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Xiangrui Jiang

Shanghai Institute of Materia Medica
H指数:20
被引数:1,985

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Design, synthesis, and biological evaluation of thioamide-linked spiropyrrolidine derivatives as novel 3CLpro inhibitors against SARS-CoV-2

硫酰胺连接的螺吡咯烷衍生物的设计、合成及其作为新型3CLpro抑制剂对抗SARS-CoV-2的生物学评价

Bioorganic & Medicinal Chemistry
IF3
2025-05-140
PRE
Samuel Desta Guma; Kang Song; Haiguo Sun; Lei Yang; Zhaoyin Zhou; Jin Suo; Emmanuel Mintah Bonku; Wei Zheng; Guanghui Tian; Xiangrui Jiang; Qiumeng Zhang; Yan Zhang; Jingshan Shen
Design, Synthesis, and Biological Evaluation of Peptidomimetic Tetrahydropyrrole Spirodihydroindolones as SARS-CoV-2 3CL Protease Inhibitors

拟肽四氢吡咯螺二氢吲哚酮作为SARS-CoV-2 3CL蛋白酶抑制剂的设计，合成和生物学评价

ACS MEDICINAL CHEMISTRY LETTERS
IF4
2025-04-010
PRE
Hu, Liuyan; Zhao, Zhi; Zhang, Shujing; Yang, Lei; Cui, Wenjie; Hu, Tianwen; Suo, Jin; Sun, Haiguo; Zhang, Qiumeng; Zhang, Leike; Zhu, Weiliang; Xu, Zhijian; Zhang, Yumin; Jiang, Xiangrui; Zhang, Yan; Shen, Jingshan
A first-in-human phase 1 study of simnotrelvir, a 3CL-like protease inhibitor for treatment of COVID-19, in healthy adult subjects
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
IF4.7
2023-12-0113
OA
Yang, Xin-Mei; Yang, Yang; Yao, Bu-Fan; Ye, Pan-Pan; Xu, Yan; Peng, Shao-Ping; Yang, Yu-Mei; Shu, Pan; Li, Pei-Jin; Li, Shan; Hu, Hong-Lin; Li, Qian; Song, Lin-Lin; Chen, Ke-Guang; Zhou, Hai-Yan; Zhang, Ye-Hui; Zhao, Fu-Rong; Tang, Bo-Hao; Zhang, Wei; Zhang, Xin-Fang; Fu, Shu-Meng; Hao, Guo-Xiang; Zheng, Yi; Shen, Jing-Shan; Xu, Ye-Chun; Jiang, Xiang-Rui; Zhang, Lei-Ke; Tang, Ren-Hong; Zhao, Wei
Glimepiride, a novel soluble epoxide hydrolase inhibitor, protects against heart failure via increasing epoxyeicosatrienoic acids

格列美脲是一种新型的可溶性环氧化物水解酶抑制剂，可通过增加环氧二十碳三烯酸来预防心力衰竭

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
IF4.7
2023-12-012
PRE
Zhao, Chengcheng; Jiang, Xiangrui; Peng, Liyuan; Zhang, Yan; Li, Huihui; Zhang, Qiumeng; Wang, Yinhui; Yang, Feipu; Wu, Junfang; Wen, Zheng; He, Zuowen; Shen, Jingshan; Chen, Chen; Wang, Dao Wen
Repurposing of Rutan showed effective treatment for COVID-19 disease
FRONTIERS IN MEDICINE
IF3
2023-11-291
OAAI
Salikhov, Shavkat I.; Abdurakhmonov, Ibrokhim Y.; Oshchepkova, Yuliya I.; Ziyavitdinov, Jamolitdin F.; Berdiev, Nodir Sh.; Aisa, Haji Akber; Shen, Jingshan; Xu, Yechun; Xu, H. Eric; Jiang, Xiangrui; Zhang, Leike; Vypova, Natalia L.; Allaberganov, Dilshod Sh.; Tagayalieva, Nigora A.; Musabaev, Erkin I.; Ibadova, Gulnara A.; Rajabov, Ilxom B.; Lokteva, Lyubov M.
Efficacy and safety of SIM0417 (SSD8432) plus ritonavir for COVID-19 treatment: a randomised, double-blind, placebo- controlled, phase 1b trial

SIM0417 (SSD8432) 联合利托那韦治疗新型冠状病毒肺炎的疗效和安全性: 一项随机、双盲、安慰剂对照的1b期试验

LANCET REGIONAL HEALTH-WESTERN PACIFIC
IF8.1
2023-09-0124
OAAI
Wang, Fuxiang; Xiao, Wen; Tang, Yimin; Cao, Mengli; Shu, Dan; Asakawa, Tetsuya; Xu, Yechun; Jiang, Xiangrui; Zhang, Leike; Wang, Wei; Tang, Jianxing; Huang, Yuansheng; Yang, Yang; Yang, Yumei; Tang, Renhong; Shen, Jingshan; Lu, Hongzhou

研究方向

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J
Jingshan Shen
H 指数:30论文数:237被引数:4,987
蒋
蒋华良
H 指数:101论文数:986被引数:5.4万
F
Feipu Yang
H 指数:10论文数:35被引数:526
J
Jin Suo
H 指数:8论文数:29被引数:157
Z
Zhen Wang
H 指数:29论文数:124被引数:2,253
L
Leike Zhang
H 指数:41论文数:141被引数:2.0万
T
Tianwen Hu
H 指数:9论文数:49被引数:258
G
Guanghui Tian
H 指数:13论文数:53被引数:2,021
Y
Yechun Xu
H 指数:46论文数:185被引数:1.1万
Q
Qiumeng Zhang
H 指数:17论文数:44被引数:765