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Durable response to CAR T is associated with elevated activation and clonotypic expansion of the cytotoxic native T cell repertoire CAR T的持久性应答与细胞毒性固有T细胞库的激活水平升高及克隆型扩增相关。 Cheloni, Giulia; Karagkouni, Dimitra; Pita-Juarez, Yered; Torres, Daniela; Kanata, Eleni; Liegel, Jessica; Avigan, Zachary; Saldarriaga, Isabella; Chedid, Georges; Rallis, Kathrine; Miles, Brodie; Tiwari, Gayatri; Kim, Jenny; Mattie, Mike; Rosenblatt, Jacalyn; Vlachos, Ioannis S.; Avigan, David 分享 收藏
Final analysis of a phase II trial of daratumumab, carfilzomib, lenalidomide, and dexamethasone in newly diagnosed multiple myeloma without transplant Derman, Benjamin A.; Cooperrider, Jennifer; Rosenblatt, Jacalyn; Avigan, David E.; Rampurwala, Murtuza; Barnidge, David; Major, Ajay; Karrison, Theodore; Jiang, Ken; Ramsland, Aubrianna; Kubicki, Tadeusz; Jakubowiak, Andrzej J. 分享 收藏
Dendritic cell/myeloma fusion vaccine with lenalidomide maintenance following autologous hematopoietic cell transplant induced T cell activation and expansion Cheloni, Giulia; Karagkouni, Dimitra; Torres, Daniela; Chung, David J.; Shah, Nina; Callander, Natalie S.; Chodon, Thinle; Efebera, Yvonne; Geller, Nancy; Hematti, Peiman; Lazarus, Hillard; Malek, Ehsan; McCarthy, Philip L.; Nooka, Ajay K.; Rosenblatt, Jacalyn; Rapoport, Aaron P.; Soiffer, Robert J.; Stroopinsky, Dina; Waller, Edmund K.; Pasquini, Marcelo C.; Vlachos, Ioannis; Avigan, David 分享 收藏
Activation and clonotypic expansion of the native T cell repertoire identifies durable response to CD19 CAR T cell therapy Karagkouni, Dimitra; Cheloni, Giulia; Pita-Juarez, Yered; Torres, Daniela; Kanata, Eleni; Avigan, Zachary; Liegel, Jessica; Stroopinsky, Dina; Miles, Brodie; Tiwari, Gayatri; Kim, Jenny; Mattie, Mike; Rosenblatt, Jacalyn; Avigan, David; Vlachos, Ioannis 分享 收藏
4-1bb selection augments DC/AML fusion vaccine-educated T cells for adoptive cell therapy Rallis, Kathrine S.; Liegel, Jessica; Cheloni, Giulia; Stroopinsky, Dina; Bindal, Poorva; Dufort, Kenel; Torres, Daniela; Saldarriaga, Isabella; Herzlinger, Samuel; Morin, Abigael; Kesselman, Raphael; Rosenbaum, Jeremy; Chedid, Georges; Adamia, Sophia; Kufe, Donald; Rosenblatt, Jacalyn; Avigan, David 分享 收藏
CART-ddBCMA for multiple myeloma: Interim results from phase I study Frigault, M.; Rosenblatt, J.; Raje, N.; Cook, D.; Gaballa, M.; Emmanuel-Alejandro, E.; Cornwell, C.; Banerjee, K.; Rotte, A.; Heery, C.; Avigan, D.; Jakubowiak, A.; Bishop, M. 分享 收藏
GM-CSF secreting leukemia cell vaccination for MDS/AML after allogeneic HSCT: a randomized, double-blinded, phase 2 trial Ho, Vincent T.; Kim, Haesook T.; Brock, Jennifer; Galinsky, Ilene; Daley, Heather; Reynolds, Carol; Weber, Augustine; Pozdnyakova, Olga; Severgnini, Mariano; Nikiforow, Sarah; Cutler, Corey; Koreth, John; Alyea, Edwin P.; Antin, Joseph H.; Gooptu, Mahasweta; Romee, Rizwan; Shapiro, Roman; Chen, Yi-Bin; Rosenblatt, Jacalyn; Avigan, David; Hodi, F. Stephen; Dranoff, Glenn; Wu, Catherine J.; Ritz, Jerome; Soiffer, Robert J. 分享 收藏
Combining a CAR and a chimeric costimulatory receptor enhances T cell sensitivity to low antigen density and promotes persistence 结合CAR和嵌合共刺激受体可增强T细胞对低抗原密度的敏感性并促进持久性 Katsarou, Afroditi; Sjostrand, Maria; Naik, Jyoti; Mansilla-Soto, Jorge; Kefala, Dionysia; Kladis, Georgios; Nianias, Alexandros; Ruiter, Ruud; Poels, Renee; Sarkar, Irene; Patankar, Yash R.; Merino, Elena; Reijmers, Rogier M.; Frerichs, Kristine A.; Yuan, Huipin; de Bruijn, Joost; Stroopinsky, Dina; Avigan, David; van de Donk, Niels W. C. J.; Zweegman, Sonja; Mutis, Tuna; Sadelain, Michel; Groen, Richard W. J.; Themeli, Maria 分享 收藏
Ciltacabtagene autoleucel, a B-cell maturation antigendirected chimeric antigen receptor T-cell therapy in patients with relapsed or refractory multiple myeloma (CARTITUDE-1): a phase 1b/2 open-label study Ciltacabtagene autoleucel，一种用于复发性或难治性多发性骨髓瘤 (CARTITUDE-1) 患者的b细胞成熟抗原导向的嵌合抗原受体T细胞疗法: 1b/2期开放标签研究 Berdeja, Jesus G.; Madduri, Deepu; Usmani, Saad Z.; Jakubowiak, Andrzej; Agha, Mounzer; Cohen, Adam D.; Stewart, A. Keith; Hari, Parameswaran; Htut, Myo; Lesokhin, Alexander; Deol, Abhinav; Munshi, Nikhil C.; O'Donnell, Elizabeth; Avigan, David; Singh, Indrajeet; Zudaire, Enrique; Yeh, Tzu-Min; Allred, Alicia J.; Olyslager, Yunsi; Banerjee, Arnob; Jackson, Carolyn C.; Goldberg, Jenna D.; Schecter, Jordan M.; Deraedt, William; Zhuang, Sen Hong; Infante, Jeffrey; Geng, Dong; Wu, Xiaoling; Carrasco-Alfonso, Marlene J.; Akram, Muhammad; Hossain, Farah; Rizvi, Syed; Fan, Frank; Lin, Yi; Martin, Thomas; Jagannath, Sundar 分享 收藏
Leukemia vaccine overcomes limitations of checkpoint blockade by evoking clonal T-cell responses in a murine acute myeloid leukemia model Stroopinsky, Dina; Liegel, Jessica; Bhasin, Manoj; Cheloni, Giulia; Thomas, Beena; Bhasin, Swati; Panchal, Ruchit; Ghiasuddin, Haider; Rahimian, Maryam; Nahas, Myrna; Orr, Shira; Capelletti, Marzia; Torres, Daniela; Tacettin, Cansu; Weinstock, Matthew; Bisharat, Lina; Morin, Adam; Mahoney, Kathleen M.; Ebert, Benjamin; Stone, Richard; Kufe, Donald; Freeman, Gordon J.; Rosenblatt, Jacalyn; Avigan, David 分享 收藏
Alisertib plus induction chemotherapy in previously untreated patients with high-risk, acute myeloid leukaemia: a single-arm, phase 2 trial Brunner, Andrew M.; Blonquist, Traci M.; DeAngelo, Daniel J.; McMasters, Malgorzata; Fell, Geoffrey; Hermance, Nicole M.; Winer, Eric S.; Lindsley, R. Coleman; Hobbs, Gabriela S.; Amrein, Philip C.; Hock, Hanno R.; Steensma, David P.; Garcia, Jacqueline S.; Luskin, Marlise R.; Stone, Richard M.; Ballen, Karen K.; Rosenblatt, Jacalyn; Avigan, David; Nahas, Myrna R.; Mendez, Lourdes M.; McAfee, Steven L.; Moran, Jenna A.; Bergeron, Meghan; Foster, Julia; Bertoli, Christina; Manning, Amity L.; McGregor, Kristin L.; Fishman, Kaitlyn M.; Kuo, Frank C.; Baltay, Michele T.; Macrae, Molly; Burke, Meghan; Behnan, Tanya; Wey, Margaret C.; Som, Tina T.; Ramos, Aura Y.; Rae, Jessica; Story, Jennifer Lombardi; Nelson, Nicole; Logan, Emma; Connolly, Christine; Neuberg, Donna S.; Chen, Yi-Bin; Graubert, Timothy A.; Fathi, Amir T. 分享 收藏
Vulnerabilities in mIDH2 AML confer sensitivity to APL-like targeted combination therapy Mugoni, Vera; Panella, Riccardo; Cheloni, Giulia; Chen, Ming; Pozdnyakova, Olga; Stroopinsky, Dina; Guarnerio, Jlenia; Monteleone, Emanuele; Lee, Jonathan David; Mendez, Lourdes; Menon, Archita Venugopal; Aster, Jon Christopher; Lane, Andrew A.; Stones, Richard Maury; Galinsky, Ilene; Zamora, Jose Cervera; Lo-Coco, Francesco; Bhasin, Manoj Kumar; Avigan, David; Longo, Letizia; Clohessy, John Gerard; Pandolfi, Pier Paolo 分享 收藏
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First results on survival from a large Phase 3 clinical trial of an autologous dendritic cell vaccine in newly diagnosed glioblastoma (vol 16, 142, 2018) 自体树突状细胞疫苗在新诊断的胶质母细胞瘤中的大型3期临床试验的初步结果 (第16卷，142，2018) Liau, Linda M.; Ashkan, Keyoumars; Tran, David D.; Campian, Jian L.; Trusheim, John E.; Cobbs, Charles S.; Heth, Jason A.; Salacz, Michael; Taylor, Sarah; D'Andre, Stacy D.; Iwamoto, Fabio M.; Dropcho, Edward J.; Moshel, Yaron A.; Walter, Kevin A.; Pillainayagam, Clement P.; Aiken, Robert; Chaudhary, Rekha; Goldlust, Samuel A.; Bota, Daniela A.; Duic, Paul; Grewal, Jai; Elinzano, Heinrich; Toms, Steven A.; Lillehei, Kevin O.; Mikkelsen, Tom; Walbert, Tobias; Abram, Steven R.; Brenner, Andrew J.; Brem, Steven; Ewend, Matthew G.; Khagi, Simon; Portnow, Jana; Kim, Lyndon J.; Loudon, William G.; Thompson, Reid C.; Avigan, David E.; Fink, Karen L.; Geoffroy, Francois J.; Lindhorst, Scott; Lutzky, Jose; Sloan, Andrew E.; Schackert, Gabriele; Krex, Dietmar; Meisel, Hans-Jorg; Wu, Julian; Davis, Raphael P.; Duma, Christopher; Etame, Arnold B.; Mathieu, David; Kesari, Santosh; Piccioni, David; Westphal, Manfred; Baskin, David S.; New, Pamela Z.; Lacroix, Michel; May, Sven-Axel; Pluard, Timothy J.; Tse, Victor; Green, Richard M.; Villano, John L.; Pearlman, Michael; Petrecca, Kevin; Schulder, Michael; Taylor, Lynne P.; Maida, Anthony E.; Prins, Robert M.; Cloughesy, Timothy F.; Mulholland, Paul; Bosch, Marnix L. 分享 收藏
Epstein-Barr virus-encoded EBNA2 alters immune checkpoint PD-L1 expression by downregulating miR-34a in B-cell lymphomas Anastasiadou, Eleni; Stroopinsky, Dina; Alimperti, Stella; Jiao, Alan L.; Pyzer, Athalia R.; Cippitelli, Claudia; Pepe, Giuseppina; Severa, Martina; Rosenblatt, Jacalyn; Etna, Marilena P.; Rieger, Simone; Kempkes, Bettina; Coccia, Eliana M.; Sui, Shannan J. Ho; Chen, Christopher S.; Uccini, Stefania; Avigan, David; Faggioni, Alberto; Trivedi, Pankaj; Slack, Frank J. 分享 收藏
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