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D

David M. Ashley

duke university

60H指数
587论文数
1.8W被引数
收录论文 133
发表时间
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STING activation induces cytotoxic and immune responses in meningiomas via inflammatory cell death pathwaysSTING激活通过炎症性细胞死亡通路诱导脑膜瘤中的细胞毒性及免疫反应
errNature Communications
IF15.7
err2026-02-12
err0
errOAAI
errMark W. Youngblood; Shashwat Tripathi; Hinda Najem; Harrshavasan Congivaram; Mateo Gomez; Thomas K. Sears; Lisa Hurley; Leah K. Billingham; Caylee Silvers; Wenxia Wang; Deanna Tiek; Nishanth Sadagopan; Rahul Chaliparambil; Qianyi Pu; Ching Man Wai; Abrar Choudhury; Alicia Steffens; Kathleen McCortney; Gustavo Ignacio Vazquez Cervantes; Daniel Oyon; Luis Fernandez; Ashley Selner; Jawad Fares; Matthew Hagan; S. Joy Trybula; Jacky Yeung; Matthieu Peyre; Michel Kalamarides; Peng Zhang; Alexander H. Stegh; David M. Ashley; Craig M. Horbinski; Jared T. Ahrendsen; Pouya Jamshidi; Daniel J. Brat; Rimas V. Lukas; Roger Stupp; Maciej S. Lesniak; Adam M. Sonabend; Gavin P. Dunn; James P. Chandler; Matthew C. Tate; Stephen T. Magill; Jason Miska; Michael A. Curran; David R. Raleigh; Amy B. Heimberger
err分享
err收藏
Clinical trial of feasibility for mindfulness intervention for patients with newly diagnosed high grade glioma对 newly diagnosed high grade glioma 患者进行正念干预可行性的临床试验
errJournal of Neuro-Oncology
IF3.1
err2025-11-05
err0
PREAI
errKavya Ramamurthy; Dina M. Randazzo; Nicole Cort; James E. Herndon; Evan Buckley; Mary Lou Affronti; Jung-Young Kim; Mallika P. Patel; Justin T. Low; Margaret O. Johnson; Mustafa Khasraw; Annick Desjardins; David M. Ashley; Henry S. Friedman; Katherine B. Peters
err分享
err收藏
INVESTIGATION OF THE COMBINATION OF D2C7-IT WITH AN FC-ENGINEERED ANTI-HUMANCD40 MONOCLONAL ANTIBODY (2141-V11) WHEN ADMINISTERED INTRATUMORALLY VIA CONVECTION-ENHANCED DELIVERY (CED) FOLLOWED BY CERVICAL PERILYMPHATIC INJECTIONS (CPLIS) OF 2141-V11 COMPARED TO D2C7-IT CED MONOTHERAPY IN PATIENTS WITH RECURRENT GLIOBLASTOMA (RGBM)探究通过促进增强递送（CED）途径瘤内给药D2C7-IT与FC工程化抗人CD40单克隆抗体（2141-V11）联合应用，并随后进行2141-V11颈部淋巴周围注射（CPLIS）与D2C7-IT CED单药治疗相比，在复发性胶质母细胞瘤（RGBM）患者中的效果。
errNEURO-ONCOLOGY
IF13.4
err2025-11-01
err0
errOAAI
errDesjardins, Annick; Chandramohan, Vidya; Herndon II, James E.; Bradbury, Claire; Shoaf, Madison; Peters, Katherine B.; Johnson, Margaret O.; Batich, Kristen; Low, Justin; Khasraw, Mustafa; Friedman, Allan H.; Friedman, Henry S.; Ashley, David M.; Grant, Gerald; Osorio, Juan; Ravetch, Jeffrey; Bigner, Darell D.
err分享
err收藏
INTERROGATE-GBM Phase I trial: Immunotherapy peptide vaccine targeting cytomegalovirus (CMV) antigens in glioblastomaINTERROGATE-GBM Ⅰ期临床试验：针对巨细胞病毒（CMV）抗原的胶质母细胞瘤免疫治疗肽疫苗
errNEURO-ONCOLOGY
IF13.4
err2025-11-01
err0
errOAAI
errChung, Sylvia; Holst, Jeff; Teng, Christina; Cooper, Adam; Wei, Joe; Koh, Eng-Siew; Yeo, Nicholas; Sim, Hao-Wen; Killen, Andrew J.; Gayaman, Regienald; Lynch, Sarah; Mandala, Anusha; Murray, Clare; Joshi, Swapna; Mcdonald, Kerrie; Ashley, David; Desjardins, Annick; Sampson, John; Archer, Gerald; Lemech, Charlotte; Hovey, Elizabeth
err分享
err收藏
SMARCAL1 inhibition synergizes with TOP1 inhibitors to induce replication catastrophe and inflammation in ALT plus gliomasSMARCAL1抑制与TOP1抑制剂协同作用，诱导ALT阳性胶质瘤中的复制灾难和炎症。
errNEURO-ONCOLOGY
IF13.4
err2025-11-01
err0
errOAAI
errErman, Elise; Gibson, Emiley; Strickland, Laura; Brown, Alexandrea; Keir, Stephen; Ashley, David; Waitkus, Matthew
err分享
err收藏
STING-induced blood-brain barrier opening in combination with radiation therapy potentiates anti-glioma immune and therapeutic activity monitored with [18F]-FLT PETSTING诱导的血脑屏障开放与放射治疗相结合，增强了抗胶质瘤免疫和治疗活性，并通过[18F]-FLT PET进行监测
errNEURO-ONCOLOGY
IF13.4
err2025-11-01
err0
PREAI
errNajem, Hinda; Tripathi, Shashwat; Hurley, Lisa; Dmello, Crismita; Ali, Hebi; Mccortney, Kathleen; Habashy, Karl J.; Zhang, Peng; Horbinski, Craig M.; Lucas, Rimas, V; Sita, Tim; Raleigh, David R.; Sachdev, Sean; Stupp, Roger; Lesniak, Maciej S.; Ashley, David M.; Procissi, Daniele; Currran, Michael A.; Balyasnikova, Irina; Heimberger, Amy B.
err分享
err收藏
Vitamin B6 supplementation for levetiracetam-associated mood changes in patients with brain tumor-related epilepsy维生素B6补充剂对脑肿瘤相关癫痫患者左乙拉西坦相关情绪变化的影响
errNEURO-ONCOLOGY
IF13.4
err2025-11-01
err0
errOAAI
errBartman, Kristin; Patel, Mallika P.; Vaios, Kristen Batich; Johnson, Margaret O.; Friedman, Henry S.; Shoaf, Madison L.; Low, Justin; Desjardins, Annick; Khasraw, Mustafa; Ashley, David M.; Peters, Katherine
err分享
err收藏
TARGETING FGFR ALTERATIONS IN GLIOMAS: A SINGLE-INSTITUTION CASE SERIES靶向FGFR改变在胶质瘤中的应用：一项单机构病例系列研究
errNEURO-ONCOLOGY
IF13.4
err2025-11-01
err0
errOAAI
errShoaf, Madison L.; Patel, Mallika P.; Ashley, David M.; Batich, Kristen; Friedman, Henry S.; Johnson, Margaret O.; Khasraw, Mustafa; Low, Justin T.; Peters, Katherine B.; Desjardins, Annick
err分享
err收藏
An assessment of the Tumor Monorail Device (TMD) for repeated sampling as part of a trial evaluating the combination of D2C7-IT and an Fc-engineered anti-CD40 monoclonal antibody (2141-V11) administered intratumorally via convection-enhanced delivery (CED) and cervical perilymphatic injections (CPLIs) of 2141-V11 in recurrent glioblastoma (rGBM) patients对Tumor Monorail Device (TMD)进行重复采样的评估，作为一项评估通过对流增强递送（CED）和颈周淋巴间隙注射（CPLIs）分别经瘤内给予D2C7-IT以及Fc工程化抗CD40单克隆抗体（2141-V11）的联合方案在复发性胶质母细胞瘤（rGBM）患者中疗效试验的一部分。
errNEURO-ONCOLOGY
IF13.4
err2025-11-01
err0
errOAAI
errDesjardins, Annick; Chandramohan, Vidya; Mokarram, Nassir; Meehan, Sean; Sharma, Shaili; Herndon Ii, James E.; Shoaf, Madison; Peters, Katherine B.; Johnson, Margaret O.; Batich, Kristen; Low, Justin; Khasraw, Mustafa; Friedman, Allan H.; Friedman, Henry S.; Ashley, David M.; Grant, Gerald; Osorio, Juan; Ravetch, Jeffrey; Bellamkonda, Ravi; Bigner, Darell D.
err分享
err收藏
INTEGRATIVE SINGLE-NUCLEI SPATIAL TRANSCRIPTOMIC PROFILING OF PRIMARY AND RECURRENT HUMAN IDH-WILDTYPE GLIOBLASTOMA REVEALS CELL-SPECIFIC EGFRVIII EXPRESSION AND ANXA1 SIGNALING AXIS整合单核空间转录组学分析揭示了原发性和复发性人类IDH野生型胶质母细胞瘤的细胞特异性EGFRvIII表达和ANXA1信号轴
errNEURO-ONCOLOGY
IF13.4
err2025-11-01
err0
errOAAI
errPowers, Lauren; Jain, Vaibhav; Aksu, Michael; Hocke, Emily; Smith, Alan; Arvai, Stephanie; Haukefrers, Ellora; Stevenson, Kevin; Patel, Khooshbu; Satterfield, Diane; Thomas, Elizabeth; Abramson, Karen; Lopez, Giselle; McLendon, Roger; Ashley, David; Gregory, Simon
err分享
err收藏
Response to next interventions after treatment with off-label ivosidenib in patients with mutant IDH low grade glioma接受过非适应症ivosidenib治疗的患者中，突变IDH低级别胶质瘤对后续干预措施的应答
errNEURO-ONCOLOGY
IF13.4
err2025-11-01
err0
errOAAI
errMinor, Maria; Zhang, Jikai; Dewey, Jonathon; Elkholi, Rana; Patel, Mallika; Savelli, Alicia; Johnson, Margaret; Batich, Kristen; Low, Justin; Shoaf, Madison; Khasraw, Mustafa; Desjardins, Annick; Friedman, Henry; Ashley, David; Calabrese, Evan; Peters, Katherine
err分享
err收藏
PI3K PATHWAY ALTERATIONS ARE DRIVERS OF PROGRESSION AND PREDICT WORSE OVERALL SURVIVAL IN NEWLY DIAGNOSED MOLECULARLY-DEFINED OLIGODENDROGLIOMAPI3K通路改变是驱动进展的因素，并且预测在 newly diagnosed molecularly-defined oligodendroglioma 中总体生存期更差。
errNEURO-ONCOLOGY
IF13.4
err2025-11-01
err0
PREAI
errLopez, Giselle; Desjardins, Annick; Smith, Vanessa; Stevenson, Kevin; McLendon, Roger; Gregory, Simon; Ashley, David
err分享
err收藏
Randomized phase 2 clinical trial of repeated intratumoral and cervical perilymphatic injections (CPLIs) of lerapolturev vs. lomustine in recurrent glioblastoma (rGBM): safety lead-in resultslerapolturev与洛莫司汀在复发性胶质母细胞瘤(rGBM)中的随机化Ⅱ期临床试验：重复肿瘤内和颈部淋巴周围注射(CPLIs)的安全导引入组结果
errNEURO-ONCOLOGY
IF13.4
err2025-11-01
err0
errOAAI
errShoaf, Madison L.; Gromeier, Matthias; Brown, Michael C.; Buckley, Evan D.; Herndon II, James E.; Batich, Kristen; Johnson, Margaret O.; Khasraw, Mustafa; Low, Justin T.; Peters, Katherine B.; Friedman, Allan H.; Friedman, Henry S.; Ashley, David M.; Bigner, Darell D.; Desjardins, Annick
err分享
err收藏
Synergistic STING activation in meningioma neoplastic and immune populations triggers programmed necrosis and modulates the collagen-rich immunosuppressive microenvironment在脑膜瘤的肿瘤和免疫细胞群体中，协同的STING激活会触发程序性坏死并调节富含胶原的免疫抑制性微环境。
errNEURO-ONCOLOGY
IF13.4
err2025-11-01
err0
errOAAI
errYoungblood, Mark; Tripathi, Shashwat; Najem, Hinda; Congivaram, Harrshavasan; Gomez, Mateo; Sears, Thomas; Hurley, Lisa; Billingham, Leah; Silvers, Caylee; Wang, Wenxia; Tiek, Deanna; Sadagopan, Nishanth; Chaliparambil, Rahul; Pu, Qianyi; Wai, Ching Man; Choudhury, Abrar; Steffens, Alicia; Mccortney, Kathleen; Cervantes, Gustavo; Oyon, Daniel; Fernandez, Luis; Selner, Ashley; Fares, Jawad; Hagan, Matthew; Trybula, Joy; Yeung, Jacky; Peyre, Matthieu; Kalamarides, Michel; Zhang, Peng; Stegh, Alexander; Ashley, David; Horbinski, Craig; Ahrendsen, Jared; Jamshidi, Pouya; Brat, Daniel; Lukas, Rimas; Stupp, Roger; Lesniak, Maciej; Sonabend, Adam; Dunn, Gavin; Chandler, James; Tate, Matthew; Magill, Stephen; Miska, Jason; Curran, Michael; Raleigh, David; Heimberger, Amy
err分享
err收藏
P30-EPS PEPTIDE VACCINE IS SAFE AND IMMUNOGENIC IN NEWLY DIAGNOSED GLIOBLASTOMA: A PHASE 1B TRIALP30-EPS多肽疫苗在 newly diagnosed glioblastoma 患者中安全且具有免疫原性：一项1B期临床试验
errNEURO-ONCOLOGY
IF13.4
err2025-10-01
err0
errOAAI
errHotchkiss, K. M.; Norberg, P.; Buckley, E.; Ayasoufi, K.; Threatt, S.; Low, J. T.; Shoaf, M. L.; Goldston, M.; Batich, K.; Johnson, M. O.; Nair, S.; Weinhold, K.; Friedman, H. S.; Ashley, D. M.; Desjardins, A.; Sampson, J. H.; Khasraw, M.
err分享
err收藏
INTRATUMORAL IL-12/ANTI-PD-1 ONCOLYTIC HSV1 (MVR-C5252) IS SAFE AND IMMUNOACTIVE IN RECURRENT HIGH-GRADE GLIOMA: PRELIMINARY PHASE 1 RESULTS FROM A MULTICENTER MULTISTAGE CLINICAL TRIAL瘤内IL-12/抗PD-1溶瘤HSV1（MVR-C5252）在复发性高级别胶质瘤中是安全且具有免疫活性的：一项多中心多阶段临床试验的初步I期结果
errNEURO-ONCOLOGY
IF13.4
err2025-10-01
err0
errOAAI
errHotchkiss, K. M.; Brown, M. C.; Owens, E.; Threatt, S.; Low, J. T.; Anand, M.; Goldston, M.; Johnson, M. O.; Bradbury, C.; Herndon II, J. E.; Grant, G. A.; Ashley, D. M.; Patel, A. P.; Desjardins, A.; Khasraw, M.
err分享
err收藏
DECIPHERING THE LONGITUDINAL TRAJECTORIES OF GLIOBLASTOMA ECOSYSTEMS BY INTEGRATIVE SINGLE-CELL GENOMICS通过整合单细胞基因组学解析胶质母细胞瘤生态系统的纵向轨迹
errNEURO-ONCOLOGY
IF13.4
err2025-10-01
err0
errOAAI
errSpitzer, A.; Johnson, K.; Nomura, M.; Garofano, L.; Nehar-Belaid, D.; Galili Darnell, N.; Greenwald, A.; Bussema, L.; Oh, Y.; Varn, F. S.; D'Angelo, F.; Gritsch, S.; Anderson, K. J.; Migliozzi, S.; Gonzalez Castro, L.; Chowdhury, T.; Robine, N.; Reeves, C.; Park, J.; Lipsa, A.; Hertel, F.; Golebiewska, A.; Niclou, S.; Nusrat, L.; Kellett, S.; Das, S.; Moon, H.; Paek, S.; Bielle, F.; Laurenge, A.; Di Stefano, A.; Mathon, B.; Picca, A.; Sanson, M.; Tanaka, S.; Saito, N.; Ashley, D. M.; Keir, S. T.; Ligon, K. L.; Huse, J. T.; Yung, W.; Lasorella, A.; Iavarone, A.; Verhaak, R.; Tirosh, I; Suva, M. L.
err分享
err收藏
Advances in neuro-oncology: contributions of the Asilomar Conference on brain tumor research and therapy
errJOURNAL OF NEUROSURGERY
IF3.6
err2024-12-01
err0
PREAI
errWestphal, Manfred; Levin, Victor A.; Berger, Mitchel S.; Pieper, Russell; Nishikawa, Ryo; Bjerkvig, Rolf; Ashley, David M.; Bigner, Darell; Sampson, John H.; Ichimura, Koichi; Rutka, James T.
err分享
err收藏
OUTCOMES AND IMMUNE RESPONSES AFTER PEPTIDE VACCINATION TARGETING HUMAN CYTOMEGALOVIRUS ANTIGEN PP65 IN CHILDREN AND YOUNG ADULTS WITH RECURRENT HIGH-GRADE GLIOMA AND MEDULLOBLASTOMA: RESULTS OF A PHASE 1 TRIAL
errNEURO-ONCOLOGY
IF13.4
err2024-11-11
err0
PREAI
errThompson, Eric; Ashley, David; Ayasoufi, Kathy; Norberg, Pam; Archer, Gerald; Buckley, Evan; Herndon, James; Walter, Ashley; Archambault, Bridget; Balajonda, Bea; Flahiff, Charlene; Jaggers, Denise; Gorski, Laura; Vlahovic, Gordana; Reap, Elizabeth; Schroeder, Kristin; Desjardins, Annick; Johnson, Margaret; Peters, Katherine; Khasraw, Mustafa; Mitchell, Duane; Sampson, John; Landi, Daniel
err分享
err收藏
REAL-WORLD OUTCOMES AMONG HIGH GRADE IDH1-MUTANT GLIOMA PATIENTS TREATED WITH AN IDH INHIBITOR
errNEURO-ONCOLOGY
IF13.4
err2024-11-11
err0
PREAI
errZiv, Michal Nisnboym; Patel, Mallika P.; Minor, Maria; Johnson, Margaret O.; Batich, Kristen; Low, Justin; Shoaf, Madison L.; Khasraw, Mustafa; Desjardins, Annick; Friedman, Henry S.; Ashley, David M.; Peters, Katherine B.
err分享
err收藏

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