfajaro, Mia Madel; Cai, Wesley L. L.; Graziano, Vincent R. R.; Strine, Madison S. S.; Filler, Renata B. B.; Biering, Scott B. B.; Sarnik, Sylvia A. A.; Patel, Sonam; Menasche, Bridget L. L.; Compton, Susan R. R.; Konermann, Silvana; Hsu, Patrick D. D.; Orchard, Robert C. C.; Yan, Qin; Wilen, Craig B. B.

Systematic discovery of recombinases for efficient integration of large DNA sequences into the human genome 重组酶的系统发现可将大DNA序列有效整合到人类基因组中

NATURE BIOTECHNOLOGY

IF41.7

2022-10-10

OAAI

Durrant, Matthew G.; Fanton, Alison; Tycko, Josh; Hinks, Michaela; Chandrasekaran, Sita S.; Perry, Nicholas T.; Schaepe, Julia; Du, Peter P.; Lotfy, Peter; Bassik, Michael C.; Bintu, Lacramioara; Bhatt, Ami S.; Hsu, Patrick D.

Rapid detection of SARS-CoV-2 RNA in saliva via Cas13

NATURE BIOMEDICAL ENGINEERING

IF26.6

2022-08-11

OAAI

Chandrasekaran, Sita S.; Agrawal, Shreeya; Fanton, Alison; Jangid, Aditya R.; Charrez, Berenice; Escajeda, Arturo M.; Son, Sungmin; Mcintosh, Roger; Tran, Huyen; Bhuiya, Abdul; Derby, Maria Diaz de Leon; Switz, Neil A.; Armstrong, Maxim; Harris, Andrew R.; Prywes, Noam; Lukarska, Maria; Biering, Scott B.; Smock, Dylan C. J.; Mok, Amanda; Knott, Gavin J.; Dang, Qi; Van Dis, Erik; Dugan, Eli; Kim, Shin; Liu, Tina Y.; Consortium, Igi Testing; Moehle, Erica A.; Kogut, Katherine; Eskenazi, Brenda; Harris, Eva; Stanley, Sarah A.; Lareau, Liana F.; Tan, Ming X.; Fletcher, Daniel A.; Doudna, Jennifer A.; Savage, David F.; Hsu, Patrick D.

Genome-wide bidirectional CRISPR screens identify mucins as host factors modulating SARS-CoV-2 infection 全基因组双向CRISPR筛选将粘蛋白鉴定为调节SARS-CoV-2感染的宿主因子

NATURE GENETICS

IF31.8

2022-07-25

OAAI

Biering, Scott B.; Sarnik, Sylvia A.; Wang, Eleanor; Zengel, James R.; Leist, Sarah R.; Schafer, Alexandra; Sathyan, Varun; Hawkins, Padraig; Okuda, Kenichi; Tau, Cyrus; Jangid, Aditya R.; Duffy, Connor, V; Wei, Jin; Gilmore, Rodney C.; Alfajaro, Mia Madel; Strine, Madison S.; Nguyenla, Xammy; Van Dis, Erik; Catamura, Carmelle; Yamashiro, Livia H.; Belk, Julia A.; Begeman, Adam; Stark, Jessica C.; Shon, D. Judy; Fox, Douglas M.; Ezzatpour, Shahrzad; Huang, Emily; Olegario, Nico; Rustagi, Arjun; Volmer, Allison S.; Livraghi-Butrico, Alessandra; Wehri, Eddie; Behringer, Richard R.; Cheon, Dong-Joo; Schaletzky, Julia; Aguilar, Hector C.; Puschnik, Andreas S.; Button, Brian; Pinsky, Benjamin A.; Blish, Catherine A.; Baric, Ralph S.; O'Neal, Wanda K.; Bertozzi, Carolyn R.; Wilen, Craig B.; Boucher, Richard C.; Carette, Jan E.; Stanley, Sarah A.; Harris, Eva; Konermann, Silvana; Hsu, Patrick D.

How Has the COVID-19 Pandemic Changed How You Will Approach Research and Lab Work in the Future?

CELL SYSTEMS

IF7.7

2020-12-01

OAAI

Haynes, Karmella; Yau, Christopher; Bild, Andrea; Laughney, Ashley; Morsut, Leonardo; Yang, Xia; Zaugg, Judith; Hsu, Patrick; Pancaldi, Vera; Iyer-Biswas, Srividya

A Catalogue of Cas9 Orthologs to Advance Genome Engineering

CRISPR JOURNAL

IF4

2020-12-01

OAAI

Wang, Eleanor; Hsu, Patrick D.

Evaluation of SARS-CoV-2 serology assays reveals a range of test performance SARS-CoV-2血清学测定的评估揭示了一系列测试性能

NATURE BIOTECHNOLOGY

IF41.7

2020-08-27

304

OAAI

Whitman, Jeffrey D.; Hiatt, Joseph; Mowery, Cody T.; Shy, Brian R.; Yu, Ruby; Yamamoto, Tori N.; Rathore, Ujjwal; Goldgof, Gregory M.; Whitty, Caroline; Woo, Jonathan M.; Gallman, Antonia E.; Miller, Tyler E.; Levine, Andrew G.; Nguyen, David N.; Bapat, Sagar P.; Balcerek, Joanna; Bylsma, Sophia A.; Lyons, Ana M.; Li, Stacy; Wong, Allison Wai-yi; Gillis-Buck, Eva Mae; Steinhart, Zachary B.; Lee, Youjin; Apathy, Ryan; Lipke, Mitchell J.; Smith, Jennifer Anne; Zheng, Tina; Boothby, Ian C.; Isaza, Erin; Chan, Jackie; Acenas, Dante D., II; Lee, Jinwoo; Macrae, Trisha A.; Kyaw, Than S.; Wu, David; Ng, Dianna L.; Gu, Wei; York, Vanessa A.; Eskandarian, Haig Alexander; Callaway, Perri C.; Warrier, Lakshmi; Moreno, Mary E.; Levan, Justine; Torres, Leonel; Farrington, Lila A.; Loudermilk, Rita P.; Koshal, Kanishka; Zorn, Kelsey C.; Garcia-Beltran, Wilfredo F.; Yang, Diane; Astudillo, Michael G.; Bernstein, Bradley E.; Gelfand, Jeffrey A.; Ryan, Edward T.; Charles, Richelle C.; Iafrate, A. John; Lennerz, Jochen K.; Miller, Steve; Chiu, Charles Y.; Stramer, Susan L.; Wilson, Michael R.; Manglik, Aashish; Ye, Chun Jimmie; Krogan, Nevan J.; Anderson, Mark S.; Cyster, Jason G.; Ernst, Joel D.; Wu, Alan H. B.; Lynch, Kara L.; Bern, Caryn; Hsu, Patrick D.; Marson, Alexander

Ribosomal protein S11 influences glioma response to TOP2 poisons

ONCOGENE

IF7.3

2020-06-11

OAAI

Awah, Chidiebere U.; Chen, Li; Bansal, Mukesh; Mahajan, Aayushi; Winter, Jan; Lad, Meeki; Warnke, Louisa; Gonzalez-Buendia, Edgar; Park, Cheol; Zhang, Daniel; Feldstein, Eric; Yu, Dou; Zannikou, Markella; Balyasnikova, Irina, V; Martuscello, Regina; Konerman, Silvana; Gyorffy, Balazs; Burdett, Kirsten B.; Scholtens, Denise M.; Stupp, Roger; Ahmed, Atique; Hsu, Patrick; Sonabend, Adam M.

Programmable RNA Targeting Using CasRx in Flies

CRISPR JOURNAL

IF4

2020-06-01

OAAI

Buchman, Anna; Brogan, Dan J.; Sun, Ruichen; Yang, Ting; Hsu, Patrick; Akbari, Omar S.

Pairwise library screen systematically interrogates Staphylococcus aureus Cas9 specificity in human cells (vol 9, 2962, 2018)

NATURE COMMUNICATIONS

IF15.7

2018-08-28

OAAI

Tycko, Josh; Barrera, Luis A.; Huston, Nicholas C.; Friedland, Ari E.; Wu, Xuebing; Gootenberg, Jonathan S.; Abudayyeh, Omar O.; Myer, Vic E.; Wilson, Christopher J.; Hsu, Patrick D.

Pairwise library screen systematically interrogates Staphylococcus aureus Cas9 specificity in human cells

NATURE COMMUNICATIONS

IF15.7

2018-07-27

OAAI

Tycko, Josh; Barrera, Luis A.; Huston, Nicholas C.; Friedland, Ari E.; Wu, Xuebing; Gootenberg, Jonathan S.; Abudayyeh, Omar O.; Myer, Vic E.; Wilson, Christopher J.; Hsu, Patrick D.

研究方向