Paul J. Higgins - Publications, H-index & Citations

Paul J. Higgins

Albany Medical College

50H指数

326论文数

1.0W被引数

收录论文 66

发表时间

Targeted Interference with USF2 Binding to the SERPINE1 Proximal Promoter E-Box in Dual Mutant p53R282Q,H179Y Human Keratinocytes Inhibits Serum-/TGF-β1-Induced SERPINE1 Expression and Stimulates Epithelial Cell Proliferation 靶向干扰USF2与SERPINE1近端启动子E-Box在双突变p53R282Q,H179Y人角质形成细胞中的结合，抑制了血清/TGF-β1诱导的SERPINE1表达并刺激上皮细胞增殖

Biomedicines

IF3.9

2026-03-22

OAAI

Stephen P. Higgins; Ralf-Peter Czekay; Craig E. Higgins; Paul J. Higgins

Involvement of c-Myc/WWP1/TRIM65 Axis in Renal Fibrosis c-Myc/WWP1/TRIM65轴在肾纤维化中的作用

Biomolecules

IF4.8

2026-03-02

OAAI

Sonia Mazumder; Cody Gifford; Jiaqi Tang; Fortis Gaba; Varsha Mondal; Roel Goldschmeding; Rohan Samarakoon; Paul J. Higgins

SEPT9 and PAI-1 are immunohistochemical biomarkers of the hepatocellular carcinoma immune microenvironment SEPT9和PAI-1是肝细胞癌免疫微环境的免疫组化生物标志物。

DISCOVER ONCOLOGY

IF2.9

2025-04-07

OAAI

Park, Eundong; Wang, Xin; Subasi, Nusret Bekir; Kmeid, Michel; Higgins, Paul J.; Chen, Anne; Lee, Hwajeong

SERPINE1: Role in Cholangiocarcinoma Progression and a Therapeutic Target in the Desmoplastic Microenvironment

CELLS

IF5.2

2024-05-07

OAAI

Czekay, Ralf-Peter; Higgins, Craig E.; Aydin, Hasan Basri; Samarakoon, Rohan; Subasi, Nusret Bekir; Higgins, Stephen P.; Lee, Hwajeong; Higgins, Paul J.

Mineralocorticoid receptor (MR)-associated mechanisms in diabetic kidney disease and clinical significance of MR antagonists

AMERICAN JOURNAL OF NEPHROLOGY

IF3.2

2023-01-20

OAAI

Mende, Christian Werner; Samarakoon, Rohan; Higgins, Paul J.

Emerging role of tumor suppressor p53 in acute and chronic kidney diseases

CELLULAR AND MOLECULAR LIFE SCIENCES

IF6.2

2022-08-09

OAAI

Overstreet, Jessica M.; Gifford, Cody C.; Tang, Jiaqi; Higgins, Paul J.; Samarakoon, Rohan

Potential renal stem/progenitor cells identified by in vivo lineage tracing

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY

IF3.4

2022-04-01

OAAI

Zhang, Wenzheng; Gao, Chao; Tsilosani, Akaki; Samarakoon, Rohan; Plews, Robert; Higgins, Paul J.

PAI-1 induction during kidney injury promotes fibrotic epithelial dysfunction via deregulation of klotho, p53, and TGF-β1-receptor signaling

FASEB JOURNAL

IF4.2

2021-06-10

OAAI

Gifford, Cody C.; Lian, Fei; Tang, Jiaqi; Costello, Angelica; Goldschmeding, Roel; Samarakoon, Rohan; Higgins, Paul J.

Negative regulators of TGF-β1 signaling in renal fibrosis; pathological mechanisms and novel therapeutic opportunities

CLINICAL SCIENCE

IF7.7

2021-01-22

PREAI

Gifford, Cody C.; Tang, Jiaqi; Costello, Angelica; Khakoo, Nidah S.; Nguyen, Tri Q.; Goldschmeding, Roel; Higgins, Paul J.; Samarakoon, Rohan

AQP2: Mutations Associated with Congenital Nephrogenic Diabetes Insipidus and Regulation by Post-Translational Modifications and Protein-Protein Interactions AQP2: 与先天性肾源性尿崩症相关的突变以及翻译后修饰和蛋白质-蛋白质相互作用的调节

CELLS

IF5.2

2020-09-26

OAAI

Gao, Chao; Higgins, Paul J.; Zhang, Wenzheng

Protein phosphatase Mg2+/Mn2+ dependent-1A and PTEN deregulation in renal fibrosis: Novel mechanisms and co-dependency of expression

FASEB JOURNAL

IF4.2

2019-12-23

PREAI

Tang, Jiaqi; Goldschmeding, Roel; Samarakoon, Rohan; Higgins, Paul J.

TGF-β1-p53 cooperativity regulates a profibrotic genomic program in the kidney: molecular mechanisms and clinical implications

FASEB JOURNAL

IF4.2

2019-07-06

OAAI

Higgins, Craig E.; Tang, Jiaqi; Mian, Badar M.; Higgins, Stephen P.; Gifford, Cody C.; Conti, David J.; Meldrum, Kirstan K.; Samarakoon, Rohan; Higgins, Paul J.

Rac-GTPase promotes fibrotic TGF-β1 signaling and chronic kidney disease via EGFR, p53, and Hippo/YAP/TAZ pathways

FASEB JOURNAL

IF4.2

2019-05-16

OAAI

Patel, Samik; Tang, Jiaqi; Overstreet, Jessica M.; Anorga, Sandybell; Lian, Fei; Arnouk, Alex; Goldschmeding, Roel; Higgins, Paul J.; Samarakoon, Rohan

TGF-β1/p53 signaling in renal fibrogenesis

CELLULAR SIGNALLING

IF3.7

2018-03-01

130

OAAI

Higgins, Stephen P.; Tang, Yi; Higgins, Craig E.; Mian, Badar; Zhang, Wenzheng; Czekay, Ralf-Peter; Samarakoon, Rohan; Conti, David J.; Higgins, Paul J.

Deregulation of Hippo-TAZ pathway during renal injury confers a fibrotic maladaptive phenotype

FASEB JOURNAL

IF4.2

2018-01-03

OAAI

Anorga, Sandybell; Overstreet, Jessica M.; Falke, Lucas L.; Tang, Jiaqi; Goldschmeding, Roel G.; Higgins, Paul J.; Samarakoon, Rohan

Integration of non-SMAD and SMAD signaling in TGF-β1-induced plasminogen activator inhibitor type-1 gene expression in vascular smooth muscle cells

THROMBOSIS AND HAEMOSTASIS

IF4.3

2017-11-23

117

OAAI

Samarakoon, Rohan; Higgins, Paul J.

Insights into cellular and molecular basis for urinary tract infection in autosomal-dominant polycystic kidney disease 了解常染色体显性多囊肾病尿路感染的细胞和分子基础

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY

IF3.4

2017-11-01

OAAI

Gao, Chao; Zhang, Long; Zhang, Ye; Wallace, Darren P.; Lopez-Soler, Reynold I.; Higgins, Paul J.; Zhang, Wenzheng

CONNECTIVE TISSUE GROWTH FACTOR INDUCTION PROMOTES EPITHELIAL MALADAPTIVE REPAIR IN RENAL FIBROSIS

JOURNAL OF UROLOGY

IF6.8

2017-04-01

OAAI

Arnouk, Alex; Goldschmeding, Roel; Higgins, Paul; Samarakoon, Rohan

CUB domain-containing protein 1 and the epidermal growth factor receptor cooperate to induce cell detachment

BREAST CANCER RESEARCH

IF5.6

2016-08-05

OAAI

Law, Mary E.; Ferreira, Renan B.; Davis, Bradley J.; Higgins, Paul J.; Kim, Jae-Sung; Castellano, Ronald K.; Chen, Sixue; Luesch, Hendrik; Law, Brian K.

Loss of expression of protein phosphatase magnesium-dependent 1A during kidney injury promotes fibrotic maladaptive repair

FASEB JOURNAL

IF4.2

2016-06-21

OAAI

Samarakoon, Rohan; Rehfuss, Alexandra; Khakoo, Nidah S.; Falke, Lucas L.; Dobberfuhl, Amy D.; Helo, Sevann; Overstreet, Jessica M.; Goldschmeding, Roel; Higgins, Paul J.

研究方向