Edward B. Lee - Publications, H-index & Citations

Edward B. Lee

University of Pennsylvania

78H指数

430论文数

2.7W被引数

收录论文 216

发表时间

Repositioning of polyubiquitin alters the pathologic tau filament structure

NATURE STRUCTURAL & MOLECULAR BIOLOGY

IF10.1

2026-08-31

OAAI

Ryohei Watanabe; Benjamin C. Creekmore; Nabil F. Darwich; Courtney L. Smith; Hong Xu; Angelina Baltazar; Sacha Salphati; Lakshmi Changolkar; Kevt’her Hoxha; Bin Zhang; Caroline M. O’Rourke; George M. Burslem; Virginia M.-Y. Lee; Yi-Wei Chang; Edward B. Lee

An acetylated Tau-174 CSF biomarker discriminates between TDP-43 and tau pathology in patients with frontotemporal lobar degeneration 乙酰化Tau-174 CSF生物标志物区分额颞叶变性患者的TDP-43和tau病理

Nature Medicine

IF50

2026-04-15

OAAI

Madison I. J. Honey; Yanaika S. Hok-A-Hin; Elisabeth H. Thijssen; Katheryn A. Q. Cousins; Babette van der Weijden; Lisanne in ‘t Veld; Erik Stoops; Sterre C. M. de Boer; Flora H. Duits; Julie F. H. de Houwer; Tjado H. J. Morrema; Daniel Alcolea; Ignacio Illán-Gala; Juan Fortea; Alberto Lleó; Adam L. Boxer; David J. Irwin; Edward B. Lee; Leslie Shaw; Corey T. McMillan; David A. Wolk; Jeroen J. M. Hoozemans; Wiesje M. van der Flier; Emma van der Ende; Harro Seelaar; Inge M. W. Verberk; Li Gan; Yolande Pijnenburg; Charlotte E. Teunissen

VIOLET: Volumetric Image registration via Optimization and Learning for Efficient image Translation VIOLET：基于优化和学习的体素图像配准高效图像转换

SIMULATION AND SYNTHESIS IN MEDICAL IMAGING, SASHIMI 2025

IF0

2026-01-01

PREAI

Khandelwal, Pulkit; Duong, Michael Tran; Levorse, Lisa M.; Lim, Sydney A.; Gauthier, Nathaniel; Shenoy, Ved; Chung, Eunice; Denning, Amanda E.; Bahena, Alejandra; Trotman, Winifred; Olm, Christopher A.; Radhakrishnan, Hamsanandini; Ittyerah, Ranjit; Prabhakaran, Karthik; Mizsei, Gabor; Schuck, Theresa; Robinson, John; Ohm, Daniel T.; Phillips, Jeffrey S.; Detre, John A.; Lee, Edward B.; Irwin, David J.; McMillan, Corey T.; Tisdall, M. Dylan; Das, Sandhitsu R.; Wolk, David A.; Yushkevich, Paul A.

Polygenic associations with clinical and neuropathological trait heterogeneity across TDP-43 proteinopathies 多基因与TDP-43蛋白病中临床和神经病理学表型异质性的关联

PLoS One

IF2.6

2025-12-30

PREAI

Spencer, Barbara E.; Irwin, David J.; Van Deerlin, Vivianna M.; Suh, EunRan; Lee, Edward B.; Elman, Lauren; Quinn, Colin C.; Amado, Defne; Baer, Michael; Grossman, Murray; Wolk, David A.; McMillan, Corey T.

Morphological and Hyperphosphorylation Transitions of Nanoscale Tau Aggregates in Alzheimer's Disease 阿尔茨海默病中纳米级Tau聚集体的形态学和高磷酸化转变

Advanced Science

IF14.1

2025-11-19

OAAI

Adriana N. Santiago-Ruiz; Siewert Hugelier; Gabriela L. Correa; Charles R. Bond; Edward B. Lee; Melike Lakadamyali

LRRK2 kinase-mediated accumulation of lysosome-associated phospho-Rabs in tauopathies and synucleinopathies LRRK2激酶介导的溶酶体相关磷酸化Rabs在tau蛋白病和synucleinopathy中的积聚

Acta Neuropathologica

IF9.3

2025-10-23

OAAI

Silas A. Buck; Tuyana Malankhanova; Samuel Strader; Eileen B. Ma; Sarah Yim; Harrison W. Pratt; John Ervin; Edward B. Lee; Shih-Hsiu J. Wang; Todd J. Cohen; Andrew B. West; Laurie H. Sanders

Celebrating neuropathology's contributions to Alzheimer's Disease Research Centers 庆祝神经病理学对阿尔茨海默病研究中心的贡献

Alzheimer's & Dementia

IF11.1

2025-10-14

OAAI

D. Luke Fischer; Lea T. Grinberg; Jared T. Ahrendsen; Thomas G. Beach; Kevin F. Bieniek; Rudolph J. Castellani; Rati Chkheidze; Inma Cobos; Mark Cohen; John F. Crary; Dennis W. Dickson; Brittany N. Dugger; Sara R. Dunlop; Kurt Farrell; Bernardino Ghetti; Mohammad Haeri; William Harrison; Elizabeth Head; Annie Hiniker; Eric J. Huang; Anita Huttner; Pouya Jamshidi; Alifiya Kapasi; C. Dirk Keene; Julia Kofler; Caitlin S. Latimer; Ann C. McKee; Karin Mente; Michael B. Miller; Thomas J. Montine; Meaghan Morris; Melissa E. Murray; Peter T. Nelson; Kathy L. Newell; Richard J. Perrin; Biswarathan Ramani; R. Ross Reichard; Subhojit Roy; Johannes C. M. Schlachetzki; William W. Seeley; Geidy E. Serrano; Salvatore Spina; Andrew F. Teich; Shih-Hsiu J. Wang; Thomas Wisniewski; Edward B. Lee

Connectivity as a universal predictor of tau progression in atypical Alzheimer's disease 连接性作为非典型阿尔茨海默病中tau进展的通用预测因子。

BRAIN

IF11.7

2025-10-01

PREAI

de Bruin, Hannah; Groot, Colin; Barthel, Henryk; Bischof, Gerard N.; Blazhenets, Ganna; Boellaard, Ronald; Boon, Baayla D. C.; Brendel, Matthias; Cash, David M.; Coath, William; Day, Gregory S.; Dickerson, Bradford C.; Doering, Elena; Drzezga, Alexander; van Dyck, Christopher H.; van Eimeren, Thilo; van der Flier, Wiesje M.; Fredericks, Carolyn A.; Fryer, Tim D.; van de Giessen, Elsmarieke; Gordon, Brian A.; Graff-Radford, Jonathan; Grinberg, Lea T.; Hansson, Oskar; Hobbs, Diana A.; Hoenig, Merle C.; Hoglinger, Gunter; Irwin, David J.; Jones, P. Simon; Josephs, Keith A.; Katsumi, Yuta; La Joie, Renaud; Lee, Edward B.; Levin, Johannes; Malpetti, Maura; Mcginnis, Scott M.; Mecca, Adam P.; Mohanty, Rosaleena; Nasrallah, Ilya M.; O'Brien, John T.; O'Dell, Ryan S.; Palleis, Carla; Perneczky, Robert; Phillips, Jeffrey S.; Putcha, Deepti; Rabinovici, Gil D.; Rahmouni, Nesrine; Rosa-Neto, Pedro; Rowe, James B.; Rullmann, Michael; Sabri, Osama; Saur, Dorothee; Schildan, Andreas; Schott, Jonathan M.; Schroeter, Matthias L.; Seeley, William W.; Servaes, Stijn; Sintini, Irene; Smith, Ruben; Spina, Salvatore; Stevenson, Jenna; Stomrud, Erik; Strandberg, Olof; Therriault, Joseph; Tideman, Pontus; Touroutoglou, Alexandra; Trainer, Anne E.; Visser, Denise; Wekselman, Fattin; Weston, Philip S. J.; Whitwell, Jennifer L.; Wolk, David A.; Yong, Keir; Pijnenburg, Yolande A. L.; Franzmeier, Nicolai; Ossenkoppele, Rik

Comparison of plasma p-tau217/Aβ42, p-tau217, and Aβ42/Aβ40 biomarkers by race to detect Alzheimer's disease 比较不同种族中血浆p-tau217/Aβ42、p-tau217和Aβ42/Aβ40生物标志物对阿尔茨海默病的检测能力

Alzheimer's & Dementia

IF11.1

2025-08-13

OAAI

Katheryn A. Q. Cousins; Magdalena Korecka; Yang Wan; Amberley Vulaj; Christopher Brown; Thomas F. Tropea; Edward B. Lee; Duygu Tosun; Susan M. Landau; Ozioma C. Okonkwo; Monica Rivera Mindt; Michael W. Weiner; David J. Irwin; David A. Wolk; Leslie M. Shaw; and the Alzheimer's Disease Neuroimaging Initiative

Accelerating biomedical discoveries in brain health through transformative neuropathology of aging and neurodegeneration 通过衰老和神经退行性变的变革性神经病理学加速脑健康生物医学发现

Neuron

IF15

2025-07-18

OAAI

Melissa E. Murray; Colin Smith; Vilas Menon; C. Dirk Keene; Ed Lein; Michael Hawrylycz; Adriano Aguzzi; Brett Benedetti; Katja Brose; Kelsey Caetano-Anolles; Maria Inmaculada Cobos Sillero; John F. Crary; Philip L. De Jager; Arline Faustin; Margaret E. Flanagan; Ozgun Gokce; Seth G.N. Grant; Lea T. Grinberg; David A. Gutman; Elizabeth M.C. Hillman; Zhi Huang; David J. Irwin; David T. Jones; Alifiya Kapasi; Celeste M. Karch; Walter T. Kukull; Tammaryn Lashley; Edward B. Lee; Thomas Lehner; Laura Parkkinen; Maria Pedersen; Dominique Pritchett; Matthew H. Rutledge; Julie A. Schneider; William W. Seeley; Claire E. Shepherd; Tara L. Spires-Jones; Judith A. Steen; Margaret Sutherland; Sanja Vickovic; Bin Zhang; David J. Stewart; Michael J. Keiser; Jacob W. Vogel; Brittany N. Dugger; Hemali Phatnani

Deciphering distinct genetic risk factors for FTLD-TDP pathological subtypes via whole-genome sequencing 通过全基因组测序破译ftld-tdp病理亚型的不同遗传危险因素

NATURE COMMUNICATIONS

IF15.7

2025-04-25

OAAI

Pottier, Cyril; Kuecuekali, Fahri; Baker, Matt; Batzler, Anthony; Jenkins, Gregory D.; van Blitterswijk, Marka; Vicente, Cristina T.; De Coster, Wouter; Wynants, Sarah; van de Walle, Pieter; Ross, Owen A.; Murray, Melissa E.; Faura, Julia; Haggarty, Stephen J.; van Rooij, Jeroen GJ.; Mol, Merel O.; Hsiung, Ging-Yuek R.; Graff, Caroline; Oeijerstedt, Linn; Neumann, Manuela; Asmann, Yan; Mcdonnell, Shannon K.; Baheti, Saurabh; Josephs, Keith A.; Whitwell, Jennifer L.; Bieniek, Kevin F.; Forsberg, Leah; Heuer, Hilary; Lago, Argentina Lario; Geier, Ethan G.; Yokoyama, Jennifer S.; Oddi, Alexis P.; Flanagan, Margaret; Mao, Qinwen; Hodges, John R.; Kwok, John B.; Domoto-Reilly, Kimiko; Synofzik, Matthis; Wilke, Carlo; Onyike, Chiadi; Dickerson, Bradford C.; Evers, Bret M.; Dugger, Brittany N.; Munoz, David G.; Keith, Julia; Zinman, Lorne; Rogaeva, Ekaterina; Suh, Eunran; Gefen, Tamar; Geula, Changiz; Weintraub, Sandra; Diehl-Schmid, Janine; Farlow, Martin R.; Edbauer, Dieter; Woodruff, Bryan K.; Caselli, Richard J.; Donker Kaat, Laura L.; Huey, Edward D.; Reiman, Eric M.; Mead, Simon; King, Andrew; Roeber, Sigrun; Nana, Alissa L.; Ertekin-Taner, Nilufer; Knopman, David S.; Petersen, Ronald C.; Petrucelli, Leonard; Uitti, Ryan J.; Wszolek, Zbigniew K.; Ramos, Eliana Marisa; Grinberg, Lea T.; Tempini, Maria Luisa Gorno; Rosen, Howard J.; Spina, Salvatore; Piguet, Olivier; Grossman, Murray; Trojanowski, John Q.; Keene, C. Dirk; Jin, Lee-Way; Prudlo, Johannes; Geschwind, Daniel H.; Rissman, Robert A.; Cruchaga, Carlos; Ghetti, Bernardino; Halliday, Glenda M.; Beach, Thomas G.; Serrano, Geidy E.; Arzberger, Thomas; Herms, Jochen; Boxer, Adam L.; Honig, Lawrence S.; Vonsattel, Jean P.; Lopez, Oscar L.; Kofler, Julia; White, Charles L.; Gearing, Marla; Glass, Jonathan; Rohrer, Jonathan D.; Irwin, David J.; Lee, Edward B.; Van Deerlin, Vivianna; Castellani, Rudolph; Mesulam, Marsel M.; Tartaglia, Maria C.; Finger, Elizabeth C.; Troakes, Claire; Al-Sarraj, Safa; Dalgard, Clifton L.; Miller, Bruce L.; Seelaar, Harro; Graff-Radford, Neill R.; Boeve, Bradley F.; Mackenzie, Ian RA.; van Swieten, John C.; Seeley, William W.; Sleegers, Kristel; Dickson, Dennis W.; Biernacka, Joanna M.; Rademakers, Rosa

Consecutive brain biopsies illustrate the histological evolution of acute hemorrhagic leukoencephalitis 连续脑活检显示了急性出血性 leukoencephalitis 的组织学演变。

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

IF3

2025-04-04

PREAI

Jones, Felipe J. S.; Pai, Emily Ling-Lin; Magee, Rogan; Boylan, Kelly; Chioma, Vivian; Little, Jessica; Yoshor, Daniel; Pascual, Jose L.; Banihashemi, Amir; Prasad, Sashank; Lee, Edward B.

Traumatic brain injury or head impacts from contact sports are associated with tau astrogliopathy 创伤性脑损伤或接触性运动中的头部冲击与tau星形胶质细胞病相关联

BRAIN

IF11.7

2025-04-02

PREAI

Arena, John D.; Stewart, William; Kovacs, Gabor G.; Lee, Edward B.; Robinson, John L.; Lee, Virginia M. Y.; Trojanowski, John Q.; Schneider, Andrea L. C.; Smith, Douglas H.; Johnson, Victoria E.

Calcium modulating ligand confers risk for Parkinson's disease and impacts lysosomes

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY

IF3.9

2025-03-01

OAAI

Zhang, Hanwen; Kargilis, Daniel; Tropea, Thomas; Robinson, John; Shen, Junchao; Brody, Eliza M.; Brinkmalm, Ann; Sjodin, Simon; Berndt, Adama J.; Carceles-Cordon, Marc; Suh, Eunran; Van Deerlin, Vivianna M.; Blennow, Kaj; Weintraub, Daniel; Lee, Edward B.; Zetterberg, Henrik; Chen-Plotkin, Alice S.

Disparate and shared transcriptomic signatures associated with cortical atrophy in genetic behavioral variant frontotemporal degeneration 与遗传性行为变异型额颞叶萎缩相关的差异性和共享性转录组特征

MOLECULAR NEURODEGENERATION

IF17.5

2025-02-07

OAAI

Shen, Ting; Vogel, Jacob W.; Van Deerlin, Vivianna M.; Suh, Eunran; Dratch, Laynie; Phillips, Jeffrey S.; Massimo, Lauren; Lee, Edward B.; Irwin, David J.; Mcmillan, Corey T.

Comparison of the amyloid plaque proteome in Down syndrome, early-onset Alzheimer's disease, and late-onset Alzheimer's disease Down综合征、早发性阿尔茨海默病和晚发性阿尔茨海默病中淀粉样斑块蛋白质组的比较

ACTA NEUROPATHOLOGICA

IF0

2025-01-18

OAAI

Martá-Ariza, M; Leitner, DF; Kanshin, E; Suazo, J; Pedrosa, AG; Thierry, M; Lee, EB; Devinsky, O; Drummond, E; Fortea, J; Lleó, A; Ueberheide, B; Wisniewski, T

Posterior hippocampal sparing in Lewy body disorders with Alzheimer's copathology: An in vivo MRI study 具有阿尔茨海默氏病的路易斯体疾病的海马后部保留: 体内MRI研究

NEUROIMAGE-CLINICAL

IF3.6

2025-01-01

OAAI

Cohen, Jesse S.; Phillips, Jeffrey; Das, Sandhitsu R.; Olm, Christopher A.; Radhakrishnan, Hamsanandini; Rhodes, Emma; Cousins, Katheryn A. Q.; Xie, Sharon X.; Nasrallah, Ilya M.; Yushkevich, Paul A.; Wolk, David A.; Lee, Edward B.; Weintraub, Daniel; Irwin, David J.; Mcmillan, Corey T.

Cumulative incidence of motor and cognitive features in the amyotrophic lateral sclerosis-frontotemporal degeneration spectrum 运动和认知特征在肌萎缩侧索硬化症-额颞叶变性谱系中的累积发生率

BRAIN COMMUNICATIONS

IF4.5

2025-01-01

OAAI

Spencer, Barbara E.; Xie, Sharon X.; Ohm, Daniel T.; Elman, Lauren; Quinn, Colin C.; Amado, Defne A.; Baer, Michael; Lee, Edward B.; Van Deerlin, Vivianna M.; Dratch, Laynie; Massimo, Lauren; Irwin, David J.; Mcmillan, Corey T.

Overview of Alzheimer's Disease Neuroimaging Initiative and future clinical trials 阿尔茨海默病神经影像学倡议和未来临床试验概述

ALZHEIMERS & DEMENTIA

IF11.1

2024-12-22

OAAI

Weiner, Michael W.; Kanoria, Shaveta; Miller, Melanie J.; Aisen, Paul S.; Beckett, Laurel A.; Conti, Catherine; Diaz, Adam; Flenniken, Derek; Green, Robert C.; Harvey, Danielle J.; Jack Jr, Clifford R.; Jagust, William; Lee, Edward B.; Morris, John C.; Nho, Kwangsik; Nosheny, Rachel; Okonkwo, Ozioma C.; Perrin, Richard J.; Petersen, Ronald C.; Rivera-Mindt, Monica; Saykin, Andrew J.; Shaw, Leslie M.; Toga, Arthur W.; Tosun, Duygu; Veitch, Dallas P.; Alzheimers Disease Neuroimaging Initiative

ADNI Biomarker Core: A review of progress since 2004 and future challenges ADNI生物标志物核心: 2004年进展和未来挑战的回顾

ALZHEIMERS & DEMENTIA

IF11.1

2024-11-30

PREAI

Shaw, Leslie M.; Korecka, Magdalena; Lee, Edward B.; Cousins, Katheryn A. Q.; Vanderstichele, Hugo; Schindler, Suzanne E.; Tosun, Duygu; Demarco, Mari L.; Brylska, Magdalena; Wan, Yang; Burnham, Samantha; Sciulli, Alexandria; Vulaj, Amberley; Tropea, Thomas F.; Chen-Plotkin, Alice; Wolk, David A.

研究方向