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G

Grant A. Challen

Washington University School of Medicine
H指数:38
被引数:7,712

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TET2 loss triggers ssDNA gap accumulation and heightened PARP inhibitor sensitivity

TET2缺失引发单链DNA缺口积累和增强的PARP抑制剂敏感性

Nature Communications
IF15.7
2026-09-120
OA
Sumedha Agashe; Nidhi Athreya; William Jacobs; Christopher T. Letson; Vladislav O. Sviderskiy; Celia D. Rouault; Yixuan Xie; Carolina Brás-Costa; Emily Zahn; Mary Claire Kendall; Alice Meroni; Matthew Wood; Barbara Soares; Jin Shao; Maggie J. Cox; Luis Francisco Zirnberger Batista; Grant A. Challen; John Krais; Matthew J. Walter; Stephen T. Oh; Benjamin A. Garcia; John Edwards; Priyanka Verma; Alessandro Vindigni
RSK1 is an exploitable dependency in myeloproliferative neoplasms and secondary acute myeloid leukemia

RSK1是骨髓增殖性肿瘤和继发性急性髓系白血病的一个可利用的依赖性。

NATURE COMMUNICATIONS
IF15.7
2025-01-160
OA
Kong, Tim; Laranjeira, Angelo B. A.; Letson, Christopher T.; Yu, Layow; Lin, Shuyang; Fowles, Jared S.; Fisher, Daniel A. C.; Ng, Sherwin; Yang, Wei; He, Fan; Youn, Minyoung; Mark, Kailen; Jose, Ana San; Liu, Jingxian; Kim, Alexander B.; Cox, Maggie J.; Fulbright, Mary C.; Jayanthan, Aarthi; Los, Gerrit; Rentschler, Stacey L.; Ding, Li; Sakamoto, Kathleen M.; Dunn, Sandra E.; Challen, Grant A.; Oh, Stephen T.
KDM6B protects T-ALL cells from NOTCH1-induced oncogenic stress
LEUKEMIA
IF13.4
2023-02-175
OA
Issa, Nancy; Bjeije, Hassan; Wilson, Elisabeth R.; Krishnan, Aishwarya; Dunuwille, Wangisa M. B.; Parsons, Tyler M.; Zhang, Christine R.; Han, Wentao; Young, Andrew L.; Ren, Zhizhong; Ge, Kai; Wang, Eunice S.; Weng, Andrew P.; Cashen, Amanda; Spencer, David H.; Challen, Grant A.
TET2 and DNMT3A Mutations Exert Divergent Effects on DNA Repair and Sensitivity of Leukemia Cells to PARP Inhibitors

TET2和DNMT3A突变对DNA修复和白血病细胞对PARP抑制剂的敏感性产生不同的影响

CANCER RESEARCH
IF16.6
2021-07-0227
OA
Maifrede, Silvia; Le, Bac Viet; Nieborowska-Skorska, Margaret; Golovine, Konstantin; Sullivan-Reed, Katherine; Dunuwille, Wangisa M. B.; Nacson, Joseph; Hulse, Michael; Keith, Kelsey; Madzo, Jozef; Caruso, Lisa Beatrice; Gazze, Zachary; Lian, Zhaorui; Padella, Antonella; Chitrala, Kumaraswamy N.; Bartholdy, Boris A.; Matlawska-Wasowska, Ksenia; Di Marcantonio, Daniela; Simonetti, Giorgia; Greiner, Georg; Sykes, Stephen M.; Valent, Peter; Paietta, Elisabeth M.; Tallman, Martin S.; Fernandez, Hugo F.; Litzow, Mark R.; Minden, Mark D.; Huang, Jian; Martinelli, Giovanni; Vassiliou, George S.; Tempera, Italo; Piwocka, Katarzyna; Johnson, Neil; Challen, Grant A.; Skorski, Tomasz

研究方向

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A
Andrew L. Young
H 指数:16论文数:82被引数:3,438
S
Stephen T. Oh
H 指数:45论文数:475被引数:9,232
C
Christine Zhang
H 指数:18论文数:103被引数:1,011
H
Hamza Celik
H 指数:15论文数:79被引数:1,425
T
Tyler M. Parsons
H 指数:5论文数:45被引数:104
H
Hassan Bjeije
H 指数:5论文数:31被引数:115
M
Margaret A. Goodell
H 指数:88论文数:424被引数:3.4万
W
Won Kyun Koh
H 指数:8论文数:31被引数:342
A
Ashley C. Kramer
H 指数:15论文数:41被引数:912
W
Wentao Han
H 指数:4论文数:23被引数:96