Sebastian M. Waszak - Publications, H-index & Citations

Sebastian M. Waszak

European Molecular Biology Laboratory

59H指数

370论文数

2.6W被引数

收录论文 71

发表时间

Divergent medulloblastoma chromatin states disclose KDM2B as a selective dependency Divergent medulloblastoma chromatin states disclose KDM2B as a selective dependency 不同小脑髓母细胞瘤染色质状态揭示KDM2B为一种选择性依赖

Nature Genetics

IF29

2026-09-24

OAAI

Ran Tao; Serap Erkek-Ozhan; Beisi Xu; Yurika Matsui; Priya Mittal; Kyle S. Smith; Yiran Li; David Filipovic; Ruijie Xu; Qingsong Gao; Emily Darrow; Rahul Kumar; Nadhir Djekidel; Richa Bajpai; Jennifer Hadley; Melissa Batts; Sara A. Lewis; Taha Soliman; Colleen Reilly; Natarajan V. Bhanu; Leena Paul; Hong Lin; Brian Gudenas; Kim Lowe; Marc Zapatka; Laura Sieber; David T. W. Jones; Marcel Kool; Sebastian M. Waszak; Volker Hovestadt; Ivo Buchhalter; Marina Ryzhova; Andrey Korshunov; Peter Lichter; Lukas Chavez; Lena M. Kutscher; Benjamin A. Garcia; Shondra M. Pruett-Miller; Xin Zhou; Brent A. Orr; Giles W. Robinson; Gang Wu; Jan O. Korbel; Jamy C. Peng; Stefan M. Pfister; Paul A. Northcott

Germline pathogenic variation impacts somatic alterations and patient outcomes in pediatric central nervous system tumors 生殖系致病变异影响儿童中枢神经系统肿瘤的体细胞改变和患者结局

Nature Communications

IF15.7

2025-11-21

OAAI

Ryan J. Corbett; Rebecca S. Kaufman; Shelly W. McQuaid; Zalman Vaksman; Saksham Phul; Miguel A. Brown; Jennifer L. Mason; Sebastian M. Waszak; Bo Zhang; Chuwei Zhong; Emily Blauel; Heena Desai; Ryan Hausler; Ammar S. Naqvi; Jessica M. Daggett; Alex Sickler; Evan C. Cresswell-Clay; Patricia J. Sullivan; Antonia Chroni; Zhuangzhuang Geng; Elizabeth M. Gonzalez; Yuankun Zhu; Allison P. Heath; Marilyn Li; Phillip B. Storm; Adam C. Resnick; Kara N. Maxwell; Kristina A. Cole; Angela J. Waanders; Miriam Bornhorst; Suzanne P. MacFarland; Jo Lynne Rokita; Sharon J. Diskin

ENHANCING GENOME ANALYSIS WITH WHOLE PROTEOME PROFILING FOR IMPROVED THERAPEUTIC DECISION MAKING IN DIFFUSE MIDLINE GLIOMA 通过全蛋白质组分析增强基因组分析，以改善弥漫性中线胶质瘤的治疗决策制定

NEURO-ONCOLOGY

IF13.4

2025-11-01

OAAI

Findlay, Izac; Staudt, Dilana; Duchatel, Ryan; Jackson, Evangeline; Persson, Mika; McEwen, Holly; Delevaux, Katherine; Smith, Nathan; Vitanza, Nicholas; Cain, Jason; Hansen, Mitchell; Alvaro, Frank; Jakobsen, Lene; Larsen, Martin; Savary, Clara; Waszak, Sebastian; Dun, Matthew

EGFR metabolically suppresses differentiation in H3K27M-mutant diffuse midline glioma EGFR代谢性地抑制H3K27M突变型中线弥漫性胶质瘤的分化。

NEURO-ONCOLOGY

IF13.4

2025-11-01

OAAI

Ji, Sunjong; Doherty, Robert; Mota, Mateus; Natarajan, Siva Kumar; de la Nava, Daniel; Sajjakulnukit, Peter; Peterson, Erik R.; Adam, Tiffany; Niculcea, Michael; Vo, Katie; Wink, Kelsey; Bavani, Subramaniam; Sridevi, Yadavilli; Nazarian, Javad; Phillips, Joanna J.; Mueller, Sabine; Filbin, Mariella; Solomon, David A.; Wahl, Daniel R.; Lyssiotis, Costas; Qin, Tingting; Beck, Alexander; Viswanath, Pavithra; Nuechterlein, Nicholas; Waszak, Sebastian M.; Venneti, Sriram; Koschmann, Carl

DISRUPTING INTEGRIN SIGNALING IMPAIRS MIGRATION, MYC-DRIVEN PURINE BIOSYNTHESIS, AND STEMNESS IN H3K27M DIFFUSE MIDLINE GLIOMAS 阻断整合素信号传导损害H3K27M弥漫性中线胶质瘤的迁移、MYC驱动的嘌呤生物合成和干性。

NEURO-ONCOLOGY

IF13.4

2025-11-01

OAAI

Cartaxo, Rodrigo T.; De La Nava, Daniel; Nieblas-Bedolla, Edwin; Niculcea, Michael; Ji, Sunjong; Natarajan, Siva Kumar; Adam, Tiffany; Clausen, Madison; Miclea, Madeline; Siada, Ruby; Schwark, Kallen; Gera, Ananya; Doherty, Robert; Lyssiotis, Costas A.; Favro, Noemi; Covato, Carmelo; Brunschwig, Lucas; Waszak, Sebastian M.; Nuechterlein, Nicholas; Filbin, Mariella; Vo, Tuan; Dun, Matthew D.; Venneti, Sriram; Hara, Toshiro; Koschmann, Carl

Effective targeting of EGFR-driven diffuse midline glioma with BLU5082, a novel brain-penetrant EGFR-targeting tyrosine kinase inhibitor (TKI)BLU5082是一种新型的能够穿透血脑屏障的EGFR靶向酪氨酸激酶抑制剂（TKI），可有效靶向EGFR驱动的中线弥漫性胶质瘤。

NEURO-ONCOLOGY

IF13.4

2025-11-01

OAAI

Doherty, Robert; Wink, Kelsey; Schwark, Kallen; Ji, Sunjong; Gera, Ananya; Messinger, Dana; de la Martin, Daniel Nava; Knowles, Truman; Subramaniam, Bavani; Millet, Yves; Waszak, Sebastian; Phillips, Joanna; Solomon, David; Nazarian, Javad; Mueller, Sabine; Beck, Alexander; Coppe, Jean-Phillipe; Koschmann, Carl

Genetic modeling of ELP1-associated Sonic hedgehog medulloblastoma identifies MDM2 as a selective therapeutic target ELP1相关Sonic hedgehog型髓母细胞瘤的遗传建模识别MDM2为选择性治疗靶点

NEURO-ONCOLOGY

IF13.4

2025-11-01

PREAI

Ahmad, Shiekh Tanveer; Li, Yiran; Garcia-Lopez, Jesus; Gudenas, Brian; Hadley, Jennifer; Paul, Leena; Wu, Stephanie; Refaat, Alaa; Kojic, Marija; Batts, Melissa; Soliman, Taha; Pitre, Aaron; Arnskotter, Frederik; Zindy, Frederique; Jones, Alun; Twarog, Nathaniel; Mayasundari, Anand; Bianski, Brandon; Tinkle, Christopher; Shirinifard, Abbas; Janke, Laura; Lu, Meifen; Lewis, Sara; Onar-Thomas, Arzu; Pfister, Stefan; Gajjar, Amar; Baker, Suzanne; Roussel, Martine; Rankovic, Zoran; Robinson, Giles; Orr, Brent; Wainwright, Brandon; Shelat, Anang; Waszak, Sebastian; Kutscher, Lena; Lin, Hong; Northcott, Paul

Combinatorial targeting of avapritinib-driven MAPK activation in pediatric high-grade glioma 阿伐普利尼布诱导的MAPK激活在儿童高级别胶质瘤中的组合靶向治疗

NEURO-ONCOLOGY

IF13.4

2025-11-01

OAAI

Schwark, Kallen; Miclea, Madeline; Patel, Tirth; Kong, Seongbae; Stanczak, Alina; Lau, Benison; Cartaxo, Rodrigo; Messinger, Dana; Doherty, Robert; Ji, Sunjong; Wadden, Jack; Clausen, Madison; Momen, Fareen; Adam, Tiffany; Wink, Kelsey; Hutchinson, Aria; Niculcea, Michael; Serhan, Habib; Merrill, Nathan; Edmonds, Amy; Mayr, Lisa; Neyazi, Sina; Munoz, Denise; Nuechterlein, Nicholas; Fernandez, Ester Calvo; Califano, Andrea; Pavisic, Jovana; Garton, Hugh; Rao, Rama; Upadhyaya, Santhosh; Skrypek, Mary; Bendel, Anne; Lobbous, Mina; Klawinski, Darren; Merajver, Sofia; Koptyra, Mateusz; Resnick, Adam; Nazarian, Javad; Venneti, Sriram; Waszak, Sebastian; Chavez, Lukas; Beck, Alexander; Gojo, Johannes; Filbin, Mariella; Coppe, Jean-Philippe; Koschmann, Carl

3D spatial sampling to quantify morphologic heterogeneity in isocitrate dehydrogenase-wildtype glioblastoma 3D空间采样用于量化异柠檬酸脱氢酶野生型胶质母细胞瘤的形态学异质性

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

IF3

2025-09-01

OAAI

Voong, Viva; Beccari, Sol; Hashemi, Elaheh; Kriener, Birgit; Mathur, Radhika; Lafontaine, Marisa; Shai, Anny; Lupo, Janine M.; Chang, Edward F.; Hervey-Jumper, Shawn L.; Berger, Mitchel S.; Waszak, Sebastian M.; Costello, Joseph F.; Phillips, Joanna J.

Genetic modeling of ELP1-associated Sonic hedgehog medulloblastoma identifies MDM2 as a selective therapeutic target ELP1相关Sonic hedgehog型髓母细胞瘤的遗传建模鉴定MDM2为选择性治疗靶点

Cancer Cell

IF44.5

2025-05-15

OAAI

Shiekh Tanveer Ahmad; Yiran Li; Jesus Garcia-Lopez; Brian L. Gudenas; Jennifer Hadley; Leena Paul; Stephanie C. Wu; Alaa Refaat; Marija Kojic; Melissa Batts; Taha Soliman; Aaron Pitre; Frederik Arnskötter; Frederique Zindy; Alun Jones; Nathaniel R. Twarog; Anand Mayasundari; Brandon Bianski; Christopher Tinkle; Abbas Shirinifard; Laura Janke; Meifen Lu; Sara A. Lewis; Arzu Onar-Thomas; Stefan M. Pfister; Amar Gajjar; Suzanne J. Baker; Martine F. Roussel; Zoran Rankovic; Giles W. Robinson; Brent A. Orr; Brandon Wainwright; Anang A. Shelat; Sebastian M. Waszak; Lena M. Kutscher; Hong Lin; Paul A. Northcott

Isocitrate dehydrogenase 1 primes group-3 medulloblastomas for cuproptosis 异柠檬酸脱氢酶1为组3型髓母细胞瘤的铜死亡做准备

Cancer Cell

IF44.5

2025-05-15

PREAI

Derek Dang; Akash Deogharkar; John McKolay; Kyle S. Smith; Pooja Panwalkar; Simon Hoffman; Wentao Tian; Sunjong Ji; Ana P. Azambuja; Siva Kumar Natarajan; Joanna Lum; Jill Bayliss; Katie Manzeck; Stefan R. Sweha; Erin Hamanishi; Matthew Pun; Diya Patel; Sagar Rau; Olamide Animasahun; Abhinav Achreja; Martin P. Ogrodzinski; Jutta Diessl; Jennifer Cotter; Debra Hawes; Fusheng Yang; Robert Doherty; Andrea T. Franson; Allison R. Hanaford; Charles G. Eberhart; Eric H. Raabe; Brent A. Orr; Robert J. Wechsler-Reya; Brandon Chen; Costas A. Lyssiotis; Yatrik M. Shah; Sophia Y. Lunt; Ruma Banerjee; Alexander R. Judkins; John R. Prensner; Carl Koschmann; Sebastian M. Waszak; Deepak Nagrath; Marcos Simoes-Costa; Paul A. Northcott; Sriram Venneti

Germline analysis of an international cohort of pediatric diffuse midline glioma patients 对国际队列儿童弥漫性中线胶质瘤患者的生殖系分析

NEURO-ONCOLOGY

IF13.4

2025-03-12

PREAI

Marion K Mateos; Pamela Ajuyah; Noemi Fuentes-Bolanos; Sam El-Kamand; Paulette Barahona; Ann-Kristin Altekoester; Chelsea Mayoh; Holly Holliday; Jie Liu; Louise Cui; Elke Pfaff; Alan Mackay; Adam C Resnick; Mark Pinese; Loretta M S Lau; Dong-Anh Khuong-Quang; Kimberly Dias; Catherine Goudie; Alison Salkeld; Jo Lynne Rokita; David T W Jones; Nikoleta Juretic; Elisha Hayden; Stefan M Pfister; Christof M Kramm; Mirjam Blattner-Johnson; Nada Jabado; Maria Tsoli; Orazio Vittorio; Sabine Mueller; Yiran Guo; Katherine Tucker; Sebastian M Waszak; Sebastien Perreault; Chris Jones; Marie Wong-Erasmus; Mark J Cowley; David S Ziegler

Genetic ancestry superpopulations show distinct prevalence and outcomes across pediatric central nervous system tumors from the Pediatric Brain Tumor Atlas and Pediatric Neuro-Oncology Consortium 遗传祖先超人群在儿科中枢神经系统肿瘤中的患病率和结局存在差异，该结果来自儿科脑肿瘤图谱和儿科神经肿瘤学联盟。

NEURO-ONCOLOGY

IF13.4

2025-01-23

PREAI

Corbett, Ryan J.; Gullickson, Cricket C.; Geng, Zhuangzhuang; Brown, Miguel A.; Zhang, Bo; Zhong, Chuwei; Van Kuren, Nicholas; Chroni, Antonia; Blackden, Christopher; Naqvi, Ammar S.; Plisiewicz, Alexa; Mchugh, Sean; Drake, Emmett; Lehmann, Kaitlin; Davidson, Tom B.; Prados, Michael; Storm, Phillip B.; Resnick, Adam C.; Waanders, Angela J.; Waszak, Sebastian M.; Mueller, Sabine; Rokita, Jo Lynne; Kline, Cassie

Germline loss-of-function variant in the E3 ubiquitin ligase TRAF2 in a young adult patient with medulloblastoma: a case report

ACTA NEUROPATHOLOGICA COMMUNICATIONS

IF5.7

2024-12-20

OAAI

Vo, Josh N.; Franson, Andrea; Waszak, Sebastian M.; Wu, Yi-Mi; Becker, Nicole; Chinnaiyan, Arul M.; Robinson, Dan R.

GERMLINEELP1 DEFICIENCY SENSITIZES CEREBELLAR GRANULE NEURON PROGENITORS TO SHH MEDULLOBLASTOMA

NEURO-ONCOLOGY

IF13.4

2024-11-11

PREAI

Tanveer Ahmad, Shiekh; Garcia-Lopez, Jesus; Li, Yiran; Hadley, Jennifer; Paul, Leena; Gudenas, Brian; Batts, Melissa; Soliman, Taha; Pitre, Aaron; Kojic, Marija; Manz, Frederik; Zindy, Frederique; Jones, Alun; Mayasundari, Anand; Bianski, Brandon; Tinkle, Christopher; Shirinifard, Abbas; Janke, Laura Janke; Lu, Meifen; Onar-Thomas, Arzu; Pfister, Stefan; Gajjar, Amar; Baker, Suzanne; Roussel, Martine; Rankovic, Zoran; Robinson, Giles; Orr, Brent; Wainwright, Brandon; Kutscher, Lena; Waszak, Sebastian; Lin, Hong; Northcott, Paul

PNOC008: A PILOT TRIAL TESTING THE CLINICAL BENEFIT OF USING MOLECULAR PROFILING TO DETERMINE AN INDIVIDUALIZED TREATMENT PLAN IN CHILDREN AND YOUNG ADULTS WITH NEWLY DIAGNOSED HIGH-GRADE GLIOMA (EXCLUDING DIFFUSE INTRINSIC PONTINE GLIOMA)

NEURO-ONCOLOGY

IF13.4

2024-11-11

PREAI

Kilburn, Lindsay; Franson, Andrea; Cooney, Tab; Kline, Cassie; Stoller, Schuyler; Reddy, Alyssa; Banerjee, Anu; Packer, Roger; Bendel, Anne; Skrypek, Maggie; Minturn, Jane; Abdelbaki, Mohamed; Whipple, Nicholas; Chan, Priya; Crawford, John; Crotty, Erin; Waanders, Angela; Elster, Jennifer; Raabe, Eric; George, Elizabeth; Pinto, Soniya; Supakul, Nucharin; Kraya, Adam; Prados, Michael; Nazarian, Javad; Solomon, David; Long-Boyle, Janel; Molinaro, Annette; Waszak, Sebastian; Mueller, Sabine

Somatic CpG hypermutation is associated with mismatch repair deficiency in cancer 体细胞CpG高突变与癌症中的错配修复缺陷相关

MOLECULAR SYSTEMS BIOLOGY

IF7.7

2024-07-18

OAAI

Flynn, Aidan; Waszak, Sebastian M.; Weischenfeldt, Joachim

NEURO-ONCOLOGY

IF13.4

2024-06-18

OAAI

Franson, Andrea T.; Kilburn, Lindsay B.; Cooney, Tab M.; Stoller, Schuyler; Reddy, Alyssa T.; Banerjee, Anu; Packer, Roger J.; Bendel, Anne E.; Skrypek, Mary M.; Minturn, Jane E.; Abdelbaki, Mohamed S.; Whipple, Nicholas S.; Chan, Priya; Crawford, John R.; Crotty, Erin E.; Waanders, Angela J.; Elster, Jennifer D.; Raabe, Eric H.; George, Elizabeth; Pinto, Soniya N.; Vossough, Arastoo; Kraya, Adam A.; Prados, Michael; Kline, Cassie; Nazarian, Javad; Solomon, David A.; Long-Boyle, Janel R.; Molinaro, Annette M.; Waszak, Sebastian M.; Mueller, Sabine

PEDIATRIC PATIENTS WITH DIFFUSE MIDLINE GLIOMA DEMONSTRATE AN UNEXPECTED PREVALENCE OF GERMLINE VARIANTS IN HOMOLOGOUS RECOMBINATION GENES 弥漫性中线胶质瘤的儿科患者在同源重组基因中表现出意想不到的种系变异患病率

NEURO-ONCOLOGY

IF13.4

2024-06-18

OAAI

Mateos, Marion K.; Ajuyah, Pamela; Fuentes-Bolanos, Noemi; El Kamand, Sam; Barahona, Paulette; Altekoester, Ann; Mayoh, Chelsea; Holiday, Holly; Liu, Jie; Cui, Louise; Pfaff, Elke; Mackay, Alan; Resnick, Adam; Pinese, Mark; Lau, Loretta M. S.; Khuong-Quang, Dong-Anh; Dias, Kimberly; Goudie, Catherine; Salkeld, Alison; Rokita, Jo Lynne; Jones, David T. W.; Juretic, Nikoleta; Hayden, Elisha; Pfister, Stefan M.; Kramm, Christof M.; Blattner-Johnson, Mirjam; Jabado, Nada; Tsoli, Maria; Vittorio, Orazio; Mueller, Sabine; Guo, Yiran; Tucker, Katherine; Waszak, Sebastian M.; Perreault, Sebastien; Jones, Chris; Wong-Erasmus, Marie; Cowley, Mark J.; Ziegler, David S.

GERMLINEELP1 DEFICIENCY SENSITIZES CEREBELLAR GRANULE NEURON PROGENITORS TO SHH MEDULLOBLASTOMA

NEURO-ONCOLOGY

IF13.4

2024-06-18

OAAI

Ahmad, Shiekh Tanveer; Garcia-Lopez, Jesus; Li, Yiran; Gudenas, Brian; Hadley, Jennifer; Paul, Leena; Batts, Melissa; Soliman, Taha; Kojic, Marija; Pitre, Aaron; Manz, Frederik; Zindy, Frederique; Jones, Alun; Mayasundari, Anand; Bianski, Brandon; Tinkle, Christopher; Shirinifard, Abbas; Janke, Laura; Lu, Meifen; Pfister, Stefan M.; Gajjar, Amar; Baker, Suzanne J.; Roussel, Martine F.; Rankovic, Zoran; Waszak, Sebastian M.; Robinson, Giles W.; Orr, Brent A.; Wainwright, Brandon; Kutscher, Lena M.; Lin, Hong; Northcott, Paul A.

研究方向