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S

Shane C. Wright

karolinska institutet
H指数:16
被引数:788

个人简介

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荣誉奖项

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Molecular mechanisms of native ligand selectivity in catecholamine G protein-coupled receptors

儿茶酚胺G蛋白偶联受体中内源性配体选择性的分子机制

Nature Communications
IF15.7
2026-04-230
OAAI
Nour Aldin Kahlous; Maiju K. Rinne; Xin Zhang; Yanying Li; Yue Chen; Aikaterini Motso; Kaixuan Gao; Christina Bergqvist; Hongda Sheng; Yi Wang; Israel Cabeza de Vaca; Alejandro Díaz-Holguín; Philip Ullmann; Tore Bengtsson; Volker M. Lauschke; Jyrki P. Kukkonen; Lucie Delemotte; Shane C. Wright; Xiangyu Liu; Dan Larhammar; Jens Carlsson
GRK-biased adrenergic agonists for the treatment of type 2 diabetes and obesity

GPRK-biased肾上腺素能激动剂在2型糖尿病和肥胖症治疗中的应用

Cell
IF42.5
2025-06-230
OAAI
Aikaterini Motso; Benjamin Pelcman; Anastasia Kalinovich; Nour Aldin Kahlous; Muhammad Hamza Bokhari; Nodi Dehvari; Carina Halleskog; Erik Waara; Jasper de Jong; Elizabeth Cheesman; Christine Kallenberg; Gopala Krishna Yakala; Praerona Murad; Erika Wetterdal; Pia Andersson; Sten van Beek; Anna Sandström; Diane Natacha Alleluia; Emanuela Talamonti; Sonia Youhanna; Pierre Sabatier; Claire Koenig; Sabine Willems; Aurino M. Kemas; Dana S. Hutchinson; Seungmin Ham; Lukas Grätz; Jan Voss; Jose G. Marchan-Alvarez; Martins Priede; Krista Jaunsleine; Jana Spura; Vadims Kovada; Linda Supe; Leigh A. Stoddart; Nicholas D. Holliday; Phillip T. Newton; Nicolas J. Pillon; Gunnar Schulte; Roger J. Summers; Ilga Mutule; Edgars Suna; Jesper V. Olsen; Peter Molenaar; Jens Carlsson; Volker M. Lauschke; Shane C. Wright; Tore Bengtsson
Chemogenomic Screening in a Patient-Derived 3D Fatty Liver Disease Model Reveals the CHRM1-TRPM8 Axis as a Novel Module for Targeted Intervention
ADVANCED SCIENCE
IF14.1
2024-11-280
OAAI
Youhanna, Sonia; Kemas, Aurino M.; Wright, Shane C.; Zhong, Yi; Klumpp, Britta; Klein, Kathrin; Motso, Aikaterini; Michel, Maurice; Ziegler, Nicole; Shang, Mingmei; Sabatier, Pierre; Kannt, Aimo; Sheng, Hongda; Oliva-Vilarnau, Nuria; Buettner, Florian A.; Seashore-Ludlow, Brinton; Schreiner, Jonas; Windbergs, Maike; Cornillet, Martin; Bjorkstrom, Niklas K.; Hulsmeier, Andreas J.; Hornemann, Thorsten; Olsen, Jesper V.; Wang, Yi; Gramignoli, Roberto; Sundstrom, Michael; Lauschke, Volker M.
Discovery of a novel inhibitor of macropinocytosis with antiviral activity

发现具有抗病毒活性的新型巨胞饮抑制剂

MOLECULAR THERAPY
IF12
2024-09-011
OAAI
Porebski, Bartlomiej; Christ, Wanda; Corman, Alba; Haraldsson, Martin; Barz, Myriam; Lidemalm, Louise; Haggblad, Maria; Ilmain, Juliana; Wright, Shane C.; Murga, Matilde; Schlegel, Jan; Jarvius, Malin; Lapins, Maris; Sezgin, Erdinc; Bhabha, Gira; Lauschke, Volker M.; Carreras-Puigvert, Jordi; Lafarga, Miguel; Klingstrom, Jonas; Huhn, Daniela; Fernandez-Capetillo, Oscar
The novel adrenergic agonist ATR-127 targets skeletal muscle and brown adipose tissue to tackle diabesity and steatohepatitis
MOLECULAR METABOLISM
IF6.6
2024-07-011
OAAI
Talamonti, Emanuela; Davegardh, Jelena; Kalinovich, Anastasia; van Beek, Sten M. M.; Dehvari, Nodi; Halleskog, Carina; Bokhari, Hamza M.; Hutchinson, Dana S.; Ham, Seungmin; Humphrys, Laura J.; Dijon, Nicola C.; Motso, Aikaterini; Sandstrom, Anna; Zacharewicz, Evelyn; Mutule, Ilga; Suna, Edgars; Spura, Jana; Ditrychova, Karolina; Stoddart, Leigh A.; Holliday, Nicholas D.; Wright, Shane C.; Lauschke, Volker M.; Nielsen, Soren; Scheele, Camilla; Cheesman, Elizabeth; Hoeks, Joris; Molenaar, Peter; Summers, Roger J.; Pelcman, Benjamin; Yakala, Gopala K.; Bengtsson, Tore
Altered desensitization and internalization patterns of rodent versus human glucose-dependent insulinotropic polypeptide (GIP) receptors. An important drug discovery challenge
BRITISH JOURNAL OF PHARMACOLOGY
IF7.7
2024-07-010
OA
Gasbjerg, Laerke Smidt; Rasmussen, Rasmus Syberg; Dragan, Adrian; Lindquist, Peter; Melchiorsen, Josefine Ulrikke; Stepniewski, Tomasz Maciej; Schiellerup, Sine; Tordrup, Esther Karen; Gadgaard, Sarina; Kizilkaya, Husun Sheyma; Willems, Sabine; Zhong, Yi; Wang, Yi; Wright, Shane C.; Lauschke, Volker M.; Hartmann, Bolette; Holst, Jens Juul; Selent, Jana; Rosenkilde, Mette Marie
Characterization of genetic variants of GIPR reveals a contribution of β-arrestin to metabolic phenotypes

GIPR遗传变异的表征揭示了 β-arrestin对代谢表型的贡献

NATURE METABOLISM
IF20.8
2024-06-139
OAAI
Kizilkaya, Husun S.; Sorensen, Kimmie V.; Madsen, Jakob S.; Lindquist, Peter; Douros, Jonathan D.; Bork-Jensen, Jette; Berghella, Alessandro; Gerlach, Peter A.; Gasbjerg, Laerke S.; Mokrosinski, Jacek; Mowery, Stephanie A.; Knerr, Patrick J.; Finan, Brian; Campbell, Jonathan E.; D'Alessio, David A.; Perez-Tilve, Diego; Faas, Felix; Mathiasen, Signe; Rungby, Jorgen; Sorensen, Henrik T.; Vaag, Allan; Nielsen, Jens S.; Holm, Jens-Christian; Lauenborg, Jeannet; Damm, Peter; Pedersen, Oluf; Linneberg, Allan; Hartmann, Bolette; Holst, Jens J.; Hansen, Torben; Wright, Shane C.; Lauschke, Volker M.; Grarup, Niels; Hauser, Alexander S.; Rosenkilde, Mette M.
Crimean–Congo haemorrhagic fever virus uses LDLR to bind and enter host cells
Nature Microbiology
IF19.4
2024-03-280
OAAI
Vanessa M. Monteil; Shane C. Wright; Matheus Dyczynski; Max J. Kellner; Sofia Appelberg; Sebastian W. Platzer; Ahmed Ibrahim; Hyesoo Kwon; Ioannis Pittarokoilis; Mattia Mirandola; Georg Michlits; Stephanie Devignot; Elizabeth Elder; Samir Abdurahman; Sándor Bereczky; Binnur Bagci; Sonia Youhanna; Teodor Aastrup; Volker M. Lauschke; Cristiano Salata; Nazif Elaldi; Friedemann Weber; Nuria Monserrat; David W. Hawman; Heinz Feldmann; Moritz Horn; Josef M. Penninger; Ali Mirazimi
GLP-1R signaling neighborhoods associate with the susceptibility to adverse drug reactions of incretin mimetics
NATURE COMMUNICATIONS
IF15.7
2023-10-0912
OAAI
Wright, Shane C.; Motso, Aikaterini; Koutsilieri, Stefania; Beusch, Christian M.; Sabatier, Pierre; Berghella, Alessandro; Blondel-Tepaz, Elodie; Mangenot, Kimberley; Pittarokoilis, Ioannis; Sismanoglou, Despoina-Christina; Le Gouill, Christian; Olsen, Jesper V.; Zubarev, Roman A.; Lambert, Nevin A.; Hauser, Alexander S.; Bouvier, Michel; Lauschke, Volker M.
BRET-based effector membrane translocation assay monitors GPCR-promoted and endocytosis-mediated Gq activation at early endosomes

基于BRET的效应物膜易位分析可监测早期内体中GPCR促进和内吞作用介导的Gq激活

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
2021-05-1434
OA
Wright, Shane C.; Lukasheva, Viktoriya; Le Gouill, Christian; Kobayashi, Hiroyuki; Breton, Billy; Mailhot-Larouche, Samuel; Blondel-Tepaz, Elodie; Vieira, Nichelle Antunes; Costa-Neto, Claudio; Heroux, Madeleine; Lambert, Nevin A.; Parreiras-e-Silva, Lucas Tabajara; Bouvier, Michel

研究方向

暂未获取到该数据
V
Volker M. Lauschke
H 指数:54论文数:274被引数:1.0万
M
Michel Bouvier
H 指数:108论文数:812被引数:3.9万
G
Gunnar Schulte
H 指数:50论文数:152被引数:8,774
J
Jens Carlsson
H 指数:39论文数:119被引数:5,146
A
Aikaterini Motso
H 指数:5论文数:8被引数:125
N
Nevin A. Lambert
H 指数:50论文数:163被引数:7,904
C
Christian Le Gouill
H 指数:33论文数:88被引数:2,951
P
Pierre Sabatier
H 指数:18论文数:78被引数:1,341
T
Tore Bengtsson
H 指数:34论文数:116被引数:5,018
S
Sonia Youhanna
H 指数:27论文数:76被引数:2,377