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李

李剑勇 (Jianyong Li)

Chinese Academy of Agricultural Sciences

43H指数
266论文数
5.7K被引数
收录论文 93
发表时间
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Design, synthesis, anti-MRSA activity evaluation, and mechanism of action study of 1,3-diamino-7H-pyrrolo[3,2-f]quinazoline derivatives1,3-二氨基-7H-吡咯并[3,2-f]喹唑啉衍生物的设计、合成、抗MRSA活性评价及作用机制研究
errEuropean Journal of Medicinal Chemistry
IF5.9
err2026-07-01
err0
PREAI
errZhang, Qing-Jie; Li, Yu-Xi; Yan, Ying-Xu; Gu, Ri-Fei; Zhang, He-Chao; Zhu, An-Ji; Ge, Wen-Bo; Xu, Xiao; Yang, Ya-Jun; Liu, Xi-Wang; Li, Jian-Yong
err分享
err收藏
Aspirin Eugenol Ester Ameliorates Fatty Liver Hemorrhagic Syndrome in Laying Hens by Reducing Oxidative Stress and Inflammation阿司匹林-丁香酚酯通过减轻氧化应激和炎症来改善产蛋鸡的脂肪肝出血综合征
errInternational Journal of Molecular Sciences
IF4.9
err2026-05-27
err0
errOAAI
errWenbo Ge; Kai Yan; Yajun Yang; Xiwang Liu; Xiao Xu; Shihong Li; Lixia Bai; Zhe Qin; Zhun Li; Di Lu; Jianyong Li
err分享
err收藏
In Silico Prediction of Potential pTLR7/pSTING Dual-Targeting Ligands via Virtual Screening and Molecular Dynamics Simulation基于虚拟筛选和分子动力学模拟的潜在pTLR7/pSTING双靶点配体In Silico预测
errInternational Journal of Molecular Sciences
IF4.9
err2026-03-04
err0
errOAAI
errChang Liu; Zhe Qin; Lixia Bai; Xiao Xu; Wenbo Ge; Zhun Li; Jianyong Li
err分享
err收藏
Aspirin Eugenol Ester Alleviates Vascular Endothelial Ferroptosis by Enhancing Antioxidant Ability and Inhibiting the JNK/c-Jun/NCOA4/FTH Signaling Pathway阿司匹林愈创木酚酯通过增强抗氧化能力并抑制JNK/c-Jun/NCOA4/FTH信号通路来减轻血管内皮细胞的铁死亡。
errAntioxidants
IF6.6
err2026-03-03
err0
errOAAI
errJi Feng; Qi Tao; Zhi-Jie Zhang; Qin-Fang Yu; Ya-Jun Yang; Jian-Yong Li
err分享
err收藏
Aspirin Eugenol Ester Alleviates Gastric Injury by Inhibiting Ferroptosis and Oxidative Stress阿司匹林愈创木酚酯通过抑制铁死亡和氧化应激减轻胃损伤
errAntioxidants
IF6.6
err2026-02-09
err0
errOAAI
errQi Tao; Zhijie Zhang; Ji Feng; Liping Fan; Yajun Yang; Jianyong Li
err分享
err收藏
Multicellular Model Reveals the Mechanism of AEE Alleviating Vascular Endothelial Cell Injury via Anti-Inflammatory and Antioxidant Effects多细胞模型揭示了AEE通过抗炎和抗氧化作用减轻血管内皮细胞损伤的机制
errInternational Journal of Molecular Sciences
IF4.9
err2026-01-16
err0
errOAAI
errJi Feng; Qi Tao; Meng-Zhen Li; Zhi-Jie Zhang; Qin-Fang Yu; Jian-Yong Li
err分享
err收藏
Separation and detection of Gram-negative bacteria via vancomycin-functionalized magnetic beads and aminopeptidase test strips通过万古霉素功能化磁珠和氨基肽酶试纸条分离和检测革兰氏阴性菌
errFrontiers in Bioengineering and Biotechnology
IF4.8
err2025-11-20
err0
errOAAI
errXiao Xu†; Anji Zhu†; Lixia Bai; Shihong Li; Wenbo Ge; Yajun Yang; Xiwang Liu; Zhe Qin; Zhun Li; Jianyong Li
err分享
err收藏
Frontier advances in bionic-driven low-frequency nonlinear vibration isolation systems: a review of design mechanisms and analytical methods仿生驱动低频非线性隔振系统的前沿进展：设计机制与分析方法的综述
errSmart Materials and Structures
IF3.8
err2025-09-17
err0
PREAI
errShuo Yang; Huixuan Li; Tianshuo Meng; Yinghao Qi; Yongqi Zhang; Jianyong Li; Jia Man
err分享
err收藏
Synthesis and biological activity evaluation of a novel pleuromutilin derivative 22-((2-methyl-1-(1H-pyrrole-2-carboxamido)propan-2-yl)thio)-deoxypleuromutilin新型双戊烯基衍生物22-((2-甲基-1-(1H-吡咯-2-甲酰胺基)丙-2-基)硫代)-去氧双戊烯基的合成与生物活性评价
errFrontiers in Pharmacology
IF4.8
err2025-09-06
err0
errOAAI
errZhun Li; Danqian Ma; Chang Liu; Zhe Qin; Lixia Bai; Wenbo Ge; Xiao Xu; Jianyong Li
err分享
err收藏
Integrated transcriptomics and metabolomics revealed improvement of the nervous system in old rats by aspirin eugenol ester整合转录组学和代谢组学揭示了阿司匹林丁香酚酯对老年大鼠神经系统的改善作用
errbiochimica et biophysica acta molecular basis of disease
IF0
err2025-08-06
err0
PREAI
errQi Tao; Ji Feng; Li-Ping Fan; Zhi-Jie Zhang; Chen-Jing Feng; Jian-Yong Li; Ya-Jun Yang
err分享
err收藏
Design, synthesis, and bioactivity of newly potent pleuromutilin derivatives设计、合成及新型强效苯并吲哚类衍生物的生物活性
errEuropean Journal of Medicinal Chemistry
IF5.9
err2025-08-04
err0
PREAI
errZhun Li; Danqian Ma; Chang Liu; Xianlong Qi; Zhe Qin; Yajun Yang; Jianyong Li
err分享
err收藏
3,4-Dihydroxyphenylacetaldehyde synthase evolved an ordered structure to deliver oxygen to pyridoxal 5'-phosphate for cuticle assembly in the mosquito Aedes aegypti3,4-二羟基苯乙醛合酶进化出有序结构，以向烟酰胺醛5'-磷酸输送氧气，用于埃及伊蚊(Aedes aegypti)的表皮组装。
errNATURE COMMUNICATIONS
IF15.7
err2025-05-14
err0
errOAAI
errChen, Jing; Vavricka, Christopher J.; Wei, Shuangshuang; Nakazawa, Yasumoto; Matsumoto, Yuri; Chen, Huaqing; Tang, Yu; Liang, Jing; Chen, Jiukai; Huang, Yaneng; Noguchi, Keiichi; Hasunuma, Tomohisa; Guan, Huai; Li, Jianyong; Liao, Chenghong; Han, Qian
err分享
err收藏
Discovery of novel thiazole-pleuromutilin derivatives with potent antibacterial activity
errEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
err2025-04-01
err0
errOAAI
errQi, Xian-Long; Zhang, He-Chao; Xu, Xiao; Liu, Xi-Wang; Yang, Ya-Jun; Li, Zhun; Li, Jian-Yong
err分享
err收藏
Aspirin Eugenol Ester Modulates the Hypothalamus Transcriptome in Broilers Under High Stocking Density阿司匹林丁香酚酯调控高饲养密度下肉鸡的下丘脑转录组
errANIMALS
IF2.7
err2025-03-13
err0
errOAAI
errZhao, Xiaodie; Zhang, Yi; Bai, Dongying; Zhen, Wenrui; Guo, Caifang; Wang, Ziwei; Ma, Penghui; Ma, Xiqiang; Xie, Xiaolin; Ito, Koichi; Zhang, Bingkun; Yang, Yajun; Li, Jianyong; Ma, Yanbo
err分享
err收藏
Aspirin Eugenol Ester Alleviates Energy Metabolism Disorders by Reducing Oxidative Damage and Inflammation in the Livers of Broilers Under High-Stocking-Density Stress阿司匹林愈创木酚酯通过减少氧化损伤和炎症，缓解高饲养密度应激下肉鸡肝脏的能量代谢紊乱。
errINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
IF4.9
err2025-02-21
err0
errOAAI
errGuo, Caifang; Zhang, Yi; Bai, Dongying; Zhen, Wenrui; Ma, Penghui; Wang, Ziwei; Zhao, Xiaodie; Ma, Xiqiang; Xie, Xiaolin; Ito, Koichi; Zhang, Bingkun; Yang, Yajun; Li, Jianyong; Ma, Yanbo
err分享
err收藏
Synthesis, Antimicrobial Activities, and Model of Action of Indolyl Derivatives Containing Amino-Guanidinium Moieties含有氨基胍鎓部分的吲哚基衍生物的合成，抗菌活性和作用模型
errMOLECULES
IF4.6
err2025-02-14
err0
errOAAI
errLi, Yu-Xi; Geng, Xiang; Tao, Qi; Hao, Ruo-Chen; Yang, Ya-Jun; Liu, Xi-Wang; Li, Jian-Yong
err分享
err收藏
Optimization of drag-reduction microstructure parameters and study of the drag reduction mechanism in a rotating flow field
errPHYSICS OF FLUIDS
IF4.3
err2025-01-24
err0
PREAI
errYuan, Zhiyi; Ji, Maocheng; Li, Jianyong; Zhang, Yongqi; Song, Xinzhong; Wang, Zunxing; Li, Jianfeng; Man, Jia
err分享
err收藏
The Aedes aegypti mosquito evolves two types of prophenoloxidases with diversified functions埃及伊蚊进化出两种具有多样化功能的前酚氧化酶。
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2025-01-14
err1
PREAI
errZhu, Xiaojing; Zhang, Lei; Jiang, Linlong; Chen, Huaqing; Tang, Yu; Yang, Xiaoyun; Bao, Pengkun; Liao, Chenghong; Li, Jianyong; Vavricka, Christopher J.; Ren, Delin; Chen, Zhaohui; Guo, Yingying; Han, Qian
err分享
err收藏
Development of a Method for the Determination of Rifaximin and Rifampicin Residues in Foods of Animal Origin
errMOLECULES
IF4.6
err2024-09-27
err0
errOAAI
errFan, Li-Ping; Tao, Qi; Wang, Xiao-Qiao; Xu, Xiao-Hui; Yang, Ya-Jun; Li, Jian-Yong
err分享
err收藏
Effect of dietary aspirin eugenol ester on the growth performance, antioxidant capacity, intestinal inflammation, and cecal microbiota of broilers under high stocking density
errPOULTRY SCIENCE
IF4.2
err2024-07-01
err5
errOAAI
errZhang, Haojie; Zhang, Yi; Bai, Dongying; Zhong, Jiale; Hu, Xiaodi; Zhang, Ruilin; Zhen, Wenrui; Ito, Koichi; Zhang, Bingkun; Yang, Yajun; Li, Jianyong; Ma, Yanbo
err分享
err收藏

研究方向

兽医药理与毒理学新兽药研发新药筛选食品安全兽药制剂寄生虫性病毒性和炎症等疾病，利用药物化学分析化学计算机辅助设计代谢组学蛋白组学现代药物评价创新兽药的基础和应用研究开发高效兽药安全的新型药物。重点开展新药筛选技术理论和方法研究药物作用机理研究新兽药新兽药评价国家支撑计划项目公益性行业专项项目农业行业标准项目甘肃省重大专项兰州市重大专项研制出兽用新制剂3个，授权发明专利7项兽药设计和筛选理论计算机辅助药物设计抑制剂设计合成及活性研究以分子印迹-液质联用技术为手段，开展了中药抗病毒成分的筛选鉴定一体化高通量筛选技术借助高分辨质谱，开展了药物的代谢组学蛋白组学研究转录组学研究药物作用机理阐明药用化合物AEE创制及成药性研究质量标准研究明确了AEE的抗高血脂抗血栓抗氧化损伤药理作用阐明了基于“组学”的AEE降血脂和防治血栓的调控机制证明了AEE对实验动物的极低毒性作用动物疾病防治新制剂研制鸡呼吸道感染性疾病双氯芬酸钠注射液新制剂药理学毒理学及临床研究内容，为国家新兽药证书申报和产业化奠定了基础
合作学者
合作期刊
刘洋 封面图
刘洋 (Yang Liu)
H 指数: 128 · 论文数: 2.2K
A
Akihiko Kondo
H 指数: 98 · 论文数: 1.1K
李冰 封面图
李冰 (Bing Li)
H 指数: 79 · 论文数: 869
陈锐 封面图
陈锐 (Rui Chen)
H 指数: 71 · 论文数: 846
Liwang Cui 封面图
Liwang Cui (Liwang Cui)
H 指数: 69 · 论文数: 487
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