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D

Darell D. Bigner

Duke University
H指数:147
被引数:15.0万

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INVESTIGATION OF THE COMBINATION OF D2C7-IT WITH AN FC-ENGINEERED ANTI-HUMANCD40 MONOCLONAL ANTIBODY (2141-V11) WHEN ADMINISTERED INTRATUMORALLY VIA CONVECTION-ENHANCED DELIVERY (CED) FOLLOWED BY CERVICAL PERILYMPHATIC INJECTIONS (CPLIS) OF 2141-V11 COMPARED TO D2C7-IT CED MONOTHERAPY IN PATIENTS WITH RECURRENT GLIOBLASTOMA (RGBM)

探究通过促进增强递送（CED）途径瘤内给药D2C7-IT与FC工程化抗人CD40单克隆抗体（2141-V11）联合应用，并随后进行2141-V11颈部淋巴周围注射（CPLIS）与D2C7-IT CED单药治疗相比，在复发性胶质母细胞瘤（RGBM）患者中的效果。

NEURO-ONCOLOGY
IF13.4
2025-11-010
OAAI
Desjardins, Annick; Chandramohan, Vidya; Herndon II, James E.; Bradbury, Claire; Shoaf, Madison; Peters, Katherine B.; Johnson, Margaret O.; Batich, Kristen; Low, Justin; Khasraw, Mustafa; Friedman, Allan H.; Friedman, Henry S.; Ashley, David M.; Grant, Gerald; Osorio, Juan; Ravetch, Jeffrey; Bigner, Darell D.
An assessment of the Tumor Monorail Device (TMD) for repeated sampling as part of a trial evaluating the combination of D2C7-IT and an Fc-engineered anti-CD40 monoclonal antibody (2141-V11) administered intratumorally via convection-enhanced delivery (CED) and cervical perilymphatic injections (CPLIs) of 2141-V11 in recurrent glioblastoma (rGBM) patients

对Tumor Monorail Device (TMD)进行重复采样的评估，作为一项评估通过对流增强递送（CED）和颈周淋巴间隙注射（CPLIs）分别经瘤内给予D2C7-IT以及Fc工程化抗CD40单克隆抗体（2141-V11）的联合方案在复发性胶质母细胞瘤（rGBM）患者中疗效试验的一部分。

NEURO-ONCOLOGY
IF13.4
2025-11-010
OAAI
Desjardins, Annick; Chandramohan, Vidya; Mokarram, Nassir; Meehan, Sean; Sharma, Shaili; Herndon Ii, James E.; Shoaf, Madison; Peters, Katherine B.; Johnson, Margaret O.; Batich, Kristen; Low, Justin; Khasraw, Mustafa; Friedman, Allan H.; Friedman, Henry S.; Ashley, David M.; Grant, Gerald; Osorio, Juan; Ravetch, Jeffrey; Bellamkonda, Ravi; Bigner, Darell D.
Randomized phase 2 clinical trial of repeated intratumoral and cervical perilymphatic injections (CPLIs) of lerapolturev vs. lomustine in recurrent glioblastoma (rGBM): safety lead-in results

lerapolturev与洛莫司汀在复发性胶质母细胞瘤(rGBM)中的随机化Ⅱ期临床试验：重复肿瘤内和颈部淋巴周围注射(CPLIs)的安全导引入组结果

NEURO-ONCOLOGY
IF13.4
2025-11-010
OAAI
Shoaf, Madison L.; Gromeier, Matthias; Brown, Michael C.; Buckley, Evan D.; Herndon II, James E.; Batich, Kristen; Johnson, Margaret O.; Khasraw, Mustafa; Low, Justin T.; Peters, Katherine B.; Friedman, Allan H.; Friedman, Henry S.; Ashley, David M.; Bigner, Darell D.; Desjardins, Annick
D2C7-IT IN COMBINATION WITH AN FC-ENGINEERED ANTI-HUMANCD40 MONOCLONAL ANTIBODY (2141-V11) ADMINISTERED INTRATUMORALLY VIA CONVECTION-ENHANCED DELIVERY (CED) FOLLOWED BY CERVICAL PERILYMPHATIC INJECTIONS (CPLIS) OF 2141-V11 IN PATIENTS WITH RECURRENT GLIOBLASTOMA (RGBM)
NEURO-ONCOLOGY
IF13.4
2024-11-110
PRE
Desjardins, Annick; Chandramohan, Vidya; Herndon, James E., II; Threatt, Stevie; Bullock, Chevelle; Bradbury, Claire; Johnson, Margaret O.; Khasraw, Mustafa; Low, Justin T.; Peters, Katherine B.; Shoaf, Madison; Landi, Daniel; Batich, Kristen; Friedman, Allan H.; Friedman, Henry S.; Ashley, David M.; Knorr, David; Osorio, Juan; Ravetch, Jeffrey; Bigner, Darell D.
Recombinant polio-rhinovirus immunotherapy for recurrent paediatric high-grade glioma: a phase 1b trial
LANCET CHILD & ADOLESCENT HEALTH
IF15.5
2023-07-0116
OAAI
Thompson, Eric M.; Landi, Daniel; Brown, Michael C.; Friedman, Henry S.; McLendon, Roger; Herndon II, James E.; Buckley, Evan; Bolognesi, Dani P.; Lipp, Eric; Schroeder, Kristin; Becher, Oren J.; Friedman, Allan H.; McKay, Zachary; Walter, Ashley; Threatt, Stevie; Jaggers, Denise; Desjardins, Annick; Gromeier, Matthias; Bigner, Darell; Ashley, David M.
Immunotoxin-αCD40 therapy activates innate and adaptive immunity and generates a durable antitumor response in glioblastoma models
SCIENCE TRANSLATIONAL MEDICINE
IF14.6
2023-02-0810
OA
Parker, Scott; McDowall, Charlotte; Sanchez-Perez, Luis; Osorio, Cristina; Duncker, Patrick C.; Briley, Aaron; Swartz, Adam M.; Herndon, James E.; Yu, Yen-Rei A.; McLendon, Roger E.; Tedder, Thomas F.; Desjardins, Annick; Ashley, David M.; Gunn, Michael Dee; Enterline, David S.; Knorr, David A.; Pastan, Ira H.; Nair, Smita K.; Bigner, Darell D.; Chandramohan, Vidyalakshmi
Very low mutation burden is a feature of inflamed recurrent glioblastomas responsive to cancer immunotherapy
NATURE COMMUNICATIONS
IF15.7
2021-01-1393
OAAI
Gromeier, Matthias; Brown, Michael C.; Zhang, Gao; Lin, Xiang; Chen, Yeqing; Wei, Zhi; Beaubier, Nike; Yan, Hai; He, Yiping; Desjardins, Annick; Herndon, James E., II; Varn, Frederick S.; Verhaak, Roel G.; Zhao, Junfei; Bolognesi, Dani P.; Friedman, Allan H.; Friedman, Henry S.; McSherry, Frances; Muscat, Andrea M.; Lipp, Eric S.; Nair, Smita K.; Khasraw, Mustafa; Peters, Katherine B.; Randazzo, Dina; Sampson, John H.; McLendon, Roger E.; Bigner, Darell D.; Ashley, David M.
MTAP Loss Promotes Stemness in Glioblastoma and Confers Unique Susceptibility to Purine Starvation
CANCER RESEARCH
IF16.6
2019-07-0130
OAAI
Hansen, Landon J.; Sun, Ran; Yang, Rui; Singh, Simranjit X.; Chen, Lee H.; Pirozzi, Christopher J.; Moure, Casey J.; Hemphill, Carlee; Carpenter, Austin B.; Healy, Patrick; Ruger, Ryan C.; Chen, Chin-Pu J.; Greer, Paula K.; Zhao, Fangping; Spasojevic, Ivan; Grenier, Carole; Huang, Zhiqing; Murphy, Susan K.; McLendon, Roger E.; Friedman, Henry S.; Friedman, Allan H.; Herndonll, James E.; Sampson, John H.; Keir, Stephen T.; Bigner, Darell D.; Yan, Hai; He, Yiping

研究方向

暂未获取到该数据
H
Henry S. Friedman
H 指数:113论文数:809被引数:5.7万
R
Roger E. McLendon
H 指数:131论文数:735被引数:11.6万
J
John H. Sampson
H 指数:101论文数:721被引数:3.6万
A
Allan H. Friedman
H 指数:97论文数:650被引数:3.9万
J
James E. Herndon
H 指数:116论文数:708被引数:5.2万
Hai YAN 封面图
Hai YAN
H 指数:56论文数:318被引数:2.6万
S
Stephen T. Keir
H 指数:56论文数:350被引数:1.5万
A
Annick Desjardins
H 指数:60论文数:440被引数:1.5万
D
David A. Reardon
H 指数:119论文数:1,223被引数:6.2万
D
David M. Ashley
H 指数:60论文数:589被引数:1.7万