Simon C. Lovell - Publications, H-index & Citations

Simon C. Lovell

University of Manchester

41H指数

134论文数

1.9W被引数

收录论文 50

发表时间

Structural Constraints Acting on the SARS-CoV-2 Spike Protein Reveal Limited Space for Viral Adaptation SARS-CoV-2刺突蛋白的结构约束揭示病毒适应的有限空间

Genome Biology and Evolution

IF2.8

2026-03-01

PREAI

Herzig, James C.; Magwira, Michael L.; Lovell, Simon C.

From single-sequences to evolutionary trajectories: protein language models capture the evolutionary potential of SARS-CoV-2 从单一序列到进化轨迹：蛋白质语言模型捕获SARS-CoV-2的进化潜力

Nature Communications

IF15.7

2026-02-19

OAAI

Kieran D. Lamb; Joseph Hughes; Spyros Lytras; Francesca Young; Orges Koci; James C. Herzig; Simon C. Lovell; Joe Grove; Ke Yuan; David L. Robertson

Deciphering the Impact of Temperature on Pleiotropic Consequences of RNA Polymerase Mutations 解析温度对RNA聚合酶突变多效性后果的影响

MOLECULAR BIOLOGY AND EVOLUTION

IF5.3

2025-10-01

PREAI

Ozbilek, Deniz; Soley, Jake K.; Gifford, Danna R.; Knight, Christopher G.; Lovell, Simon C.; Lagator, Mato

Antimutator and Mutational Spectrum Effects Can Combine to Reduce Evolutionary Potential in Escherichia coli ΔnudJ 抗突变体和突变谱效应可以结合以降低大肠杆菌ΔnudJ的进化潜力

MOLECULAR BIOLOGY AND EVOLUTION

IF5.3

2025-08-01

OAAI

Green, Rowan; Richards, Huw; Ozbilek, Deniz; Tyrrell, Francesca; Barton, Victoria; Zhang, Ziang; Lovell, Simon C.; Gifford, Danna R.; Lagator, Mato; McBain, Andrew J.; Krasovec, Rok; Knight, Christopher G.

Human cytomegalovirus (HCMV) glycoprotein M occurs in three distinct genotypes in laboratory strains and clinical isolates 人类巨细胞病毒（HCMV）糖蛋白M在实验室株和临床分离株中存在三种不同的基因型

JOURNAL OF CLINICAL VIROLOGY

IF3.4

2025-06-01

PREAI

Al-Alfard, Alia; Buhamad, Zahrah; Duffey, Julia; Lovell, Simon; Klapper, Paul; Vallely, Pamela

Essentiality, protein-protein interactions and evolutionary properties are key predictors for identifying cancer-associated genes using machine learning

SCIENTIFIC REPORTS

IF3.9

2024-04-22

OAAI

Safadi, Amro; Lovell, Simon C.; Doig, Andrew J.

Clinical, genetic, epidemiologic, evolutionary, and functional delineation of TSPEAR-related autosomal recessive ectodermal dysplasia 14

HUMAN GENETICS AND GENOMICS ADVANCES

IF3.6

2023-04-01

OAAI

Jackson, Adam; Lin, Sheng-Jia; Jones, Elizabeth A.; Chandler, Kate E.; Orr, David; Moss, Celia; Haider, Zahra; Ryan, Gavin; Holden, Simon; Harrison, Mike; Burrows, Nigel; Jones, Wendy D.; Loveless, Mary; Petree, Cassidy; Stewart, Helen; Low, Karen; Donnelly, Deirdre; Lovell, Simon; Drosou, Konstantina; Varshney, Gaurav K.; Banka, Siddharth

Assessing the Pathogenicity of In-Frame CACNA1F Indel Variants Using Structural Modeling

JOURNAL OF MOLECULAR DIAGNOSTICS

IF3.4

2022-12-01

PREAI

Sallah, Shalaw R.; Sergouniotis, Panagiotis, I; Hardcastle, Claire; Ramsden, Simon; Lotery, Andrew J.; Lench, Nick; Lovell, Simon C.; Black, Graeme C. M.

Improving the clinical interpretation of missense variants in X linked genes using structural analysis

JOURNAL OF MEDICAL GENETICS

IF3.7

2021-03-25

OAAI

Sallah, Shalaw Rassul; Ellingford, Jamie M.; Sergouniotis, Panagiotis, I; Ramsden, Simon C.; Lench, Nicholas; Lovell, Simon C.; Black, Graeme C.

EVI1 phosphorylation at S436 regulates interactions with CtBP1 and DNMT3A and promotes self-renewal

CELL DEATH & DISEASE

IF9.6

2020-10-20

OAAI

Paredes, Roberto; Kelly, James R.; Geary, Bethany; Almarzouq, Batool; Schneider, Marion; Pearson, Stella; Narayanan, Prakrithi; Williamson, Andrew; Lovell, Simon C.; Wiseman, Daniel H.; Chadwick, John A.; Jones, Nigel J.; Kustikova, Olga; Schambach, Axel; Garner, Terence; Amaral, Fabio M. R.; Pierce, Andrew; Stevens, Adam; Somervaille, Tim C. P.; Whetton, Anthony D.; Meyer, Stefan

Using an integrative machine learning approach utilising homology modelling to clinically interpret genetic variants: CACNA1F as an exemplar

EUROPEAN JOURNAL OF HUMAN GENETICS

IF4.6

2020-04-20

OAAI

Sallah, Shalaw R.; Sergouniotis, Panagiotis I.; Barton, Stephanie; Ramsden, Simon; Taylor, Rachel L.; Safadi, Amro; Kabir, Mitra; Ellingford, Jamie M.; Lench, Nick; Lovell, Simon C.; Black, Graeme C. M.

Severe type I interferonopathy and unrestrained interferon signaling due to a homozygous germline mutation in STAT2

SCIENCE IMMUNOLOGY

IF16.3

2019-12-06

OAAI

Duncan, Christopher J. A.; Thompson, Benjamin J.; Chen, Rui; Rice, Gillian, I; Gothe, Florian; Young, Dan F.; Lovell, Simon C.; Shuttleworth, Victoria G.; Brocklebank, Vicky; Corner, Bronte; Skelton, Andrew J.; Bondet, Vincent; Coxhead, Jonathan; Duffy, Darragh; Fourrage, Cecile; Livingston, John H.; Pavaine, Julija; Cheesman, Edmund; Bitetti, Stephania; Grainger, Angela; Acres, Meghan; Innes, Barbara A.; Mikulasova, Aneta; Sun, Ruyue; Hussain, Rafiqul; Wright, Ronnie; Wynn, Robert; Zarhrate, Mohammed; Zeef, Leo A. H.; Wood, Katrina; Hughes, Stephen M.; Harris, Claire L.; Engelhardt, Karin R.; Crow, Yanick J.; Randall, Richard E.; Kavanagh, David; Hambleton, Sophie; Briggs, Tracy A.

Mutations in PCYT2 disrupt etherlipid biosynthesis and cause a complex hereditary spastic paraplegia

BRAIN

IF11.7

2019-10-22

OAAI

Vaz, Frederic M.; McDermott, John H.; Alders, Marielle; Wortmann, Saskia B.; Koelker, Stefan; Pras-Raves, Mia L.; Vervaart, Martin A. T.; van Lenthe, Henk; Luyf, Angela C. M.; Elfrink, Hyung L.; Metcalfe, Kay; Cuvertino, Sara; Clayton, Peter E.; Yarwood, Rebecca; Lowe, Martin P.; Lovell, Simon; Rogers, Richard C.; van Kampen, Antoine H. C.; Ruiter, Jos P. N.; Wanders, Ronald J. A.; Ferdinandusse, Sacha; van Weeghel, Michel; Engelen, Marc; Banka, Siddharth

Biochemical and structural analyses suggest that plasminogen activators coevolved with their cognate protein substrates and inhibitors

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2019-03-01

OAAI

Jendroszek, Agnieszka; Madsen, Jeppe B.; Chana-Munoz, Andres; Dupont, Daniel M.; Christensen, Anni; Panitz, Frank; Fuchtbauer, Ernst-Martin; Lovell, Simon C.; Jensen, Jan K.

Improved fragment-based protein structure prediction by redesign of search heuristics

SCIENTIFIC REPORTS

IF3.9

2018-09-12

OAAI

Kandathil, Shaun M.; Garza-Fabre, Mario; Handl, Julia; Lovell, Simon C.

EVI1 carboxy-terminal phosphorylation is ATM-mediated and sustains transcriptional modulation and self-renewal via enhanced CtBP1 association (vol 46, gky536, 2018)

NUCLEIC ACIDS RESEARCH

IF13.1

2018-08-08

OAAI

Paredes, Roberto; Schneider, Marion; Stevens, Adam; White, Daniel J.; Williamson, Andrew J. K.; Muter, Joanne; Pearson, Stella; Kelly, James R.; Connors, Kathleen; Wiseman, Daniel H.; Chadwick, John A.; Loeffler, Harald; Teng, Hsiang Ying; Lovell, Simon; Unwin, Richard; van de Vrugt, Henri J.; Smith, Helen; Kustikova, Olga; Schambach, Axel; Somervaille, Tim C. P.; Pierce, Andrew; Whetton, Anthony D.; Meyer, Stefan

EVI1 carboxy-terminal phosphorylation is ATM-mediated and sustains transcriptional modulation and self-renewal via enhanced CtBP1 association

NUCLEIC ACIDS RESEARCH

IF13.1

2018-06-25

OAAI

Non-muscle myosin IIB (Myh10) is required for epicardial function and coronary vessel formation during mammalian development 在哺乳动物发育过程中，心外膜功能和冠状血管形成需要非肌肉肌球蛋白IIB (Myh10)

PLOS GENETICS

IF3.7

2017-10-30

OAAI

Ridge, Liam A.; Mitchell, Karen; Al-Anbaki, Ali; Qureshi, Wasay Mohiuddin Shaikh; Stephen, Louise A.; Tenin, Gennadiy; Lu, Yinhui; Lupu, Irina-Elena; Clowes, Christopher; Robertson, Abigail; Barnes, Emma; Wright, Jayne A.; Keavney, Bernard; Ehler, Elisabeth; Lovell, Simon C.; Kadler, Karl E.; Hentges, Kathryn E.

Rapid functional and evolutionary changes follow gene duplication in yeast 酵母基因复制后的快速功能和进化变化

PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

IF3.5

2017-08-23

OAAI

Naseeb, Samina; Ames, Ryan M.; Delneri, Daniela; Lovell, Simon C.

Adaptive HIV-1 evolutionary trajectories are constrained by protein stability

VIRUS EVOLUTION

IF4

2017-08-01

OAAI

Olabode, Abayomi S.; Kandathil, Shaun M.; Lovell, Simon C.; Robertson, David L.

研究方向