Maureen E. Murphy - Publications, H-index & Citations

Maureen E. Murphy

the wistar institute

62H指数

447论文数

3.4W被引数

收录论文 122

发表时间

Mutant p53 binds and controls estrogen receptor activity to drive endocrine resistance in ovarian cancer 邵, C.; Indeglia, A.; Foster, M.; Casey, K.; Leung, J.; Modarai, S.R.; Leu, J.I.-J.; Duong, B.; Mes-Masson, A.-M.; Sims-Mourtada, J.; 等. 突变P53与雌激素受体结合并调控其活性以驱动卵巢癌内分泌耐药. Genes Dev. 2025; epub ahead of print. [Google Scholar] [CrossRef] [PubMed]

GENES & DEVELOPMENT

IF7.7

2026-02-01

PREAI

Shao, Chunlei; Indeglia, Alexandra; Foster, Maya; Casey, Kaitlyn; Leung, Jessica; Modarai, Shirin R.; Leu, Julia I-Ju; Duong, Bryant; Mes-Masson, Anne-Marie; Sims-Mourtada, Jennifer; Auslander, Noam; Drapkin, Ronny; Bitler, Benjamin G.; Zhang, Nan; Murphy, Maureen E.

A quantitative, Bayesian-informed approach to gene-specific variant classification: Updated Expert Panel recommendations improve classification of TP53 germline variants for Li-Fraumeni syndrome 一种基于贝叶斯定量分析的基因特异性变异分类方法：更新的专家小组建议改进了TP53生殖细胞变异在Li-Fraumeni综合征中的分类

Genome Medicine

IF11.2

2025-10-24

OAAI

Cristina Fortuno; Megan N. Frone; Jessica Mester; Miguel de la Hoya; Phuong L. Mai; Tina Pesaran; Maria Isabel Achatz; Rebecca Bassett; Carolina Bustamante; Stephanie Crowley; Kelvin Cesar de Andrade; D. Gareth Evans; Bingjian Feng; Laura Fuqua; Maria Isabel Harrell; Jessica N. Hatton; Robert Huether; Chimene Kesserwan; Kristy Lee; Suzanne P. MacFarland; Jamie L. Maciaszek; Kara Maxwell; Kelly McGoldrick; Maureen Murphy; Bita Nehoray; Judith Penkert; Emilia Modolo Pinto; Sharon E. Plon; Alison Schwartz-Levine; Ashley S. Thompson; Wenyi Wang; Gerard P. Zambetti; Kristin Zelley; Paul A. James; Sharon A. Savage; Christian P. Kratz; Amanda B. Spurdle

Targeted citrullination enables p53 binding to non-canonical sites 靶向瓜氨酸化使p53能够结合到非经典位点

Molecular Cell

IF16.6

2025-10-02

OAAI

Alexandra Indeglia; Andrea Valdespino; Giulia Pantella; Sarah Offley; Connor Hill; Maya Foster; Kaitlyn Casey; Hsin-Yao Tang; Anneliese M. Faustino; Alessandro Gardini; Maureen E. Murphy

Kaposi's sarcoma-associated herpesvirus induces mitochondrial fission to evade host immune responses and promote viral production 卡波西肉瘤相关疱疹病毒诱导线粒体分裂以逃避宿主免疫反应并促进病毒产生

NATURE MICROBIOLOGY

IF19.4

2025-05-22

PREAI

Zhu, Qing; Mcelroy, Robert; Machhar, Janvhi Suresh; Cassel, Joel; Zheng, Zihan; Mansoori, Behzad; Guo, Hongrui; Guo, Sen; Pangilinan, Christian; Liang, Jinghui; Shen, Dongliang; Zhang, Lu; Liu, Qin; Kossenkov, Andrew V.; Altieri, Dario C.; Lieberman, Paul M.; Gao, Shou-Jiang; Feng, Pinghui; Murphy, Maureen E.; Song, Jikui; Salvino, Joseph M.; Liang, Qiming; Jung, Jae U.; Liang, Chengyu

Selective abrogation of S6K2 identifies lipid homeostasis as a survival vulnerability in MAPK inhibitor-resistant NRAS-mutant melanoma 选择性废除S6K2将脂质稳态识别为MAPK抑制剂耐药的NRAS突变黑色素瘤的生存易损性

SCIENCE TRANSLATIONAL MEDICINE

IF14.6

2025-02-05

PREAI

Lipchick, Brittany; Guterres, Adam N.; Chen, Hsin-Yi; Zundell, Delaine M.; Del Aguila, Segundo; Reyes-Uribe, Patricia I.; Tirado, Yulissa; Basu, Subhasree; Yin, Xiangfan; Kossenkov, Andrew V.; Lu, Yiling; Mills, Gordon B.; Liu, Qin; Goldman, Aaron R.; Murphy, Maureen E.; Speicher, David W.; Villanueva, Jessie

The Ashkenazi-Centric G334R Variant of TP53 is Severely Impaired for Transactivation but Retains Tumor Suppressor Function in a Mouse Model

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2024-11-08

PREAI

Stieg, David C.; Casey, Kaitlyn; Karisetty, Bhanu Chandra; Leu, Julia I-Ju; Larkin, Fiona; Vogel, Peter; Madzo, Jozef; Murphy, Maureen E.

Editorial: Double-edged swords: important factors connecting metabolic disorders and cancer development - from basic research to translational applications, volume II

FRONTIERS IN ENDOCRINOLOGY

IF4.6

2024-06-19

OAAI

Kung, Che-Pei; Barnoud, Thibaut; Yao, Cong-Hui; Bertolini, Irene; Murphy, Maureen E.

Elucidating the chain of command: our current understanding of critical target genes for p53-mediated tumor suppression

CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

IF6.4

2024-04-25

OAAI

Indeglia, Alexandra; Murphy, Maureen E.

Exploiting lurbinectedin-driven nucleolar relocalization of EWS-FLI1 to develop novel combination therapies for Ewing sarcoma

CANCER RESEARCH

IF16.6

2024-03-22

PREAI

Veluvolu, Sridhar M.; Lopez, Raphael D.; Gedminas, Jenna M.; Boguslawski, Elissa A.; Wilson, Elizabeth R.; Caiello, Benjamin P.; Murphy, Maureen E.; Grohar, Patrick J.

Germline p53 R181 variants and DNA binding cooperativity in tumorigenesis

CANCER RESEARCH

IF16.6

2024-03-22

PREAI

Moses, Renyta; Hausler, Ryan; Kelly, Gregory; Indeglia, Alexandra; Miller, Sven; Karanicolas, John; Murphy, Maureen; Maxwell, Kara

Exploring the genetic and molecular basis of differences in multiple myeloma of individuals of African and European descent

CELL DEATH AND DIFFERENTIATION

IF15.4

2023-11-24

OAAI

Levine, Arnold J.; Carpten, John D.; Murphy, Maureen; Hainaut, Pierre

p53 restoration in small cell lung cancer identifies a latent cyclophilin-dependent necrosis mechanism

NATURE COMMUNICATIONS

IF15.7

2023-07-21

OAAI

Acosta, Jonuelle; Li, Qinglan; Freeburg, Nelson F.; Murali, Nivitha; Indeglia, Alexandra; Grothusen, Grant P.; Cicchini, Michelle; Mai, Hung; Gladstein, Amy C.; Adler, Keren M.; Doerig, Katherine R.; Li, Jinyang; Ruiz-Torres, Miguel; Manning, Kimberly L.; Stanger, Ben Z.; Busino, Luca; Murphy, Maureen; Wan, Liling; Feldser, David M.

An African-Specific Variant of TP53 Reveals PADI4 as a Regulator of p53-Mediated Tumor Suppression

CANCER DISCOVERY

IF33.3

2023-05-04

OAAI

Indeglia, Alexandra; Leung, Jessica C.; Miller, Sven A.; Leu, Julia I-Ju; Dougherty, James F.; Clarke, Nicole L.; Kirven, Nicole A.; Shao, Chunlei; Ke, Lei; Lovell, Scott; Barnoud, Thibaut; Lu, David Y.; Lin, Cindy; Kannan, Toshitha; Battaile, Kevin P.; Yang, Tyler Hong Loong; Batista Oliva, Isabela; Claiborne, Daniel T.; Vogel, Peter; Liu, Lijun; Liu, Qin; Nefedova, Yulia; Cassel, Joel; Auslander, Noam; Kossenkov, Andrew V.; Karanicolas, John; Murphy, Maureen E.

p53 Oligomerization Domain Mutants: A New Class of Mutants That Retain License to Kill

CANCER DISCOVERY

IF33.3

2023-05-04

PREAI

Stieg, David; Casey, Kaitlyn; Murphy, Maureen E.

Defining the function of tumor suppressor p53 arginine 181 residue in tumorigenesis

CANCER RESEARCH

IF16.6

2023-04-04

PREAI

Moses, Renyta; Kelly, Gregory; Indeglia, Alexandra; Miller, Sven; Karanicolas, John; Murphy, Maureen; Maxwell, Kara

Regulation of p53 by hypoxia: Dissociation of transcriptional repression and apoptosis from p53-dependent transactivation

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-28

349

OAAI

Koumenis, C; Alarcon, R; Hammond, E; Sutphin, P; Hoffman, W; Murphy, M; Derr, J; Taya, Y; Lowe, SW; Kastan, M; Giaccia, A

p53 differentially inhibits cell growth depending on the mechanism of telomere maintenance

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-27

OAAI

Razak, ZRA; Varkonyi, RJ; Kulp-McEliece, M; Caslini, C; Testa, JR; Murphy, ME; Broccoli, D

The Codon 72 Polymorphism of p53 Regulates Interaction with NF-κB and Transactivation of Genes Involved in Immunity and Inflammation

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-20

103

OAAI

Frank, Amanda K.; Leu, Julia I-Ju; Zhou, Yan; Devarajan, Karthik; Nedelko, Tatiana; Klein-Szanto, Andres; Hollstein, Monica; Murphy, Maureen E.

Editorial: Double-edged swords: Important factors connecting metabolic disorders and cancer development - from basic research to translational applications

FRONTIERS IN ENDOCRINOLOGY

IF4.6

2023-03-02

OAAI

Kung, Che-Pei; Barnoud, Thibaut; Yao, Cong-Hui; Murphy, Maureen E.

Common activities and predictive gene signature identified for genetic hypomorphs of TP53

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2023-02-07

OAAI

Leung, Jessica C.; Leu, Julia I-Ju; Indeglia, Alexandra; Kannan, Toshitha; Clarke, Nicole L.; Kirven, Nicole A.; Dweep, Harsh; Garlick, David; Barnoud, Thibaut; Kossenkov, Andrew V.; George, Donna L.; Murphy, Maureen E.

研究方向