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M

Maria Kowalski-Jahn

karolinska institutet

H指数:11

被引数:453

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Pathway selectivity in Frizzleds is achieved by conserved micro-switches defining pathway-determining, active conformations

NATURE COMMUNICATIONS

IF15.7

2023-07-2911

OAAI

WNT stimulation induces dynamic conformational changes in the Frizzled-Dishevelled interaction

SCIENCE SIGNALING

IF6.6

2023-04-0414

PRE

Frizzled BRET sensors based on bioorthogonal labeling of unnatural amino acids reveal WNT-induced dynamics of the cysteine-rich domain

SCIENCE ADVANCES

IF12.5

2021-11-1219

OAAI

Cryo-EM structure of constitutively active human Frizzled 7 in complex with heterotrimeric Gs

具有异源三聚体Gs的组成型活性人卷曲7的cryo-em结构

IF25.9

2021-07-0829

OAAI

Deconvolution of WNT-induced Frizzled conformational dynamics with fluorescent biosensors

BIOSENSORS & BIOELECTRONICS

IF10.5

2021-04-0124

OA

A conserved molecular switch in Class F receptors regulates receptor activation and pathway selection

NATURE COMMUNICATIONS

IF15.7

2019-02-0858

OAAI

Functional dissection of the N-terminal extracellular domains of Frizzled 6 reveals their roles for receptor localization and Dishevelled recruitment

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2018-11-0123

OAAI

Dishevelled enables casein kinase 1-mediated phosphorylation of Frizzled 6 required for cell membrane localization

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2018-11-0117

OAAI

Inter-subunit disulfide locking of the human P2X3 receptor elucidates ectodomain movements associated with channel gating

PURINERGIC SIGNALLING

IF2.4

2016-01-294

OA

Conformational flexibility of the agonist binding jaw of the human P2X3 receptor is a prerequisite for channel opening

BRITISH JOURNAL OF PHARMACOLOGY

IF7.7

2014-09-0524

OAAI