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李

李世华 (Shihua Li)

GHM Institute of CNS Regeneration

47H指数
149论文数
8.9K被引数
收录论文 91
发表时间
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Species-dependent activities of the PINK1–parkin axisPINK1–parkin轴的物种依赖性活性
errTranslational Neurodegeneration
IF15.2
err2026-09-18
err0
errOAAI
errWei Huang; Kecheng Chen; Jiayi Wen; Tong Zhang; Shihua Li; Xiao-Jiang Li; Weili Yang
err分享
err收藏
Proteomic profiling of cortex and spinal cord in Tau-P301L transgenic cynomolgus macaquesTau-P301L转基因食蟹猴大脑皮层和脊髓的蛋白质组学分析
errScientific Data
IF6.9
err2026-09-08
err0
errOAAI
errWeien Liang; Bofeng Han; Liyan Wu; Chengxi Wei; Xudong Zhang; Jiawei Li; Danyi Chen; Weijie Ouyang; Yan Chen; Shihua Li; Zhuchi Tu
err分享
err收藏
Modeling Tau-Mediated Pathology in Monkey Brain Slices利用猴脑切片模拟tau介导的病理学
errBiology-Basel
IF3.5
err2026-09-03
err0
errOAAI
errMingtian Pan; Qintian Guo; Peisi Huang; Xiang Han; Sitong Yang; Fengwei Sun; Jiawei Zhang; Laiqiang Chen; Bang Li; Dajian He; Shihua Li; Xiao-Jiang Li; Xiangyu Guo
err分享
err收藏
Pyraclostrobin triggers pulmonary inflammation, oxidative stress, and fibrosis in mouse via Wnt/β-catenin signaling嘧菌酯通过Wnt/β-连环蛋白信号通路触发小鼠肺部炎症、氧化应激和纤维化
errChemico-Biological Interactions
IF5.4
err2026-05-27
err0
PREAI
errJun Wang; Shihua Li; Yan Cao; Feibiao Wang; Xiangjun Li; Yuyan Zha; Yiwen Wang; Huizhen Chen
err分享
err收藏
Caspase-4 transgenic mice exhibit cytoplasmic TDP-43 accumulation and age-dependent neuropathologyCaspase-4转基因小鼠表现出细胞质TDP-43积聚和年龄依赖性神经病理学变化
errNature Communications
IF15.7
err2026-05-27
err0
errOAAI
errQingqing Jia; Longhong Zhu; Dandan Li; Zhenchun Nan; Junqi Hou; Yue Zhao; Gaolu Zhu; Kaili Ou; Mingwei Guo; Huajie Dui; Xiangyi Liu; Xiao-Xin Yan; Su Yang; Li’an Huang; Dongsheng Fan; Shihua Li; Xiao-Jiang Li; Peng Yin
err分享
err收藏
MANF is essential for astrocyte survival in the monkey brainMANF对猴脑中星形胶质细胞的存活至关重要
errProtein & Cell
IF0
err2026-05-03
err0
errOAAI
errTingting Xing; Laiqiang Chen; Xuezhi Duan; Yiran Zhang; Yiyang Qin; Jinpan Lin; Eshu Ruan; Tingting Guo; Changcheng Ye; Jiating He; Suien Xie; Jiawei Zhang; Xichen Song; Wei Huang; Bang Li; Weili Yang; Shihua Li; Xiao-Jiang Li; Su Yang; null
err分享
err收藏
Single-nucleus transcriptomics of an engineered pig model reveals microglia–T cell interactions driving Huntington’s disease neurodegeneration工程猪模型的单核转录组学揭示驱动亨廷顿病神经退行性变的微胶质细胞–T细胞相互作用
errNature Biomedical Engineering
IF26.6
err2026-02-24
err0
PREAI
errJiawei Li; Yingqi Lin; Jiale Gao; Fan Yang; Caijuan Li; Yizhi Chen; Chunhui Huang; Xichen Song; Zebu Song; Jianhao Wu; Jiaxi Wu; Wei Wang; Junzhu Song; Chunxiang Shi; Guangchao Cao; Yan Xu; Yankuo Sun; Zhuchi Tu; Liangxue Lai; Shihua Li; Xiao-Jiang Li; Sen Yan
err分享
err收藏
Precise excision of expanded GGC repeats in NOTCH2NLC via CRISPR/Cas9 for treating neuronal intranuclear inclusion disease通过CRISPR/Cas9对NOTCH2NLC中的扩展GGC重复序列进行精确切除，以治疗神经元核内包涵体病
errNature Communications
IF15.7
err2026-01-13
err0
errOAAI
errNina Xie; Yongcheng Pan; Huichun Tong; Yingqi Lin; Ying Jiang; Zhiqin Wang; Juan Wan; Wendiao Zhang; Xinhui Wang; Xiaobo Sun; Sen Yan; Peng Yin; Qiying Sun; Chengzhi Qi; Yun Tian; Lu Shen; Hong Jiang; Desheng Liang; Beisha Tang; Shihua Li; Xiao-Jiang Li; Qiong Liu
err分享
err收藏
Alleviation of mutant TDP-43-mediated neuropathology by inducible stem cells in monkeys通过可诱导干细胞缓解猴中突变TDP-43介导的神经病理学
errInternational Journal of Biological Sciences
IF10
err2026-01-01
err0
PREAI
errSong, Xichen; Li, Caijuan; Yang, Yang; Huang, Chunhui; Chen, Min; Lin, Song; Huang, Zhonghai; Wang, Wei; Liao, Kai; Wei, Huiyi; Wang, Lu; Xu, Hao; Chen, Yizhi; Lin, Yingqi; Li, Jiawei; Dai, Zhen; Xie, Wenguang; Zheng, Xiao; Wu, Jianhao; Gao, Jiale; Wu, Jiaxi; Tu, Zhuchi; Zhou, Libing; Huang, Lu; Ren, Chaoran; So, Kwok-Fai; Yin, Peng; Yang, Huiming; Li, Shihua; Lai, Liangxue; Li, Xiao-Jiang; Yan, Sen
err分享
err收藏
Inhibition of UBE2N promotes the clearance of mutant HTT (huntingtin) in HD knock-in mice抑制UBE2N促进HD基因敲入小鼠中突变型HTT（huntingtin）的清除
errAutophagy
IF14.3
err2025-08-20
err0
PREAI
errKaili Ou; Xiang Wang; Mingwei Guo; Dandan Li; Chen Zhang; Laiqiang Chen; Junqi Hou; Qingqing Jia; Longhong Zhu; Su Yang; Shihua Li; Xiao-Jiang Li; Peng Yin
err分享
err收藏
Application of antisense oligonucleotide drugs in amyotrophic lateral sclerosis and Huntington's disease反义寡核苷酸药物在肌萎缩侧索硬化和亨廷顿病中的应用
errTRANSLATIONAL NEURODEGENERATION
IF15.2
err2025-01-21
err0
errOAAI
errOu, Kaili; Jia, Qingqing; Li, Dandan; Li, Shihua; Li, Xiao-Jiang
err分享
err收藏
Ribosome-associated pathological TDP-43 alters the expression of multiple mRNAs in the monkey brain
errZOOLOGICAL RESEARCH
IF4.7
err2025-01-01
err0
errOAAI
errDeng, Fu-Yu; Zhu, Gao-Lu; Ou, Kai-Li; Zhu, Long-Hong; Jia, Qing-Qing; Wang, Xiang; Guo, Ming-Wei; Li, Bang; Li, Shi-Hua; Li, Xiao-Jiang; Yin, Peng
err分享
err收藏
Deficiency of parkin causes neurodegeneration and accumulation of pathological α-synuclein in monkey models
errJOURNAL OF CLINICAL INVESTIGATION
IF13.6
err2024-10-15
err2
PREAI
errHan, Rui; Wang, Qi; Xiong, Xin; Chen, Xiusheng; Tu, Zhuchi; Li, Bang; Zhang, Fei; Chen, Chunyu; Pan, Mingtian; Xu, Ting; Chen, Laiqiang; Wang, Zhifu; Liu, Yanting; He, Dajian; Guo, Xiangyu; He, Feng; Wu, Peng; Yin, Peng; Liu, Yunbo; Yan, Xiaoxin; Li, Shihua; Li, Xiao-Jiang; Yang, Weili
err分享
err收藏
Pathogenic TDP-43 accelerates the generation of toxic exon1 HTT in Huntington's disease knock-in mice
errAGING CELL
IF7.1
err2024-08-26
err0
errOAAI
errBai, Dazhang; Deng, Fuyu; Jia, Qingqing; Ou, Kaili; Wang, Xiang; Hou, Junqi; Zhu, Longhong; Guo, Mingwei; Yang, Su; Jiang, Guohui; Li, Shihua; Li, Xiao-Jiang; Yin, Peng
err分享
err收藏
Reduced mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor contributes to neurodegeneration in a model of spinal and bulbar muscular atrophy pathology突变型雄激素受体减少的中脑星形胶质细胞源性神经营养因子表达有助于脊髓和延髓肌萎缩病理模型中的神经变性
errNEURAL REGENERATION RESEARCH
IF6.7
err2024-06-26
err1
errOAAI
errQin, Yiyang; Zhu, Wenzhen; Guo, Tingting; Zhang, Yiran; Xing, Tingting; Yin, Peng; Li, Shihua; Li, Xiao-Jiang; Yang, Su
err分享
err收藏
Pathologic TDP-43 downregulates myelin gene expression in the monkey brain
errBRAIN PATHOLOGY
IF6.2
err2024-05-23
err2
errOAAI
errZhu, Longhong; Bai, Dazhang; Wang, Xiang; Ou, Kaili; Li, Bang; Jia, Qingqing; Tan, Zhiqiang; Liang, Jiahui; He, Dajian; Yan, Sen; Wang, Lu; Li, Shihua; Li, Xiao-Jiang; Yin, Peng
err分享
err收藏
TRIM37 is a primate-specific E3 ligase for Huntingtin and accounts for the striatal degeneration in Huntington's disease
errSCIENCE ADVANCES
IF12.5
err2024-05-17
err1
errOAAI
errQin, Yiyang; Chen, Laiqiang; Zhu, Wenzhen; Song, Jiahong; Lin, Jingpan; Li, Yuwei; Zhang, Jiawei; Song, Xichen; Xing, Tingting; Guo, Tingting; Duan, Xuezhi; Zhang, Yiran; Ruan, Eshu; Wang, Qi; Li, Bang; Yang, Weili; Yin, Peng; Yan, Xiao-Xin; Li, Shihua; Li, Xiao-Jiang; Yang, Su
err分享
err收藏
HAP40 modulates mutant Huntingtin aggregation and toxicity in Huntington's disease mice
errCELL DEATH & DISEASE
IF9.6
err2024-05-14
err2
errOAAI
errChen, Laiqiang; Qin, Yiyang; Guo, Tingting; Zhu, Wenzhen; Lin, Jingpan; Xing, Tingting; Duan, Xuezhi; Zhang, Yiran; Ruan, Eshu; Li, Xiang; Yin, Peng; Li, Shihua; Li, Xiao-Jiang; Yang, Su
err分享
err收藏
Loss of TDP-43 mediates severe neurotoxicity by suppressing PJA1 gene transcription in the monkey brain
errCELLULAR AND MOLECULAR LIFE SCIENCES
IF6.2
err2024-01-09
err0
errOAAI
errZhu, Longhong; Deng, Fuyu; Bai, Dazhang; Hou, Junqi; Jia, Qingqing; Zhang, Chen; Ou, Kaili; Li, Shihua; Li, Xiao-Jiang; Yin, Peng
err分享
err收藏
Comparing HD knockin pigs and mice reveals the pathological role of IL-17
errCELL REPORTS
IF6.9
err2023-12-01
err2
errOAAI
errJia, Qingqing; Bai, Dazhang; Zheng, Xiao; Zhu, Longhong; Ou, Kaili; Wang, Xiang; Tong, Huichun; Zhang, Yiran; Wang, Jing; Zeng, Jun; Yan, Sen; Li, Shihua; Li, Xiao-Jiang; Yin, Peng
err分享
err收藏

研究方向

神经退行性疾病的致病机理
合作学者
合作期刊
谭蔚泓 封面图
谭蔚泓 (Weihong Tan)
H 指数: 168 · 论文数: 1.4K
M
Michael R. Hayden
H 指数: 146 · 论文数: 1.2K
K
Kerry J. Ressler
H 指数: 124 · 论文数: 887
杨黄浩 封面图
杨黄浩 (Huanghao Yang)
H 指数: 110 · 论文数: 546
T
Tianzi Jiang
H 指数: 91 · 论文数: 707
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