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I

Isidro Hötzel

roche holding usa
H指数:26
被引数:2,685

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Antibody-Mediated Delivery of BRM/BRG1 Protein Degraders Affords Strong Antitumor Efficacy in Multiple BRM-Dependent Non-Small Cell Lung Cancer Xenograft Models

抗体介导的BRM/BRG1蛋白降解剂递送在多种BRM依赖性非小细胞肺癌异种移植模型中显示出强大的抗肿瘤疗效

Journal of Medicinal Chemistry
IF6.8
2026-05-170
PRE
Summer A. Baker Dockrey; Pravin Chandra; Huifen Chen; Shu Chen; Tommy K. Cheung; Ely Cosino; Yusi Cui; Stephanie Dale; Martine Darwish; Nicholas Dompe; Geoffrey Del Rosario; Mary Ann Go; Nikkia Hamidi; Mingtao He; Isidro Hötzel; Thomas Januario; Hartmut Koeppen; Julien Lafrance-Vanasse; Douglas Leipold; Chunsing Li; Joyce Liu; Ying Lu; Shabkhaiz Masih; Stephanie Monson; Rachana Ohri; Woody Perng; Thomas H. Pillow; Christopher M. Rose; Rebecca K. Rowntree; Jack Sadowsky; William Sawyer; Richard Vandlen; John Wai; Jian Wang; XinXin Wang; Yanmei Xin; Xiaofen Ye; Shang-Fan Yu; Donglu Zhang; Fang Zhang; Nancy Zhang; Robert L. Yauch; Peter S. Dragovich
Characterization of an anti-STEAP1 T-cell dependent bispecific antibody for the treatment of prostate cancer and associated toxicity in cynomolgus monkeys

抗STEAP1 T细胞依赖性双特异性抗体在前列腺癌治疗中的应用及其在食蟹猴中的相关性毒性表征

Toxicological Sciences
IF4.1
2026-03-010
PRE
Tonkin, Elizabeth G.; Lepherd, Michelle; Davies, John; Gampa, Gautham; Hotzel, Isidro; Koeppen, Hartmut; Liu, Wenyu; Melnikov, Fjodor; Niu, Xiang; Nickles, Dorothee; Romero-Lopez, Monica; Shao, Lily; Totpal, Klara; Schaefer, Gabriele
Primate cerebrospinal fluid CHI3L1 reflects brain TREM2 agonism
ALZHEIMERS & DEMENTIA
IF11.1
2024-08-010
OA
Schauer, Stephen P.; Cho, Chang Hoon; Novikova, Gloriia; Roth, Gillie A.; Lee, Julie; Sharma, Anup D.; Foley, Alejandro R.; Ng, Carl; Shen, Philip; Choi, Meena; Ma, Taylur P.; Phu, Lilian; Budayeva, Hanna G.; Cheung, Tommy K.; Lalehzadeh, Guita; Imperio, Jose; Ngu, Hai; Etxeberria, Ainhoa; Liang, Yuxin; Rezzonico, Mitchell G.; Dourado, Michelle; Huang, Kevin; Lai, Zijuan; Hokom, Martha; Pandya, Nikhil J.; Newton, Dwight; Abdel-Haleem, Alyaa M.; Chan, Pamela; Lee, Donna; Tassew, Nardos G.; Sangaraju, Dewakar; O'Connor, Deborah; Hotzel, Isidro; Stark, Kimberly L.; Chou, Carolina; Foreman, Oded; Easton, Amy; Wildsmith, Kristin R.; Sperinde, Gizette; Rose, Christopher M.; Friedman, Brad A.; Fuji, Reina N.; Weimer, Robby M.; Meilandt, William J.; Sadekar, Shraddha; Nugent, Alicia A.; Biever, Anne
Loss of the intracellular enzyme QPCTL limits chemokine function and reshapes myeloid infiltration to augment tumor immunity
NATURE IMMUNOLOGY
IF27.6
2022-03-2125
OA
da Silva, Rosa Barreira; Leitao, Ricardo M.; Pechuan-Jorge, Ximo; Werneke, Scott; Oeh, Jason; Javinal, Vincent; Wang, Yingyun; Phung, Wilson; Everett, Christine; Nonomiya, Jim; Arnott, David; Lu, Cheng; Hsiao, Yi-Chun; Koerber, James T.; Hotzel, Isidro; Ziai, James; Modrusan, Zora; Pillow, Thomas H.; Roose-Girma, Merone; Schartner, Jill M.; Merchant, Mark; Rutz, Sascha; Eidenschenk, Celine; Mellman, Ira; Albert, Matthew L.
Antibody semorinemab reduces tau pathology in a transgenic mouse model and engages tau in patients with Alzheimer's disease
SCIENCE TRANSLATIONAL MEDICINE
IF14.6
2021-05-1260
PRE
Ayalon, Gai; Lee, Seung-Hye; Adolfsson, Oskar; Foo-Atkins, Corinne; Atwal, Jasvinder K.; Blendstrup, Mira; Booler, Helen; Bravo, Joseph; Brendza, Robert; Brunstein, Flavia; Chan, Ruby; Chandra, Priya; Couch, Jessica A.; Datwani, Akash; Demeule, Barthelemy; DiCara, Danielle; Erickson, Rich; Ernst, James A.; Foreman, Oded; He, Dongping; Hotzel, Isidro; Keeley, Michael; Kwok, Michael C. M.; Lafrance-Vanasse, Julien; Lin, Han; Lu, Yanmei; Luk, Wilman; Manser, Paul; Muhs, Andreas; Ngu, Hai; Pfeifer, Andrea; Pihlgren, Maria; Rao, Gautham K.; Scearce-Levie, Kimberly; Schauer, Stephen P.; Smith, William B.; Solanoy, Hilda; Teng, Edmond; Wildsmith, Kristin R.; Yadav, Daniela Bumbaca; Ying, Yong; Fuji, Reina N.; Kerchner, Geoffrey A.
Muscle specific kinase (MuSK) activation preserves neuromuscular junctions in the diaphragm but is not sufficient to provide a functional benefit in the SOD1G93A mouse model of ALS (vol 124, pg 340, 2019)
NEUROBIOLOGY OF DISEASE
IF5.6
2019-12-011
OAAI
Sengupta-Ghosh, Arundhati; Dominguez, Sara L.; Xie, Luke; Barck, Kai H.; Jiang, Zhiyu; Earr, Timothy; Imperio, Jose; Phu, Lilian; Budayeva, Hanna G.; Kirkpatrick, Donald S.; Cai, Hao; He, Dongping; Eastham-Anderson, Jeffrey; Ngu, Hai; Foreman, Oded; Hedehus, Maj; Reichelt, Michael; Hotzel, Isidro; Shang, Yonglei; Carano, Richard A. D.; Ayalon, Gai; Easton, Amy
Muscle specific kinase (MuSK) activation preserves neuromuscular junctions in the diaphragm but is not sufficient to provide a functional benefit in the SOD1G93A mouse model of ALS
NEUROBIOLOGY OF DISEASE
IF5.6
2019-04-0130
PREAI
Sengupta-Ghosh, Arundhati; Dominguez, Sara L.; Xie, Luke; Barck, Kai H.; Jiang, Zhiyu; Earr, Timothy; Imperio, Jose; Phu, Lilian; Budayeva, Hanna G.; Kirkpatrick, Donald S.; Cai, Hao; Eastham-Anderson, Jeffrey; Ngu, Hai; Foreman, Oded; Hedehus, Maj; Reichelt, Michael; Hotzel, Isidro; Shang, Yonglei; Carano, Richard A. D.; Ayalon, Gai; Easton, Amy

研究方向

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D
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G
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O
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H 指数:47论文数:211被引数:1.0万
D
Danielle DiCara
H 指数:12论文数:49被引数:1,045
A
Amy Easton
H 指数:25论文数:66被引数:4,849
M
Meredith Hazen
H 指数:7论文数:15被引数:293
R
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H 指数:51论文数:200被引数:8,166
Z
Zhonghua Lin
H 指数:28论文数:98被引数:4,961
Y
Yonglei Shang
H 指数:9论文数:25被引数:946