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Discovery of STX-721, a Covalent, Potent, and Highly Mutant-Selective EGFR/HER2 Exon20 Insertion Inhibitor for the Treatment of Non-Small Cell Lung Cancer 发现STX-721，一种用于治疗非小细胞肺癌的共价、强效且高度突变选择性的EGFR/HER2外显子20插入抑制剂。 Milgram, Benjamin C.; Borrelli, Deanna R.; Brooijmans, Natasja; Henderson, Jack A.; Hilbert, Brendan J.; Huff, Michael R.; Ito, Takahiro; Jackson, Erica L.; Jonsson, Philip; Ladd, Brendon; O'Hearn, Erin L.; Pagliarini, Raymond A.; Roberts, Simon A.; Ronseaux, Sebastien; Stuart, Darrin D.; Wang, Weixue; Guzman-Perez, Angel 分享 收藏
Mice with deficiency in Pcdh15, a gene associated with bipolar disorders, exhibit significantly elevated diurnal amplitudes of locomotion and body temperature Mori, Daisuke; Inami, Chihiro; Ikeda, Ryosuke; Sawahata, Masahito; Urata, Shinji; Yamaguchi, Sho T.; Kobayashi, Yohei; Fujita, Kosuke; Arioka, Yuko; Okumura, Hiroki; Kushima, Itaru; Kodama, Akiko; Suzuki, Toshiaki; Hirao, Takashi; Yoshimi, Akira; Sobue, Akira; Ito, Takahiro; Noda, Yukikiro; Mizoguchi, Hiroyuki; Nagai, Taku; Kaibuchi, Kozo; Okabe, Shigeo; Nishiguchi, Koji; Kume, Kazuhiko; Yamada, Kiyofumi; Ozaki, Norio 分享 收藏
Systematic profiling of conditional pathway activation identifies context-dependent synthetic lethalities (vol 55, pg 1709, 2023) Chang, Liang; Jung, Nancy Y.; Atari, Adel; Rodriguez, Diego J.; Kesar, Devishi; Song, Tian-Yu; Rees, Matthew G.; Ronan, Melissa; Li, Ruitong; Ruiz, Paloma; Chaturantabut, Saireudee; Ito, Takahiro; van Tienen, Laurens M.; Tseng, Yuen-Yi; Roth, Jennifer A.; Sellers, William R. 分享 收藏
Corticosteroids impair epithelial regeneration in immune-mediated intestinal damage Arnhold, Viktor; Chang, Winston Y.; Jansen, Suze A.; Thangavelu, Govindarajan; Calafiore, Marco; Vinci, Paola; Fu, Ya-Yuan; Ito, Takahiro; Takashima, Shuichiro; Egorova, Anastasiya; Kuttiyara, Jason; Perlstein, Adam; van Hoesel, Marliek; Liu, Chen; Blazar, Bruce R.; Lindemans, Caroline A.; Hanash, Alan M. 分享 收藏
Systematic profiling of conditional pathway activation identifies context-dependent synthetic lethalities Chang, Liang; Jung, Nancy Y.; Atari, Adel; Rodriguez, Diego J.; Kesar, Devishi; Song, Tian-Yu; Rees, Matthew G.; Ronan, Melissa; Li, Ruitong; Ruiz, Paloma; Chaturantabut, Saireudee; Ito, Takahiro; van Tienen, Laurens M.; Tseng, Yuen-Yi; Roth, Jennifer A.; Sellers, William R. 分享 收藏
A tissue-intrinsic IL-33/EGF circuit promotes epithelial regeneration after intestinal injury Calafiore, Marco; Fu, Ya-Yuan; Vinci, Paola; Arnhold, Viktor; Chang, Winston Y.; Jansen, Suze A.; Egorova, Anastasiya; Takashima, Shuichiro; Kuttiyara, Jason; Ito, Takahiro; Serody, Jonathan; Nakae, Susumu; Turnquist, Heth; Van Es, Johan; Clevers, Hans; Lindemans, Caroline A.; Blazar, Bruce R.; Hanash, Alan M. 分享 收藏
Comparative optimization of combinatorial CRISPR screens Li, Ruitong; Klingbeil, Olaf; Monducci, Davide; Young, Michael J.; Rodriguez, Diego J.; Bayyat, Zaid; Dempster, Joshua M.; Kesar, Devishi; Yang, Xiaoping; Zamanighomi, Mahdi; Vakoc, Christopher R.; Ito, Takahiro; Sellers, William R. 分享 收藏
Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers Ito, Takahiro; Young, Michael J.; Li, Ruitong; Jain, Sidharth; Wernitznig, Andreas; Krill-Burger, John M.; Lemke, Christopher T.; Monducci, Davide; Rodriguez, Diego J.; Chang, Liang; Dutta, Sanjukta; Pal, Debjani; Paolella, Brenton R.; Rothberg, Michael V.; Root, David E.; Johannessen, Cory M.; Parida, Laxmi; Getz, Gad; Vazquez, Francisca; Doench, John G.; Zamanighomi, Mahdi; Sellers, William R. 分享 收藏
Critical amino acid variants in HLA-DRB1 allotypes in the development of Graves' disease and Hashimoto's thyroiditis in the Japanese population Katahira, Masahito; Ogata, Hidetada; Takashima, Hiromi; Ito, Takahiro; Hodai, Yuichi; Miwata, Tsutomu; Goto, Megumi; Yamaguchi, Mariko; Mizoguchi, Akira; Kawakubo, Mitsuhiro; Nakamura, Shizuka 分享 收藏
Distinct CDK6 complexes determine tumor cell response to CDK4/6 inhibitors and degraders Wu, Xuewei; Yang, Xiaobao; Xiong, Yan; Li, Ruitong; Ito, Takahiro; Ahmed, Tamer A.; Karoulia, Zoi; Adamopoulos, Christos; Wang, Hong; Wang, Li; Xie, Ling; Liu, Jing; Ueberheide, Beatrix; Aaronson, Stuart A.; Chen, Xian; Buchanan, Sean G.; Sellers, William R.; Jin, Jian; Poulikakos, Poulikos I. 分享 收藏
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RESPONSE GENE TO COMPLEMENT-32 MEDIATES C5B-9 INDUCED PROLIFERATION AND MIGRATION IN ENDOTHELIAL CELLS Vlaicu, S. I.; Tegla, C. A.; Cudrici, C.; Ito, T.; Nguyen, V.; Boodhoo, D.; Rus, V.; Niculescu, F.; Mircea, P. A.; Rus, H. 分享 收藏
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