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K

Keith T. Flaherty

Harvard Medical School
H指数:146
被引数:12.1万

个人简介

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荣誉奖项

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Multimodal blood based proteomic profiling reveals insights into mechanisms of immunotherapy resistance

多模态血液蛋白质组学分析揭示了免疫治疗耐药机制的见解

Nature Communications
IF15.7
2026-06-240
OA
Samuel J. Wright; Izabella Zamora; Milan Parikh; Deepika Yeramosu; Marijana Rucevic; Moshe Sade-Feldman; Thomas J. LaSalle; Emily M. Blaum; Baolin Liu; Lynn Bi; Sarah Kang; Steven M. Blum; Ngan Nguyen; Jamey Guess; Amrita Kar; Alexis M. Schneider; David Lieb; Elliot Woods; William Michaud; Aleigha R. Lawless; Tatyana Sharova; Sonia Cohen; Gyulnara Kasumova; Michelle S. Kim; Li-Chun Cheng; Alexandra-Chloé Villani; Ryan J. Park; Russell W. Jenkins; Samuel J. Klempner; Ryan J. Sullivan; Keith T. Flaherty; Nir Hacohen; Arnav Mehta; Genevieve M. Boland
Retraction Note: sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance

撤稿说明：sFRP2在衰老微环境中驱动黑色素瘤转移和疗法抵抗

Nature
IF48.5
2025-10-290
OAAI
Amanpreet Kaur; Marie R. Webster; Katie Marchbank; Reeti Behera; Abibatou Ndoye; Curtis H. Kugel; Vanessa M. Dang; Jessica Appleton; Michael P. O’Connell; Phil Cheng; Alexander A. Valiga; Rachel Morissette; Nazli B. McDonnell; Luigi Ferrucci; Andrew V. Kossenkov; Katrina Meeth; Hsin-Yao Tang; Xiangfan Yin; William H. Wood; Elin Lehrmann; Kevin G. Becker; Keith T. Flaherty; Dennie T. Frederick; Jennifer A. Wargo; Zachary A. Cooper; Michael T. Tetzlaff; Courtney Hudgens; Katherine M. Aird; Rugang Zhang; Xiaowei Xu; Qin Liu; Edmund Bartlett; Giorgos Karakousis; Zeynep Eroglu; Roger S. Lo; Matthew Chan; Alexander M. Menzies; Georgina V. Long; Douglas B. Johnson; Jeffrey Sosman; Bastian Schilling; Dirk Schadendorf; David W. Speicher; Marcus Bosenberg; Antoni Ribas; Ashani T. Weeraratna
Overcoming resistance to immunotherapy by targeting CD38 in human tumor explants

通过靶向CD38克服人类肿瘤移植组织对免疫治疗的抵抗

Cell Reports Medicine
IF10.6
2025-06-270
OAAI
Or-Yam Revach; Angelina M. Cicerchia; Ofir Shorer; Claire A. Palin; Boryana Petrova; Seth Anderson; Baolin Liu; Joshua Park; Lee Chen; Arnav Mehta; Samuel J. Wright; Niamh McNamee; Aya Tal-Mason; Giulia Cattaneo; Payal Tiwari; Hongyan Xie; Johanna M. Sweere; Li-Chun Cheng; Natalia Sigal; Elizabeth Enrico; Marisa Miljkovic; Shane A. Evans; Ngan Nguyen; Mark E. Whidden; Ramji Srinivasan; Matthew H. Spitzer; Yi Sun; Tatyana Sharova; Aleigha R. Lawless; William A. Michaud; Martin Q. Rasmussen; Jacy Fang; Jeannette R. Brook; Feng Chen; Xinhui Wang; Cristina R. Ferrone; Donald P. Lawrence; Ryan J. Sullivan; David Liu; Uma M. Sachdeva; Debattama R. Sen; Keith T. Flaherty; Robert T. Manguso; Lloyd Bod; Manolis Kellis; Genevieve M. Boland; Keren Yizhak; Jiekun Yang; Naama Kanarek; Moshe Sade-Feldman; Nir Hacohen; Russell W. Jenkins
Inherited mitochondrial genetics as a predictor of immune checkpoint inhibition efficacy in melanoma

Monson, K.R.; Ferguson, R.; Handzlik, J.E.; Morales, L.; Xiong, J.; Chat, V.; Dagayev, S.; Khodadadi-Jamayran, A.; Simpson, D.; Kazlow, E.; 等. 继承的线粒体遗传学作为预测黑色素瘤免疫检查点抑制疗效的指标。Nat. Med. 2025, 31, 2385–2396. [Google Scholar] [CrossRef]

Nature Medicine
IF50
2025-06-050
OAAI
Kelsey R. Monson; Robert Ferguson; Joanna E. Handzlik; Leah Morales; Jiahan Xiong; Vylyny Chat; Sasha Dagayev; Alireza Khodadadi-Jamayran; Danny Simpson; Esther Kazlow; Anabelle Bunis; Chaitra Sreenivasaiah; Milad Ibrahim; Iryna Voloshyna; Wouter Ouwerkerk; Rosalie M. Luiten; Mariaelena Capone; Gabriele Madonna; Yuting Lu; Yongzhao Shao; Anna Pavlick; Michelle Krogsgaard; Janice Mehnert; Hao Tang; Sonia Dolfi; Daniel Tenney; John B. A. G. Haanen; Thomas F. Gajewski; F. Stephen Hodi; Keith T. Flaherty; Kasey Couts; William Robinson; Igor Puzanov; Marc S. Ernstoff; Osama Rahma; Michael Postow; Ryan J. Sullivan; Jason J. Luke; Paolo A. Ascierto; Iman Osman; Tomas Kirchhoff
A plain language summary of POLARIS: a study to look at different doses of encorafenib plus binimetinib for people with BRAF V600-mutant melanoma with brain metastasis

POLARIS研究的简明语言摘要：一项针对BRAF V600突变黑色素瘤脑转移患者，评估encorafenib联合binimetinib不同剂量的研究

FUTURE ONCOLOGY
IF2.6
2025-05-260
OA
Menzies, Alexander M.; Long, Georgina V.; Kohn, Amiee; Tawbi, Hussein; Webe, Jeffrey; Flaherty, Keith; McArthur, Grant A.; Ascierto, Paolo A.; Pfluger, Yanina; Lewis, Karl; Tsai, Katy K.; Hamid, Omid; Prenen, Hans; Fein, Luis; Wang, Erjian; Guenzel, Carolin; Zhang, Fan; Kleh, Joseph F.; di Pietro, Alessandra; Davies, Michael A.
A model for decoding resistance in precision oncology: acquired resistance to FGFR inhibitors in cholangiocarcinoma

精准肿瘤学中耐药性解码模型：胆管癌对FGFR抑制剂的获得性耐药

ANNALS OF ONCOLOGY
IF65.4
2024-12-011
OAAI
Goyal, L.; DiToro, D.; Facchinetti, F.; Martin, E. E.; Peng, P.; Baiev, I.; Iyer, R.; Maurer, J.; Reyes, S.; Zhang, K.; Majeed, U.; Berchuck, J. E.; Chen, C. T.; Walmsley, C.; Pinto, C.; Vasseur, D.; Gordan, J. D.; Mody, K.; Borad, M.; Karasic, T.; Damjanov, N.; Danysh, B. P.; Wehrenberg-Klee, E.; Kambadakone, A. R.; Saha, S. K.; Hoffman, I. D.; Nelson, K. J.; Iyer, S.; Qiang, X.; Sun, C.; Wang, H.; Li, L.; Javle, M.; Lin, B.; Harris, W.; Zhu, A. X.; Cleary, J. M.; Flaherty, K. T.; Harris, T.; Shroff, R. T.; Leshchiner, I.; Parida, L.; Kelley, R. K.; Fan, J.; Stone, J. R.; Uboha, N. V.; Hirai, H.; Sootome, H.; Wu, F.; Bensen, D. C.; Hollebecque, A.; Friboulet, L.; Lennerz, J. K.; Getz, G.; Juric, D.
Dabrafenib plus trametinib versus anti-PD-1 monotherapy as adjuvant therapy in BRAF V600-mutant stage III melanoma after de fi nitive surgery: a multicenter, retrospective cohort study (vol 65, 102290, 2023)

Dabrafenib联合曲美替尼与anti-PD-1单药治疗BRAF V600-mutant III期黑色素瘤术后的辅助治疗: 一项多中心，回顾性队列研究 (第65卷，102290，2023)

ECLINICALMEDICINE
IF10
2024-05-010
OAAI
Bai, Xue; Shaheen, Ahmed; Grieco, Charlotte; Arienzo, Paolo D.; Mina, Florentia; Czapla, Juliane A.; Lawless, Aleigha R.; Bongiovanni, Eleonora; Santaniello, Umberto; Zappi, Helena; Dulak, Dominika; Williamson, Andrew; Lee, Rebecca; Gupta, Avinash; Li, Caili; Si, Lu; Ubaldi, Martina; Yamazaki, Naoya; Ogata, Dai; Johnson, Rebecca; Park, Benjamin C.; Jung, Seungyeon; Madonna, Gabriele; Hochherz, Juliane; Umeda, Yoshiyasu; Nakamura, Yasuhiro; Gebhardt, Christoffer; Festino, Lucia; Capone, Mariaelena; Ascierto, Paolo Antonio; Johnson, Douglas B.; Lo, Serigne N.; V. Long, Georgina; Menzies, Alexander M.; Namikawa, Kenjiro; Mandala, Mario; Guo, Jun; Lorigan, Paul; Najjar, Yana G.; Haydon, Andrew; Quaglino, Pietro; Boland, Genevieve M.; Sullivan, Ryan J.; Furness, Andrew J. S.; Plummer, Ruth; Flaherty, Keith T.
Analysis of biomarker and outcomes data: 7-year update from COLUMBUS
CANCER RESEARCH
IF16.6
2024-03-220
PRE
Dummer, Reinhard; Flaherty, Keith; Deng, Shibing; Xie, Tao; Hamilton, Phineas; Pathan, Nuzhat; Robert, Caroline; Arance, Ana; de Groot, Jan Willem; Garbe, Claus; Gogas, Helen J.; Gutzmer, Ralf; Krajsova, Ivana; Liszkay, Gabriella; Loquai, Carmen; Mandala, Mario; Schadendorf, Dirk; Yamazaki, Naoya; Ascierto, Paolo A.; di Pietro, Alessandra; Davis, Craig B.
POLARIS: A phase 2 trial of encorafenib plus binimetinib evaluating high-dose and standard-dose regimens in patients with BRAF V600-mutant melanoma with brain metastasis

POLARIS: 一项2期试验，评估BRAF V600-mutant黑色素瘤脑转移患者的高剂量和标准剂量方案

NEURO-ONCOLOGY ADVANCES
IF4.1
2024-03-181
OAAI
Menzies, Alexander M.; Long, Georgina, V; Kohn, Amiee; Tawbi, Hussein; Weber, Jeffrey; Flaherty, Keith; McArthur, Grant A.; Ascierto, Paolo A.; Pfluger, Yanina; Lewis, Karl; Tsai, Katy K.; Hamid, Omid; Prenen, Hans; Fein, Luis; Wang, Erjian; Guenzel, Carolin; Zhang, Fan; Kleha, Joseph F.; di Pietro, Alessandra; Davies, Michael A.
Dabrafenib plus trametinib versus anti-PD-1 monotherapy as adjuvant therapy in BRAF V600-mutant stage III melanoma after definitive surgery: a multicenter, retrospective cohort study

Dabrafenib联合曲美替尼与anti-PD-1单药治疗BRAF V600-mutant III期黑色素瘤确定性手术后的辅助治疗: 一项多中心，回顾性队列研究

ECLINICALMEDICINE
IF10
2023-11-017
OAAI
Bai, Xue; Shaheen, Ahmed; Grieco, Charlotte; d'Arienzo, Paolo D.; Mina, Florentia; Czapla, Juliane A.; Lawless, Aleigha R.; Bongiovanni, Eleonora; Santaniello, Umberto; Zappi, Helena; Dulak, Dominika; Williamson, Andrew; Lee, Rebecca; Gupta, Avinash; Li, Caili; Si, Lu; Ubaldi, Martina; Yamazaki, Naoya; Ogata, Dai; Johnson, Rebecca; Park, Benjamin C.; Jung, Seungyeon; Madonna, Gabriele; Hochherz, Juliane; Umeda, Yoshiyasu; Nakamura, Yasuhiro; Gebhardt, Christoffer; Festino, Lucia; Capone, Mariaelena; Ascierto, Paolo Antonio; Johnson, Douglas B.; Lo, Serigne N.; Long, Georgina L.; Menzies, Alexander M.; Namikawa, Kenjiro; Mandala, Mario; Guo, Jun; Lorigan, Paul; Najjar, Yana G.; Haydon, Andrew; Quaglino, Pietro; Boland, Genevieve M.; Sullivan, Ryan J.; Furness, Andrew J. S.; Plummer, Ruth; Flaherty, Keith T.

研究方向

暂未获取到该数据
D
Dennie T. Frederick
H 指数:65论文数:533被引数:3.0万
R
Ryan J. Sullivan
H 指数:90论文数:1,082被引数:4.4万
J
Jennifer A. Wargo
H 指数:125论文数:1,466被引数:8.5万
G
Genevieve M. Boland
H 指数:69论文数:770被引数:2.8万
D
Dirk Schadendorf
H 指数:182论文数:2,386被引数:22.1万
A
Antoni Ribas
H 指数:158论文数:1,717被引数:16.1万
M
Meenhard Herlyn
H 指数:136论文数:1,707被引数:7.5万
G
Georgina V. Long
H 指数:169论文数:1,833被引数:17.2万
P
Paolo A. Ascierto
H 指数:126论文数:1,662被引数:10.8万
C
Caroline Robert
H 指数:154论文数:1,485被引数:15.7万