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Daniel R. Southworth

university of california san francisco

42H指数
112论文数
5.4K被引数
收录论文 39
发表时间
Hypoxia rescues complex 1-associated disease caused by proteostatic defects缺氧可挽救由蛋白抑制缺陷引起的复合物1相关疾病
err2026-07-08
err0
errOAAI
errAnkur Garg; Brandon R. Desousa; Raju Roy; Amy Flis; Skyler Y. Blume; Yohei Abe; Arthur A. Melo; Ryan R. Cupo; Gabriela Grigorean; Daniel R. Southworth; James Shorter; Isha H. Jain
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An Optimized Route to the Syringolin Natural Products Enables Combinatorial Synthesis of Selective; Bioactive Inhibitors of the Plasmodium falciparum 20S Proteasome优化硫链丝菌素类天然产物合成路线,实现了对恶性疟原虫20S蛋白酶体的选择性生物活性抑制剂的组合合成
err2026-04-01
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PREAI
errXilin Gu; Pavla Fajtova; Nicholas L. Yan; Aditi Saxena; Fan Fei; Jiyun Zhu; Eric Tse; Arthur Melo; Euna Yoo; Nathan H. Buchwald; Daniel R. Southworth; Matthew Bogyo; Joseph L. Derisi; Jason E. Gestwicki; Anthony J. O’Donoghue; Jason K. Sello
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2024 VCP International Conference: Exploring multi-disciplinary approaches from basic science of valosin containing protein, an AAA plus ATPase protein, to the therapeutic advancement for VCP-associated multisystem proteinopathy
err2025-03-01
err0
errOAAI
errPeck, A.; Dadi, A.; Yavarow, Z.; Alfano, L. N.; Anderson, D.; Arkin, M. R.; Chou, T. F.; D'Ambrosio, E. S.; Diaz-Manera, J.; Dudley, J. P.; Elder, A. G.; Ghoshal, N.; Hart, C. E.; Hart, M. M.; Huryn, D. M.; Johnson, A. E.; Jones, K. B.; Kimonis, V.; Kiskinis, E.; Lee, E. B.; Lloyd, T. E.; Mapstone, M.; Martin, A.; Meyer, H.; Mozaffar, T.; Onyike, C. U.; Pfeffer, G.; Pindon, A.; Raman, M.; Richard, I.; Rubinsztein, D. C.; Schiava, M.; Schuetz, A. K.; Shen, P. S.; Southworth, D. R.; Staffaroni, A. M.; Taralio-Gravovac, M.; Weihl, C. C.; Yao, Q.; Ye, Y.; Peck, N.
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Cryo-EM structure of a novel α-synuclein filament subtype from multiple system atrophy
err2024-11-07
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errOAAI
errYan, Nicholas L.; Candido, Francisco; Tse, Eric; Melo, Arthur A.; Prusiner, Stanley B.; Mordes, Daniel A.; Southworth, Daniel R.; Paras, Nick A.; Merz, Gregory E.
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Phosphorylation of tau at a single residue inhibits binding to the E3 ubiquitin ligase, CHIP
err2024-09-12
err0
errOAAI
errNadel, Cory M.; Pokhrel, Saugat; Wucherer, Kristin; Oehler, Abby; Thwin, Aye C.; Basu, Koli; Callahan, Matthew D.; Southworth, Daniel R.; Mordes, Daniel A.; Craik, Charles S.; Gestwicki, Jason E.
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Asymmetric apical domain states of mitochondrial Hsp60 coordinate substrate engagement and chaperonin assembly
err2024-07-01
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errOAAI
errBraxton, Julian R.; Shao, Hao; Tse, Eric; Gestwicki, Jason E.; Southworth, Daniel R.
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Cryo-EM structures reveal tau filaments from Down syndrome adopt Alzheimer's disease fold
err2024-06-12
err0
errOAAI
errGhosh, Ujjayini; Tse, Eric; Yang, Hyunjun; Shi, Marie; Caro, Christoffer D.; Wang, Feng; Merz, Gregory E.; Prusiner, Stanley B.; Southworth, Daniel R.; Condello, Carlo
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Mapping interactions of calmodulin and neuronal NO synthase by crosslinking and mass spectrometry
err2024-01-01
err5
errOAAI
errFelker, Dana; Lee, Kanghyun; Pospiech, Thomas H.; Morishima, Yoshihiro; Zhang, Haoming; Lau, Miranda; Southworth, Daniel R.; Osawa, Yoichi
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The p97/VCP adaptor UBXD1 drives AAA plus remodeling and ring opening through multi-domain tethered interactions
err2023-11-09
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errOAAI
errBraxton, Julian R.; Altobelli, Chad R.; Tucker, Maxwell R.; Tse, Eric; Thwin, Aye C.; Arkin, Michelle R.; Southworth, Daniel R.
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Stacked binding of a PET ligand to Alzheimer's tau paired helical filaments
err2023-05-26
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errOAAI
errMerz, Gregory E. E.; Chalkley, Matthew J. J.; Tan, Sophia K. K.; Tse, Eric; Lee, Joanne; Prusiner, Stanley B. B.; Paras, Nick A. A.; DeGrado, William F. F.; Southworth, Daniel R. R.
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Chemical Features of Polyanions Modulate Tau Aggregation and Conformational States
err2023-02-08
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errOAAI
errMontgomery, Kelly M.; Carroll, Emma C.; Thwin, Aye C.; Quddus, Athena Y.; Hodges, Paige; Southworth, Daniel R.; Gestwicki, Jason E.
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Unique structural features govern the activity of a human mitochondrial AAA plus disaggregase, Skd3
err2022-09-01
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errOAAI
errCupo, Ryan R.; Rizo, Alexandrea N.; Braun, Gabriel A.; Tse, Eric; Chuang, Edward; Gupta, Kushol; Southworth, Daniel R.; Shorter, James
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Practical considerations for using K3 cameras in CDS mode for high-resolution and high-throughput single particle cryo-EM在CDS模式下使用K3相机进行高分辨率和高通量单粒子冷冻EM的实际注意事项
err2021-09-01
err36
errOAAI
errSun, Ming; Azumaya, Caleigh M.; Tse, Eric; Bulkley, David P.; Harrington, Matthew B.; Gilbert, Glenn; Frost, Adam; Southworth, Daniel; Verba, Kliment A.; Cheng, Yifan; Agard, David A.
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The structure of an Hsp90-immunophilin complex reveals cochaperone recognition of the client maturation state
err2021-09-01
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errOAAI
errLee, Kanghyun; Thwin, Aye C.; Nadel, Cory M.; Tse, Eric; Gates, Stephanie N.; Gestwicki, Jason E.; Southworth, Daniel R.
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Conformational plasticity of the ClpAP AAA plus protease couples protein unfolding and proteolysis
err2020-04-20
err51
errOAAI
errLopez, Kyle E.; Rizo, Alexandrea N.; Tse, Eric; Lin, JiaBei; Scull, Nathaniel W.; Thwin, Aye C.; Lucius, Aaron L.; Shorter, James; Southworth, Daniel R.
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Compromised function of the ESCRT pathway promotes endolysosomal escape of tau seeds and propagation of tau aggregation
err2019-12-01
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errOAAI
errChen, John J.; Nathaniel, Diane L.; Raghavan, Preethi; Nelson, Maxine; Tian, Ruilin; Tse, Eric; Hong, Jason Y.; See, Stephanie K.; Mok, Sue-Ann; Hein, Marco Y.; Southworth, Daniel R.; Grinberg, Lea T.; Gestwicki, Jason E.; Leonetti, Manuel D.; Kampmann, Martin
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Mechanistic insights into the protective roles of polyphosphate against amyloid cytotoxicity
err2019-09-18
err19
errOAAI
errLempart, Justine; Tse, Eric; Lauer, James A.; Ivanova, Magdalena I.; Sutter, Alexandra; Yoo, Nicholas; Huettemann, Philipp; Southworth, Daniel; Jakob, Ursula
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Mining Disaggregase Sequence Space to Safely Counter TDP-43, FUS, and α-Synuclein Proteotoxicity
err2019-08-01
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errOAAI
errTariq, Amber; Lin, JiaBei; Jackrel, Meredith E.; Hesketh, Christina D.; Carman, Peter J.; Mack, Korrie L.; Weitzman, Rachel; Gambogi, Craig; Murillo, Oscar A. Hernandez; Sweeny, Elizabeth A.; Gurpinar, Esin; Yokom, Adam L.; Gates, Stephanie N.; Yee, Keolamau; Sudesh, Saurabh; Stillman, Jacob; Rizo, Alexandra N.; Southworth, Daniel R.; Shorter, James
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Allosteric Regulation of Oligomerization by a B12 Trafficking G-Protein Is Corrupted in Methylmalonic Aciduria
err2019-07-01
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errOAAI
errRuetz, Markus; Campanello, Gregory C.; McDevitt, Liam; Yokom, Adam L.; Yadav, Pramod K.; Watkins, David; Rosenblatt, David S.; Ohi, Melanie D.; Southworth, Daniel R.; Banerjee, Ruma
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