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欧

欧阳亮 (Liang Ouyang)

sichuan university

54H指数
249论文数
1.0W被引数
收录论文 153
发表时间
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Small-molecule inhibitors of SGK1: Structural basis, structure-activity relationships, and therapeutic perspectivesSGK1的小分子抑制剂：结构基础、构效关系及治疗前景
errEuropean Journal of Medicinal Chemistry
IF5.9
err2026-08-16
err0
PREAI
errJingjing Xie; Wu Wu; Guonian Zhu; Jinghong Xian; Liang Ouyang; Yiwen Zhang; Yuxi Wang
err分享
err收藏
Small-Molecule Autophagy Modulators: Mechanisms, Therapeutic Potential, and Development Challenges in Pathological Settings小分子自噬调节剂：机制、治疗潜力及病理环境下的开发挑战
errFundamental Research
IF6.3
err2026-04-15
err0
errOAAI
errYongya Wu; Jiaxiang Luo; Haolin Tang; Aoxue Wang; Maolin Duan; Jie Liu; Guan Wang; Liang Ouyang
err分享
err收藏
Acrylamide Bioisosterism: Alkenyl Aromatic Heterocycles as Reactivity-Tunable Warheads for Covalent BTK Inhibitors丙烯酰胺生物电子等排体：烯基芳香杂环作为反应性可调的 Warheads 用于共价 BTK 抑制剂
errJournal of Medicinal Chemistry
IF6.8
err2026-02-24
err0
PREAI
errYang Li; Siyu Fu; Jun Yang; Wentao Tang; Jifa Zhang; Wuyu Mao; Liang Ouyang
err分享
err收藏
First Selective Covalent FGFR3 Inhibitors: Conquering Toxicity and Resistance首个选择性共价FGFR3抑制剂：克服毒性和耐药性
errJournal of Medicinal Chemistry
IF6.8
err2026-02-01
err0
PREAI
errOuyang, Liang
err分享
err收藏
The epigenetic landscape of rheumatoid arthritis: Pathogenesis and drug therapeutic potentials类风湿关节炎的表观遗传景观：发病机制和药物治疗潜力
errActa Pharmaceutica Sinica B
IF14.6
err2025-08-30
err0
errOAAI
errChengcheng Huang; Yuxiang Liang; Yang Li; Quan Wei; Liang Ouyang; Jifa Zhang
err分享
err收藏
Identification of a Selective YTHDF1 Inhibitor Targeting the m6A Recognition Domain for Breast Cancer鉴定一种靶向m6A识别域的乳腺癌选择性YTHDF1抑制剂
errAngewandte Chemie International Edition
IF0
err2025-08-19
err0
PREAI
errYongya Wu; Guotai Feng; Wen Shuai; Xiao Yang; Xiaoli Pan; Chunyan Zhu; Aoxue Wang; Qiu Sun; Guan Wang; Prof. Dr. Liang Ouyang
err分享
err收藏
REST/NRSF Regulation of Epilepsy and Cognitive Impairment: Mechanisms and EEG CorrelationsREST/NRSF对癫痫和认知障碍的调控：机制与EEG相关性
errMolecular Neurobiology
IF4.3
err2025-07-17
err0
PREAI
errLiang OUyang; Xiao-Xuan Li; Bing Li
err分享
err收藏
GSBC-SNet: a novel graph-aware bidirectional contrastive semantic network for multilabel text classificationGSBC-SNet：一种用于多标签文本分类的新型图感知双向对比语义网络
errKNOWLEDGE AND INFORMATION SYSTEMS
IF3.1
err2025-04-29
err0
PREAI
errPang, Rui; Zhang, Qiongbing; Lin, Yating; Ouyang, Liang; Cui, Zhangwei
err分享
err收藏
Unraveling Small Molecule-Mediated Sirtuin 3 Activation at a Distinct Binding Site for Cardioprotective Therapies解析小分子介导的Sirtuin 3在特定结合位点上的激活以用于心脏保护疗法
errACS CENTRAL SCIENCE
IF10.4
err2025-04-14
err0
errOAAI
errZhang, D; Zhang, JF; Wu, CY; Xiao, Y; Ji, LW; Hu, JR; Ding, JJ; Li, T; Zhang, YW; Ouyang, L
err分享
err收藏
A first-in-class selective inhibitor of ERK1/2 and ERK5 overcomes drug resistance with a single-molecule strategy一类针对ERK1/2和ERK5的选择性抑制剂，通过单分子策略克服耐药性。
errSIGNAL TRANSDUCTION AND TARGETED THERAPY
IF52.7
err2025-02-20
err0
errOAAI
errXiao, Huan; Wang, Aoxue; Shuai, Wen; Qian, Yuping; Wu, Chengyong; Wang, Xin; Yang, Panpan; Sun, Qian; Wang, Guan; Ouyang, Liang
err分享
err收藏
Mitophagy in Neurodegenerative Diseases: Mechanisms of Action and the Advances of Drug Discovery神经退行性疾病中的线粒体自噬：作用机制与药物发现进展
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2025-02-05
err0
PREAI
errYang, Panpan; Shuai, Wen; Wang, Xin; Hu, Xiuying; Zhao, Min; Wang, Aoxue; Wu, Yongya; Ouyang, Liang
err分享
err收藏
Acquired resistance to tyrosine kinase targeted therapy: mechanism and tackling strategies酪氨酸激酶靶向治疗获得性耐药: 机制及应对策略
errDRUG RESISTANCE UPDATES
IF21.7
err2025-01-01
err0
PREAI
errWu, Defa; Sun, Qian; Tang, Haolin; Xiao, Huan; Luo, Jiaxiang; Ouyang, Liang; Sun, Qiu
err分享
err收藏
SHP2-mediated mitophagy boosted by lovastatin in neuronal cells alleviates parkinsonism in mice (vol 6, 34, 2021)洛伐他汀增强的SHP2介导的神经元细胞线粒体自噬减轻小鼠的帕金森病表型（卷6，34，2021）
errSIGNAL TRANSDUCTION AND TARGETED THERAPY
IF52.7
err2024-12-26
err0
errOAAI
errLiu, Wen; Wang, Meijing; Shen, Lihong; Zhu, Yuyu; Ma, Hongyue; Liu, Bo; Ouyang, Liang; Xu, Qiang; Sun, Yang
err分享
err收藏
Transcription of a centromere-enriched retroelement and local retention of its RNA are significant features of the CENP-A chromatin landscape
errGENOME BIOLOGY
IF9.4
err2024-11-18
err0
errOAAI
errChabot, B. J.; Sun, R.; Amjad, A.; Hoyt, S. J.; Ouyang, L.; Courret, C.; Drennan, R.; Leo, L.; Larracuente, A. M.; Core, L. J.; O'Neill, R. J.; Mellone, B. G.
err分享
err收藏
Selective Covalent Inhibiting JNK3 by Small Molecules for Parkinson's Diseases
errANGEWANDTE CHEMIE-INTERNATIONAL EDITION
IF16.9
err2024-10-31
err0
PREAI
errShuai, Wen; Yang, Panpan; Xiao, Huan; Zhu, Yumeng; Bu, Faqian; Wang, Aoxue; Sun, Qiu; Wang, Guan; Liang, Ouyang
err分享
err收藏
α-Synuclein disrupts microglial autophagy through STAT1-dependent suppression of Ulk1 transcription
errJOURNAL OF NEUROINFLAMMATION
IF10.1
err2024-10-26
err0
errOAAI
errPei, Chong-Shuang; Hou, Xiao-Ou; Ma, Zhen-Yuan; Tu, Hai-Yue; Qian, Hai-Chun; Li, Yang; Li, Kai; Liu, Chun-Feng; Ouyang, Liang; Liu, Jun-Yi; Hu, Li-Fang
err分享
err收藏
Boosting Med Chem Education: Integrating Biology for Drug Discovery Talents
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2024-09-24
err1
PREAI
errSun, Qiu; Ouyang, Liang
err分享
err收藏
Update on JNK inhibitor patents: 2015 to present
errEXPERT OPINION ON THERAPEUTIC PATENTS
IF4.6
err2024-09-08
err2
PREAI
errFeng, Guotai; Yang, Xiao; Shuai, Wen; Wang, Guan; Ouyang, Liang
err分享
err收藏
Journal of Medicinal Chemistry Collection: Drug Discovery in China
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2024-08-29
err1
errOAAI
errBin, Yu; Liang, Ouyang
err分享
err收藏
Structure-Guided Discovery and Preclinical Assessment of Novel (Thiophen-3-yl)aminopyrimidine Derivatives as Potent ERK1/2 Inhibitors
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2024-04-13
err0
PREAI
errShuai, Wen; Xiao, Huan; Yang, Panpan; Zhang, Yiwen; Bu, Faqian; Wu, Yongya; Sun, Qiu; Wang, Guan; Ouyang, Liang
err分享
err收藏

研究方向

创新药物的发现及其成药性计算机辅助小分子药物设计与合成结构生物学 ：利用生物物理手段，结合可药靶标，开展分子克隆生物信息学计算机辅助活性分子设计合成构-效关系研究成药性预测药物化学生物学小分子化合物库和筛选技术细胞内生物学过程药物靶标鉴定和先导化合物发现药理学药物作用新机制新靶标研究疾病病理机制新动物模型精准干预克服耐药策略系统生物学表观遗传学新药和组合用药新策略基于片段的药物设计具有生物活性小分子的发现小分子和蛋白共结晶
合作学者
合作期刊
陈豪 封面图
陈豪 (Hao Chen)
H 指数: 139 · 论文数: 5.6K
Y
Yuquan Wei
H 指数: 111 · 论文数: 1.2K
李威 封面图
李威 (Wěi Li)
H 指数: 107 · 论文数: 2.2K
J
J. Joshua Yang
H 指数: 91 · 论文数: 474
彭成 封面图
彭成 (Cheng Peng)
H 指数: 89 · 论文数: 1.8K
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