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石

石磊 (Lei Shi)

Tianjin Medical University

37H指数
164论文数
5.1K被引数
收录论文 93
发表时间
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The DNTTIP1-PARP1 interaction orchestrates MiDAC recruitment and activity for NHEJ-mediated genome stabilityDNTTIP1-PARP1相互作用调控MiDAC的招募和活性以介导NHEJ依赖的基因组稳定性
errJournal of Biological Chemistry
IF3.9
err2026-08-01
err0
PREAI
errQin, Yan; Ma, Yanhui; Wei, Ao; Zhang, Zhao; Bao, Peida; Jia, Shaowei; Zhou, Mengyu; Liu, Ling; Yang, Zhenzhen; Shi, Lei; Bao, Kaiwen
err分享
err收藏
RNA exonuclease REXO4 resolves m6A-marked R-loops and suppresses anti-tumor immunityRNA外切酶REXO4解析m6A标记的R-环并抑制抗肿瘤免疫
errMolecular Cell
IF16.6
err2026-07-20
err0
PREAI
errJieyou Zhang; Kaiwen Bao; Yayan Hou; Nixian Zhao; Qi Chen; Zhenzhen Yang; Rongfang Nie; Chunyong Zhang; Huasheng Wang; Heng Zhang; Jihui Hao; Jie Yang; Zhi Yao; Ying Yu; Chen Wu; Jian Zhang; Lei Shi
err分享
err收藏
Ag-coated Cu powder/Nb dual interlayers for steel/titanium diffusion bonding via hot isostatic pressing: Interfacial microstructure and mechanical properties钢/钛扩散焊用Ag涂层Cu粉末/Nb双中间层热等静压工艺：界面微观结构与力学性能
errMaterials Characterization
IF5.5
err2026-07-01
err1
PREAI
errTian, Chunmao; Zhou, Wenyan; Cheng, Kun; Shi, Lei; Ouyang, Di; Cai, Chao
err分享
err收藏
Structural mechanism of diacetylated histone H2A recognition by Bromodomain-containing protein 4 in Regulation of non-homologous end-joining DNA repair组蛋白H2A二乙酰化结构机制在Bromodomain-containing protein 4对非同源末端连接DNA修复的调控中的作用
errInternational Journal of Biological Macromolecules
IF8.5
err2026-06-01
err0
PREAI
errWang, Xiaodan; Ji, Jiahui; Ma, Yanhui; Liu, Lin; Bao, Kaiwen; Yang, Hongwu; Li, Zibin; Li, Ting; Shi, Lei; Yang, Na
err分享
err收藏
LAP2α drives breast tumorigenesis by mitigating replication stress
errCell Death & Disease
IF9.6
err2026-02-03
err0
errOAAI
errYanhui Ma; Yan Qin; Peida Bao; Ao Wei; Zhenzhen Yang; Ling Liu; Shuai Liu; Roland Foisner; Lei Shi; Qi Zhang; Kaiwen Bao
err分享
err收藏
ACSS1 co-opts acetyl-CoA metabolism to drive DNA repair and undermine radiotherapy efficacy in breast cancerACSS1利用乙酰辅酶A代谢来驱动DNA修复并削弱乳腺癌的放射治疗效果。
errCell Death & Disease
IF9.6
err2025-12-18
err0
errOAAI
errXiao Fu; Yingyu Zhu; Xin Lu; Xingjie Gao; Lingbiao Xin; Yuanyuan Ren; Xin Liu; Lin Ge; Jihui Hao; Zhi Yao; Lei Shi; Jie Yang
err分享
err收藏
Auranofin attenuates TOPBP1-mediated ATR replication stress response and improves chemotherapeutic response in breast tumor models奥拉帕尼减弱TOPBP1介导的ATR复制应激反应，并改善乳腺癌模型中的化疗反应
errJournal of Clinical Investigation
IF13.6
err2025-12-15
err0
PREAI
errMa, Shuai; Han, Yingying; Gu, Rui; Chen, Qi; Guo, Qiushi; Yue, Yuan; Cao, Cheng; Liu, Ling; Yang, Zhenzhen; Qin, Yan; Yang, Ying; Zhang, Kai; Liu, Fei; Liu, Lin; Yang, Na; Hao, Jihui; Yang, Jie; Yao, Zhi; Mao, Xiaoyun; Shi, Lei
err分享
err收藏
Tudor-SN, a novel regulator in mesoderm-derived endochondral ossification, is functionally related to postnatal osteogenesis imperfecta in miceTudor-SN，一种间充质来源的软骨内成骨的新型调节因子，在功能上与小鼠出生后的成骨不全症相关。
errFundamental Research
IF6.3
err2025-11-24
err0
errOAAI
errLingbiao Xin; Xinxin Zhang; Chuanbo Ha; Dan Wang; Rui Chen; Peiying Li; Lihong Hu; Yuanyan Ren; Yang Yang; Lei Shi; Zhi Yao; Xudong Wu; Xiaoteng Cui; Xingjie Gao; Jie Yang
err分享
err收藏
IDR-driven LLPS of GAS2L3 scaffolds CHMP4B condensates to accelerate cytokinesis in hepatocellular carcinoma cellsIDR驱动的GAS2L3支架蛋白通过LLPS使CHMP4B凝聚体聚集，以加速肝细胞癌细胞的细胞质分裂。
errJournal of Advanced Research
IF13
err2025-10-31
err0
errOAAI
errYan Zhao; Miao Zheng; Peiying Li; Chunyan Zhao; Rui Chen; Baoxin Qian; Xiaoteng Cui; Yuanyuan Ren; Chao Su; Lei Shi; Jihui Hao; Zhi Yao; Xingjie Gao; Jie Yang
err分享
err收藏
Arachidonic acid fuels inflammation by unlocking macrophage protein phosphatase 5 after myocardial infarction花生四烯酸通过在心肌梗死后激活巨噬细胞蛋白磷酸酶5来促进炎症。
errEUROPEAN HEART JOURNAL
IF35.6
err2025-09-01
err1
PREAI
errChen, Zhipeng; Song, Jiawei; Feng, Suli; Liu, Mingming; Zhang, Yan; Shen, Xilin; Zhou, Ting; Xian, Zhong; Jiang, Hongfeng; Chen, Chen; Wang, Daowen; Cai, Wenbin; Li, Mulin Jun; Yang, Hongxi; Shi, Lei; Weng, Haoyu; Fan, Fangfang; Li, Jianping; Liu, Qiang; Ai, Ding
err分享
err收藏
CLT-003 exerts anti-tumor activity in pancreatic cancer by blocking the PI3K/AKT/HIF-1α pathwayCLT-003通过阻断PI3K/AKT/HIF-1α通路在胰腺癌中发挥抗肿瘤活性。
errCANCER BIOLOGY & MEDICINE
IF8.4
err2025-09-01
err0
PREAI
errXu, Chao; Li, Zekun; Shan, Yueying; She, Chunhua; Yang, Yanfang; Zhou, Tianxing; Xie, Yongjie; Ni, Bo; Meng, Chenyang; Shen, Guangcong; Fu, Boyang; Sheng, Guannan; Wu, Liangliang; Pei, Jinlong; Zhao, Tiansuo; Gao, Song; Wang, Hongwei; Deng, Chengqi; Wang, Kaiyuan; Chang, Antao; Huang, Chongbiao; Shi, Lei; Yang, Shengyu; Yu, Jun; Hao, Jihui; Wang, Xiuchao
err分享
err收藏
Multi-omics integration and machine learning identify and validate neutrophil extracellular trap-associated gene signatures in chronic rhinosinusitis with nasal polyps多组学整合与机器学习用于识别和验证慢性鼻窦炎伴鼻息肉中中性粒细胞胞外陷阱相关基因特征
errclinical immunology
IF3.8
err2025-06-01
err0
PREAI
errShu, Fu; Wang, Yaping; Li, Linglong; Shi, Lei; Zhang, Feng; Ma, Zhixuan; Mao, Dehong
err分享
err收藏
The application of organoids in investigating immune evasion in the microenvironment of gastric cancer and screening novel drug candidates类器官在胃癌微环境中免疫逃逸研究及新型药物候选物筛选中的应用
errMOLECULAR CANCER
IF33.9
err2025-04-26
err0
errOAAI
errKan, Liuyue; Yu, Ying; Wang, Yaxue; Shi, Lei; Fan, Tingyuan; Chen, Hui
err分享
err收藏
Prognostic significance of miR-378 in cancers: a meta-analysis
errBMC CANCER
IF3.4
err2025-03-10
err0
errOAAI
errShi, Lei; Wei, Jie; Shen, Yankun; Zhang, Xiaoqiang; Li, Lixin; Deng, Ying
err分享
err收藏
The PGAM5-NEK7 interaction is a therapeutic target for NLRP3 inflammasome activation in colitisPGAM5-NEK7相互作用是结肠炎中NLRP3炎症小体激活的 therapeutic target。
errACTA PHARMACEUTICA SINICA B
IF14.6
err2025-01-01
err0
errOAAI
errGao, CL; Song, JQ; Wang, HJ; Shang, QH; Guan, X; Xu, G; Wu, JY; Wu, DL; Zheng, YQ; Wu, XD; Zhao, F; Liu, XD; Shi, L; Pang, T
err分享
err收藏
Interplay between lncRNAs and the PI3K/AKT signaling pathway in the progression of digestive system neoplasms (Review)
errINTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
IF5.8
err2024-11-07
err0
errOAAI
errZhang, Xiaoyu; Shi, Lei; Xing, Mengzhen; Li, Chunjing; Ma, Fengjun; Ma, Yuning; Ma, Yuxia
err分享
err收藏
LAP2α orchestrates alternative lengthening of telomeres suppression through telomeric heterochromatin regulation with HDAC1: unveiling a potential therapeutic target
errCELL DEATH & DISEASE
IF9.6
err2024-10-19
err0
errOAAI
errWang, Bing; Kou, Haomeng; Wang, Yuwen; Zhang, Qi; Jiang, Duo; Wang, Juan; Zhao, Ziqin; Zhou, Yao; Zhang, Miaomiao; Sui, Lei; Zhao, Mingfeng; Liu, Yancheng; Liu, Yang; Shi, Lei; Wang, Feng
err分享
err收藏
Photothermal therapy improves the efficacy of topical immunotherapy against melanoma
errPHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
IF2.6
err2024-10-01
err3
errOAAI
errShi, Lei; Zhang, Fuhe; Yan, Jia; Luo, Min; Liu, Kaili; Liu, Pei; Yan, Guorong; Li, Chunxiao; Yang, Yutong; Zeng, Qingyu; Zhang, Guolong; Chen, Wei R.; Wang, Xiuli
err分享
err收藏
The role of miRNA in IBS pathogenesis, diagnosis and therapy: The latest thought
errDIGESTIVE AND LIVER DISEASE
IF3.8
err2024-09-01
err0
PREAI
errZhang, Xiaoyu; Shi, Lei; Chen, Chen; Ma, Yuning; Ma, Yuxia
err分享
err收藏
KLF7 promotes neuroblastoma differentiation through the GTPase signaling pathway by upregulating neuroblast differentiation-associated protein AHNAKs and glycerophosphodiesterase GDPD5KLF7通过上调成神经细胞分化相关蛋白AHNAKs和甘油磷酸二酯酶GDPD5，通过GTPase信号通路促进成神经细胞瘤分化
errFEBS JOURNAL
IF4.2
err2024-06-26
err0
PREAI
errQiao, Shupei; Jia, Ying; Xie, Li; Jing, Wenwen; Xia, Yang; Song, Yue; Zhang, Jiahui; Cao, Tianhua; Song, Huilin; Meng, Lingdi; Shi, Lei; Zhang, Xue
err分享
err收藏

研究方向

血栓炎症调控心脑血管疾病病理进展的分子机制靶向干预药物研发代谢器官功能异常与循环系统间的交互影响及机制研究【在研项目】微小RNA调控血小板蛋白从头合成对血栓炎症疾病的影响及机制研究血栓性炎症反应【近5年代表作文章】Pharmacological inhibition of Septinsthrombus formationsignaling pathways in platelets胆汁酸转运与胆结石形成机制NLRP3 inflammasome activationcolitisPGAM5-NEK7 interactionplatelet beta 3 integrin-dependentthrombosis research229(0):53-68. Kui, LiuZhen, HaoHao, ZhengHaojie, WangLuying, ZhangMinghui, YanReyisha, TuerhongYuling, ZhouYan, Wang*Tao, Pang*胆汁胆固醇分泌通路【近年获奖情况及荣誉称号】2025年，荣获2024年度大连医科大学优秀科研工作者称号【社会兼职】辽宁省动物学会理事、常务理事，2020-今辽宁省医学会医学遗传学会，理事，2022-今细胞生物学2免疫学
合作学者
合作期刊
仉华 封面图
仉华 (Hua Zhang)
H 指数: 205 · 论文数: 2.7K
林军 封面图
林军 (Jun Lin)
H 指数: 149 · 论文数: 1.2K
M
Michelle Petri
H 指数: 136 · 论文数: 981
Chu Chen 封面图
Chu Chen (Chu Chen)
H 指数: 91 · 论文数: 762
D
Dao Wen Wang
H 指数: 88 · 论文数: 845
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