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Compromised lipid metabolism, mitochondria respiration and neuroprotective effects in iPSC-derived astrocytes from a Smith-Lemli-Opitz syndrome patient Smith-Lemli-Opitz综合征患者iPSC来源的星形胶质细胞中脂质代谢、线粒体呼吸和神经保护作用的受损 Kawatani, Keiji; Baker, Samantha K.; Yaeger, Jazmine D. W.; Anderson, Ruthellen H.; Ren, Yingxue; Li, Zonghua; Bao, Hanmei; Han, Xianlin; Francis, Kevin R.; Kanekiyo, Takahisa 分享 收藏
Characterizing the expression profile of 3R tau pathology in Pick's disease 表征Pick病中3R tau病理的表达谱 Tamvaka, Nicole; Soto-Beasley, Alexandra I.; Gavrielatos, Marios; Heckman, Michael G.; Ren, Yingxue; Udine, Evan; Quicksall, Zachary S.; Liskey, Delaney; Castanedes-Casey, Monica; Wszolek, Zbigniew K.; Boeve, Bradley F.; Josephs, Keith A.; Graff-Radford, Neill; van Blitterswijk, Marka; Murray, Melissa E.; Roemer, Shanu F.; Dickson, Dennis W. 分享 收藏
Neuronal ABCA7 deficiency aggravates mitochondrial dysfunction and neurodegeneration in Alzheimer's disease 神经元ABCA7缺乏加剧阿尔茨海默病中的线粒体功能障碍和神经退行性变 Wang, N; Pan, YN; Starling, SC; Haskell, DH; Quintero, AC; Kawatani, K; Inoue, Y; Shue, F; Ma, XY; Aikawa, T; Martens, YA; Kurti, A; Parsons, TM; Perkerson, RB; Roy, B; Raulin, AC; Ren, YX; Deture, M; Dickson, DW; Bao, HM; Han, XL; Bu, GJ; Kanekiyo, T 分享 收藏
Alzheimer's disease risk ABCA7 p.A696S variant disturbs the microglial response to amyloid pathology in mice 阿尔茨海默病风险ABCA7 p.A696S变体干扰小鼠小胶质细胞对淀粉样蛋白病理的反应 Ma, Xiaoye; Prokopenko, Dmitry; Wang, Ni; Aikawa, Tomonori; Choi, Younjung; Zhang, Can; Lei, Dan; Ren, Yingxue; Kawatani, Keiji; Starling, Skylar C.; Perkerson, Ralph B.; Roy, Bhaskar; Quintero, Astrid C.; Parsons, Tammee M.; Pan, Yining; Li, Zonghua; Wang, Minghui; Bao, Hanmei; Han, Xianlin; Bu, Guojun; Tanzi, Rudolph E.; Kanekiyo, Takahisa 分享 收藏
Meningeal lymphatic function promotes oligodendrocyte survival and brain myelination das Neves, Sofia P.; Delivanoglou, Nickoleta; Ren, Yingxue; Cucuzza, Chiara Starvaggi; Makuch, Mateusz; Almeida, Francisco; Sanchez, Guadalupe; Barber, Megan J.; Rego, Shanon; Schrader, Racquelle; Faroqi, Ayman H.; Thomas, Jean-Leon; McLean, Pamela J.; Oliveira, Tiago Gil; Irani, Sarosh R.; Piehl, Fredrik; Da Mesquita, Sandro 分享 收藏
Secretome from iPSC-derived MSCs exerts proangiogenic and immunosuppressive effects to alleviate radiation-induced vascular endothelial cell damage 来自iPSC来源的msc的分泌蛋白具有促血管生成和免疫抑制作用，以减轻辐射诱导的血管内皮细胞损伤 Gupta, Kshama; Perkerson, Ralph B.; Parsons, Tammee M.; Angom, Ramacharan; Amerna, Danilyn; Burgess, Jeremy D.; Ren, Yingxue; Mclean, Pamela J.; Mukhopadhyay, Debabrata; Vibhute, Prasanna; Wszolek, Zbigniew K.; Zubair, Abba C.; Quinones-Hinojosa, Alfredo; Kanekiyo, Takahisa 分享 收藏
A novel histone deacetylase inhibitor W2A-16 improves the barrier integrity in brain vascular endothelial cells Inoue, Yasuteru; Ren, Yingxue; Zhang, Shuwen; Bamkole, Michael; Islam, Naeyma N.; Selvaraj, Manikandan; Lu, Wenyan; Caulfield, Thomas R.; Li, Yonghe; Kanekiyo, Takahisa 分享 收藏
CSF biomarkers of immune activation and Alzheimer's disease for predicting cognitive impairment risk in the elderly Shue, Francis; White, Launia J.; Hendrix, Rachel; Ulrich, Jason; Henson, Rachel L.; Knight, William; Martens, Yuka A.; Wang, Ni; Roy, Bhaskar; Starling, Skylar C.; Ren, Yingxue; Xiong, Chengjie; Asmann, Yan W.; Syrjanen, Jeremy A.; Vassilaki, Maria; Mielke, Michelle M.; Timsina, Jigyasha; Sung, Yun Ju; Cruchaga, Carlos; Holtzman, David M.; Bu, Guojun; Petersen, Ronald C.; Heckman, Michael G.; Kanekiyo, Takahisa 分享 收藏
Genetics of Parkinson's disease heterogeneity: A genome-wide association study of clinical subtypes 帕金森病异质性的遗传学: 临床亚型的全基因组关联研究 Dulski, Jaros law; Uitti, Ryan J.; Beasley, Alexandra; Hernandez, Dena; Ramanan, Vijay K.; Cahn, Elliot J.; Ren, Yingxue; Johnson, Patrick W.; Quicksall, Zachary S.; Wszolek, Zbigniew K.; Ross, Owen A.; Heckman, Michael G. 分享 收藏
ABCA7 deficiency causes neuronal dysregulation by altering mitochondrial lipid metabolism Kawatani, Keiji; Holm, Marie-Louise; Starling, Skylar C.; Martens, Yuka A.; Zhao, Jing; Lu, Wenyan; Ren, Yingxue; Li, Zonghua; Jiang, Peizhou; Jiang, Yangying; Baker, Samantha K.; Wang, Ni; Roy, Bhaskar; Parsons, Tammee M.; Perkerson, Ralph B.; Bao, Hanmei; Han, Xianlin; Bu, Guojun; Kanekiyo, Takahisa 分享 收藏
Cell-autonomous effects of APOE4 in restricting microglial response in brain homeostasis and Alzheimer's disease Liu, Chia-Chen; Wang, Na; Chen, Yuanxin; Inoue, Yasuteru; Shue, Francis; Ren, Yingxue; Wang, Minghui; Qiao, Wenhui; Ikezu, Tadafumi C.; Li, Zonghua; Zhao, Jing; Martens, Yuka; Doss, Sydney V.; Rosenberg, Cassandra L.; Jeevaratnam, Suren; Jia, Lin; Raulin, Ana-Caroline; Qi, Fangfang; Zhu, Yiyang; Alnobani, Alla; Knight, Joshua; Chen, Yixing; Linares, Cynthia; Kurti, Aishe; Fryer, John D.; Zhang, Bin; Wu, Long-Jun; Kim, Betty Y. S.; Bu, Guojun 分享 收藏
Deconvolution reveals cell-type-specific transcriptomic changes in the aging mouse brain Ren, Yingxue; Wang, Xue; Zhang, Shuwen; Hu, Hongru; Quicksall, Zachary; Lee, Sangderk; Morganti, Josh M.; Johnson, Lance A.; Asmann, Yan W.; Zhao, Na 分享 收藏
APOE deficiency impacts neural differentiation and cholesterol biosynthesis in human iPSC-derived cerebral organoids Zhao, Jing; Ikezu, Tadafumi C.; Lu, Wenyan; Macyczko, Jesse R.; Li, Yonghe; Lewis-Tuffin, Laura J.; Martens, Yuka A.; Ren, Yingxue; Zhu, Yiyang; Asmann, Yan W.; Ertekin-Taner, Nilufer; Kanekiyo, Takahisa; Bu, Guojun 分享 收藏
LRP1 in vascular mural cells modulates cerebrovascular integrity and function in the presence of APOE4 Oue, Hiroshi; Yamazaki, Yu; Qiao, Wenhui; Yuanxin, Chen; Ren, Yingxue; Kurti, Aishe; Shue, Francis; Parsons, Tammee M.; Perkerson, Ralph B.; Kawatani, Keiji; Wang, Ni; Starling, Skylar C.; Roy, Bhaskar; Mosneag, Ioana-Emilia; Aikawa, Tomonori; Holm, Marie-Louise; Liu, Chia-Chen; Inoue, Yasuteru; Sullivan, Patrick M.; Asmann, Yan W.; Kim, Betty Y. S.; Bu, Guojun; Kanekiyo, Takahisa 分享 收藏
Elevating microglia TREM2 reduces amyloid seeding and suppresses disease-associated microglia Zhao, Na; Qiao, Wenhui; Li, Fuyao; Ren, Yingxue; Zheng, Jiaying; Martens, Yuka A.; Wang, Xusheng; Li, Ling; Liu, Chia-Chen; Chen, Kai; Zhu, Yiyang; Ikezu, Tadafumi C.; Li, Zonghua; Meneses, Axel D.; Jin, Yunjung; Knight, Joshua A.; Chen, Yixing; Bastea, Ligia; Linares, Cynthia; Sonustun, Berkiye; Job, Lucy; Smith, Madeleine L.; Xie, Manling; Liu, Yong U.; Umpierre, Anthony D.; Haruwaka, Koichiro; Quicksall, Zachary S.; Storz, Peter; Asmann, Yan W.; Wu, Long-Jun; Bu, Guojun 分享 收藏
Shared brain transcriptomic signature in TDP-43 type A FTLD patients with or without GRN mutations Pottier, Cyril; Mateiu, Ligia; Baker, Matthew C.; DeJesus-Hernandez, Mariely; Vicente, Cristina Teixeira; Finch, NiCole A.; Tian, Shulan; van Blitterswijk, Marka; Murray, Melissa E.; Ren, Yingxue; Petrucelli, Leonard; Oskarsson, Bjorn; Biernacka, Joanna M.; Graff-Radford, Neill R.; Boeve, Bradley F.; Petersen, Ronald C.; Josephs, Keith A.; Asmann, Yan W.; Dickson, Dennis W.; Rademakers, Rosa 分享 收藏
Apolipoprotein E regulates lipid metabolism and α-synuclein pathology in human iPSC-derived cerebral organoids (vol 142, pg 807, 2021) Zhao, Jing; Lu, Wenyan; Ren, Yingxue; Fu, Yuan; Martens, Yuka A.; Shue, Francis; Davis, Mary D.; Wang, Xue; Chen, Kai; Li, Fuyao; Liu, Chia-Chen; Graff-Radford, Neill R.; Wszolek, Zbigniew K.; Younkin, Steven G.; Brafman, David A.; Ertekin-Taner, Nilufer; Asmann, Yan W.; Dickson, Dennis W.; Xu, Ziying; Pan, Meixia; Han, Xianlin; Kanekiyo, Takahisa; Bu, Guojun 分享 收藏
APOE3-Jacksonville (V236E) variant reduces self-aggregation and risk of dementia Liu, Chia-Chen; Murray, Melissa E.; Li, Xia; Zhao, Na; Wang, Na; Heckman, Michael G.; Shue, Francis; Martens, Yuka; Li, Yonghe; Raulin, Ana-Caroline; Rosenberg, Cassandra L.; Doss, Sydney, V; Zhao, Jing; Wren, Melissa C.; Jia, Lin; Ren, Yingxue; Ikezu, Tadafumi C.; Lu, Wenyan; Fu, Yuan; Caulfield, Thomas; Trottier, Zachary A.; Knight, Joshua; Chen, Yixing; Linares, Cynthia; Wang, Xue; Kurti, Aishe; Asmann, Yan W.; Wszolek, Zbigniew K.; Smith, Glenn E.; Vemuri, Prashanthi; Kantarci, Kejal; Knopman, David S.; Lowe, Val J.; Jack, Clifford R. Jr Jr; Parisi, Joseph E.; Ferman, Tanis J.; Boeve, Bradley F.; Graff-Radford, Neill R.; Petersen, Ronald C.; Younkin, Steven G.; Fryer, John D.; Wang, Hu; Han, Xianlin; Frieden, Carl; Dickson, Dennis W.; Ross, Owen A.; Bu, Guojun 分享 收藏
Apolipoprotein E regulates lipid metabolism and α-synuclein pathology in human iPSC-derived cerebral organoids Zhao, Jing; Lu, Wenyan; Ren, Yingxue; Fu, Yuan; Martens, Yuka A.; Shue, Francis; Davis, Mary D.; Wang, Xue; Chen, Kai; Li, Fuyao; Liu, Chia-Chen; Graff-Radford, Neill R.; Wszolek, Zbigniew K.; Younkin, Steven G.; Brafman, David A.; Ertekin-Taner, Nilufer; Asmann, Yan W.; Dickson, Dennis W.; Xu, Ziying; Pan, Meixia; Han, Xianlin; Kanekiyo, Takahisa; Bu, Guojun 分享 收藏
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