未登录An experimental medicine protocol for exploring the haemodynamic effects of dual agonism at the glucagon-like peptide-1 and glucagon receptor in healthy subjects一项探索健康受试者中胰高血糖素样肽-1和胰高血糖素受体双重激动作用的血流动力学效应的实验性药物方案
Goodman, James; Parker, Victoria E.; McEniery, Carmel M.; Di Stefano, Giovanni; Hubsch, Annette; Vamvaka, Evangelia; Helmy, Jo; Kaloyirou, Fotini; Jalaludeen, Navazh; Barker, Peter; Jermutus, Lutz; Cheriyan, Joseph; Ambery, Philip; Wilkinson, Ian B. .png)
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收藏Cotadutide reversible self-assembly based long-acting injectable depot for sustained delivery of GLP-1 glucagon receptor agonists with controlled burst release基于Cotadutide可逆自组装的长效注射 depot，用于GLP-1胰高血糖素受体激动剂的持续递送与可控爆发释放Yang, Bin; Devalla, Durga; Sonzini, Silvia; Boberg, Mikael; Gopaul, Sashi; Sundqvist, Monika; Grant, Iain; Jones, Christopher; Brookes, Stephanie; Weidauer, Cindy; Paladino, Eleonora; Mahmoudi, Najet; van Rooyen, Jason; Santos, Ana Gomes dos; Laru, Johanna; Campbell, Andy; Jermutus, Lutz; Bak, Annette 分享 收藏 A novel long-acting relaxin-2 fusion, AZD3427, improves cardiac performance in non-human primates with cardiac dysfunction一种新型的长效松弛素-2融合蛋白AZD3427能够改善心脏功能不全的非人灵长类动物的心脏功能。Papworth, Monika; Kulkarni, Spoorthy; Antonsson, Madeleine; Sermadiras, Isabelle; Hovdal, Daniel; Connolly, Kathleen; Olsson, Jan; Shukla, Animesh; Cotton, Peter; Althage, Magnus; Paterson, Judy; Martin, Esther; Wolny, Marcin; Ferraro, Franco; Sadowska, Agnieszka; Hao, Weidong; Larsson, Niklas; Backmark, Anna; Marlow, Tom; Perez, Rosario; Jermutus, Lutz; Omar, Sami; George, Richard T.; Gabrielsen, Anders; Pettersen, Daniel; Jennbacken, Karin 分享 收藏 A randomized phase 2b trial examined the effects of the glucagon-like peptide-1 and glucagon receptor agonist cotadutide on kidney outcomes in patients with diabetic kidney disease一项随机2b期试验研究了胰高血糖素样肽-1和胰高血糖素受体激动剂阿他多肽对糖尿病肾病患者肾脏结局的影响Selvarajah, Viknesh; Robertson, Darren; Hansen, Lars; Jermutus, Lutz; Smith, Kirsten; Coggi, Angela; Chang, Yi-Ting; Sanchez, Jose; Yu, Hongtao; Parkinson, Joanna; Khan, Anis; Chung, H. Sophia; Hess, Sonja; Dumas, Richard; Duck, Tabbatha; Jolly, Simran; Elliott, Tom G.; Baker, John; Lecube, Albert; Peters, Carl; Derwahl, Karl-Michael; Scott, Russell; Morales, Cristobal; Goldenberg, Ronald; Parker, Victoria E. R.; Heerspink, Hiddo J. L. 分享 收藏 The dual GLP-1/glucagon receptor agonist G49 mimics bariatric surgery effects by inducing metabolic rewiring and inter-organ crosstalkValdecantos, M. Pilar; Ruiz, Laura; Folgueira, Cintia; Rada, Patricia; Gomez-Santos, Beatriz; Solas, Maite; Hitos, Ana B.; Field, Joss; Francisco, Vera; Escalona-Garrido, Carmen; Zagmutt, Sebastian; Calderon-Dominguez, Maria; Mera, Paula; Garcia-Martinez, Irma; Maymo-Masip, Elsa; Grajales, Diana; Alen, Rosa; Mora, Alfonso; Sainz, Neira; Vides-Urrestarazu, Irene; Vilarrasa, Nuria; Arbones-Mainar, Jose M.; Zaragoza, Carlos; Moreno-Aliaga, Maria J.; Aspichueta, Patricia; Fernandez-Veledo, Sonia; Vendrell, Joan; Serra, Dolors; Herrero, Laura; Schreiber, Renate; Zechner, Rudolf; Sabio, Guadalupe; Hornigold, David; Rondinone, Cristina M.; Jermutus, Lutz; Grimsby, Joseph; Valverde, angela M. 分享 收藏 分享 收藏 Dual glucagon-like peptide-1 and glucagon receptor agonism reduces energy intake in type 2 diabetes with obesityGolubic, Rajna; Kennet, Jane; Parker, Victoria; Robertson, Darren; Luo, Dan; Hansen, Lars; Jermutus, Lutz; Ambery, Phil; Ryaboshapkina, Maria; Surakala, Manasa; Laker, Rhianna C.; Venables, Michelle; Koulman, Albert; Park, Adrian; Evans, Mark 分享 收藏 分享 收藏 Erratum. Effects of Cotadutide on Metabolic and Hepatic Parameters in Adults With Overweight or Obesity and Type 2 Diabetes: A 54-Week Randomized Phase 2b Study. Diabetes Care (vol 44,pg 1433-1442, 2022)Nahra, Rajaa; Wang, Tao; Gadde, Kishore M.; Oscarsson, Jan; Stumvoll, Michael; Jermutus, Lutz; Hirshberg, Boaz; Ambery, Philip 分享 收藏 分享 收藏 Efficacy and safety of cotadutide, a dual glucagon-like peptide-1 and glucagon receptor agonist, in a randomized phase 2a study of patients with type 2 diabetes and chronic kidney diseaseParker, Victoria E. R.; Hoang, Thuong; Schlichthaar, Heike; Gibb, Fraser W.; Wenzel, Barbara; Posch, Maximillian G.; Rose, Ludger; Chang, Yi-Ting; Petrone, Marcella; Hansen, Lars; Ambery, Philip; Jermutus, Lutz; Heerspink, Hiddo J. L.; McCrimmon, Rory J. 分享 收藏 分享 收藏 The Human and Mouse Islet Peptidome: Effects of Obesity and Type 2 Diabetes, and Assessment of Intraislet Production of Glucagon-like Peptide-1人类和小鼠胰岛肽组: 肥胖和2型糖尿病的影响，以及胰高血糖素样肽-1的胰岛内产生的评估Galvin, Sam G.; Kay, Richard G.; Foreman, Rachel; Larraufie, Pierre; Meek, Claire L.; Biggs, Emma; Ravn, Peter; Jermutus, Lutz; Reimann, Frank; Gribble, Fiona M. 分享 收藏 分享 收藏 Efficacy and Safety of Cotadutide, a Dual GLP-1 and Glucagon Receptor Agonist in Patients with T2DM and DKDParker, Victoria E.; Hoang, Thuong; Schlichthaar, Heike; Gibb, Fraser W.; Wenzel, Barbara; Posch, Maximilian G.; Chang, Yi-Ting; Petrone, Marcella; Hansen, Lars; Ambery, Philip; Heerspink, Hiddo L.; Mccrimmon, Rory J.; Jermutus, Lutz 分享 收藏 An Exploratory Phase 2a, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Effect of Cotadutide on Energy Balance in Overweight and Obese Subjects with Type 2 Diabetes MellitusGolubic, Rajna; Kennet, Jane; Parker, Victoria E.; Robertson, Darren; Luo, Dan; Hansen, Lars; Jermutus, Lutz; Ambery, Philip; Park, Adrian; Evans, Mark 分享 收藏 Pharmacokinetics, safety, tolerability and efficacy of cotadutide, a glucagon-like peptide-1 and glucagon receptor dual agonist, in phase 1 and 2 trials in overweight or obese participants of Asian descent with or without type 2 diabetesAsano, Michiko; Sekikawa, Akiko; Kim, Hyosung; Gasser, Robert A., Jr.; Robertson, Darren; Petrone, Marcella; Jermutus, Lutz; Ambery, Philip 分享 收藏 Follicular helper T cell profiles predict response to costimulation blockade in type 1 diabetes滤泡辅助T细胞谱可预测1型糖尿病对共刺激阻滞的反应Edner, Natalie M.; Heuts, Frank; Thomas, Niclas; Wang, Chun Jing; Petersone, Lina; Kenefeck, Rupert; Kogimtzis, Alexandros; Ovcinnikovs, Vitalijs; Ross, Ellen M.; Ntavli, Elisavet; Elfaki, Yassin; Eichmann, Martin; Baptista, Roman; Ambery, Philip; Jermutus, Lutz; Peakman, Mark; Rosenthal, Miranda; Walker, Lucy S. K. 分享 收藏 Cotadutide (medi0382), a Dual Receptor Agonist with Glucagon-Like Peptide-1 and Glucagon Activity, Modulates Hepatic Glycogen and Fat ContentRobertson, Darren; Hansen, Lars; Ambery, Philip; Esterline, Russell L.; Jermutus, Lutz; Chang, Yi-Ting; Petrone, Marcella; Johansson, Edvin; Johansson, Lars; Sjoberg, Folke B.; Parker, Victoria 分享 收藏 Cotadutide, a GLP-1/GCG Receptor Co-Agonist, Improves Insulin Sensitivity and Restores Normal Insulin Secretory Capacity in DIO MiceLaker, Rhianna C.; Lantier, Louise; Mcguinness, Owen; Will, Sarah; Kuszpit, Kyle; Alfaro, Alex R.; Jermutus, Lutz; Rhodes, Christopher J. 分享 收藏 
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