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Advancing TET Inhibitor Development: From Structural Insights to Biological Evaluation Willems, Suzanne; Maksumic, Lejla; Niggenaber, Janina; Lin, Tzu-Chen; Schulz, Tom; Weisner, Joern; Sievers, Sonja; Mueller, Matthias P.; Summerer, Daniel; Rauh, Daniel 分享 收藏
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Avapritinib-based SAR studies unveil a binding pocket in KIT and PDGFRA Teuber, A.; Schulz, T.; Fletcher, B. S.; Gontla, R.; Muehlenberg, T.; Zischinsky, M. -L.; Niggenaber, J.; Weisner, J.; Kleinboelting, S. B.; Lategahn, J.; Sievers, S.; Mueller, M. P.; Bauer, S.; Rauh, D. 分享 收藏
A high-throughput effector screen identifies a novel small molecule scaffold for inhibition of ten-eleven translocation dioxygenase 2 (vol 13, pg 1540, 2022) Palei, Shubhendu; Weisner, Joern; Vogt, Melina; Gontla, Rajesh; Buchmuller, Benjamin; Ehrt, Christiane; Grabe, Tobias; Kleinboelting, Silke; Mueller, Matthias; Clever, Guido H.; Rauh, Daniel; Summerer, Daniel 分享 收藏
FRAGTORY: Pharmacophore-Focused Design, Synthesis, and Evaluation of an sp3-Enriched Fragment Library Buehrmann, Mike; Kallepu, Shivakrishna; Warmuth, Jonas D.; Wiese, Jan N.; Ehrt, Christiane; Vatheuer, Helge; Hiller, Wolf; Seitz, Carina; Levy, Laura; Czodrowski, Paul; Sievers, Sonja; Mueller, Matthias P.; Rauh, Daniel 分享 收藏
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Targeting oncogenic KRasG13C with nucleotide-based covalent inhibitors 用基于核苷酸的共价抑制剂靶向致癌KRasG13C Goebel, Lisa; Kirschner, Tonia; Koska, Sandra; Rai, Amrita; Janning, Petra; Maffini, Stefano; Vatheuer, Helge; Czodrowski, Paul; Goody, Roger S.; Mueller, Matthias P.; Rauh, Daniel 分享 收藏
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Functional noninvasive detection of glycolytic pancreatic ductal adenocarcinoma 糖酵解性胰腺导管腺癌的功能性无创检测 Heid, Irina; Muench, Corinna; Karakaya, Sinan; Lueong, Smiths S.; Winkelkotte, Alina M.; Liffers, Sven T.; Godfrey, Laura; Cheung, Phyllis F. Y.; Savvatakis, Konstantinos; Topping, Geoffrey J.; Englert, Florian; Kritzner, Lukas; Grashei, Martin; Tannapfel, Andrea; Viebahn, Richard; Wolters, Heiner; Uhl, Waldemar; Vangala, Deepak; Smeets, Esther M. M.; Aarntzen, Erik H. J. G.; Rauh, Daniel; Weichert, Wilko; Hoheisel, Joerg D.; Hahn, Stephan A.; Schilling, Franz; Braren, Rickmer; Trajkovic-Arsic, Marija; Siveke, Jens T. 分享 收藏
Optimization of Covalent MKK7 Inhibitors via Crude Nanomole- Scale Libraries Gehrtz, Paul; Marom, Shir; Buehrmann, Mike; Hardick, Julia; Kleinboelting, Silke; Shraga, Amit; Dubiella, Christian; Gabizon, Ronen; Wiese, Jan N.; Mueller, Matthias P.; Cohen, Galit; Babaev, Ilana; Shurrush, Khriesto; Avram, Liat; Resnick, Efrat; Barr, Haim; Rauh, Daniel; London, Nir 分享 收藏
Persister state-directed transitioning and vulnerability in melanoma Chauvistre, Heike; Shannan, Batool; Daignault-Mill, Sheena M.; Ju, Robert J.; Picard, Daniel; Egetemaier, Stefanie; Varaljai, Renata; Gibhardt, Christine S.; Sechi, Antonio; Kaschani, Farnusch; Keminer, Oliver; Stehbens, Samantha J.; Liu, Qin; Yin, Xiangfan; Jeyakumar, Kirujan; Vogel, Felix C. E.; Krepler, Clemens; Rebecca, Vito W.; Kubat, Linda; Lueong, Smiths S.; Forster, Jan; Horn, Susanne; Remke, Marc; Ehrmann, Michael; Paschen, Annette; Becker, Juergen C.; Helfrich, Iris; Rauh, Daniel; Kaiser, Markus; Gul, Sheraz; Herlyn, Meenhard; Bogeski, Ivan; Rodriguez-Lopez, Jose Neptuno; Haass, Nikolas K.; Schadendorf, Dirk; Roesch, Alexander 分享 收藏
Insight into Targeting Exon20 Insertion Mutations of the Epidermal Growth Factor Receptor with Wild Type-Sparing Inhibitors Lategahn, Jonas; Tumbrink, Hannah L.; Schultz-Fademrecht, Carsten; Heimsoeth, Alena; Werr, Lisa; Niggenaber, Janina; Keul, Marina; Parmaksiz, Fatma; Baumann, Matthias; Menninger, Sascha; Zent, Eldar; Landel, Ina; Weisner, Joern; Jeyakumar, Kirujan; Heyden, Leonie; Russ, Nicole; Mueller, Fabienne; Lorenz, Carina; Braegelmann, Johannes; Spille, Inga; Grabe, Tobias; Mueller, Matthias P.; Heuckmann, Johannes M.; Klebl, Bert M.; Nussbaumer, Peter; Sos, Martin L.; Rauh, Daniel 分享 收藏
Covalent Allosteric Inhibitors of Akt Generated Using a Click Fragment Approach 使用点击片段方法产生的Akt的共价变构抑制剂 Westhuizen, Leandi; Weisner, Joern; Taher, Abu; Landel, Ina; Quambusch, Lena; Lindemann, Marius; Uhlenbrock, Niklas; Mueller, Matthias P.; Green, Ivan R.; Pelly, Stephen C.; Rauh, Daniel; van Otterlo, Willem A. L. 分享 收藏
A high-throughput effector screen identifies a novel small molecule scaffold for inhibition of ten-eleven translocation dioxygenase 2 Palei, Shubhendu; Weisner, Jorn; Vogt, Melina; Gontla, Rajesh; Buchmuller, Benjamin; Ehrt, Christiane; Grabe, Tobias; Kleinbolting, Silke; Muller, Matthias; Clever, Guido H.; Rauh, Daniel; Summerer, Daniel 分享 收藏
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