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O

Olli Silvennoinen

tampere university

72H指数
186论文数
2.0W被引数
收录论文 78
发表时间
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Janus kinase 2 activation loop as a regulator of catalysis and trans-activationJAK2激酶活化环作为催化和转激活的调节剂
errInternational Journal of Biological Macromolecules
IF8.5
err2026-07-01
err0
PREAI
errMiao, Ya; Mykuliak, Vasyl V.; Hubbard, Stevan R.; Silvennoinen, Olli; Hytonen, Vesa; Haikarainen, Teemu
err分享
err收藏
A rare JAK2 mutation associated with adult-onset Still’s disease and exacerbated vaccine-induced innate immune response一种与成人斯蒂尔病及加剧疫苗诱导的先天免疫反应相关的罕见JAK2突变
errRheumatology
IF4.4
err2026-04-16
err0
PREAI
errHye Kyung Lee; Sivahari Prasad Gorantla; Teemu Haikarainen; Sung-Gwon Lee; Yasemin Caf; Nikolas von Bubnoff; Olli Silvennoinen; Priscilla A Furth; Ludwig Knabl; Lothar Hennighausen
err分享
err收藏
Heritability and Transcriptional Impact of JAK3, STAT5A and STAT6 Variants in a Tyrolean FamilyJAK3、STAT5A和STAT6变异在蒂罗尔家族中的遗传率和转录影响
errInternational Journal of Molecular Sciences
IF4.9
err2026-01-17
err0
errOAAI
errHye Kyung Lee; Teemu Haikarainen; Yasemin Caf; Priscilla A. Furth; Ludwig Knabl; Olli Silvennoinen; Lothar Hennighausen
err分享
err收藏
Pharmacological targeting of the JAK–STAT pathway: new concepts and emerging indicationsJak-stat途径的药理学靶向: 新概念和新兴适应症
errNature Reviews Drug Discovery
IF101.8
err2026-01-05
err0
PREAI
errTeemu Haikarainen; Anniina T. Virtanen; Benjamin F. Cravatt; Olli Silvennoinen
err分享
err收藏
Investigation of the transcriptional impact of rare germline JAK/STAT variants found in a Tyrolean alpine community对在蒂罗尔阿尔卑斯山社区中发现的一种罕见种系JAK/STAT变异转录影响的研究
errBMC Genomics
IF3.7
err2025-12-01
err0
errOAAI
errLothar Hennighausen; Teemu Haikarainen; Sung-Gwon Lee; Yasemin Caf; Priscilla A. Furth; Olli Silvennoinen; Hye Kyung Lee; Ludwig Knabl
err分享
err收藏
JAK2/JAK2V617F heterodimers activate STAT1 and AhR to promote thrombocytosisJAK2/JAK2V617F异源二聚体激活STAT1和AhR以促进血小板增多症
errJOURNAL OF EXPERIMENTAL MEDICINE
IF10.6
err2025-11-11
err0
PREAI
errSkoda, Radek C.; Silvennoinen, Olli
err分享
err收藏
JAK inhibitor selectivity: new opportunities, better drugs?JAK抑制剂的选择性: 新的机会，更好的药物？
errNATURE REVIEWS RHEUMATOLOGY
IF32.7
err2024-09-09
err1
PREAI
errVirtanen, Anniina; Spinelli, Francesca Romana; Telliez, Jean Baptiste; O'Shea, John J.; Silvennoinen, Olli; Gadina, Massimo
err分享
err收藏
Functional and Structural Characterization of Clinical-Stage Janus Kinase 2 Inhibitors Identifies Determinants for Drug Selectivity临床阶段Janus激酶2抑制剂的功能和结构表征确定了药物选择性的决定因素
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2024-06-06
err1
errOAAI
errMiao, Ya; Virtanen, Anniina; Zmajkovic, Jakub; Hilpert, Morgane; Skoda, Radek C.; Silvennoinen, Olli; Haikarainen, Teemu
err分享
err收藏
Molecular basis of JAK2 activation in erythropoietin receptor and pathogenic JAK2 signaling促红细胞生成素受体和致病性JAK2信号通路中JAK2活化的分子基础
errSCIENCE ADVANCES
IF12.5
err2024-03-08
err0
errOAAI
errAbraham, Bobin George; Haikarainen, Teemu; Vuorio, Joni; Girych, Mykhailo; Virtanen, Anniina T.; Kurttila, Antti; Karathanasis, Christos; Heilemann, Mike; Sharma, Vivek; Vattulainen, Ilpo; Silvennoinen, Olli
err分享
err收藏
Differences in JAK Isoform Selectivity Among Different Types of JAK Inhibitors Evaluated for Rheumatic Diseases Through In Vitro Profiling通过体外分析评估风湿性疾病的不同类型JAK抑制剂之间JAK同工型选择性的差异
errARTHRITIS & RHEUMATOLOGY
IF10.9
err2023-08-03
err5
errOAAI
errVirtanen, Anniina; Palmroth, Maaria; Liukkonen, Sanna; Kurttila, Antti; Haikarainen, Teemu; Isomaki, Pia; Silvennoinen, Olli
err分享
err收藏
New scaffolds for type II JAK2 inhibitors overcome the acquired G993A resistance mutationII型JAK2抑制剂的新型支架克服了获得性G993A耐药突变
errCELL CHEMICAL BIOLOGY
IF7.2
err2023-06-01
err3
errOAAI
errArwood, Matthew L.; Liu, Yao; Harkins, Shannon K.; Weinstock, David M.; Yang, Lei; Stevenson, Kristen E.; Plana, Olivia D.; Dong, Jingyun; Cirka, Haley; Jones, Kristen L.; Virtanen, Anniina T.; Gupta, Dikshat G.; Ceas, Amanda; Lawney, Brian; Yoda, Akinori; Leahy, Catharine; Hao, Mingfeng; He, Zhixiang; Choi, Hwan Geun; Wang, Yaning; Silvennoinen, Olli; Hubbard, Stevan R.; Zhang, Tinghu; Gray, Nathanael S.; Li, Loretta S.
err分享
err收藏
Beta interferon and oncostatin M activate Raf-1 and mitogen-activated protein kinase through a Jak1-dependent pathway
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-29
err106
errOAAI
errStancato, LF; Sakatsume, M; David, M; Dent, P; Dong, F; Petricoin, EF; Krolewski, JJ; Silvennoinen, O; Saharinen, P; Pierce, J; Marshall, CJ; Sturgill, T; Finbloom, DS; Larner, AC
err分享
err收藏
Binding of SH2-B family members within a potential negative regulatory region maintains JAK2 in an active state
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-27
err45
errOAAI
errKurzer, Jason H.; Saharinen, Pipsa; Silvennoinen, Olli; Carter-Su, Christin
err分享
err收藏
Regulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with SOCS-1
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-27
err261
errOAAI
errUngureanu, D; Saharinen, P; Junttila, I; Hilton, DJ; Silvennoinen, O
err分享
err收藏
Regulation of the Jak2 tyrosine kinase by its pseudokinase domain
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-27
err343
errOAAI
errSaharinen, P; Takaluoma, K; Silvennoinen, O
err分享
err收藏
Identification of Novel Small Molecule Ligands for JAK2 Pseudokinase DomainJAK2假激酶结构域新型小分子配体的鉴定
errPHARMACEUTICALS
IF4.8
err2023-01-04
err12
errOAAI
errVirtanen, Anniina T.; Haikarainen, Teemu; Sampathkumar, Parthasarathy; Palmroth, Maaria; Liukkonen, Sanna; Liu, Jianping; Nekhotiaeva, Natalia; Hubbard, Stevan R.; Silvennoinen, Olli
err分享
err收藏
Editorial: JAK inhibition in autoimmune and inflammatory diseases社论: 自身免疫和炎症性疾病中的JAK抑制
errFRONTIERS IN IMMUNOLOGY
IF5.9
err2022-12-28
err1
errOAAI
errTelliez, Jean-Baptiste; Gadina, Massimo; Ghoreschi, Kamran; Silvennoinen, Olli; Spinelli, Francesca Romana
err分享
err收藏
Tofacitinib treatment modulates the levels of several inflammation-related plasma proteins in rheumatoid arthritis and baseline levels of soluble biomarkers associate with the treatment response
errCLINICAL AND EXPERIMENTAL IMMUNOLOGY
IF3.8
err2022-09-17
err9
errOAAI
errValli, Atte; Kuuliala, Krista; Virtanen, Anniina; Kuuliala, Antti; Palmroth, Maaria; Peltomaa, Ritva; Vidqvist, Krista-Liisa; Leirisalo-Repo, Marjatta; Silvennoinen, Olli; Isomaki, Pia
err分享
err收藏
Aiming for the pocket
errNATURE CHEMICAL BIOLOGY
IF13.7
err2022-09-12
err1
PREAI
errSilvennoinen, Olli; Haikarainen, Teemu; Virtanen, Anniina
err分享
err收藏
Tofacitinib Suppresses Several JAK-STAT Pathways in Rheumatoid Arthritis In Vivo and Baseline Signaling Profile Associates With Treatment Response
errFRONTIERS IN IMMUNOLOGY
IF5.9
err2021-09-24
err34
errOAAI
errPalmroth, Maaria; Kuuliala, Krista; Peltomaa, Ritva; Virtanen, Anniina; Kuuliala, Antti; Kurttila, Antti; Kinnunen, Anna; Leirisalo-Repo, Marjatta; Silvennoinen, Olli; Isomaeki, Pia
err分享
err收藏

研究方向

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