Leonard W. Seymour - Publications, H-index & Citations

Leonard W. Seymour

department of oncology

76H指数

350论文数

1.9W被引数

收录论文 101

发表时间

Hypoxia increases the activity of oncolytic adenoviruses through HIF-2α-stimulated E1A expression 缺氧通过HIF-2α刺激E1A表达增加溶瘤腺病毒活性

Signal Transduction and Targeted Therapy

IF52.7

2026-08-11

OAAI

Egon J. Jacobus; Véronique N. Lafleur; Kerry D. Fisher; David R. Mole; Leonard W. Seymour

T cell engagers: expanding horizons in oncology and beyond T细胞交联剂：拓展肿瘤学及其以外领域的视野

British Journal of Cancer

IF6.8

2025-07-23

OAAI

Gulsah Albayrak; Peter Kok-Ting Wan; Kerry Fisher; Leonard W. Seymour

Targeting NKG2D ligands in glioblastoma with a bispecific T-cell engager is augmented with conventional therapy and enhances oncolytic virotherapy of glioma stem-like cells

JOURNAL FOR IMMUNOTHERAPY OF CANCER

IF10.6

2024-05-09

OAAI

Baugh, Richard; Khalique, Hena; Page, Emma; Lei-Rossmann, Janet; Wan, Peter Kok-Ting; Johanssen, Timothy; Ebner, Daniel; Ansorge, Olaf; Seymour, Leonard W.

AAV production in stable packaging cells requires expression of adenovirus 22/33K protein to allow episomal amplification of integrated rep/cap genes

SCIENTIFIC REPORTS

IF3.9

2023-12-07

OAAI

Su, Weiheng; Seymour, Leonard W.; Cawood, Ryan

Oncolytic viruses and antibodies: are they more successful when delivered separately or when engineered as a single agent?

JOURNAL FOR IMMUNOTHERAPY OF CANCER

IF10.6

2023-08-04

OAAI

Wan, Peter Kok-Ting; Fernandes, Ricardo A.; Seymour, Leonard W.

Optogenetically Engineered Neurons Differentiated from Human SH-SY5Y Cells Survived and Expressed ChR2 in 3D Hydrogel

BIOMEDICINES

IF3.9

2022-06-28

OAAI

Lee, Si-Yuen; George, Julian; Nagel, David; Ye, Hua; Seymour, Leonard

Self-attenuating adenovirus enables production of recombinant adeno-associated virus for high manufacturing yield without contamination

NATURE COMMUNICATIONS

IF15.7

2022-03-07

OAAI

Su, Weiheng; Patricio, Maria I.; Duffy, Margaret R.; Krakowiak, Jakub M.; Seymour, Leonard W.; Cawood, Ryan

Beyond cancer cells: Targeting the tumor microenvironment with gene therapy and armed oncolytic virus

MOLECULAR THERAPY

IF12

2021-05-01

OAAI

Wan, Peter Kok-Ting; Ryan, Anderson J.; Seymour, Leonard W.

Promises and challenges of adoptive T-cell therapies for solid tumours

BRITISH JOURNAL OF CANCER

IF6.8

2021-03-29

167

OAAI

Morotti, Matteo; Albukhari, Ashwag; Alsaadi, Abdulkhaliq; Artibani, Mara; Brenton, James D.; Curbishley, Stuart M.; Dong, Tao; Dustin, Michael L.; Hu, Zhiyuan; McGranahan, Nicholas; Miller, Martin L.; Santana-Gonzalez, Laura; Seymour, Leonard W.; Shi, Tingyan; Van Loo, Peter; Yau, Christopher; White, Helen; Wietek, Nina; Church, David N.; Wedge, David C.; Ahmed, Ahmed A.

The role of cancer metabolism in defining the success of oncolytic viro-immunotherapy

CYTOKINE & GROWTH FACTOR REVIEWS

IF11.8

2020-12-01

OAAI

Dyer, Arthur; Frost, Sally; Fisher, Kerry D.; Seymour, Len W.

A liposome-based cancer vaccine for a rapid and high-titre anti-ErbB-2 antibody response

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

IF4.7

2020-09-01

OAAI

Wallis, Jamie; Katti, Prateek; Martin, Alexander M.; Hills, Tom; Seymour, Leonard W.; Shenton, Daniel P.; Carlisle, Robert C.

A phase 1 trial of the safety, tolerability and biological effects of intravenous Enadenotucirev, a novel oncolytic virus, in combination with chemoradiotherapy in locally advanced rectal cancer (CEDAR)

RADIATION ONCOLOGY

IF3.2

2020-06-12

OAAI

O'Cathail, Sean M.; Davis, Steven; Holmes, Jane; Brown, Richard; Fisher, Kerry; Seymour, Leonard; Adams, Richard; Good, James; Sebag-Montefiore, David; Maughan, Tim; Hawkins, Maria A.

Peptide-TLR-7/8a conjugate vaccines chemically programmed for nanoparticle self-assembly enhance CD8 T-cell immunity to tumor antigens 化学编程用于纳米颗粒自组装的Peptide-TLR-7/8a结合疫苗可增强对肿瘤抗原的CD8 T细胞免疫力

NATURE BIOTECHNOLOGY

IF41.7

2020-01-13

266

OAAI

Lynn, Geoffrey M.; Sedlik, Christine; Baharom, Faezzah; Zhu, Yaling; Ramirez-Valdez, Ramiro A.; Coble, Vincent L.; Tobin, Kennedy; Nichols, Sarah R.; Itzkowitz, Yaakov; Zaidi, Neeha; Gammon, Joshua M.; Blobel, Nicolas J.; Denizeau, Jordan; de la Rochere, Philippe; Francica, Brian J.; Decker, Brennan; Maciejewski, Mateusz; Cheung, Justin; Yamane, Hidehiro; Smelkinson, Margery G.; Francica, Joseph R.; Laga, Richard; Bernstock, Joshua D.; Seymour, Leonard W.; Drake, Charles G.; Jewell, Christopher M.; Lantz, Olivier; Piaggio, Eliane; Ishizuka, Andrew S.; Seder, Robert A.

Calcium Influx Caused by ER Stress Inducers Enhances Oncolytic Adenovirus Enadenotucirev Replication and Killing through PKCα Activation

MOLECULAR THERAPY-ONCOLYTICS

IF0

2019-12-01

OAAI

Taverner, William K.; Jacobus, Egon J.; Christianson, John; Champion, Brian; Paton, Adrienne W.; Paton, James C.; Su, Weiheng; Cawood, Ryan; Seymour, Len W.; Lei-Rossmann, Janet

Nanomedicines for the Delivery of Biologics 用于递送生物制剂的纳米药物

PHARMACEUTICS

IF5.5

2019-05-03

OAAI

Wahlich, John; Desai, Arpan; Greco, Francesca; Hill, Kathryn; Jones, Arwyn T.; Mrsny, Randall J.; Pasut, Gianfranco; Perrie, Yvonne; Seib, E. Philipp; Seymour, Leonard W.; Uchegbu, Ijeoma F.

Polyvalent Diazonium Polymers Provide Efficient Protection of Oncolytic Adenovirus Enadenotucirev from Neutralizing Antibodies while Maintaining Biological Activity In Vitro and In Vivo

BIOCONJUGATE CHEMISTRY

IF3.9

2019-03-15

OAAI

Francini, Nora; Cochrane, Daniel; Illingworth, Sam; Purdie, Laura; Mantovani, Giuseppe; Fisher, Kerry; Seymour, Leonard W.; Spain, Sebastian G.; Alexander, Cameron

Optogenetic control of iPS cell-derived neurons in 2D and 3D culture systems using channelrhodopsin-2 expression driven by the synapsin-1 and calcium-calmodulin kinase II promoters

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE

IF2.6

2019-01-30

OAAI

Lee, Si-Yuen; George, Julian H.; Nagel, David A.; Ye, Hua; Kueberuwa, Gray; Seymour, Leonard W.

Antagonism of Glycolysis and Reductive Carboxylation of Glutamine Potentiates Activity of Oncolytic Adenoviruses in Cancer Cells

CANCER RESEARCH

IF16.6

2019-01-15

PREAI

Dyer, Arthur; Schoeps, Benjamin; Frost, Sally; Jakeman, Philip; Scott, Eleanor M.; Freedman, Joshua; Jacobus, Egon J.; Seymour, Leonard W.

Impact of Polymer-TLR-7/8 Agonist (Adjuvant) Morphology on the Potency and Mechanism of CD8 T Cell Induction

BIOMACROMOLECULES

IF5.4

2019-01-04

PREAI

Lynn, Geoffrey M.; Chytil, Petr; Francica, Joseph R.; Lagova, Anna; Kueberuwa, Gray; Ishizuka, Andrew S.; Zaidi, Neeha; Ramirez-Valdez, Ramiro A.; Blobel, Nicolas J.; Baharom, Faezzah; Leal, Joseph; Wang, Amy Q.; Gemer, Michael Y.; Etrych, Tomas; Ulbrich, Karel; Seymour, Leonard W.; Seder, Robert A.; Laga, Richard

An Oncolytic Virus Expressing a T-cell Engager Simultaneously Targets Cancer and Immunosuppressive Stromal Cells

CANCER RESEARCH

IF16.6

2018-12-13

134

OAAI

Freedman, Joshua D.; Duffy, Margaret R.; Lei-Rossmann, Janet; Muntzer, Alice; Scott, Eleanor M.; Hagel, Joachim; Campo, Leticia; Bryant, Richard J.; Verrill, Clare; Lambert, Adam; Miller, Paul; Champion, Brian R.; Seymour, Leonard W.; Fisher, Kerry D.

研究方向