未登录 The dual GLP-1/glucagon receptor agonist G49 mimics bariatric surgery effects by inducing metabolic rewiring and inter-organ crosstalk Valdecantos, M. Pilar; Ruiz, Laura; Folgueira, Cintia; Rada, Patricia; Gomez-Santos, Beatriz; Solas, Maite; Hitos, Ana B.; Field, Joss; Francisco, Vera; Escalona-Garrido, Carmen; Zagmutt, Sebastian; Calderon-Dominguez, Maria; Mera, Paula; Garcia-Martinez, Irma; Maymo-Masip, Elsa; Grajales, Diana; Alen, Rosa; Mora, Alfonso; Sainz, Neira; Vides-Urrestarazu, Irene; Vilarrasa, Nuria; Arbones-Mainar, Jose M.; Zaragoza, Carlos; Moreno-Aliaga, Maria J.; Aspichueta, Patricia; Fernandez-Veledo, Sonia; Vendrell, Joan; Serra, Dolors; Herrero, Laura; Schreiber, Renate; Zechner, Rudolf; Sabio, Guadalupe; Hornigold, David; Rondinone, Cristina M.; Jermutus, Lutz; Grimsby, Joseph; Valverde, angela M. 分享 收藏
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High-throughput mediation analysis of human proteome and metabolome identifies mediators of post-bariatric surgical diabetes control Dreyfuss, Jonathan M.; Yuchi, Yixing; Dong, Xuehong; Efthymiou, Vissarion; Pan, Hui; Simonson, Donald C.; Vernon, Ashley; Halperin, Florencia; Aryal, Pratik; Konkar, Anish; Sebastian, Yinong; Higgs, Brandon W.; Grimsby, Joseph; Rondinone, Cristina M.; Kasif, Simon; Kahn, Barbara B.; Foster, Kathleen; Seeley, Randy; Goldfine, Allison; Djordjilovic, Vera; Patti, Mary Elizabeth 分享 收藏
Resolution of NASH and hepatic fibrosis by the GLP-1R and GCGR dual-agonist cotadutide via modulating mitochondrial function and lipogenesis GLP-1R和GCGR双激动剂可通过调节线粒体功能和脂肪生成来解决NASH和肝纤维化 Boland, Michelle L.; Laker, Rhianna C.; Mather, Karly; Nawrocki, Arkadiusz; Oldham, Stephanie; Boland, Brandon B.; Lewis, Hilary; Conway, James; Naylor, Jacqueline; Guionaud, Silvia; Feigh, Michael; Veidal, Sanne S.; Lantier, Louise; McGuinness, Owen P.; Grimsby, Joseph; Rondinone, Cristina M.; Jermutus, Lutz; Larsen, Martin R.; Trevaskis, James L.; Rhodes, Christopher J. 分享 收藏
Engineering of a GLP-1 analogue peptide/anti-PCSK9 antibody fusion for type 2 diabetes treatment Chodorge, Matthieu; Celeste, Anthony J.; Grimsby, Joseph; Konkar, Anish; Davidsson, Pia; Fairman, David; Jenkinson, Lesley; Naylor, Jacqueline; White, Nicholas; Seaman, Jonathan C.; Dickson, Karen; Kemp, Benjamin; Spooner, Jennifer; Rossy, Emmanuel; Hornigold, David C.; Trevaskis, James L.; Bond, Nicholas J.; London, Timothy B.; Buchanan, Andrew; Vaughan, Tristan; Rondinone, Cristina M.; Osbourn, Jane K. 分享 收藏
Differential Effects of a Glucagon-Like Peptide 1 Receptor Agonist in Non-Alcoholic Fatty Liver Disease and in Response to Hepatectomy Pilar Valdecantos, M.; Ruiz, Laura; Pardo, Virginia; Castro-Sanchez, Luis; Garcia-Monzon, Carmelo; Lanzon, Borja; Ruperez, Javier; Barbas, Coral; Naylor, Jaqueline; Trevaskis, James L.; Grimsby, Joseph; Rondinone, Cristina M.; Valverde, Angela M. 分享 收藏
Pancreatic β-Cell Rest Replenishes Insulin Secretory Capacity and Attenuates Diabetes in an Extreme Model of Obese Type 2 Diabetes Boland, Brandon B.; Brown, Charles, Jr.; Boland, Michelle L.; Cann, Jennifer; Sulikowski, Michal; Hansen, Gitte; Gronlund, Rikke V.; King, Wanda; Rondinone, Cristina; Trevaskis, James; Rhodes, Christopher J.; Grimsby, Joseph S. 分享 收藏
MEDI0382, a GLP-1/glucagon receptor dual agonist, meets safety and tolerability endpoints in a single-dose, healthy-subject, randomized, Phase 1 study Ambery, Philip D.; Klammt, Sebastian; Posch, Maximillian G.; Petrone, Marcella; Pu, Wenji; Rondinone, Cristina; Jermutus, Lutz; Hirshberg, Boaz 分享 收藏
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MEDI0382, a GLP-1/Glucagon Receptor Dual Agonist, in Patients with Type 2 Diabetes-A Multiple-Ascending-Dose Study Robertson, Darren; Stumvoll, Michael W.; Posch, Maximilian G.; Heise, Tim; Plum-Moerschel, Leona; Klein, Gernot; Tsai, Lan-Feng; Petrone, Marcella; Hirshberg, Boaz; Rondinone, Cristina; Parker, Victoria E.; Jermutus, Lutz; Ambery, Philip 分享 收藏
Robust Glucose Control and Weight Loss after Six Weeks of Treatment with MEDI0382, a Balanced GLP-1/Glucagon Receptor Dual Agonist, in Patients with Type 2 Diabetes Ambery, Philip; Stumvoll, Michael W.; Posch, Maximilian G.; Heise, Tim; Plum-Moerschel, Leona; Tsai, Lan-Feng; Robertson, Darren; Petrone, Marcella; Rondinone, Cristina; Parker, Victoria E.; Hirshberg, Boaz; Jermutus, Lutz 分享 收藏
MEDI0382, a GLP-1 and glucagon receptor dual agonist, in obese or overweight patients with type 2 diabetes: a randomised, controlled, double-blind, ascending dose and phase 2a study MEDI0382，一种GLP-1和胰高血糖素受体双重激动剂，用于肥胖或超重2型糖尿病患者: 一项随机、对照、双盲、递增剂量和2a期研究 Ambery, Philip; Parker, Victoria E.; Stumvoll, Michael; Posch, Maximilian G.; Heise, Tim; Plum-Moerschel, Leona; Tsai, Lan-Feng; Robertson, Darren; Jain, Meena; Petrone, Marcella; Rondinone, Cristina; Hirshberg, Boaz; Jermutus, Lutz 分享 收藏
Neurturin and a GLP-1 Analogue Act Synergistically to Alleviate Diabetes in Zucker Diabetic Fatty Rats Trevaskis, James L.; Sacramento, Chester Bittencourt; Jouihan, Hani; Ali, Safina; Le Lay, John; Oldham, Stephanie; Bhagroo, Nicholas; Boland, Brandon B.; Cann, Jennifer; Chang, Yuan; O'Day, Terrence; Howard, Victor; Reers, Christina; Winzell, Maria Sorhede; Smith, David M.; Feigh, Michael; Barkholt, Pernille; Schreiter, Kay; Austen, Matthias; Andag, Uwe; Thompson, Simon; Jermutus, Lutz; Coghlan, Matthew P.; Grimsby, Joseph; Dohrmann, Cord; Rhodes, Christopher J.; Rondinone, Cristina M.; Sharma, Arun 分享 收藏
Inhibition of T-cell activation by the CTLA4-Fc Abatacept is sufficient to ameliorate proteinuric kidney disease Herrera, Marcela; Soderberg, Magnus; Sabirsh, Alan; Valastro, Barbara; Molne, Johan; Santamaria, Beatriz; Valverde, Angela M.; Guionaud, Silvia; Heasman, Stephanie; Bigley, Alison; Jermutus, Lutz; Rondinone, Cristina; Coghlan, Matthew; Baker, David; Quinn, Carol Moreno 分享 收藏
Apelin-36 Modulates Blood Glucose and Body Weight Independently of Canonical APJ Receptor Signaling Galon-Tilleman, Hadas; Yang, Hong; Bednarek, Maria A.; Spurlock, Sandra M.; Paavola, Kevin J.; Ko, Brian; To, Carmen; Luo, Jian; Tian, Hui; Jermutus, Lutz; Grimsby, Joseph; Rondinone, Cristina M.; Konkar, Anish; Kaplan, Daniel D. 分享 收藏
A Novel Glucagon-Like Peptide 1/Glucagon Receptor Dual Agonist Improves Steatohepatitis and Liver Regeneration in Mice Valdecantos, M. Pilar; Pardo, Virginia; Ruiz, Laura; Castro-Sanchez, Luis; Lanzon, Borja; Fernandez-Millan, Elisa; Garcia-Monzon, Carmelo; Arroba, Ana I.; Gonzalez-Rodriguez, Agueda; Escriva, Fernando; Alvarez, Carmen; Ruperez, Francisco J.; Barbas, Coral; Konkar, Anish; Naylor, Jacqui; Hornigold, David; Dos Santos, Ana; Bednarek, Maria; Grimsby, Joseph; Rondinone, Cristina M.; Valverde, Angela M. 分享 收藏
Robust anti-obesity and metabolic effects of a dual GLP-1/glucagon receptor peptide agonist in rodents and non-human primates 双重GLP-1/胰高血糖素受体肽激动剂在啮齿动物和非人灵长类动物中的抗肥胖和代谢作用 Henderson, S. J.; Konkar, A.; Hornigold, D. C.; Trevaskis, J. L.; Jackson, R.; Fritsch Fredin, M.; Jansson-Loefmark, R.; Naylor, J.; Rossi, A.; Bednarek, M. A.; Bhagroo, N.; Salari, H.; Will, S.; Oldham, S.; Hansen, G.; Feigh, M.; Klein, T.; Grimsby, J.; Maguire, S.; Jermutus, L.; Rondinone, C. M.; Coghlan, M. P. 分享 收藏
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