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A phase I, first-in-human, dose escalation and expansion study of oral pan-RAF/MEK molecular glue NST-628 in subjects with solid tumors harboring RAS-MAPK pathway alterations 一项I期、首次人体、剂量递增和扩展研究，评估口服泛RAF/MEK分子胶NST-628在携带RAS-MAPK通路异常的实体瘤受试者中的效果。 Lemech, C.; Luke, J. J.; Falchook, G. S.; Mckean, M.; Kichenadasse, G.; Teng, C.; Vandross, A. L.; Salkeni, M. A.; Atkinson, V. G.; Liu, J. J.; Kennedy, A. M.; Clark, J.; Ryan, M.; Schmidt-Kittler, O.; Steinhubel, D.; Wages, D.; Komarnitsky, P.; Puzanov, I. 分享 收藏
Human Tim8a, Tim8b and Tim13 are auxiliary assembly factors of mature Complex IV Anderson, Alexander J.; Crameri, Jordan J.; Ang, Ching-Seng; Malcolm, Tess R.; Kang, Yilin; Baker, Megan J.; Palmer, Catherine S.; Sharpe, Alice J.; Formosa, Luke E.; Ganio, Katherine; Baker, Michael J.; McDevitt, Christopher A.; Ryan, Michael T.; Maher, Megan J.; Stojanovski, Diana 分享 收藏
The African killifish: A short-lived vertebrate model to study the biology of sarcopenia and longevity Ruparelia, Avnika A.; Salavaty, Adrian; Barlow, Christopher K.; Lu, Yansong; Sonntag, Carmen; Hersey, Lucy; Eramo, Matthew J.; Krug, Johannes; Reuter, Hanna; Schittenhelm, Ralf B.; Ramialison, Mirana; Cox, Andrew; Ryan, Michael T.; Creek, Darren J.; Englert, Christoph; Currie, Peter D. 分享 收藏
High ploidy large cytoplasmic megakaryocytes are hematopoietic stem cells regulators and essential for platelet production 高倍性大细胞质巨核细胞是造血干细胞调节剂，对血小板产生至关重要 Heazlewood, Shen Y. Y.; Ahmad, Tanveer; Cao, Benjamin; Cao, Huimin; Domingues, Melanie; Sun, Xuan; Heazlewood, Chad K. K.; Li, Songhui; Williams, Brenda; Fulton, Madeline; White, Jacinta F. F.; Nebl, Tom; Nefzger, Christian M. M.; Polo, Jose M. M.; Kile, Benjamin T. T.; Kraus, Felix; Ryan, Michael T. T.; Sun, Yu B. B.; Choong, Peter F. M.; Ellis, Sarah L. L.; Anko, Minna-Liisa; Nilsson, Susan K. K. 分享 收藏
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Protein import channel of the outer mitochondrial membrane:: a highly stable Tom40-Tom22 core structure differentially interacts with preproteins, small Tom proteins, and import receptors Meisinger, C; Ryan, MT; Hill, K; Model, K; Lim, JH; Sickmann, A; Müller, H; Meyer, HE; Wagner, R; Pfanner, N 分享 收藏
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Caveolae sense oxidative stress through membrane lipid peroxidation and cytosolic release of CAVIN1 to NRF2 Wu, Yeping; Lim, Ye-Wheen; Stroud, David A.; Martel, Nick; Hall, Thomas E.; Lo, Harriet P.; Ferguson, Charles; Ryan, Michael T.; McMahon, Kerrie-Ann; Parton, Robert G. 分享 收藏
Two independent respiratory chains adapt OXPHOS performance to glycolytic switch Fernandez-Vizarra, Erika; Lopez-Calcerrada, Sandra; Sierra-Magro, Ana; Perez-Perez, Rafael; Formosa, Luke E.; Hock, Daniella H.; Illescas, Maria; Penas, Ana; Brischigliaro, Michele; Ding, Shujing; Fearnley, Ian M.; Tzoulis, Charalampos; Pitceathly, Robert D. S.; Arenas, Joaquin; Martin, Miguel A.; Stroud, David A.; Zeviani, Massimo; Ryan, Michael T.; Ugalde, Cristina 分享 收藏
Biallelic pathogenic variants in COX11 are associated with an infantile-onset mitochondrial encephalopathy COX11的双等位基因致病变异与婴儿型线粒体脑病相关 Rius, Rocio; Bennett, Neal K.; Bhattacharya, Kaustuv; Riley, Lisa G.; Yuksel, Zafer; Formosa, Luke E.; Compton, Alison G.; Dale, Russell C.; Cowley, Mark J.; Gayevskiy, Velimir; Al Tala, Saeed M.; Almehery, Abdulrahman A.; Ryan, Michael T.; Thorburn, David R.; Nakamura, Ken; Christodoulou, John 分享 收藏
AIFM1 is a component of the mitochondrial disulfide relay that drives complex I assembly through efficient import of NDUFS5 Salscheider, Silja Lucia; Gerlich, Sarah; Cabrera-Orefice, Alfredo; Peker, Esra; Rothemann, Robin Alexander; Murschall, Lena Maria; Finger, Yannik; Szczepanowska, Karolina; Ahmadi, Zeinab Alsadat; Guerrero-Castillo, Sergio; Erdogan, Alican; Becker, Mark; Ali, Muna; Habich, Markus; Petrungaro, Carmelina; Burdina, Nele; Schwarz, Guenter; Klussmann, Merlin; Neundorf, Ines; Stroud, David A.; Ryan, Michael T.; Trifunovic, Aleksandra; Brandt, Ulrich; Riemer, Jan 分享 收藏
Most mitochondrial dGTP is tightly bound to respiratory complex I through the NDUFA10 subunit Molina-Granada, David; Gonzalez-Vioque, Emiliano; Dibley, Marris G.; Cabrera-Perez, Raquel; Vallbona-Garcia, Antoni; Torres-Torronteras, Javier; Sazanov, Leonid A.; Ryan, Michael T.; Camara, Yolanda; Marti, Ramon 分享 收藏
Sideroflexin 4 is a complex I assembly factor that interacts with the MCIA complex and is required for the assembly of the ND2 module Sideroflexin 4是与MCIA复合体相互作用的复杂I装配因子，是ND2模块装配所必需的 Jackson, Thomas D.; Crameri, Jordan J.; Muellner-Wong, Linden; Frazier, Ann E.; Palmer, Catherine S.; Formosa, Luke E.; Hock, Daniella H.; Fujihara, Kenji M.; Stait, Tegan; Sharpe, Alice J.; Thorburn, David R.; Ryan, Michael T.; Stroud, David A.; Stojanovski, Diana 分享 收藏
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Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context 定量高置信度人类线粒体蛋白质组及其在细胞环境中的动力学 Morgenstern, Marcel; Peikert, Christian D.; Luebbert, Philipp; Suppanz, Ida; Klemm, Cinzia; Alka, Oliver; Steiert, Conny; Naumenko, Nataliia; Schendzielorz, Alexander; Melchionda, Laura; Muehlhaeuser, Wignand W. D.; Knapp, Bettina; Busch, Jakob D.; Stiller, Sebastian B.; Dannenmaier, Stefan; Lindau, Caroline; Licheva, Mariya; Eickhorst, Christopher; Galbusera, Riccardo; Zerbes, Ralf M.; Ryan, Michael T.; Kraft, Claudine; Kozjak-Pavlovic, Vera; Drepper, Friedel; Dennerlein, Sven; Oeljeklaus, Silke; Pfanner, Nikolaus; Wiedemann, Nils; Warscheid, Bettina 分享 收藏
SILAC-based complexome profiling dissects the structural organization of the human respiratory supercomplexes in SCAFIKO cells 基于SILAC的复合体分析了SCAFIKO细胞中人类呼吸超复合体的结构组织 Fernandez-Vizarra, Erika; Lopez-Calcerrada, Sandra; Formosa, Luke E.; Perez-Perez, Rafael; Ding, Shujing; Fearnley, Ian M.; Arenas, Joaquin; Martin, Miguel A.; Zeviani, Massimo; Ryan, Michael T.; Ugalde, Cristina 分享 收藏
Cavin3 released from caveolae interacts with BRCA1 to regulate the cellular stress response 小窝释放的Cavin3与BRCA1相互作用调节细胞应激反应 Mcmahon, Kerrie-Ann; Stroud, David A.; Gambin, Yann; Tillu, Vikas; Bastiani, Michele; Sierecki, Emma; Polinkovsky, Mark E.; Hall, Thomas E.; Gomez, Guillermo A.; Wu, Yeping; Parat, Marie-Odile; Martel, Nick; Lo, Harriet P.; Khanna, Kum Kum; Alexandrov, Kirill; Daly, Roger; Yap, Alpha; Ryan, Michael T.; Parton, Robert G. 分享 收藏
Nicotinamide riboside attenuates age-associated metabolic and functional changes in hematopoietic stem cells Sun, Xuan; Cao, Benjamin; Naval-Sanchez, Marina; Pham, Tony; Sun, Yu Bo Yang; Williams, Brenda; Heazlewood, Shen Y.; Deshpande, Nikita; Li, Jinhua; Kraus, Felix; Rae, James; Nguyen, Quan; Yari, Hamed; Schroder, Jan; Heazlewood, Chad K.; Fulton, Madeline; Hatwell-Humble, Jessica; Das Gupta, Kaustav; Kapetanovic, Ronan; Chen, Xiaoli; Sweet, Matthew J.; Parton, Robert G.; Ryan, Michael T.; Polo, Jose M.; Nefzger, Christian M.; Nilsson, Susan K. 分享 收藏
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