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Conjugation to a transferrin receptor 1-binding Bicycle peptide enhances ASO and siRNA potency in skeletal and cardiac muscles 与转铁蛋白受体1结合的Bicycle肽偶联可增强ASO和siRNA在骨骼肌和心肌中的效力 Ostergaard, Michael E.; Carrer, Michele; Anderson, Brooke A.; Afetian, Megan; Bakooshli, Mohsen A.; Santos, Jinro A.; Klein, Stephanie K.; Capitanio, Juliana; Freestone, Graeme C.; Tanowitz, Michael; Galindo-Murillo, Rodrigo; Gaus, Hans J.; Dwyer, Chrissa A.; Jackson, Michaela; Jafar-nejad, Paymaan; Rigo, Frank; Seth, Punit P.; Gaynor, Katherine U.; Stanway, Steven J.; Urbonas, Liudvikas; St. Denis, Megan A.; Pellegrino, Simone; Bezerra, Gustavo A.; Rigby, Michael; Gowans, Ellen; Van Rietschoten, Katerine; Beswick, Paul; Skynner, Michael J.; Swayze, Eric E. 分享 收藏
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Bicycle Toxin Conjugates®for the treatment of solid tumors Walsh, Stephen J.; Lahdenranta, Johanna; Huxley, Philip; Mudd, Gemma; Bennett, Gavin; Brown, Amy; Rietschoten, Katerine An; Chen, Liuhong; Scott, Heather; Ivanova-Berndt, Gabriella; Dzionek, Katarzyna; Rigby, Mike; Burenkova, Olga; Jeffrey, Phil; Beswick, Paul; Skynner, Michael; Keen, Nicholas 分享 收藏
Structure-Guided Chemical Optimization of Bicyclic Peptide (Bicycle) Inhibitors of Angiotensin-Converting Enzyme 2 Harman, Maximilian A. J.; Stanway, Steven J. J.; Scott, Heather; Demydchuk, Yuliya; Bezerra, Gustavo Arruda; Pellegrino, Simone; Chen, Liuhong; Brear, Paul; Lulla, Aleksei; Hyvonen, Marko; Beswick, Paul J. J.; Skynner, Michael J. J. 分享 收藏
Multivalent bicyclic peptides are an effective antiviral modality that can potently inhibit SARS-CoV-2 Gaynor, Katherine U. U.; Vaysburd, Marina; Harman, Maximilian A. J.; Albecka, Anna; Jeffrey, Phillip; Beswick, Paul; Papa, Guido; Chen, Liuhong; Mallery, Donna; McGuinness, Brian; Van Rietschoten, Katerine; Stanway, Steven; Brear, Paul; Lulla, Aleksei; Ciazynska, Katarzyna; Chang, Veronica T. T.; Sharp, Jo; Neary, Megan; Box, Helen; Herriott, Jo; Kijak, Edyta; Tatham, Lee; Bentley, Eleanor G. G.; Sharma, Parul; Kirby, Adam; Han, Ximeng; Stewart, James P. P.; Owen, Andrew; Briggs, John A. G.; Hyvonen, Marko; Skynner, Michael J. J.; James, Leo C. C. 分享 收藏
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BT7455, A FULLY SYNTHETIC BICYCLE TUMORTARGETED IMMUNE CELL AGONIST®, LEADS TO POTENT EPHA2-DEPENDENT CD137 AGONISM AND ROBUST ANTI-TUMOR EFFICACY Hurov, Kristen; Luus, Lia; Lahdenranta, Johanna; Upadhyaya, Punit; Cohen, Heather; Shah, Chinmayee; Kristensson, Julia; Brown, Peter; Mudd, Gemma; Campbell, Carly; Repash, Elizabeth; Haines, Eric; Battula, Sailaja; Kelly, Mike; Jeffrey, Phil; Beswick, Paul; Chen, Liuhong; McDonnell, Kevin; Brandish, Philip; Keen, Nicholas 分享 收藏
Discovery of BT8009: A Nectin-4 Targeting Bicycle Toxin Conjugate for the Treatment of Cancer Mudd, Gemma E.; Scott, Heather; Chen, Liuhong; van Rietschoten, Katerine; Ivanova-Berndt, Gabriela; Dzionek, Katarzyna; Brown, Amy; Watcham, Sophie; White, Lewi; Park, Peter U.; Jeffrey, Phil; Rigby, Mike; Beswick, Paul 分享 收藏
BT8009; A Nectin-4 Targeting Bicycle Toxin Conjugate for Treatment of Solid Tumors Rigby, Michael; Bennett, Gavin; Chen, Liuhong; Mudd, Gemma E.; Harrison, Helen; Beswick, Paul J.; Van Rietschoten, Katerine; Watcham, Sophie M.; Scott, Heather S.; Brown, Amy N.; Park, Peter U.; Campbell, Carly; Haines, Eric; Lahdenranta, Johanna; Skynner, Michael J.; Jeffrey, Phil; Keen, Nicholas; Lee, Kevin 分享 收藏
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A fully synthetic EphA2/4-1BB tumor-targeted immune cell agonist (TICA™) induces tumor localized 4-1BB agonism Battula, Sailaja; Mudd, Gemma; Upadhyaya, Punit; Kristensson, Julia; Kleyman, Marianna; Repash, Elizabeth; Kublin, Jessica; Ma, Jun; Haines, Eric; Hurov, Kristen; Chen, Liuhong; Lahdenranta, Johanna; Beswick, Paul; McDonnell, Kevin; Keen, Nicholas 分享 收藏
An Assay for Periplasm Entry Advances the Development of Chimeric Peptide Antibiotics Wagstaff, James M.; Balmforth, Matthew; Lewis, Nick; Dods, Rachel; Rowland, Catherine; van Rietschoten, Katerine; Chen, Liuhong; Harrison, Helen; Skynner, Michael J.; Dawson, Michael; Ivanova-Berndt, Gabriela; Beswick, Paul 分享 收藏
BT8009, a Bicycle Toxin Conjugate targeting Nectin-4, shows target selectivity, and efficacy in preclinical large and small tumor models Rigby, Michael; Bennett, Gavin; Chen, Liuhong; Mudd, Gemma; Beswick, Paul; Harrison, Helen; Watcham, Sophie; Allen, Heather; Brown, Amy; Van Rietschoten, Katerine; Jeffrey, Philip; Park, Peter U.; Haines, Eric; Keen, Nicholas; Lahdenranta, Johanna 分享 收藏
BT8009: A bicyclic peptide toxin conjugate targeting Nectin-4 (PVRL4) displays efficacy in preclinical tumor models Rigby, Mike; Beswick, Paul; Mudd, Gemma; Van Rietschoten, Katerine; Chen, Liuhong; Watcham, Sophie M.; Allen, Heather; Brown, Amy; Harrison, Helen; Bennett, Gavin; Jeffrey, Phil; Park, Peter U.; Koehler, Maria; Keen, Nicholas 分享 收藏
African trypanosomiasis: Synthesis & SAR enabling novel drug discovery of ubiquinol mimics for trypanosome alternative oxidase West, Ryan A.; O'Doherty, Oran G.; Askwith, Trevor; Atack, John; Beswick, Paul; Laverick, Jamie; Paradowski, Michael; Pennicott, Lewis E.; Rao, Srinivasa P. S.; Williams, Gareth; Ward, Simon E. 分享 收藏
Pharmacological characterization of N-[(2S)5-(6-fluoro-3-pyridinyl)-2, 3-dihydro-1H-inden-2-yl]-2-propanesulfonamide: a novel, clinical AMPA receptor positive allosteric modulator Ward, Simon E.; Beswick, Paul; Calcinaghi, Novella; Dawson, Lee A.; Gartlon, Jane; Graziani, Francesca; Jones, Declan N. C.; Lacroix, Laurent; Mok, M. H. Selina; Oliosi, Beatrice; Pardoe, Joanne; Starr, Kathryn; Woolley, Marie L.; Harries, Mark H. 分享 收藏
Evaluation of the anti-malarial activity and cytotoxicity of 2,4-diamino-pyrimidine-based kinase inhibitors Phuangsawai, Oraphan; Beswick, Paul; Ratanabunyong, Siriluk; Tabtimmai, Lueacha; Suphakun, Praphasri; Obounchoey, Phongphat; Srisook, Pimonwan; Horata, Natharinee; Chuckowree, Irina; Hannongbua, Supa; Ward, Simon E.; Choowongkomon, Kiattawee; Gleeson, M. Paul 分享 收藏
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