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Genomic and transcriptomic features of androgen receptor signaling inhibitor resistance in metastatic castration-resistant prostate cancer Zhu, Xiaolin; Farsh, Tatyanah; Vis, Daniel; Yu, Ivan; Li, Haolong; Liu, Tianyi; Sjostrom, Martin; Shrestha, Raunak; Kneppers, Jeroen; Severson, Tesa; Zhang, Meng; Lundberg, Arian; Rodriguez, Thaidy Moreno; Weinstein, Alana S.; Foye, Adam; Mehra, Niven; Aggarwal, Rahul R.; Bergman, Andries M.; Small, Eric J.; Lack, Nathan A.; Zwart, Wilbert; Quigley, David A.; van der Heijden, Michiel S.; Feng, Felix Y. 分享 收藏
Grade Group 1 Prostate Cancers Exhibit Tumor-defining Androgen Receptor-driven Programs Linder, Simon; Severson, Tesa M.; van der Mijn, Koen J. C.; Nevedomskaya, Ekaterina; Siefert, Joseph C.; Stelloo, Suzan; Pomerantz, Mark M.; Freedman, Matthew L.; van der Poel, Henk; Jeronimo, Carmen; Henrique, Rui; Bergman, Andries M.; Zwart, Wilbert 分享 收藏
Whole genome and transcriptome analysis of paired metastatic biopsies identified resistance mechanisms in castration-resistant prostate cancer Zhu, Xiaolin; Vis, Daniel; Sjostrom, Martin; Shrestha, Raunak; Kneppers, Jeroen; Severson, Tesa; Zhu, Yanyun; Zhang, Meng; Lundberg, Arian; Rodriguez, Thaidy Moreno; Weinstein, Alana; Li, Haolong; Foye, Adam; Aggarwal, Rahul; Bergman, Andries M.; Small, Eric; Zwart, Wilbert; Quigley, David; van der Heijden, Michiel; Feng, Felix 分享 收藏
PAXIP1 and STAG2 converge to maintain 3D genome architecture and facilitate promoter/enhancer contacts to enable stress hormone-dependent transcription Mayayo-Peralta, Isabel; Gregoricchio, Sebastian; Schuurman, Karianne; Yavuz, Selcuk; Zaalberg, Anniek; Kojic, Aleksandar; Abbott, Nina; Geverts, Bart; Beerthuijzen, Suzanne; Siefert, Joseph; Severson, Tesa M.; van Baalen, Martijn; Hoekman, Liesbeth; Lieftink, Cor; Altelaar, Maarten; Beijersbergen, Roderick L.; Houtsmuller, Adriaan B.; Prekovic, Stefan; Zwart, Wilbert 分享 收藏
Extensive androgen receptor enhancer heterogeneity in primary prostate cancers underlies transcriptional diversity and metastatic potential Kneppers, Jeroen; Severson, Tesa M.; Siefert, Joseph C.; Schol, Pieter; Joosten, Stacey E. P.; Yu, Ivan Pak Lok; Huang, Chia-Chi Flora; Morova, Tunc; Altintas, Umut Berkay; Giambartolomei, Claudia; Seo, Ji-Heui; Baca, Sylvan C.; Carneiro, Isa; Emberly, Eldon; Pasaniuc, Bogdan; Jeronimo, Carmen; Henrique, Rui; Freedman, Matthew L.; Wessels, Lodewyk F. A.; Lack, Nathan A.; Bergman, Andries M.; Zwart, Wilbert 分享 收藏
Double-strand break toxicity is chromatin context independent Friskes, Anoek; Koob, Lisa; Krenning, Lenno; Severson, Tesa M.; Koeleman, Emma S.; Vergara, Xabier; Schubert, Michael; van den Berg, Jeroen; Evers, Bastiaan; Manjon, Anna G.; Joosten, Stacey; Kim, Yongsoo; Zwart, Wilbert; Medema, Rene H. 分享 收藏
Drug-Induced Epigenomic Plasticity Reprograms Circadian Rhythm Regulation to Drive Prostate Cancer toward Androgen Independence Linder, Simon; Hoogstraat, Marlous; Stelloo, Suzan; Eickhoff, Nils; Schuurman, Karianne; de Barros, Hilda; Alkemade, Maartje; Bekers, Elise M.; Severson, Tesa M.; Sanders, Joyce; Huang, Chia-Chi Flora; Morova, Tunc; Altintas, Umut Berkay; Hoekman, Liesbeth; Kim, Yongsoo; Baca, Sylvan C.; Sjostrom, Martin; Zaalberg, Anniek; Hintzen, Dorine C.; de Jong, Jeroen; Kluin, Roelof J. C.; de Rink, Iris; Giambartolomei, Claudia; Seo, Ji-Heui; Pasaniuc, Bogdan; Altelaar, Maarten; Medema, Rene H.; Feng, Felix Y.; Zoubeidi, Amina; Freedman, Matthew L.; Wessels, Lodewyk F. A.; Butler, Lisa M.; Lack, Nathan A.; van der Poel, Henk; Bergman, Andries M.; Zwart, Wilbert 分享 收藏
Androgen receptor reprogramming demarcates prognostic, context-dependent gene sets in primary and metastatic prostate cancer Severson, Tesa; Qiu, Xintao; Alshalalfa, Mohammed; Sjostrom, Martin; Quigley, David; Bergman, Andries; Long, Henry; Feng, Felix; Freedman, Matthew L.; Zwart, Wilbert; Pomerantz, Mark M. 分享 收藏
Opposing transcriptional programs of KLF5 and AR emerge during therapy for advanced prostate cancer Che, Meixia; Chaturvedi, Aashi; Munro, Sarah A.; Pitzen, Samuel P.; Ling, Alex; Zhang, Weijie; Mentzer, Josh; Ku, Sheng-Yu; Puca, Loredana; Zhu, Yanyun; Bergman, Andries M.; Severson, Tesa M.; Forster, Colleen; Liu, Yuzhen; Hildebrand, Jacob; Daniel, Mark; Wang, Ting-You; Selth, Luke A.; Hickey, Theresa; Zoubeidi, Amina; Gleave, Martin; Bareja, Rohan; Sboner, Andrea; Tilley, Wayne; Carroll, Jason S.; Tan, Winston; Kohli, Manish; Yang, Rendong; Hsieh, Andrew C.; Murugan, Paari; Zwart, Wilbert; Beltran, Himisha; Huang, R. Stephanie; Dehm, Scott M. 分享 收藏
Glucocorticoid receptor triggers a reversible drug-tolerant dormancy state with acquired therapeutic vulnerabilities in lung cancer 糖皮质激素受体触发可逆的药物耐受休眠状态，并在肺癌中获得治疗脆弱性 Prekovic, Stefan; Schuurman, Karianne; Mayayo-Peralta, Isabel; Manjon, Anna G.; Buijs, Mark; Yavuz, Selcuk; Wellenstein, Max D.; Barrera, Alejandro; Monkhorst, Kim; Huber, Anne; Morris, Ben; Lieftink, Cor; Chalkiadakis, Theofilos; Alkan, Ferhat; Silva, Joana; Gyorffy, Balazs; Hoekman, Liesbeth; van den Broek, Bram; Teunissen, Hans; Debets, Donna O.; Severson, Tesa; Jonkers, Jos; Reddy, Timothy; de Visser, Karin E.; Faller, William; Beijersbergen, Roderick; Altelaar, Maarten; de Wit, Elzo; Medema, Rene; Zwart, Wilbert 分享 收藏
Epigenetic and transcriptional analysis reveals a core transcriptional program conserved in clonal prostate cancer metastases Severson, Tesa M.; Zhu, Yanyun; De Marzo, Angelo M.; Jones, Tracy; Simons, Jonathan W.; Nelson, William G.; Yegnasubramanian, Srinivasan; Freedman, Matthew L.; Wessels, Lodewyk; Bergman, Andries M.; Haffner, Michael C.; Zwart, Wilbert 分享 收藏
The circadian cryptochrome, CRY1, is a pro-tumorigenic factor that rhythmically modulates DNA repair Shafi, Ayesha A.; McNair, Chris M.; McCann, Jennifer J.; Alshalalfa, Mohammed; Shostak, Anton; Severson, Tesa M.; Zhu, Yanyun; Bergman, Andre; Gordon, Nicolas; Mandigo, Amy C.; Chand, Saswati N.; Gallagher, Peter; Dylgjeri, Emanuela; Laufer, Talya S.; Vasilevskaya, Irina A.; Schiewer, Matthew J.; Brunner, Michael; Feng, Felix Y.; Zwart, Wilbert; Knudsen, Karen E. 分享 收藏
Prostate cancer reactivates developmental epigenomic programs during metastatic progression 前列腺癌在转移进展期间重新激活发育表观基因组计划 Pomerantz, Mark M.; Qiu, Xintao; Zhu, Yanyun; Takeda, David Y.; Pan, Wenting; Baca, Sylvan C.; Gusev, Alexander; Korthauer, Keegan D.; Severson, Tesa M.; Ha, Gavin; Viswanathan, Srinivas R.; Seo, Ji-Heui; Nguyen, Holly M.; Zhang, Baohui; Pasaniuc, Bogdan; Giambartolomei, Claudia; Alaiwi, Sarah A.; Bell, Connor A.; O'Connor, Edward P.; Chabot, Matthew S.; Stillman, David R.; Lis, Rosina; Font-Tello, Alba; Li, Lewyn; Cejas, Paloma; Bergman, Andries M.; Sanders, Joyce; van der Poel, Henk G.; Gayther, Simon A.; Lawrenson, Kate; Fonseca, Marcos A. S.; Reddy, Jessica; Corona, Rosario, I; Martovetsky, Gleb; Egan, Brian; Choueiri, Toni; Ellis, Leigh; Garraway, Isla P.; Lee, Gwo-Shu Mary; Corey, Eva; Long, Henry W.; Zwart, Wilbert; Freedman, Matthew L. 分享 收藏
The MSP-RON axis stimulates cancer cell growth in models of triple negative breast cancer Millar, Rhona; Kilbey, Anna; Remak, Sarah-Jane; Severson, Tesa M.; Dhayade, Sandeep; Sandilands, Emma; Foster, Kyla; Bryant, David M.; Blyth, Karen; Coffelt, Seth B. 分享 收藏
Noncoding mutations target cis-regulatory elements of the FOXA1 plexus in prostate cancer Zhou, Stanley; Hawley, James R.; Soares, Fraser; Grillo, Giacomo; Teng, Mona; Tonekaboni, Seyed Ali Madani; Hua, Junjie Tony; Kron, Ken J.; Mazrooei, Parisa; Ahmed, Musaddeque; Arlidge, Christopher; Yun, Hwa Young; Livingstone, Julie; Huang, Vincent; Yamaguchi, Takafumi N.; Espiritu, Shadrielle M. G.; Zhu, Yanyun; Severson, Tesa M.; Murison, Alex; Cameron, Sarina; Zwart, Wilbert; van der Kwast, Theodorus; Pugh, Trevor J.; Fraser, Michael; Boutros, Paul C.; Bristow, Robert G.; He, Housheng Hansen; Lupien, Mathieu 分享 收藏
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Lysine specific demethylase 1 inactivation enhances differentiation and promotes cytotoxic response when combined with all-trans retinoic acid in acute myeloid leukemia across subtypes Smitheman, Kimberly N.; Severson, Tesa M.; Rajapurkar, Satyajit R.; McCabe, Michael T.; Karpinich, Natalie; Foley, James; Pappalardi, Melissa B.; Hughes, Ashley; Halsey, Wendy; Thomas, Elizabeth; Traini, Christopher; Federowicz, Kelly E.; Laraio, Jenny; Mobegi, Fredrick; Ferron-Brady, Geraldine; Prinjha, Rabinder K.; Carpenter, Christopher L.; Kruger, Ryan G.; Wessels, Lodewyk; Mohammad, Helai P. 分享 收藏
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