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Invention of VH-937, a Potent HIV-1 Maturation Inhibitor with the Potential for Infrequent Oral Dosing in Humans Sit, Sing-Yuen; Chen, Yan; Chen, Jie; Venables, Brian L.; Swidorski, Jacob J.; Xu, Li; Sin, Ny; Hartz, Richard A.; Lin, Zeyu; Zhang, Sharon; Li, Zhufang; Wu, Dauh-Rurng; Li, Peng; Kempson, James; Hou, Xiaoping; Shanmugam, Yoganand; Parker, Dawn; Jenkins, Susan; Simmermacher, Jean; Falk, Paul; Mcauliffe, Brian; Cockett, Mark; Hanumegowda, Umesh; Dicker, Ira; Krystal, Mark; Meanwell, Nicholas A.; Regueiro-Ren, Alicia 分享 收藏
Preclinical Profile of the HIV-1 Maturation Inhibitor VH3739937 HIV-1成熟抑制剂VH3739937的临床前概况 McAuliffe, Brian; Falk, Paul; Chen, Jie; Chen, Yan; Sit, Sing-Yuen; Swidorski, Jacob; Hartz, Richard A.; Xu, Li; Venables, Brian; Sin, Ny; Meanwell, Nicholas A.; Regueiro-Ren, Alicia; Wensel, David; Hanumegowda, Umesh; Krystal, Mark 分享 收藏
Exploring HIV-1 Maturation: A New Frontier in Antiviral Development McGraw, Aidan; Hillmer, Grace; Medehincu, Stefania M.; Hikichi, Yuta; Gagliardi, Sophia; Narayan, Kedhar; Tibebe, Hasset; Marquez, Dacia; Bose, Lilia Mei; Keating, Adleigh; Izumi, Coco; Peese, Kevin; Joshi, Samit; Krystal, Mark; DeCicco-Skinner, Kathleen L.; Freed, Eric O.; Sardo, Luca; Izumi, Taisuke 分享 收藏
Antiviral Properties of HIV-1 Capsid Inhibitor GSK878 Wang, Chunfu; Huang, Haichang; Mallon, Kirsten; Valera, Lourdes; Parcella, Kyle; Cockett, Mark I.; Kadow, John F.; Gillis, Eric P.; Krystal, Mark; Fridell, Robert A. 分享 收藏
Potent Long-Acting Inhibitors Targeting the HIV-1 Capsid Based on a Versatile Quinazolin-4-one Scaffold Gillis, Eric P.; Parcella, Kyle; Bowsher, Michael; Cook, James H.; Iwuagwu, Christiana; Naidu, B. Narasimhulu; Patel, Manoj; Peese, Kevin; Huang, Haichang; Valera, Lourdes; Wang, Chunfu; Kieltyka, Kasia; Parker, Dawn D.; Simmermacher, Jean; Arnoult, Eric; Nolte, Robert T.; Wang, Liping; Bender, John A.; Frennesson, David B.; Saulnier, Mark; Wang, Alan Xiangdong; Meanwell, Nicholas A.; Belema, Makonen; Hanumegowda, Umesh; Jenkins, Susan; Krystal, Mark; Kadow, John F.; Cockett, Mark; Fridell, Robert 分享 收藏
Synthesis, Structure-Activity Relationships, and In Vivo Evaluation of Novel C-17 Amine Derivatives Based on GSK3640254 as HIV-1 Maturation Inhibitors with Broad Spectrum Activity Hartz, Richard A.; Xu, Li; Sit, Sing-Yuen; Chen, Jie; Venables, Brian L.; Lin, Zeyu; Zhang, Sharon; Li, Zhufang; Parker, Dawn; Simmons, Tara S.; Jenkins, Susan; Hanumegowda, Umesh M.; Dicker, Ira; Krystal, Mark; Meanwell, Nicholas A.; Regueiro-Ren, Alicia 分享 收藏
Membrane-bound mRNA immunogens lower the threshold to activate HIV Env V2 apex-directed broadly neutralizing B cell precursors in humanized mice Melzi, Eleonora; Willis, Jordan R.; Ma, Krystal M.; Lin, Ying-Cing; Kratochvil, Sven; Berndsen, Zachary T.; Landais, Elise A.; Kalyuzhniy, Oleksandr; Nair, Usha; Warner, John; Steichen, Jon M.; Kalyuzhniy, Anton; Le, Amber; Pecetta, Simone; Perez, Manfredo; Kirsch, Kathrin; Weldon, Stephanie R.; Falcone, Samantha; Himansu, Sunny; Carfi, Andrea; Sok, Devin; Ward, Andrew B.; Schief, William R.; Batista, Facundo D. 分享 收藏
Human immunoglobulin repertoire analysis guides design of vaccine priming immunogens targeting HIV V2-apex broadly neutralizing antibody precursors Willis, Jordan R.; Berndsen, Zachary T.; Ma, Krystal M.; Steichen, Jon M.; Schiffner, Torben; Landais, Elise; Liguori, Alessia; Kalyuzhniy, Oleksandr; Allen, Joel D.; Baboo, Sabyasachi; Omorodion, Oluwarotimi; Diedrich, Jolene K.; Hu, Xiaozhen; Georgeson, Erik; Phelps, Nicole; Eskandarzadeh, Saman; Groschel, Bettina; Kubitz, Michael; Adachi, Yumiko; Mullin, Tina-Marie; Alavi, Nushin B.; Falcone, Samantha; Himansu, Sunny; Carfi, Andrea; Wilson, Ian A.; Yates, John R.; Paulson, James C.; Crispin, Max; Ward, Andrew B.; Schief, William R. 分享 收藏
The Discovery of GSK3640254, a Next-Generation Inhibitor of HIV-1 Maturation Regueiro-Ren, Alicia; Sit, Sing-Yuen; Chen, Yan; Chen, Jie; Swidorski, Jacob J.; Liu, Zheng; Venables, Brian L.; Sin, Ny; Hartz, Richard A.; Protack, Tricia; Lin, Zeyu; Zhang, Sharon; Li, Zhufang; Wu, Dauh-Rurng; Li, Peng; Kempson, James; Hou, Xiaoping; Gupta, Anuradha; Rampulla, Richard; Mathur, Arvind; Park, Hyunsoo; Sarjeant, Amy; Benitex, Yulia; Rahematpura, Sandhya; Parker, Dawn; Phillips, Thomas; Haskell, Roy; Jenkins, Susan; Santone, Kenneth S.; Cockett, Mark; Hanumegowda, Umesh; Dicker, Ira; Meanwell, Nicholas A.; Krystal, Mark 分享 收藏
Improving Drug Delivery While Tailoring Prodrug Activation to Modulate Cmax and Cmin by Optimization of (Carbonyl)oxyalkyl Linker-Based Prodrugs of Atazanavir Subbaiah, Murugaiah A. M.; Subramani, Lakshumanan; Ramar, Thangeswaran; Desai, Salil; Sinha, Sarmistha; Mandlekar, Sandhya; Kadow, John F.; Jenkins, Susan; Krystal, Mark; Subramanian, Murali; Sridhar, Srikanth; Padmanabhan, Shweta; Bhutani, Priyadeep; Arla, Rambabu; Meanwell, Nicholas A. 分享 收藏
Scaffold modifications to the 4-(4,4-dimethylpiperidinyl) 2,6-dimethylpyr-idinyl class of HIV-1 allosteric integrase inhibitors Parcella, Kyle; Patel, Manoj; Tu, Yong; Eastman, Kyle; Peese, Kevin; Gillis, Eric; Belema, Makonen; Dicker, Ira B.; McAuliffe, Brian; Ding, Bo; Falk, Paul; Simmermacher, Jean; Parker, Dawn D.; Sivaprakasam, Prasanna; Khan, Javed A.; Kish, Kevin; Lewis, Hal; Hanumegowda, Umesh; Jenkins, Susan; Kadow, John F.; Krystal, Mark; Meanwell, Nicholas A.; Naidu, B. Narasimhulu 分享 收藏
Week 96 Genotypic and Phenotypic Results of the Fostemsavir Phase 3 BRIGHTE Study in Heavily Treatment-Experienced Adults Living with Multidrug-Resistant HIV-1 Gartland, Margaret; Cahn, Pedro; DeJesus, Edwin; Diaz, Ricardo Sobhie; Grossberg, Robert; Kozal, Michael; Kumar, Princy; Molina, Jean-Michel; Mendo Urbina, Fernando; Wang, Marcia; Du, Fangfang; Chabria, Shiven; Clark, Andrew; Garside, Louise; Krystal, Mark; Mannino, Frank; Pierce, Amy; Ackerman, Peter; Lataillade, Max 分享 收藏
Discovery and Preclinical Profiling of GSK3839919, a Potent HIV-1 Allosteric Integrase Inhibitor Parcella, Kyle; Wang, Tao; Eastman, Kyle; Zhang, Zhongxing; Yin, Zhiwei; Patel, Manoj; Tu, Yong; Zheng, Barbara Zhizhen; Walker, Michael A.; Saulnier, Mark G.; Frennesson, David; Bowsher, Michael; Gillis, Eric; Peese, Kevin; Belema, Makonen; Cianci, Christopher; Dicker, Ira B.; McAuli, Brian; Ding, Bo; Falk, Paul; Simmermacher, Jean; Parker, Dawn D.; Sivaprakasam, Prasanna; Kish, Kevin; Lewis, Hal; Hanumegowda, Umesh; Jenkins, Susan; Kadow, John F.; Krystal, Mark; Meanwell, Nicholas A.; Naidu, B. Narasimhulu 分享 收藏
Impact of Integrase Sequences from HIV-1 Subtypes A6/A1 on the In Vitro Potency of Cabotegravir or Rilpivirine Jeffrey, Jerry L.; St Clair, Marty; Wang, Ping; Wang, Chunfu; Li, Zhufang; Beloor, Jagadish; Talarico, Christine; Fridell, Robert; Krystal, Mark; White, C. Thomas; Griffith, Sandy; D'Amico, Ronald; Smith, Kimberly; Van Eygen, Veerle; Vingerhoets, Johan; Vandermeulen, Kati; Spreen, William; van Lunzen, Jan 分享 收藏
Design, Synthesis, and Preclinical Profiling of GSK3739936 (BMS-986180), an Allosteric Inhibitor of HIV-1 Integrase with Broad-Spectrum Activity toward 124/125 Polymorphs Naidu, B. Narasimhulu; Patel, Manoj; McAuliffe, Brian; Ding, Bo; Cianci, Christopher; Simmermacher, Jean; Jenkins, Susan; Parker, Dawn D.; Sivaprakasam, Prasanna; Khan, Javed A.; Kish, Kevin; Lewis, Hal; Hanumegowda, Umesh; Krystal, Mark; Meanwell, Nicholas A.; Kadow, John F. 分享 收藏
GSK3640254 Is a Novel HIV-1 Maturation Inhibitor with an Optimized Virology Profile Dicker, Ira; Jeffrey, Jerry L.; Protack, Tricia; Lin, Zeyu; Cockett, Mark; Chen, Yan; Sit, Sing-Yuen; Gartland, Martin; Meanwell, Nicholas A.; Regueiro-Ren, Alicia; Drexler, Dieter; Cantone, Joseph; McAuliffe, Brian; Krystal, Mark 分享 收藏
(Carbonyl)oxyalkyl linker-based amino acid prodrugs of the HIV-1 protease inhibitor atazanavir that enhance oral bioavailability and plasma trough concentration HIV-1蛋白酶抑制剂阿扎那韦的基于 (羰基) 氧烷基接头的氨基酸前药，可提高口服生物利用度和血浆谷浓度 Subbaiah, Murugaiah A. M.; Ramar, Thangeswaran; Subramani, Lakshumanan; Desai, Salil D.; Sinha, Sarmistha; Mandlekar, Sandhya; Jenkins, Susan M.; Krystal, Mark R.; Subramanian, Murali; Sridhar, Srikanth; Padmanabhan, Shweta; Bhutani, Priyadeep; Arla, Rambabu; Kadow, John F.; Meanwell, Nicholas A. 分享 收藏
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Design, synthesis and SAR study of bridged tricyclic pyrimidinone carboxamides as HIV-1 integrase inhibitors Patel, Manoj; Naidu, B. Narasimhulu; Dicker, Ira; Higley, Helen; Lin, Zeyu; Terry, Brian; Protack, Tricia; Krystal, Mark; Jenkins, Susan; Parker, Dawn; Panja, Chiradeep; Rampulla, Richard; Mathur, Arvind; Meanwell, Nicholas A.; Walker, Michael A. 分享 收藏
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