Benjamin J. Blencowe - Publications, H-index & Citations

Benjamin J. Blencowe

university of toronto

90H指数

248论文数

3.8W被引数

收录论文 127

发表时间

A genome-wide functional analysis of conserved intronic regions reveals essential roles for speckle-associated retained introns 全基因组功能分析揭示保守内含子区域中与核斑相关保留内含子的关键作用

Cell Reports

IF6.9

2026-07-20

OAAI

Shaghayegh Farhangmehr; Ulrich Braunschweig; Mingkun Wu; Syed Nabeel-Shah; Kevin R. Brown; Jacob L. Fine; Jason Moffat; Benjamin J. Blencowe

Alu-mediated RNA duplexes are associated with widespread exon skipping across primate transcriptomes Alu介导的RNA双链与灵长类转录组中广泛的外显子跳跃相关联

Genome Biology

IF9.4

2026-03-26

OAAI

Hyunbeen Lee; Xinang Cao; Guillermo E. Parada; Jack Daiyang Li; Ira A. Iosub; Ulrich Braunschweig; Kenny Rebelo; Jernej Ule; Yue Wan; Benjamin J. Blencowe

Splice isoform-perturbation coupled to single cell transcriptome profiling reveals functions of microexons in neurogenesis and autism-linked pathways 剪接同工型扰动与单细胞转录组分析相结合，揭示了微外显子在神经发生和自闭症相关途径中的功能

Nature Communications

IF15.7

2026-02-03

OAAI

Steven J. Dupas; Guillermo E. Parada; Jack Daiyang Li; Kevin R. Brown; Jason Moffat; Benjamin J. Blencowe

tRNA-overlapping long non-coding RNA loci repress codon-biased genes tRNA重叠的长链非编码RNA位点抑制密码子偏好性基因

Cell Reports

IF6.9

2025-10-09

OAAI

Sameen Ahmed; Jacob L. Fine; Jordan J. Chalmers; Katerina Kiriakopulos; Lindsay A. Clarke; Carla Casanova Suárez; Katty Soleimanpour; Winona Oliveros; Kate Delfosse; Milad Mokhtaridoost; Cassandra J. Wong; Anne-Claude Gingras; Brian Ciruna; Marc R. Fabian; Benjamin J. Blencowe; Philipp G. Maass

A highly conserved neuronal microexon in DAAM1 controls actin dynamics, RHOA/ROCK signaling, and memory formation 一个在DAAM1中高度保守的神经元微小外显子调控肌动蛋白动力学、RHOA/ROCK信号通路以及记忆形成。

NATURE COMMUNICATIONS

IF15.7

2025-05-06

OAAI

Polinski, Patryk; Miret Cuesta, Marta; Zamora-Moratalla, Alfonsa; Mantica, Federica; Cantero-Recasens, Gerard; Viana, Carlotta; Sabariego-Navarro, Miguel; Normanno, Davide; Iniguez, Luis P.; Morenilla-Palao, Cruz; Ordono, Patricia; Bonnal, Sophie; Ellis, Jonathan D.; Gomez-Riera, Raul; Fanlo-Ucar, Hugo; Yap, Dominic S.; De Lagran, Maria Martinez; Fernandez-Blanco, Alvaro; Rodriguez-Marin, Cristina; Permanyer, Jon; Folsz, Orsolya; Dominguez-Sala, Eduardo; Sierra, Cesar; Legutko, Diana; Wojnacki, Jose; Lleo, Juan Luis Musoles; Cosma, Maria Pia; Munoz, Francisco Jose; Blencowe, Benjamin J.; Herrera, Eloisa; Dierssen, Mara; Irimia, Manuel

CDC40 suppression induces CDCA5 splicing defects and anti-proliferative effects in lung cancer cells

SCIENTIFIC REPORTS

IF3.9

2025-01-02

OAAI

Hu, Die; Theriault, Brigitte L.; Talebian, Vida; Hoffer, Laurent; Owen, Julie; Lim, Justin; Blencowe, Benjamin J.; Lima-Fernandes, Evelyne; Saraon, Punit; Marcellus, Richard; Al-awar, Rima

Recruitment of the m6A/m6Am demethylase FTO to target RNAs by the telomeric zinc finger protein ZBTB48

GENOME BIOLOGY

IF9.4

2024-09-19

OAAI

Nabeel-Shah, Syed; Pu, Shuye; Burke, Giovanni L.; Ahmed, Nujhat; Braunschweig, Ulrich; Farhangmehr, Shaghayegh; Lee, Hyunmin; Wu, Mingkun; Ni, Zuyao; Tang, Hua; Zhong, Guoqing; Marcon, Edyta; Zhang, Zhaolei; Blencowe, Benjamin J.; Greenblatt, Jack F.

Matrix stiffness- dependent regulation of immunomodulatory genes in human MSCs is associated with the lncRNA CYTOR 基质刚度依赖性调控人MSCs中免疫调节基因与lncRNA CYTOR相关

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2024-07-29

PREAI

Lim, Justin J.; Vining, Kyle H.; Mooney, David J.; Blencowe, Benjamin J.

High-throughput sensitive screening of small molecule modulators of microexon alternative splicing using dual Nano and Firefly luciferase reporters

NATURE COMMUNICATIONS

IF15.7

2024-07-27

OAAI

Best, Andrew J.; Braunschweig, Ulrich; Wu, Mingkun; Farhangmehr, Shaghayegh; Pasculescu, Adrian; Lim, Justin J.; Comsa, Lim Caden; Jen, Mark; Wang, Jenny; Datti, Alessandro; Wrana, Jeffrey L.; Cordes, Sabine P.; Al-awar, Rima; Han, Hong; Blencowe, Benjamin J.

Efficient, specific, and combinatorial control of endogenous exon splicing with dCasRx-RBM25

MOLECULAR CELL

IF16.6

2024-07-01

PREAI

Li, Jack Daiyang; Taipale, Mikko; Blencowe, Benjamin J.

An activator of G protein-coupled receptor and MEK1/2-ERK1/2 signaling inhibits HIV-1 replication by altering viral RNA processing (Vol 16, e1008307, 2020)

PLOS PATHOGENS

IF4.9

2024-04-09

OAAI

Wong, Raymond W.; Balachandran, Ahalya; Cheung, Peter K.; Cheng, Ran; Pan, Qun; Stoilov, Peter; Harrigan, P. Richard; Blencowe, Benjamin J.; Branch, Donald R.; Cochrane, Alan

Identifying human pre-mRNA cleavage and polyadenylation factors by genome-wide CRISPR screens using a dual fluorescence readthrough reporter

NUCLEIC ACIDS RESEARCH

IF13.1

2024-04-08

OAAI

Ni, Zuyao; Ahmed, Nujhat; Nabeel-Shah, Syed; Guo, Xinghua; Pu, Shuye; Song, Jingwen; Marcon, Edyta; Burke, Giovanni L.; Tong, Amy Hin Yan; Chan, Katherine; Ha, Kevin C. H.; Blencowe, Benjamin J.; Moffat, Jason; Greenblatt, Jack F.

Systematic analysis of alternative exon-dependent interactome remodeling reveals multitasking functions of gene regulatory factors

MOLECULAR CELL

IF16.6

2023-12-01

OAAI

Roth, Jonathan F.; Braunschweig, Ulrich; Wu, Mingkun; Li, Jack Daiyang; Lin, Zhen-Yuan; Larsen, Brett; Weatheritt, Robert J.; Gingras, Anne-Claude; Blencowe, Benjamin J.

Arg-tRNA synthetase links inflammatory metabolism to RNA splicing and nuclear trafficking via SRRM2 (vol 25, pg 592, 2023)

NATURE CELL BIOLOGY

IF19.1

2023-05-26

OAAI

Cui, Haissi; Diedrich, Jolene K.; Wu, Douglas C.; Lim, Justin J.; Nottingham, Ryan M.; Moresco, James J.; Yates III, John R.; Blencowe, Benjamin J.; Lambowitz, Alan M.; Schimmel, Paul

Arg-tRNA synthetase links inflammatory metabolism to RNA splicing and nuclear trafficking via SRRM2 Arg-trna合成酶通过SRRM2将炎症代谢与RNA剪接和核运输联系起来

NATURE CELL BIOLOGY

IF19.1

2023-04-14

PREAI

Cui, Haissi; Diedrich, Jolene K.; Wu, Douglas C.; Lim, Justin J.; Nottingham, Ryan M.; Moresco, James J.; Yates, John R.; Blencowe, Benjamin J.; Lambowitz, Alan M.; Schimmel, Paul

RNA-binding proteins that lack canonical RNA-binding domains are rarely sequence-specific

SCIENTIFIC REPORTS

IF3.9

2023-03-31

OAAI

Ray, Debashish; Laverty, Kaitlin U.; Jolma, Arttu; Nie, Kate; Samson, Reuben; Pour, Sara E.; Tam, Cyrus L.; von Krosigk, Niklas; Nabeel-Shah, Syed; Albu, Mihai; Zheng, Hong; Perron, Gabrielle; Lee, Hyunmin; Najafabadi, Hamed; Blencowe, Benjamin; Greenblatt, Jack; Morris, Quaid; Hughes, Timothy R.

Role for PSF in mediating transcriptional activator-dependent stimulation of pre-mRNA processing in vivo

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-27

124

OAAI

Rosonina, E; Ip, JYY; Calarco, JA; Bakowski, MA; Emili, A; McCracken, S; Tucker, P; Ingles, CJ; Blencowe, BJ

Regulation of multiple core spliceosomal proteins by alternative splicing-coupled nonsense-mediated mRNA decay

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-27

198

OAAI

Saltzman, Arneet L.; Kim, Yoon Ki; Pan, Qun; Fagnani, Matthew M.; Maquat, Lynne E.; Blencowe, Benjamin J.

SRm160 splicing coactivator promotes transcript 3′-end cleavage

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-27

104

OAAI

McCracken, S; Lambermon, M; Blencowe, BJ

Global detection of human variants and isoforms by deep proteome sequencing 通过深度蛋白质组测序对人类变体和同工型进行全局检测

NATURE BIOTECHNOLOGY

IF41.7

2023-03-23

OAAI

Sinitcyn, Pavel; Richards, Alicia L.; Weatheritt, Robert J.; Brademan, Dain R.; Marx, Harald; Shishkova, Evgenia; Meyer, Jesse G.; Hebert, Alexander S.; Westphall, Michael S.; Blencowe, Benjamin J.; Cox, Juergen; Coon, Joshua J.

研究方向