Leendert A. Trouw - Publications, H-index & Citations

Leendert A. Trouw

Leiden University

63H指数

409论文数

1.3W被引数

收录论文 186

发表时间

Complement Activation by Post-Translationally Modified Proteins: Links to Chronic Inflammation and Autoimmunity 翻译后修饰蛋白对补体的激活：与慢性炎症和自身免疫的关联

Immunological Reviews

IF8.3

2026-09-24

OAAI

Marleen M. J. van Greevenbroek; Leendert A. Trouw

Complement-dependent phagocytosis in the clearance of various cellular targets 补体依赖性吞噬作用在清除各种细胞靶标中的作用

Protein & Cell

IF0

2026-08-22

OAAI

Marfa Blanter; Max L B Grönloh; Pedro E Marques; Suzan H M Rooijakkers; Andrea J Tenner; Leendert A Trouw

C1q-targeting bispecific antibodies bypass Fc to trigger complement activation and receptor clustering agonism C1q靶向双特异性抗体绕过Fc以触发补体激活和受体聚集激动作用

Molecular Immunology

IF3

2026-08-01

PREAI

Dijkstra, Douwe J.; Blanter, Marfa I.; van der Meijden, Els; Groenland, Rick J.; Rodriguez, Clifford; Bleijlevens, Boris; Beurskens, Frank J.; Trouw, Leendert A.

Shifting From Systemic to Precision-Targeted Complement Therapies: Opportunities and Hurdles 从系统性到精准靶向补体疗法：机遇与挑战

European Journal of Immunology

IF3.7

2026-06-19

OAAI

Marco Mannes; Wioleta M. Zelek; Leendert A. Trouw

Complement in tuberculosis infection and disease, a battle of two ancients 结核感染和疾病中的补体：一场两个古物的较量

Immunobiology

IF2.3

2026-05-01

PREAI

Dijkman, Karin; Joosten, Simone A.; Trouw, Leendert A.

Local complement inhibition by selective precision-targeted therapies 局部补体抑制通过选择性精准靶向疗法

Current Opinion in Immunology

IF5.8

2025-10-29

OAAI

Haiyu Wang; Daan J van den Brink; Balthasar A Heesters; Paul WHI Parren; Leendert A Trouw

Structural Insights into Complement Inhibition: Visualizing Distinct Binding Modes of C4b-binding Protein Complexes with C4b and SAP 补体抑制的结构洞察：可视化C4b结合蛋白复合物与C4b和SAP的不同结合模式

Molecular & Cellular Proteomics

IF5.5

2025-08-05

OAAI

Tereza Kadavá; Jürgen Strasser; Maryam Marefat; Victor C. Yin; Johannes Preiner; Leendert A. Trouw; Albert J.R. Heck

Corrigendum to ‘B-cell activating factor and IL-21 levels predict treatment response in autoimmune hepatitis’ [J Hepatol (2022) doi: 10.1016/j.jhepr.2022.100460]勘误：《B-cell activating factor and IL-21 levels predict treatment response in autoimmune hepatitis》 [J Hepatol (2022) doi: 10.1016/j.jhepr.2022.100460]

JHEP Reports

IF7.5

2025-07-01

OAAI

Maaike Biewenga; Sebastiaan Heidt; Manon Vergunst; Camiel J.M. Marijnissen; Rob A. de Man; Annemiek A. van der Eijk; Adriaan J. van der Meer; Leendert A. Trouw; Bart van Hoek

Modulation of immunoglobulin G oligomerization by variable domain glycans: A mechanism to regulate complement activation 免疫球蛋白G寡聚化受可变区糖基调节：一种调节补体激活的机制

PNAS Nexus

IF3.8

2025-06-30

OAAI

Roxane Biersteker; Leoni Abendstein; Sanne van de Bovenkamp; Hugo J van Dooren; Sebastiaan M W R Hamers; Joanneke C Kwekkeboom; Eva Maria Stork; Jan W Drijfhout; Theo Rispens; Carolien A M Koeleman; Manfred Wuhrer; Leendert A Trouw; Thomas H Sharp; René E M Toes; Theresa Kissel

Post-translationally modified proteins bind and activate complement with implications for cellular uptake and autoantibody formation 翻译后修饰的蛋白质能够结合并激活补体，这关系到细胞摄取和自身抗体的形成。

Journal of Autoimmunity

IF7

2025-06-23

OAAI

M.D. van den Beukel; L. Zhang; S. van der Meulen; N.V. Borggreven; S. Nugteren; M.C. Brouwer; R.B. Pouw; K.A. Gelderman; A.H. de Ru; G.M.C. Janssen; P.A. van Veelen; R. Knevel; P.W.H.I. Parren; L.A. Trouw

Anti-C1s autoantibodies as complementary serologic biomarker in lupus nephritis 抗C1s自身抗体作为狼疮肾炎的补充血清学生物标志物

clinical immunology

IF3.8

2025-06-01

PREAI

Vigne, Jeanne; Haut, Nolwenn; Clavarino, Giovanna; Jourde-Chiche, Noemie; Sarrot-Reynauld, Francoise; Trouw, Leendert A.; Defendi, Federica; Thielens, Nicole M.; Gaboriaud, Christine; Rossi, Veronique; Dumestre-Perard, Chantal

Autoantibodies and therapeutic antibodies against complement factor H 抗补体因子H的自身抗体和治疗性抗体

IMMUNOLOGY LETTERS

IF2.8

2025-04-24

PREAI

Nugteren, Saskia; Wang, Haiyu; van Kooten, Cees; Gelderman, Kyra A.; Trouw, Leendert A.

Site-directed multivalent conjugation of antibodies to ubiquitinated payloads 抗体靶向多价缀合至泛素化负载

NATURE BIOMEDICAL ENGINEERING

IF26.6

2025-04-09

OAAI

el Hebieshy, Angela F.; Wijfjes, Zacharias; Le Gall, Camille M.; Middelburg, Jim; de Roode, Kim E.; Fennemann, Felix L.; Sluijter, Marjolein; van Hall, Thorbald; Dijkstra, Douwe J.; Trouw, Leendert A.; van Dalen, Floris J.; Rodgers Furones, Andrea; van der Schoot, Johan M. S.; Derksen, Ian; de Haard, Hans; van der Woning, Bas; Ormeno, Cami M. P. Talavera; van Doodewaerd, Bjorn R.; Figdor, Carl G.; van der Heden van Noort, Gerbrand J.; Parren, Paul W. H. I.; Heskamp, Sandra; Ovaa, Huib; Verdoes, Martijn; Scheeren, Ferenc A.

Enhancing complement activation by therapeutic anti-tumor antibodies: Mechanisms, strategies, and engineering approaches 增强补体激活的疗法抗肿瘤抗体：机制、策略和工程方法

SEMINARS IN IMMUNOLOGY

IF7.8

2025-03-01

OAAI

Ovcinnikovs, Vitalijs; Dijkman, Karin; Zom, Gijs G.; Beurskens, Frank J.; Trouw, Leendert A.

Anti-myeloperoxidase IgM B cells in anti-neutrophil cytoplasmic antibody-associated vasculitis 抗髓过氧化物酶 IgM B 细胞在抗中性粒细胞胞浆抗体相关性血管炎中的作用

NATURE COMMUNICATIONS

IF15.7

2025-02-12

OAAI

Wortel, C. M.; van de Wetering, R.; Stork, E. M.; Kissel, T.; Reijm, S.; van der Woude, D.; van Schie, K. A.; Trouw, L. A.; Teng, Y. K. O.; Rutgers, A.; Heeringa, P.; Voll, R. E.; Rizzi, M.; Venhoff, N.; Toes, R. E. M.; Scherer, Hu

Clinical Remission and Reduction of Circulating Nephritic Factors by Combining Rituximab With Belimumab in a Case of Complement Factor 3 Glomerulopathy

KIDNEY INTERNATIONAL REPORTS

IF5.7

2024-06-01

OAAI

van Schaik, Mieke; de Vries, Aiko P. J.; Bemelman, Frederike J.; Rabelink, Ton J.; Trouw, Leendert A.; van Kooten, Cees; Teng, Yoe Kie Onno

Targeted complement inhibition using bispecific antibodies that bind local antigens and endogenous complement regulators 使用结合局部抗原和内源性补体调节剂的双特异性抗体进行靶向补体抑制

FRONTIERS IN IMMUNOLOGY

IF5.9

2024-05-16

OAAI

Wang, Haiyu; van de Bovenkamp, Fleur S.; Dijkstra, Douwe J.; Abendstein, Leoni; Borggreven, Nicole V.; Pool, Jos; Zuijderduijn, Rob; Gstoettner, Christoph; Gelderman, Kyra A.; Damelang, Timon; Vidarsson, Gestur; Blom, Anna M.; Dominguez-Vega, Elena; Parren, Paul W. H. I.; Sharp, Thomas H.; Trouw, Leendert A.

Autoimmune hepatitis displays distinctively high multi-antennary sialylation on plasma N-glycans compared to other liver diseases

JOURNAL OF TRANSLATIONAL MEDICINE

IF7.5

2024-05-14

OAAI

Pongracz, Tamas; Biewenga, Maaike; Stoelinga, Anna Eva Charlotte; Bladergroen, Marco Rene; Nicolardi, Simone; Trouw, Leendert Adrianus; Wuhrer, Manfred; de Haan, Noortje; van Hoek, Bart

DNA Nanostructure-Templated Antibody Complexes Provide Insights into the Geometric Requirements of Human Complement Cascade Activation

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2024-05-04

OAAI

Abendstein, Leoni; Noteborn, Willem E. M.; Veenman, Luc S.; Dijkstra, Douwe J.; van de Bovenkamp, Fleur S.; Trouw, Leendert A.; Sharp, Thomas H.

Commentary: Commentary: Antibodies against multiple post-translationally modified proteins aid in diagnosis of autoimmune hepatitis and associate with complete biochemical response to treatment

FRONTIERS IN MEDICINE

IF3

2023-10-23

OAAI

van den Beukel, Michelle D.; Stoelinga, Anna E. C.; van der Meer, Adriaan J.; van der Meulen, Stef; Zhang, Lu; Tushuizen, Maarten E.; van Hoek, Bart; Trouw, Leendert A.

研究方向