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M

Margaret A. Lindorfer

University of Virginia School of Medicine
H指数:47
被引数:6,593

个人简介

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教育背景

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工作经历

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荣誉奖项

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Potentiating CD20 monoclonal antibody therapy by targeting complement C3 fragments covalently deposited on lymphoma cells

通过靶向共价沉积在淋巴瘤细胞上的补体C3片段增强CD20单克隆抗体疗法

BLOOD
IF23.1
2025-01-072
PRE
Baskar, Sivasubramanian; Peng, Haiyong; Gaglione, Erika M.; Carstens, Elizabeth J.; Lindorfer, Margaret A.; Ahn, Inhye E.; Herman, Sarah E. M.; Skarzynski, Martin; Chang, Jing; Keyvanfar, Keyvan; Butera, Vicent; Blackburn, Amy; Vire, Berengere; Maric, Irina; Stetler-Stevenson, Maryalice; Yuan, Constance M.; Eckhaus, Michael A.; Soto, Susan; Farooqui, Mohammed Z. H.; Taylor, Ronald P.; Rader, Christoph; Wiestner, Adrian
Multifaceted mechanism of action of DuoHexaBody-CD37 involves both complement- and Fc gamma receptor-mediated cytotoxicity in pre-clinical B-cell lymphoma models
CANCER RESEARCH
IF16.6
2020-08-150
PRE
Kil, Laurens P.; Oostindie, Simone C.; Strumane, Kristin; van der Horst, Hilma J.; van Kessel, Berris; Overdijk, Marije B.; Lingnau, Andreas; Brandhorst, Marcel; van den Brakel, Jeroen; Lindorfer, Margaret A.; Taylor, Ronald P.; Chamuleau, Martine E.; Mutis, Tuna; Sasser, A. Kate; Schuurman, Janine; Parren, Paul W.; Beurskens, Frank J.; Breij, Esther C.
DuoHexaBody-CD37(R), a novel biparatopic CD37 antibody with enhanced Fc-mediated hexamerization as a potential therapy for B-cell malignancies
BLOOD CANCER JOURNAL
IF11.6
2020-04-2847
OAAI
Oostindie, Simone C.; van der Horst, Hilma J.; Kil, Laurens P.; Strumane, Kristin; Overdijk, Marije B.; van den Brink, Edward N.; van den Brakel, Jeroen H. N.; Rademaker, Hendrik J.; van Kessel, Berris; van den Noort, Juliette; Chamuleau, Martine E. D.; Mutis, Tuna; Lindorfer, Margaret A.; Taylor, Ronald P.; Schuurman, Janine; Parren, Paul W. H. I.; Beurskens, Frank J.; Breij, Esther C. W.
CD20 and CD37 antibodies synergize to activate complement by Fc-mediated clustering

CD20和CD37抗体通过Fc介导的聚集协同激活补体

HAEMATOLOGICA
IF7.9
2019-02-2146
OAAI
Oostindie, Simone C.; van der Horst, Hilma J.; Lindorfer, Margaret A.; Cook, Erika M.; Tupitza, Jillian C.; Zent, Clive S.; Burack, Richard; VanDerMeid, Karl R.; Strumane, Kristin; Chamuleau, Martine E. D.; Mutis, Tuna; de Jong, Rob N.; Schuurman, Janine; Breij, Esther C. W.; Beurskens, Frank J.; Parren, Paul W. H., I; Taylor, Ronald P.
IgG Fc domains that bind C1q but not effector Fcγ receptors delineate the importance of complement-mediated effector functions (vol 18, pg 889, 2017)
NATURE IMMUNOLOGY
IF27.6
2017-10-013
OAAI
Lee, Chang-Han; Romain, Gabrielle; Yan, Wupeng; Watanabe, Makiko; Charab, Wissam; Todorova, Biliana; Lee, Jiwon; Triplett, Kendra; Donkor, Moses; Lungu, Oana I.; Lux, Anja; Marshall, Nicholas; Lindorfer, Margaret A.; Richard-Le Goff, Odile; Balbino, Bianca; Kang, Tae Hyun; Tanno, Hidetaka; Delidakis, George; Alford, Corrine; Taylor, Ronald P.; Nimmerjahn, Falk; Varadarajan, Navin; Bruhns, Pierre; Zhang, Yan Jessie; Georgiou, George
IgG Fc domains that bind C1q but not effector Fcγ receptors delineate the importance of complement-mediated effector functions
NATURE IMMUNOLOGY
IF27.6
2017-06-12115
OAAI
Lee, Chang-Han; Romain, Gabrielle; Yan, Wupeng; Watanabe, Makiko; Charab, Wissam; Todorova, Biliana; Lee, Jiwon; Triplett, Kendra; Donkor, Moses; Lungu, Oana I.; Lux, Anja; Marshall, Nicholas; Lindorfer, Margaret A.; Goff, Odile Richard-Le; Balbino, Bianca; Kang, Tae Hyun; Tanno, Hidetaka; Delidakis, George; Alford, Corrine; Taylor, Ronald P.; Nimmerjahn, Falk; Varadarajan, Navin; Bruhns, Pierre; Zhang, Yan Jessie; Georgiou, George
Antibodies That Efficiently Form Hexamers upon Antigen Binding Can Induce Complement-Dependent Cytotoxicity under Complement-Limiting Conditions

在抗原结合后有效形成六聚体的抗体可以在补体限制条件下诱导补体依赖性细胞毒性

JOURNAL OF IMMUNOLOGY
IF3.4
2016-09-0154
OAAI
Cook, Erika M.; Lindorfer, Margaret A.; van der Horst, Hilma; Oostindie, Simone; Beurskens, Frank J.; Schuurman, Janine; Zent, Clive S.; Burack, Richard; Parren, Paul W. H. I.; Taylor, Ronald P.

研究方向

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R
Ronald P. Taylor
H 指数:52论文数:311被引数:1.0万
P
Paul W.H.I. Parren
H 指数:96论文数:474被引数:3.1万
F
Frank J. Beurskens
H 指数:35论文数:110被引数:5,793
P
Paul V. Beum
H 指数:18论文数:53被引数:2,005
J
James C. Garrison
H 指数:47论文数:201被引数:6,873
A
Andrew W. Pawluczkowycz
H 指数:9论文数:30被引数:954
J
Janine Schuurman
H 指数:46论文数:167被引数:9,407
C
Clive S. Zent
H 指数:55论文数:313被引数:9,039
E
Erika M. Cook
H 指数:9论文数:19被引数:558
S
Simone C. Oostindie
H 指数:10论文数:18被引数:903