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Aberrant basement membrane production by HSCs in MASLD is attenuated by the bile acid analog INT-767 Ramachandran, Prakash; Brice, Madara; Sutherland, Elena F.; Hoy, Anna M.; Papachristoforou, Eleni; Jia, Li; Turner, Frances; Kendall, Timothy J.; Marwick, John A.; Carragher, Neil O.; Oro, Denise; Feigh, Michael; Leeming, Diana J.; Nielsen, Mette J.; Karsdal, Morten A.; Hartmann, Nadine; Erickson, Mary; Adorini, Luciano; Roth, Jonathan D.; Fallowfield, Jonathan A. 分享 收藏
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FXR agonists INT-787 and OCA increase RECK and inhibit liver steatosis and inflammation in diet-induced ob/ob mouse model of NASH Di Pasqua, Laura G.; Cagna, Marta; Palladini, Giuseppina; Croce, Anna C.; Cadamuro, Massimiliano; Fabris, Luca; Perlini, Stefano; Adorini, Luciano; Ferrigno, Andrea; Vairetti, Mariapia 分享 收藏
An integrated analysis of fecal microbiome and metabolomic features distinguish non-cirrhotic NASH from healthy control populations Carr, Rotonya M.; Li, Yun; Chau, Lillian; Friedman, Elliot S.; Lee, Jung-Jin; Adorini, Luciano; Erickson, Mary; Zaru, Luna; Shringarpure, Reshma; Macconell, Leigh; Bittinger, Kyle; Li, Hongzhe; Wu, Gary D. 分享 收藏
The role of FXR and TGR5 in reversing and preventing progression of Western diet-induced hepatic steatosis, inflammation, and fibrosis in mice Wang, Xiaoxin X.; Xie, Cen; Libby, Andrew E.; Ranjit, Suman; Levi, Jonathan; Myakala, Komuraiah; Bhasin, Kanchan; Jones, Bryce A.; Orlicky, David J.; Takahashi, Shogo; Dvornikov, Alexander; Kleiner, David E.; Hewitt, Stephen M.; Adorini, Luciano; Kopp, Jeffrey B.; Krausz, Kristopher W.; Rosenberg, Avi; McManaman, James L.; Robertson, Charles E.; Ir, Diana; Frank, Daniel N.; Luo, Yuhuan; Gonzalez, Frank J.; Gratton, Enrico; Levi, Moshe 分享 收藏
Farnesoid X receptor activation by the novel agonist TC-100 (3?, 7?, 11?-Trihydroxy-6?-ethyl-5?-cholan-24-oic Acid) preserves the intestinal barrier integrity and promotes intestinal microbial reshaping in a mouse model of obstructed bile acid flow Marzano, M.; Fosso, Bruno; Colliva, C.; Notario, E.; Passeri, D.; Intranuovo, M.; Gioiello, A.; Adorini, L.; Pesole, G.; Pellicciari, R.; Moschetta, A.; Gadaleta, R. M. 分享 收藏
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Obeticholic acid improves fetal bile acid profile in a mouse model of gestational hypercholanemia 奥贝胆酸可改善妊娠期高胆汁性贫血小鼠模型中的胎儿胆汁酸谱 Pataia, Vanessa; McIlvride, Saraid; Papacleovoulou, Georgia; Ovadia, Caroline; McDonald, Julie A. K.; Wahlstrom, Annika; Jansen, Eugene; Adorini, Luciano; Shapiro, David; Marchesi, Julian R.; Marschall, Hanns-Ulrich; Williamson, Catherine 分享 收藏
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Microbiota-driven gut vascular barrier disruption is a prerequisite for non-alcoholic steatohepatitis development 微生物驱动的肠道血管屏障破坏是非酒精性脂肪性肝炎发展的先决条件 Mouries, Juliette; Brescia, Paola; Silvestri, Alessandra; Spadoni, Ilaria; Sorribas, Marcel; Wiest, Reiner; Mileti, Erika; Galbiati, Marianna; Invernizzi, Pietro; Adorini, Luciano; Penna, Giuseppe; Rescigno, Maria 分享 收藏
Combined obeticholic acid and elafibranor treatment promotes additive liver histological improvements in a diet-induced ob/ob mouse model of biopsy-confirmed NASH Roth, Jonathan D.; Veidal, Sanne S.; Fensholdt, Louise K. D.; Rigbolt, Kristoffer T. G.; Papazyan, Romeo; Nielsen, Jens Christian; Feigh, Michael; Vrang, Niels; Young, Mark; Jelsing, Jacob; Adorini, Luciano; Hansen, Henrik H. 分享 收藏
INOS-mediated decrease of matrix metalloproteinase activity by obeticholic acid in hepatic ischemia/reperfusion Di Pasqua, L. G.; Palladini, G.; Berardo, C.; Siciliano, V.; Adorini, L.; Richelmi, P.; Cadamuro, M.; Fabris, L.; Perlini, S.; Vairetti, M.; Ferrigno, A. 分享 收藏
Therapeutic effects of the selective farnesoid X receptor agonist obeticholic acid in a monocrotaline-induced pulmonary hypertension rat model Comeglio, P.; Filippi, S.; Sarchielli, E.; Morelli, A.; Cellai, I.; Corno, C.; Adorini, L.; Vannelli, G. B.; Maggi, M.; Vignozzi, L. 分享 收藏
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