Luke Alphey - Publications, H-index & Citations

Luke Alphey

University of York

60H指数

242论文数

1.3W被引数

收录论文 81

发表时间

Mosquito Saliva Subunit Vaccine Enhances Efficacy of VLP Vaccines Against Zika and Chikungunya Viruses 蚊唾液亚单位疫苗增强VLP疫苗对寨卡病毒和基孔肯雅病毒的防护效果

Vaccines

IF3.4

2026-08-30

OAAI

Siân Jossi; Megan Cole; Yonca Keskek Turk; Sam Verwimp; Katrien Trappeniers; James Luk; Joshua X. D. Ang; Luke Alphey; Leen Delang; Clive S. McKimmie; Olga Pleguezuelos

Integrating multiplexing into confineable gene drives effectively overrides resistance in Anopheles stephensi 将多重技术整合到可限制的基因驱动中有效克服了斯氏按蚊的抗性

Nature Communications

IF15.7

2026-05-07

OAAI

Mireia Larrosa-Godall; Lewis Shackleford; Matthew P. Edgington; Philip T. Leftwich; James C. Y. Luk; Joshua Southworth; Stewart Rosell; Jake T. Creasey; Jack M. Aked; Katherine Nevard; Alexander Dodds; Morgan Mckee; Eunice Adedeji; Estela Gonzalez; Joshua X. D. Ang; Michelle A. E. Anderson; Luke Alphey

Sequence mismatch between gene-drive and target-site flanking regions significantly impairs homing efficiency in Culex quinquefasciatus 基因驱动与靶位点侧翼序列之间的序列不匹配显著降低了库蚊(Culex quinquefasciatus)中的同源重组效率。

Genetics

IF5.1

2026-03-03

PREAI

Tim Harvey-Samuel; Rajdeep Kaur; Philip T Leftwich; Xuechun Feng; Valentino Gantz; Luke Alphey; null

Harnessing the highly adaptable barnase-barstar system for genetic biocontrol of Aedes aegypti 利用高度适应性的barnase-barstar系统对埃及伊蚊进行遗传生物控制

Communications Biology

IF5.1

2025-08-04

OAAI

Katherine Nevard; Joshua X. D. Ang; Michelle A. E. Anderson; Estela Gonzalez; Lewis Shackleford; Luke Alphey

Meeting Report on an Integrated Research Agenda for Mosquito-Borne Arboviruses 蚊媒虫媒病毒综合研究议程会议报告

OPEN FORUM INFECTIOUS DISEASES

IF3.8

2025-07-01

OAAI

Ulrich, Angela K.; Moua, Nicolina M.; Mack, Alison; Imai-Eaton, Natsuko; Staples, J. Erin; Mehr, Angela J.; Ostrowsky, Julia T.; Leighton, Tabitha; Cehovin, Ana; Fay, Petra C.; Golding, Josephine P.; Maynard, Emma; Alphey, Luke; Rojas Alvarez, Diana P.; Coffey, Lark L.; Faria, Nuno R.; Maciel-de-Freitas, Rafael; Maringer, Kevin; Murray, Kris A.; Salje, Henrik; Sang, Rosemary; Vasconcelos, Pedro F. C.; Leo, Yee-Sin; Sinkins, Steven P.; de Vasconcelos, Jocelyne Neto; Dadzie, Samuel K.; Harris, Eva; dos Santos, Thais H.; Velayudhan, Raman; Wongsawat, Jurai; Osterholm, Michael T.; Lackritz, Eve M.

Synthetic homing endonuclease gene drives to revolutionise Aedes aegypti biocontrol - game changer or pipe dream?合成归巢核酸内切酶基因驱动将革新埃及伊蚊生物防治——颠覆性变革还是空中楼阁？

CURRENT OPINION IN INSECT SCIENCE

IF4.8

2025-06-06

PREAI

Ang, Joshua X. D.; Verkuijl, Sebald A. N.; Anderson, Michelle A. E.; Alphey, Luke

Optimization of SgRNA expression with RNA pol III regulatory elements in Anopheles stephensi 利用RNA聚合酶III调控元件优化冈比亚按蚊的sgRNA表达

SCIENTIFIC REPORTS

IF3.9

2025-04-18

OAAI

Gonzalez, Estela; Anderson, Michelle A. E.; Ang, Joshua X. D.; Nevard, Katherine; Shackleford, Lewis; Larrosa-Godall, Mireia; Leftwich, Philip T.; Alphey, Luke

Challenges in developing a split drive targeting dsx for the genetic control of the invasive malaria vector Anopheles stephensi

PARASITES & VECTORS

IF3.5

2025-02-07

OAAI

Larrosa-Godall, Mireia; Ang, Joshua X. D.; Leftwich, Philip T.; Gonzalez, Estela; Shackleford, Lewis; Nevard, Katherine; Noad, Rob; Anderson, Michelle A. E.; Alphey, Luke

A change in circulating chikungunya virus variant impacts Aedes aegypti vector competence and spatiotemporal distribution of disease in Malaysia

PLOS NEGLECTED TROPICAL DISEASES

IF3.4

2024-10-31

OAAI

Azman, Izzati Kausar; Chan, Yoke Fun; Chua, Chong Long; Abd Mutalib, Zainal Abidin; Dass, Sarat Chandra; Gill, Balvinder Singh; Ismail, Nor Hayati; Jelip, Jenarun; Wan, Ming Keong; Lee, Wenn-Chyau; Vythilingam, Indra; Alphey, Luke; Sam, I-Ching

A Synthetic Biology Approach to Transgene Expression in Insects

ACS SYNTHETIC BIOLOGY

IF3.9

2024-08-28

OAAI

Leftwich, Philip T.; Purcell, Jessica C.; Anderson, Michelle A. E.; Fragkoudis, Rennos; Basu, Sanjay; Lycett, Gareth; Alphey, Luke

Transgenic expression of cif genes from Wolbachia strain wAlbB recapitulates cytoplasmic incompatibility in Aedes aegypti

NATURE COMMUNICATIONS

IF15.7

2024-01-29

OAAI

Mcnamara, Cameron J.; Ant, Thomas H.; Harvey-Samuel, Tim; White-Cooper, Helen; Martinez, Julien; Alphey, Luke; Sinkins, Steven P.

A multiplexed, confinable CRISPR/Cas9 gene drive can propagate in caged Aedes aegypti populations

NATURE COMMUNICATIONS

IF15.7

2024-01-25

OAAI

Anderson, Michelle A. E.; Gonzalez, Estela; Edgington, Matthew P.; Ang, Joshua X. D.; Purusothaman, Deepak-Kumar; Shackleford, Lewis; Nevard, Katherine; Verkuijl, Sebald A. N.; Harvey-Samuel, Timothy; Leftwich, Philip T.; Esvelt, Kevin; Alphey, Luke

Engineered Antiviral Sensor Targets Infected Mosquitoes 工程抗病毒传感器针对受感染的蚊子

CRISPR JOURNAL

IF4

2023-12-01

OAAI

Dalla Benetta, Elena; Lopez-Denman, Adam J.; Li, Hsing-Han; Masri, Reem A.; Brogan, Daniel J.; Bui, Michelle; Yang, Ting; Li, Ming; Dunn, Michael; Klein, Melissa J.; Jackson, Sarah; Catalan, Kyle; Blasdell, Kim R.; Tng, Priscilla; Antoshechkin, Igor; Alphey, Luke S.; Paradkar, Prasad N.; Akbari, Omar S.

CRISPR-based gene drives generate super-Mendelian inheritance in the disease vector Culex quinquefasciatus

NATURE COMMUNICATIONS

IF15.7

2023-11-20

OAAI

Harvey-Samuel, Tim; Feng, Xuechun; Okamoto, Emily M.; Purusothaman, Deepak-Kumar; Leftwich, Philip T.; Alphey, Luke; Gantz, Valentino M.

Mimicking superinfection exclusion disrupts alphavirus infection and transmission in the yellow fever mosquito Aedes aegypti

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2023-09-05

OAAI

Reitmayer, Christine M.; Levitt, Emily; Basu, Sanjay; Atkinson, Barry; Fragkoudis, Rennos; Merits, Andres; Lumley, Sarah; Larner, Will; Diaz, Adriana V.; Rooney, Sara; Thomas, Callum J. E.; von Wyschetzki, Katharina; Rausalu, Kai; Alphey, Luke

Susceptibility of Aedes albopictus, Ae. aegypti and human populations to Ross River virus in Kuala Lumpur, Malaysia

PLOS NEGLECTED TROPICAL DISEASES

IF3.4

2023-06-12

OAAI

Fu, Jolene Yin Ling; Chua, Chong Long; Abu Bakar, Athirah Shafiqah; Vythilingam, Indra; Sulaiman, Wan Yusoff Wan; Alphey, Luke; Chan, Yoke Fun; Sam, I-Ching

A CRISPR endonuclease gene drive reveals distinct mechanisms of inheritance bias

NATURE COMMUNICATIONS

IF15.7

2022-11-21

OAAI

Verkuijl, Sebald A. N.; Gonzalez, Estela; Li, Ming; Ang, Joshua X. D.; Kandul, Nikolay P.; Anderson, Michelle A. E.; Akbari, Omar S.; Bonsall, Michael B.; Alphey, Luke

Silencing RNAs expressed from W-linked PxyMasc retrocopies target that gene during female sex determination in Plutella xylostella

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2022-11-07

OAAI

Harvey-Samuel, Tim; Xu, Xuejiao; Anderson, Michelle. A. E.; Paladino, Leonela. Z. Carabajal; Purusothaman, Deepak; Norman, Victoria. C.; Reitmayer, Christine. M.; You, Minsheng; Alphey, Luke

Daisy-chain gene drives: The role of low cut-rate, resistance mutations, and maternal deposition

PLOS GENETICS

IF3.7

2022-09-19

OAAI

Verkuijl, Sebald A. N.; Anderson, Michelle A. E.; Alphey, Luke; Bonsall, Michael B.

The Acquisition and Retention of Lumpy Skin Disease Virus by Blood-Feeding Insects Is Influenced by the Source of Virus, the Insect Body Part, and the Time since Feeding

JOURNAL OF VIROLOGY

IF3.8

2022-08-10

OAAI

Sanz-Bernardo, Beatriz; Suckoo, Rey; Haga, Ismar R.; Wijesiriwardana, Najith; Harvey, Alice; Basu, Sanjay; Larner, Will; Rooney, Sara; Sy, Victoria; Langlands, Zoe; Denison, Eric; Sanders, Christopher; Atkinson, John; Batten, Carrie; Alphey, Luke; Darpel, Karin E.; Gubbins, Simon; Beard, Philippa M.

研究方向