未登录Splicing regulatory dynamics for precision analysis and treatment of heterogeneous leukemias异质性白血病精准分析与治疗的剪接调控动力学
Venkatasubramanian, Meenakshi; Schwartz, Leya; Ramachandra, Nandini; Bennett, Joshua; Subramanian, Krithika R.; Chen, Xiaoting; Gordon-Mitchell, Shanisha; Fromowitz, Ariel; Pradhan, Kith; Shechter, David; Sahu, Srabani; Heiser, Diane; Scherle, Peggy; Chetal, Kashish; Kulkarni, Aishwarya; Lee, Davy; Zhou, Jeff; Myers, Kasiani C.; Tseng, Elizabeth; Weirauch, Matthew T.; Grimes, H. Leighton; Starczynowski, Daniel T.; Verma, Amit; Salomonis, Nathan .png)
分享.png)
收藏CHARACTERIZATION OF SPLICING ABERRATIONS INDUCED BY PRMT5 INHIBITION IN GLIOBLASTOMAHuo, Longfei; Sharma, Pratibha; Tsai, Tsung-Lin; Chen, Xiaohua; Yu, Chunlei; Xu, Jihong; Ju, Zhenlin; Li, Ziyi; Scherle, Peggy; Vaddi, Kris; Baiocchi, Robert A.; Sampath, Deepa; Shukla, Sachet; Puduvalli, Vinay K. 分享 收藏 Targeting PRMT5 in Primary Hemophagocytic Lymphohistiocytosis: A Novel Therapeutic Approach Using a Perforin-Deficient Mouse Model靶向PRMT5在原发性噬血细胞性淋巴组织细胞增多症中的应用：一种使用穿孔素缺陷小鼠模型的全新治疗策略Steyn, Sheldon; Chen, Chia-Jo; Saadey, Rachel; Mao, Charlene; Scherle, Peggy; Bhagwat, Neha; Vaddi, Kris; Brooks, Eric; Baiocchi, Robert; Jordan, Michael B.; Shindiapina, Polina 分享 收藏 Selective SMARCA2 Degradation Promotes Leukemic Differentiation and Synergizes with CDK9 Inhibition to Potently Induce Death in Pre-Clinical Models of Acute Myeloid Leukemia选择性SMARCA2降解促进白血病分化，并与CDK9抑制协同，在急性髓系白血病临床前模型中强力诱导死亡。Fultang, Norman; Schwab, Ashley M.; Johnson, Ian; Grego, Alexander; Filler, Emma; Bachner, Carly; Karwoski, Jake; Moore, Andrew; Bartilomo, Ashley; Agarwal, Anjana; Osinubi, Olusola Peace; Ito, Koichi; Aminov, Sarah; Sahu, Srabani; Uerma, Amit; Scherle, Peggy A.; Bhagwat, Neha; Heiser, Diane 分享 收藏 分享 收藏 Discovery of first-in-class precision antibody drug conjugates with a potent SMARCA2/4 dual degrader payload that safely achieve maximal and tumor specific degradation and efficacy in mouse modelsCarter, J.; Agarwal, A.; Sivakumar, M.; Reichelderfer, A.; Park, J.; Osinubi, O.; Holmes, R.; Rager, J.; Stahl, N.; Cote, J.; Crossan, A.; Chen, C.; Pawley, S.; Wang, M.; Geeganage, S.; Lee, S.; Combs, A.; Scherle, P.; Buesking, A.; Ito, K. 分享 收藏 The brain penetrant CDK4/6 inhibitor, PRT3645, is highly effective in combination with other targeted therapies in preclinical models of breast cancer, CRC and NSCLCZou, Yue; Gallagher, Kirsten; Dhar, Srijita; Busking, Andrew; Pawley, Sarah; Holmes, Ryan; Wu, Xiaowei; Wang, Min; Rager, Joseph; Emm, Tom; Ruepp, Stefan; Cowart, Miles; Combs, Andrew; Vaddi, Kris; Geeganage, Sandy; Scherle, Peggy; Lee, Sang Hyun 分享 收藏 分享 收藏 Preclinical characterization of PRT7732: A highly potent, selective, and orally bioavailable targeted protein degrader of SMARCA2Shvartsbart, Artem; Ito, Koichi; Rager, Joseph; Hulse, Michael; Agarwal, Anjana; Vykuntam, Komali; Burtell, Jessica; Wang, Min; Kurian, Justin; Cowart, Miles; Cote, Joy; Stahl, Nick; Sivakumar, Monisha; Reichelderfer, Anthony; Carter, Jack; Grego, Alexander; Moore, Andrew; Bhagwat, Neha; Kuskovsky, Ross; Ganesan, Shanthi; Ruepp, Stefan; Emm, Tom; Pitis, Philip; Basch, Corey; Bersch, Klare; Pan, Yongchun; Mei, Song; Leal, Raul; Rose, John; Roth, Dani; Xu, Chaoyi; Cao, Ganfeng; Vaddi, Kris; Lee, Sang Hyun; Geeganage, Sandy; Combs, Andrew; Scherle, Peggy 分享 收藏 分享 收藏 Resistance to PRMT5-targeted therapy in mantle cell lymphomaLong, Mackenzie Elizabeth; Koirala, Shirsha; Sloan, Shelby; Brown-Burke, Fiona; Weigel, Christoph; Villagomez, Lynda; Corps, Kara; Sharma, Archisha; Hout, Ian; Harper, Margaret; Helmig-Mason, Jobeth; Tallada, Sheetal; Chen, Zhengming; Scherle, Peggy; Vaddi, Kris; Chen-Kiang, Selina; Di Liberto, Maurizio; Meydan, Cem; Foox, Jonathan; Butler, Daniel; Mason, Christopher; Alinari, Lapo; Blaser, Bradley W.; Baiocchi, Robert 分享 收藏 Discovery of PRT3789, a first-in-class potent and selective SMARCA2 degrader in clinical trials for the treatment of patients with SMARCA4 mutated cancersIto, Koichi; Hulse, Michael; Agarwal, Anjana; Carter, Jack; Sivakumar, Monisha; Vykuntam, Komali; Wang, Min; Cowart, Miles; Cote, Joy; -MacDonald, William Gowen; Torres, Brian Vidal; Kurian, Justin; Bhagwat, Neha; Fultang, Norman; Grego, Alexander; Moore, Andrew; Schwab, Ashley; Burtell, Jessica; Osinubi, Olusola Peace; Spruance, Jacob; Lu, Liang; Pitis, Philip; Basch, Corey; Bersch, Klare; Dai, Chaofeng; Leal, Raul; Shvartsbart, Artem; Cao, Ganfeng; Shen, Bo; Wen, Patrick; Rager, Joseph; Kuskovsky, Ross; Landman, Bob; Emm, Tom; Ruepp, Stefan; Qin, Chunhua; Paris, Gina; Xavier, Jennifer; Chiaverelli, Rachel; Lee, Sang Hyun; Geeganage, Sandy; Lin, Hong; Heiser, Diane; Ruggeri, Bruce; Babbar, Naveen; Combs, Andrew; Scherle, Peggy 分享 收藏 A phase 1 dose-escalation study of PRT2527, a cyclin-dependent kinase 9 (CDK9) inhibitor, in adult patients with advanced solid tumors: An updated analysisPatel, Manish R.; Basu-Mallick, Astrayee; Dela Cruz, Filemon; Orr, Douglas; Spira, Alex; Sonpavde, Guru P.; Ghatalia, Pooja; Lihou, Christine; Sharma, Neelesh; Scherle, Peggy; Sun, William; Sahasranaman, Sri; Henry, Jason T. 分享 收藏 PRMT5 inhibition drives therapeutic vulnerability to combination treatment with BCL-2 inhibition in mantle cell lymphomaBrown-Burke, Fiona; Hwang, Inah; Sloan, Shelby; Hinterschied, Claire; Helmig-Mason, Jobeth; Long, Mackenzie; Chan, Wing Keung; Prouty, Alexander; Chung, Ji-Hyun; Zhang, Yang; Singh, Satishkumar; Youssef, Youssef; Bhagwat, Neha; Chen, Zhengming; Chen-Kiang, Selina; Di Liberto, Maurizio; Elemento, Olivier; Sehgal, Lalit; Alinari, Lapo; Vaddi, Kris; Scherle, Peggy; Lapalombella, Rosa; Paik, Jihye; Baiocchi, Robert A. 分享 收藏 A phase 1, open-label, multicenter, dose-escalation study of PRT2527, a cyclin-dependent kinase 9 (CDK9) inhibitor, in adult patients (pts) with advanced solid tumorsHenry, Jason T.; Orr, Douglas; Basu-Mallick, Atrayee; Spira, Alex; Lihou, Christine; Sharma, Neelesh; Scherle, Peggy; Chiaverelli, Rachel; Patel, Manish R. 分享 收藏 PRT543, a methyl transferase inhibitor, has potent anti-tumor activity against adenoid cystic carcinoma of salivary glandsMishra, Vasudha; Singh, Alka; Chen, Xiangying; Korzinkin, Michael; Wing, Claudia; Sarkisova, Viktoria; Ozerova, Alexandra; Glushchenko, Oksana; Thodima, Venkat; Ito, Koichi; Scherle, Peggy; Lingen, Mark; Hasina, Rifat; Pearson, Alexander; Rosenberg, Ari; Zhavoronkov, Alex; Ruggeri, Bruce; Agrawal, Nishant; Izumchenko, Evgeny 分享 收藏 分享 收藏 Selective and orally bioavailable SMARCA2 targeted degraders induce synthetic lethality in SMARCA4-deficient solid tumorIto, Koichi; Shvartsbart, Artem; Rager, Joseph; Agarwal, Anjana; Hulse, Michael; Vykuntam, Komali; Wang, Min; Kurian, Justin; Cowart, Miles; Cote, Joy; Sivakumar, Monisha; Carter, Jack; Burtell, Jessica; Grego, Alex; Moore, Andrew; Bhagwat, Neha; Ruepp, Stefan; Emme, Tom; Lu, Liang; Pitis, Philip; Basch, Corey; Bersch, Klare; Mei, Song; Leal, Raul; Rose, John; Roth, Danielle; Cao, Ganfeng; Vaddi, Kris; Geeganage, Sandy; Ruggeri, Bruce; Combs, Andrew; Scherle, Peggy 分享 收藏 分享 收藏 
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
