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ONC213: a novel strategy to resensitize resistant AML cells to venetoclax through induction of mitochondrial stress ONC213：一种通过诱导线粒体应激使耐药AML细胞重敏于venetoclax的新型策略 Carter, Jenna L.; Su, Yongwei; Al-Antary, Eman T.; Zhao, Jianlei; Qiao, Xinan; Wang, Guan; Edwards, Holly; Polin, Lisa; Kushner, Juiwanna; Dzinic, Sijana H.; White, Kathryn; Buck, Steven A.; Huettemann, Maik; Allen, Joshua E.; Prabhu, Varun V.; Yang, Jay; Taub, Jeffrey W.; Ge, Yubin 分享 收藏
Treatment Intensification Does Not Improve Outcome for Children with Myeloid Leukemia of Down Syndrome 治疗强化并未改善唐氏综合征伴髓系白血病患儿的预后 Hitzler, Johann K.; Alonzo, Todd A.; Gerbing, Robert; Wang, Jim; Beckman, Amy; Hirsch, Betsy; Raimondi, Susana C.; Chisholm, Karen M.; Viola, Shelton A.; Verma, Anupam; Brodersen, Lisa Eidenschink; Loken, Michael R.; Taub, Jeffrey W.; Gamis, Alan S.; Kolb, E. Anders; Cooper, Todd M.; Berman, Jason N. 分享 收藏
Old Meets New: Hydroxyurea Synergistically Enhances the Antileukemic Activity of Gilteritinibagainst FLT3-ITD AML 老药新用：羟基脲协同增强Gilteritinib对FLT3-ITD AML的抗白血病活性 Eid, Nibal; Zhao, Jianlei; Thibodeau, Jenna; Edwards, Holly; Polin, Lisa; Kushner, Juiwanna; Dzinic, Sijana H.; White, Kathryn H.; Buck, Steven; Taub, Jeffrey W.; Ge, Yubin 分享 收藏
Loss of Cystathionine-β-Synthase Activity Results in Increased Oxidative Phosphorylation and Cytarabine Resistance in Myeloid Leukemia Associated with Down Syndrome 胱硫醚-β-合酶活性丧失导致唐氏综合征相关髓系白血病中氧化磷酸化增加和阿糖胞苷耐药性。 Thibodeau, Jenna; Zhao, Jianlei; Edwards, Holly; Polin, Lisa; Kushner, Juiwanna; Dzinic, Sijana H.; White, Kathryn H.; Huttemann, Maik; Arroum, Tasnim; Pham, Lucynda; Boucher, Austin C.; Crispino, John D.; Taub, Jeffrey W.; Ge, Yubin 分享 收藏
Multi-Pronged Effects of Cohesin Mutations in the Myeloid Leukemia of Down Syndrome 唐氏综合征髓系白血病的黏着素突变的多方面效应 Boucher, Austin C.; Rosikiewicz, Wojciech; Tirtakusuma, Ricky; Cotton, Anitria; Niederkorn, Madeline; Wagenblast, Elvin; Thomas, Paul G.; Ge, Yubin; Taub, Jeffrey W.; Klusmann, Jan-Henning; Crispino, John D. 分享 收藏
Panobinostat sensitizes AraC-resistant AML cells to the combination of azacitidine and venetoclax Zhao, Jianlei; Wu, Shuangshuang; Wang, Deying; Edwards, Holly; Thibodeau, Jenna; Kim, Seongho; Stemmer, Paul; Wang, Guan; Jin, Jingji; Savasan, Sureyya; Taub, Jeffrey W.; Ge, Yubin 分享 收藏
Pharmacogenomic Score Effectively Personalizes Treatment of Acute Myeloid Leukemia Marrero, Richard J.; Wu, Huiyun; Cao, Xueyuan; Parcha, Phani Krishna; Elsayed, Abdelrahman H.; Inaba, Hiroto; Kuo, Dennis John; Degar, Barbara A.; Heym, Kenneth; Taub, Jeffrey W.; Lacayo, Norman; Pui, Ching-Hon; Ribeiro, Raul C.; Rubnitz, Jeffrey E.; Pounds, Stanley B.; Lamba, Jatinder K. 分享 收藏
Targeting refractory/recurrent neuroblastoma and osteosarcoma with anti-CD3xanti-GD2 bispecific antibody armed T cells Yankelevich, Maxim; Thakur, Archana; Modak, Shakeel; Chu, Roland; Taub, Jeffrey; Martin, Alissa; Schalk, Dana; Schienshang, Amy; Whitaker, Sarah; Rea, Katie; Lee, Daniel W.; Liu, Qin; Shields, Anthony F.; Cheung, Nai-Kong, V; Lum, Lawrence G. 分享 收藏
Enhancing anti-AML activity of venetoclax by isoflavone ME-344 through suppression of OXPHOS and/or purine biosynthesis in vitro Hurrish, Katie H.; Su, Yongwei; Patel, Shraddha; Ramage, Cassandra L.; Zhao, Jianlei; Temby, Brianna R.; Carter, Jenna L.; Edwards, Holly; Buck, Steven A.; Wiley, Sandra E.; Huttemann, Maik; Polin, Lisa; Kushner, Juiwanna; Dzinic, Sijana H.; White, Kathryn; Bao, Xun; Li, Jing; Yang, Jay; Boerner, Julie; Hou, Zhanjun; Al-Atrash, Gheath; Konoplev, Sergej N.; Busquets, Jonathan; Tiziani, Stefano; Matherly, Larry H.; Taub, Jeffrey W.; Konopleva, Marina; Ge, Yubin; Baran, Natalia 分享 收藏
The Imipridone ONC213 Targets α-Ketoglutarate Dehydrogenase to Induce Mitochondrial Stress and Suppress Oxidative Phosphorylation in Acute Myeloid Leukemia Su, Yongwei; Carter, Jenna L.; Li, Xinyu; Fukuda, Yu; Gray, Ashley; Lynch, John; Edwards, Holly; Ma, Jun; Schreiner, Patrick; Polin, Lisa; Kushner, Juiwanna; Dzinic, Sijana H.; Buck, Steven A.; Pruett-Miller, Shondra M.; Hege-Hurrish, Katie; Robinson, Camenzind; Qiao, Xinan; Liu, Shuang; Wu, Shuangshuang; Wang, Guan; Li, Jing; Allen, Joshua E.; Prabhu, Varun V.; Schimmer, Aaron D.; Joshi, Dhananjay; Kalhor-Monfared, Shiva; Watson, Iain D. G.; Marcellus, Richard; Isaac, Methvin B.; Al-awar, Rima; Taub, Jeffrey W.; Lin, Hai; Schuetz, John D.; Ge, Yubin 分享 收藏
Acquired resistance to venetoclax plus azacitidine in acute myeloid leukemia: In vitro models and mechanisms Carter, Jenna L.; Su, Yongwei; Qiao, Xinan; Zhao, Jianlei; Wang, Guan; Howard, Mackenzie; Edwards, Holly; Bao, Xun; Li, Jing; Huettemann, Maik; Yang, Jay; Taub, Jeffrey W.; Ge, Yubin 分享 收藏
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Co-targeting of HDAC, PI3K, and Bcl-2 results in metabolic and transcriptional reprogramming and decreased mitochondrial function in acute myeloid leukemia Hurrish, Katie Hege; Qiao, Xinan; Li, Xinyu; Su, Yongwei; Carter, Jenna; Ma, Jun; Kalpage, Hasini A.; Huttemann, Maik; Edwards, Holly; Wang, Guan; Kim, Seongho; Dombkowski, Alan; Bao, Xun; Li, Jing; Taub, Jeffrey W.; Ge, Yubin 分享 收藏
Inhibition of Mcl-1 Synergistically Enhances the Antileukemic Activity of Gilteritinib and MRX-2843 in Preclinical Models of FLT3-Mutated Acute Myeloid Leukemia 抑制Mcl-1协同增强Gilteritinib和MRX-2843在FLT3-Mutated急性髓系白血病临床前模型中的抗白血病活性 Wu, Shuangshuang; Edwards, Holly; Wang, Deying; Liu, Shuang; Qiao, Xinan; Carter, Jenna; Wang, Yue; Taub, Jeffrey W.; Wang, Guan; Ge, Yubin 分享 收藏
c-Myc plays a critical role in the antileukemic activity of the Mcl-1-selective inhibitor AZD5991 in acute myeloid leukemia C-myc在急性髓系白血病Mcl-1-selective抑制剂AZD5991的抗白血病活性中起关键作用 Liu, Shuang; Qiao, Xinan; Wu, Shuangshuang; Gai, Yuqinq; Su, Yongwei; Edwards, Holly; Wang, Yue; Lin, Hai; Taub, Jeffrey W.; Wang, Guan; Ge, Yubin 分享 收藏
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