Michael W. Lawlor - Publications, H-index & Citations

Michael W. Lawlor

institut national de la sante et de la recherche medicale (inserm)

43H指数

201论文数

4.9K被引数

收录论文 83

发表时间

Liver Health in Myotubular and Centronuclear Myopathies: A Patient-Driven data collection study to better understand liver health and improve standards of care 肌管性肌病和中心核肌病中的肝脏健康：一项由患者驱动的数据收集研究，以更好地了解肝脏健康并改善护理标准

Neuromuscular Disorders

IF2.8

2026-02-27

PREAI

Julie Bohill; Lucy Hickson; Erin Ward; Anne Lennox; Anando Sen; Tmirah Haselkorn; Belinda Cowling; Marie Wood; Mark Ward; Anil Dhawan; Eirini Kyrana; Robert J. Graham; James J. Dowling; Michael W. Lawlor; Alan H. Beggs; Nicol C Voermans; Heinz Jungbluth; A. Reghan Foley; Chiara Marini-Bettolo

AAV8 gene therapy and dietary insults together precipitate cholestatic liver disease in a mouse model of X-linked myotubular myopathy AAV8基因治疗与饮食性损伤共同诱发X连锁肌管性肌营养不良小鼠模型的胆汁淤积性肝病

Science Translational Medicine

IF14.6

2026-02-18

PREAI

Emanuela Pannia; Rebecca Simonian; Nesrin Sabha; Nika Maani; Yingxuan Zhu; Sophie Karolczak; Vanessa Raileanu; Teodoro Bottiglieri; Gaia Andreoletti; Rachel D. Edgar; Sonya A. MacParland; Aleksandra Mitina; Clara E. Cho; Michael W. Lawlor; Kirsten E. Coleman; Barry J. Byrne; Ashish R. Deshwar; James J. Dowling

Myosin inhibition partially rescues the myofiber proteome in X-linked myotubular myopathy 肌球蛋白抑制部分恢复了X连锁肌管性肌病的肌原纤维蛋白质组

JCI Insight

IF6.1

2025-12-22

OAAI

Melhedegaard, Elise Gerlach; Rostedt, Fanny; Gineste, Charlotte; Seaborne, Robert A. E.; Dugdale, Hannah F.; Belhac, Vladimir; Zanoteli, Edmar; Lawlor, Michael W.; Mack, David L.; Wallgren-Pettersson, Carina; Hessel, Anthony L.; Jungbluth, Heinz; Laporte, Jocelyn; Saito, Yoshihiko; Nishino, Ichizo; Ochala, Julien; Laitila, Jenni

Establishment of normal myofiber size distribution in children and young adults

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

IF3

2025-11-01

PREAI

Lawlor, Michael W.; Margeta, Marta; Jones, Karra A.; Schoser, Benedikt; Cotter, Jennifer A.; Rajaram, Veena; Moore, Steven A.; Prom, Mariah J.; Beatka, Margaret; Ott, Emily; Slick, Rebecca A.; Collins, Michael P.; Esselman, Ann; Shahnoor, Nazima; Danielson, Susan; Meng, Hui; Varfaj, Fatbardha; Prasad, Suyash; Rico, Salvador; Lee, Jun; Kumar, Suresh N.; Dressman, Heather Gordish

The D2.B10-Dmdmdx/J mouse model of DMD exhibits a severe mitochondrial deficiency not observed in the C57BL/10ScSn-Dmdmdx/J mouse D2.B10-Dmdmdx/J 小鼠模型中的 Duchenne 肌营养不良（DMD）表现出严重的线粒体缺陷，而这一缺陷在 C57BL/10ScSn-Dmdmdx/J 小鼠中未观察到。

The American Journal of Pathology

IF0

2025-09-30

OAAI

Jennifer A. Tinklenberg; Jessica Sutton; Rebecca A. Slick; Hui Meng; Margaret Haberman; Mariah J. Prom; Margaret J. Beatka; Tatyana A. Vetter; Audrey L. Daugherty; Christina Pacak; J.Patrick Gonzalez; Michael W. Lawlor

A homozygous single-nucleotide variant in TNNT1 causes abnormal troponin T isoform expression in a patient with severe nemaline myopathy: A case report TNNT1基因中的一个纯合单核苷酸变异导致一名重症肌原纤维球蛋白病患者的肌钙蛋白T异构体表达异常：病例报告

JOURNAL OF NEUROMUSCULAR DISEASES

IF3.4

2025-05-21

PREAI

Milla Laarne; Ali Oghabian; Jenni Laitila; Pirjo Isohanni; Olli Tynninen; Fang Zhao; Fanny Rostedt; Jaakko Sarparanta; Lydia Sagath; Michael W Lawlor; Carina Wallgren-Pettersson; Vilma-Lotta Lehtokari; Katarina Pelin

Pathogenic TNNT1 variants are associated with aberrant thin filament compliance and myofibre hyper-contractility 致病性TNNT1变异与异常细丝柔顺性和肌纤维超收缩力相关

physiology

IF0

2025-05-05

OAAI

Jenni Laitila; Christopher T. A. Lewis; Anthony L. Hessel; Guido Primiano; Aurelio Hernandez-Lain; Chiara Fiorillo; Michael W. Lawlor

Enhancing AAV-microdystrophin gene therapy after repeat dosing by blocking phagocytosis (vol 16, 1527840, 2025)通过阻断吞噬作用增强AAV-microdystrophin基因疗法在重复给药后的效果（vol 16, 1527840, 2025）

FRONTIERS IN IMMUNOLOGY

IF5.9

2025-03-21

OAAI

Spathis, Rita; Kuriplach, Deeva Robles; Narvesen, Sabrina; Eybs, Matthew; Huang, Karen; Torres, Steven; King, Madison; Bagley, Elizabeth; Elustondo, Pia; Lawlor, Michael W.; Nagaraju, Kanneboyina; Morales, Melissa

Enhancing AAV-microdystrophin gene therapy after repeat dosing by blocking phagocytosis

FRONTIERS IN IMMUNOLOGY

IF5.9

2025-03-03

OAAI

Human skeletal muscle fiber heterogeneity beyond myosin heavy chains 肌球蛋白重链之外的骨骼肌纤维异质性

NATURE COMMUNICATIONS

IF15.7

2025-02-19

OAAI

Roger Moreno-Justicia; Thibaux Van der Stede; Ben Stocks; Jenni Laitila; Robert A. Seaborne; Alexia Van de Loock; Eline Lievens; Diana Samodova; Leyre Marín-Arraiza; Oksana Dmytriyeva; Robin Browaeys; Kim Van Vossel; Lukas Moesgaard; Nurten Yigit; Jasper Anckaert; Anneleen Weyns; Ruud Van Thienen; Ronni E. Sahl; Edmar Zanoteli; Michael W. Lawlor; Michael Wierer; Pieter Mestdagh; Jo Vandesompele; Julien Ochala; Morten Hostrup; Wim Derave; Atul S. Deshmukh

Injectable and Dynamically Crosslinked Zwitterionic Hydrogels for Anti-Fouling and Tissue Regeneration Applications 可注射和动态交联的两性离子水凝胶，用于防污和组织再生应用

ADVANCED HEALTHCARE MATERIALS

IF9.6

2024-05-11

OAAI

Pan, Zhicheng; Dorogin, Jonathan; Lofts, Andrew; Randhawa, Gurpreet; Xu, Fei; Slick, Rebecca; Abraha, Mosana; Tran, Cecilia; Lawlor, Michael; Hoare, Todd

Characterization of NEB pathogenic variants in patients reveals novel nemaline myopathy disease mechanisms and omecamtiv mecarbil force effects

ACTA NEUROPATHOLOGICA

IF9.3

2024-04-18

OAAI

Karimi, Esmat; Gohlke, Jochen; van der Borgh, Mila; Lindqvist, Johan; Hourani, Zaynab; Kolb, Justin; Cossette, Stacy; Lawlor, Michael W.; Ottenheijm, Coen; Granzier, Henk

Effects of gene replacement therapy with resamirigene bilparvovec (AT132) on skeletal muscle pathology in X-linked myotubular myopathy: results from a substudy of the ASPIRO open-label clinical trial

EBIOMEDICINE

IF10.8

2024-01-01

OAAI

Lawlor, Michael W.; Schoser, Benedikt; Margeta, Marta; Sewry, Caroline A.; Jones, Karra A.; Shieh, Perry B.; Kuntz, Nancy L.; Smith, Barbara K.; Dowling, James J.; Mueller-Felber, Wolfgang; Boennemann, Carsten G.; Seferian, Andreea M.; Blaschek, Astrid; Neuhaus, Sarah; Foley, A. Reghan; Saade, Dimah N.; Tsuchiya, Etsuko; Qasim, Ummulwara R.; Beatka, Margaret; Prom, Mariah J.; Ott, Emily; Danielson, Susan; Krakau, Paul; Kumar, Suresh N.; Meng, Hui; Vanden Avond, Mark; Wells, Clive; Gordish-Dressman, Heather; Beggs, Alan H.; Christensen, Sarah; Conner, Edward; James, Emma S.; Lee, Jun; Sadhu, Chanchal; Miller, Weston; Sepulveda, Bryan; Varfaj, Fatbardha; Prasad, Suyash; Rico, Salvador

Loss of Mtm1 causes cholestatic liver disease in a model of X-linked myotubular myopathy

JOURNAL OF CLINICAL INVESTIGATION

IF13.6

2023-09-15

OAAI

Karolczak, Sophie; Deshwar, Ashish R.; Aristegui, Evangelina; Kamath, Binita M.; Lawlor, Michael W.; Andreoletti, Gaia; Volpatti, Jonathan; Ellis, Jillian L.; Yin, Chunyue; Dowling, James J.

Injectable Macroporous Hydrogels by Combining the Rapid Evaporation of Perfluorocarbon Emulsions with Dynamic Covalent Cross-Linking Chemistry

CHEMISTRY OF MATERIALS

IF7

2023-07-19

PREAI

Toufanian, Samaneh; Lofts, Andrew; Adams, Seamus; Kostashuk, Meghan; Hopp, Amanda M.; Lawlor, Michael W.; Hoare, Todd

Prolonged voluntary wheel running reveals unique adaptations in mdx mice treated with microdystrophin constructs ± the nNOS-binding site

FRONTIERS IN PHYSIOLOGY

IF3.4

2023-06-26

OAAI

Hamm, S. E.; Yuan, C.; McQueen, L. F.; Wallace, M. A.; Zhang, H.; Arora, A.; Garafalo, A. M.; McMillan, R. P.; Lawlor, M. W.; Prom, M. J.; Ott, E. M.; Yan, J.; Addington, A. K.; Morris, C. A.; Gonzalez, J. P.; Grange, R. W.

Spinal muscular atrophy-like phenotype in a mouse model of acid ceramidase deficiency 酸性神经酰胺酶缺乏症小鼠模型中的脊髓性肌萎缩样表型

COMMUNICATIONS BIOLOGY

IF5.1

2023-05-25

OAAI

Nagree, Murtaza S.; Rybova, Jitka; Kleynerman, Annie; Ahrenhoerster, Carissa J.; Saville, Jennifer T.; Xu, TianMeng; Bachochin, Maxwell; McKillop, William M.; Lawlor, Michael W.; Pshezhetsky, Alexey V.; Isaeva, Olena; Budde, Matthew D.; Fuller, Maria; Medin, Jeffrey A.

ACTA1 H40Y mutant iPSC-derived skeletal myocytes display mitochondrial defects in an in vitro model of nemaline myopathy

EXPERIMENTAL CELL RESEARCH

IF3.5

2023-03-01

OAAI

Gartz, Melanie; Haberman, Margaret; Sutton, Jessica; Slick, Rebecca A.; Luttrell, Shawn M.; Mack, David L.; Lawlor, Michael W.

Effects of Regulatory T Cell Depletion in BALB/c Mice Infected with Low Doses of Borrelia burgdorferi

PATHOGENS

IF3.3

2023-01-25

OAAI

Santiago, Kaitlyn N.; Kozlik, Tanya; Liedhegner, Elizabeth S.; Slick, Rebecca A.; Lawlor, Michael W.; Nardelli, Dean T.

Assessment of systemic AAV-microdystrophin gene therapy in the GRMD model of Duchenne muscular dystrophy

SCIENCE TRANSLATIONAL MEDICINE

IF14.6

2023-01-04

PREAI

Birch, Sharla M.; Lawlor, Michael W.; Conlon, Thomas J.; Guo, Lee-Jae; Crudele, Julie M.; Hawkins, Eleanor C.; Nghiem, Peter P.; Ahn, Mihye; Meng, Hui; Beatka, Margaret J.; Fickau, Brittany A.; Prieto, Juan C.; Styner, Martin A.; Struharik, Michael J.; Shanks, Courtney; Brown, Kristy J.; Golebiowski, Diane; Bettis, Amanda K.; Balog-Alvarez, Cynthia J.; Clement, Nathalie; Coleman, Kirsten E.; Corti, Manuela; Pan, Xiufang; Hauschka, Stephen D.; Gonzalez, J. Patrick; Morris, Carl A.; Schneider, Joel S.; Duan, Dongsheng; Chamberlain, Jeffrey S.; Byrne, Barry J.; Kornegay, Joe. N.

研究方向