未登录 An engineered T7 RNA polymerase for efficient co-transcriptional capping with reduced dsRNA byproducts in mRNA synthesis Miller, Mathew; Alvizo, Oscar; Baskerville, Scott; Chintala, Avinash; Chng, Chinping; Dassie, Justin; Dorigatti, Jonathan; Huisman, Gjalt; Jenne, Stephan; Kadam, Supriya; Leatherbury, Neil; Lutz, Stefan; Mayo, Melissa; Mukherjee, Arpan; Sero, Antoinette; Sundseth, Stuart; Penfield, Jonathan; Riggins, James; Zhang, Xiyun 分享 收藏
An orally administered enzyme therapeutic for homocystinuria that suppresses homocysteine by metabolizing methionine in the gastrointestinal tract Skvorak, Kristen; Mitchell, Vesna; Teadt, Leann; Franklin, Kierra A.; Lee, Hyung-Ok; Kruse, Nikki; Huitt-Roehl, Callie; Hang, Julie; Du, Faye; Galanie, Stephanie; Guan, Steven; Aijaz, Hera; Zhang, Nianliu; Rajkovic, Gabriel; Kruger, Warren D.; Ismaili, Moulay Hicham Alaoui; Huisman, Gjalt; McCluskie, Kerryn; Silverman, Adam P. 分享 收藏
Optimizing human α-galactosidase for treatment of Fabry disease Hallows, William C.; Skvorak, Kristen; Agard, Nick; Kruse, Nikki; Zhang, Xiyun; Zhu, Yu; Botham, Rachel C.; Chng, Chinping; Shukla, Charu; Lao, Jessica; Miller, Mathew; Sero, Antoinette; Viduya, Judy; Ismaili, Moulay Hicham Alaoui; McCluskie, Kerryn; Schiffmann, Raphael; Silverman, Adam P.; Shen, Jin-Song; Huisman, Gjalt W. 分享 收藏
An engineered β-galactosidase with improved stability and crosscorrection for the potential treatment of GM1 Gangliosidosis via AAV gene therapy Reddy, Charu; Onguka, Ouma; Artz, Jacob; Schmitt, Christopher; Grossman, Adam; Santosh, Swetha; Akinkugbe, Oluwayomi; Wong, Victoria; Gebretsadik, Kahsay; Sedighi, Faezeh; Tang, Jinyan; Del Greco, Elizabeth; Lee, Grace S.; Kruse, Nikki; Chng, Chinping; Duan, Da; Hallows, William C.; Chen, Joseph C.; Akeefe, Hassibullah; Silverman, Adam P.; Huisman, Gjalt 分享 收藏
In vitro modeling of GM1 gangliosidosis using iPSC-derived cellular and organoid CNS models Schmitt, Christopher E.; Lee, Grace S.; Onguka, Ouma; Wong, Victoria; Del Greco, Elizabeth; Sedighi, Faezeh; Reddy, Charu; Santosh, Swetha; Akinkugbe, Oluwayomi; Artz, Jacob; Kruse, Nikki; Chng, Chinping; Hallows, William C.; Chen, Joseph C.; Akeefe, Hassibullah; Silverman, Adam P.; Huisman, Gjalt 分享 收藏
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Engineering α-glucosidase to improve protein stability and cellular uptake for the potential treatment of Pompe disease Botham, Rachel C.; Hallows, William C.; Reddy, Charu; Dellas, Nikki; Homan, David; Lao, Jessica; Zhu, Cynthia; Chng, Chinping; Sero, Antoinette; Miller, Matt; Choi, Su Jin; Sun, Baodong; McCluskie, Kerryn; Huisman, Gjalt; Silverman, Adam P. 分享 收藏
Engineering α-galactosidase A (GLA) to improve protein stability, efficacy and reduced immune response for the treatment of Fabry disease Hallows, William Casey; Skvorak, Kristen; Zhu, Cynthia Yu; Sero, Antoinette; Botham, Rachel; Agard, Nicholas; Chng, Chinping; Dellas, Nikki; Miller, Matt; Shin, Jinsong; Viduya, Judy; Zhang, Xiyun; Schiffmann, Raphael; Huisman, Gjalt; McCluskie, Kerryn; Alaoui, Hicham 分享 收藏
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Origins of stereoselectivity in evolved ketoreductases Noey, Elizabeth L.; Tibrewal, Nidhi; Jimenez-Oses, Gonzalo; Osuna, Silvia; Park, Jiyong; Bond, Carly M.; Cascio, Duilio; Liang, Jack; Zhang, Xiyun; Huisman, Gjalt W.; Tang, Yi; Houk, Kendall N. 分享 收藏
Development of a Practical, Biocatalytic Reduction for the Manufacture of (S)-Licarbazepine Using an Evolved Ketoreductase Modukuru, Naga K.; Sukumaran, Joly; Collier, Steven J.; Chan, Ann Shu; Gohel, Anupam; Huisman, Gjalt W.; Keledjian, Raquel; Narayanaswamy, Karthik; Novick, Scott J.; Palanivel, S. M.; Smith, Derek; Wei, Zhang; Wong, Brian; Yeo, Wan Lin; Entwistle, David A. 分享 收藏
The role of distant mutations and allosteric regulation on LovD active site dynamics Jimenez-Oses, Gonzalo; Osuna, Silvia; Gao, Xue; Sawaya, Michael R.; Gilson, Lynne; Collier, Steven J.; Huisman, Gjalt W.; Yeates, Todd O.; Tang, Yi; Houk, K. N. 分享 收藏
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Efficient, Chemoenzymatic Process for Manufacture of the Boceprevir Bicyclic [3.1.0]Proline Intermediate Based on Amine Oxidase-Catalyzed Desymmetrization Li, Tao; Liang, Jack; Ambrogelly, Alexandre; Brennan, Tim; Gloor, Guy; Huisman, Gjalt; Lalonde, James; Lekhal, Azzeddine; Mijts, Ben; Muley, Sheela; Newman, Lisa; Tobin, Matt; Wong, George; Zaks, Aleksey; Zhang, Xiyun 分享 收藏
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Highly Enantioselective Reduction of a Small Heterocyclic Ketone: Biocatalytic Reduction of Tetrahydrothiophene-3-one to the Corresponding (R)-Alcohol Liang, Jack; Mundorff, Emily; Voladri, Rama; Jenne, Stephan; Gilson, Lynne; Conway, Aaron; Krebber, Anke; Wong, John; Huisman, Gjalt; Truesdell, Susan; Lalonde, James 分享 收藏
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