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Nicotinic Signaling Stimulates Glucagon Secretion in Mouse and Human Pancreatic α-Cells 烟碱信号刺激小鼠和人胰腺 α 细胞的胰高血糖素分泌 Hamilton, Alexander; Zhang, Quan; Gao, Rui; Hill, Thomas G.; Salehi, Albert; Knudsen, Jakob G.; Draper, Matthew B.; Johnson, Paul R. V.; Rorsman, Patrik; Tarasov, Andrei I. 分享 收藏
Loss of electrical β-cell to δ-cell coupling underlies impaired hypoglycaemia-induced glucagon secretion in type-1 diabetes 1型糖尿病中 β 细胞与 δ 细胞的电偶联丧失是低血糖诱导的胰高血糖素分泌受损的基础 Hill, Thomas G.; Gao, Rui; Benrick, Anna; Kothegala, Lakshmi; Rorsman, Nils; Santos, Cristiano; Acreman, Samuel; Briant, Linford J.; Dou, Haiqiang; Gandasi, Nikhil R.; Guida, Claudia; Haythorne, Elizabeth; Wallace, Marsha; Knudsen, Jakob G.; Miranda, Caroline; Tolo, Johan; Clark, Anne; Davison, Lucy; Storling, Joachim; Tarasov, Andrei; Ashcroft, Frances M.; Rorsman, Patrik; Zhang, Quan 分享 收藏
GLP-1 metabolite GLP-1(9-36) is a systemic inhibitor of mouse and human pancreatic islet glucagon secretion GLP-1代谢物GLP-1(9-36) 是小鼠和人胰岛胰高血糖素分泌的全身性抑制剂 Gandasi, Nikhil R.; Gao, Rui; Kothegala, Lakshmi; Pearce, Abigail; Santos, Cristiano; Acreman, Samuel; Basco, Davide; Benrick, Anna; Chibalina, Margarita V.; Clark, Anne; Guida, Claudia; Harris, Matthew; Johnson, Paul R. V.; Knudsen, Jakob G.; Ma, Jinfang; Miranda, Caroline; Shigeto, Makoto; Tarasov, Andrei I.; Yeung, Ho Yan; Thorens, Bernard; Asterholm, Ingrid W.; Zhang, Quan; Ramracheya, Reshma; Ladds, Graham; Rorsman, Patrik 分享 收藏
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Loss of tetraspanin-7 expression reduces pancreatic β-cell exocytosis Ca2+ sensitivity but has limited effect on systemic metabolism McLaughlin, Kerry; Acreman, Samuel; Nawaz, Sameena; Cutteridge, Joseph; Clark, Anne; Knudsen, Jakob G.; Denwood, Geoffrey; Spigelman, Aliya F.; Fox, Jocelyn E. Manning; Singh, Sumeet Pal; MacDonald, Patrick E.; Hastoy, Benoit; Zhang, Quan 分享 收藏
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A critical role of the mechanosensor PIEZO1 in glucose-induced insulin secretion in pancreatic β-cells 机械传感器PIEZO1在葡萄糖诱导的胰腺 β 细胞胰岛素分泌中的关键作用 Ye, Yingying; Barghouth, Mohammad; Dou, Haiqiang; Luan, Cheng; Wang, Yongzhi; Karagiannopoulos, Alexandros; Jiang, Xiaoping; Krus, Ulrika; Fex, Malin; Zhang, Quan; Eliasson, Lena; Rorsman, Patrik; Zhang, Enming; Renstrom, Erik 分享 收藏
Acetyl-CoA-carboxylase 1 (ACC1) plays a critical role in glucagon secretion 乙酰辅酶a羧化酶1 (ACC1) 在胰高血糖素分泌中起关键作用 Veprik, Anna; Denwood, Geoffrey; Liu, Dong; Bakar, Rula Bany; Morfin, Valentin; McHugh, Kara; Tebeka, Nchimunya N.; Vetterli, Laurene; Yonova-Doing, Ekaterina; Gribble, Fiona; Reimann, Frank; Hoehn, Kyle L.; Hemsley, Piers A.; Ahnfelt-Ronne, Jonas; Rorsman, Patrik; Zhang, Quan; de Wet, Heidi; Cantley, James 分享 收藏
Gs/Gq signaling switch in β cells defines incretin effectiveness in diabetes Oduori, Okechi S.; Murao, Naoya; Shimomura, Kenju; Takahashi, Harumi; Zhang, Quan; Dou, Haiqiang; Sakai, Shihomi; Minami, Kohtaro; Chanclon, Belen; Guida, Claudia; Kothegala, Lakshmi; Tol, Johan; Maejima, Yuko; Yokoi, Norihide; Minami, Yasuhiro; Miki, Takashi; Rorsman, Patrik; Seino, Susumu 分享 收藏
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Somatostatin secretion by Na+-dependent Ca2+-induced Ca2+ release in pancreatic delta cells Vergari, Elisa; Denwood, Geoffrey; Salehi, Albert; Zhang, Quan; Adam, Julie; Alrifaiy, Ahmed; Asterholm, Ingrid Wernstedt; Benrick, Anna; Chibalina, Margarita, V; Eliasson, Lena; Guida, Claudia; Hill, Thomas G.; Hamilton, Alexander; Ramracheya, Reshma; Reimann, Frank; Rorsman, Nils J. G.; Spilliotis, Ioannis; Tarasov, Andrei, I; Walker, Jonathan N.; Rorsman, Patrik; Briant, Linford J. B. 分享 收藏
Glucose stimulates somatostatin secretion in pancreatic δ-cells by cAMP-dependent intracellular Ca2+ release Denwood, Geoffrey; Tarasov, Andrei; Salehi, Albert; Vergari, Lisa; Ramracheya, Reshma; Takahashi, Harumi; Nikolaev, ViachesLay O.; Seino, Susumo; Gribble, Fiona; Reimann, Frank; Rorsman, Patrik; Zhang, Quan 分享 收藏
Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion Vergari, Elisa; Knudsen, Jakob G.; Ramracheya, Reshma; Salehi, Albert; Zhang, Quan; Adam, Julie; Asterholm, Ingrid Wernstedt; Benrick, Anna; Briant, Linford J. B.; Chibalina, Margarita V.; Gribble, Fiona M.; Hamilton, Alexander; Hastoy, Benoit; Reimann, Frank; Rorsman, Nils J. G.; Spiliotis, Ioannis I.; Tarasov, Andrei; Wu, Yanling; Ashcroft, Frances M.; Rorsman, Patrik 分享 收藏
Adrenaline Stimulates Glucagon Secretion by Tpc2-Dependent Ca2+ Mobilization From Acidic Stores in Pancreatic α-Cells Hamilton, Alexander; Zhang, Quan; Salehi, Albert; Willems, Mara; Knudsen, Jakob G.; Ringgaard, Anna K.; Chapman, Caroline E.; Gonzalez-Alvarez, Alejandro; Surdo, Nicoletta C.; Zaccolo, Manuela; Basco, Davide; Johnson, Paul R. V.; Ramracheya, Reshma; Rutter, Guy A.; Galione, Antony; Rorsman, Patrik; Tarasov, Andrei I. 分享 收藏
α-cell glucokinase suppresses glucose-regulated glucagon secretion Basco, Davide; Zhang, Quan; Salehi, Albert; Tarasov, Andrei; Dolci, Wanda; Herrera, Pedro; Spiliotis, Ioannis; Berney, Xavier; Tarussio, David; Rorsman, Patrik; Thorens, Bernard 分享 收藏
Fumarate Hydratase Deletion in Pancreatic β Cells Leads to Progressive Diabetes Adam, Julie; Ramracheya, Reshma; Chibalina, Margarita V.; Ternette, Nicola; Hamilton, Alexander; Tarasov, Andrei I.; Zhang, Quan; Rebelato, Eduardo; Rorsman, Nils J. G.; Martin-del-Rio, Rafael; Lewis, Amy; Ozkan, Gizem; Do, Hyun Woong; Spegel, Peter; Saitoh, Kaori; Kato, Keiko; Igarashi, Kaori; Kessler, Benedikt M.; Pugh, Christopher W.; Tamarit-Rodriguez, Jorge; Mulder, Hindrik; Clark, Anne; Frizzell, Norma; Soga, Tomoyoshi; Ashcroft, Frances M.; Silver, Andrew; Pollard, Patrick J.; Rorsman, Patrik 分享 收藏
Mutant Mice With Calcium-Sensing Receptor Activation Have Hyperglycemia That Is Rectified by Calcilytic Therapy Babinsky, Valerie N.; Hannan, Fadil M.; Ramracheya, Reshma D.; Zhang, Quan; Nesbit, M. Andrew; Hugill, Alison; Bentley, Liz; Hough, Tertius A.; Joynson, Elizabeth; Stewart, Michelle; Aggarwal, Abhishek; Prinz-Wohlgenannt, Maximilian; Gorvin, Caroline M.; Kallay, Eniko; Wells, Sara; Cox, Roger D.; Richards, Duncan; Rorsman, Patrik; Thakker, Rajesh V. 分享 收藏
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