未登录 分享 收藏
分享 收藏
分享 收藏
A melanocyte lineage program confers resistance to MAP kinase pathway inhibition 黑色素细胞谱系程序赋予对MAP激酶通路抑制的抵抗性 Johannessen, Cory M.; Johnson, Laura A.; Piccioni, Federica; Townes, Aisha; Frederick, Dennie T.; Donahue, Melanie K.; Narayan, Rajiv; Flaherty, Keith T.; Wargo, Jennifer A.; Root, David E.; Garraway, Levi A. 分享 收藏
Functional screening reveals genetic dependencies and diverging cell cycle control in atypical teratoid rhabdoid tumors 功能筛选揭示了非典型畸形性横纹肌样瘤的遗传依赖性和不同的细胞周期控制 Merk, Daniel J.; Tsiami, Foteini; Hirsch, Sophie; Walter, Bianca; Haeusser, Lara A.; Maile, Jens D.; Stahl, Aaron; Jarboui, Mohamed A.; Lechado-Terradas, Anna; Klose, Franziska; Babaei, Sepideh; Admard, Jakob; Casadei, Nicolas; Roggia, Cristiana; Spohn, Michael; Schittenhelm, Jens; Singer, Stephan; Schueller, Ulrich; Piccioni, Federica; Persky, Nicole S.; Claassen, Manfred; Tatagiba, Marcos; Kahle, Philipp J.; Root, David E.; Templin, Markus; Tabatabai, Ghazaleh 分享 收藏
Deep mutational scanning of SMARCB1 identifies missense mutants that destabilize SWI/SNF complex stability and diminish remodeling activity Cooper, Garrett; Lee, Benjamin; Kim, Won; Salas, Eliseo; Su, Yongdong; Chen, Victor; Yang, Xiaoping; Lintner, Robert; Piccioni, Federica; Giacomelli, Andrew; Howard, Thomas; Conneely, Karen; Root, David; Hahn, William; Gorkin, David; Liang, Bo; Biegel, Jaclyn; Chi, Susan; Hong, Andrew 分享 收藏
Genome-wide CRISPR-Cas9 knockout screens identify DNMT1 as a druggable dependency in sonic hedgehog medulloblastoma Tsiami, Foteini; Lago, Chiara; Pozza, Noemi; Piccioni, Federica; Zhao, Xuesong; Luelsberg, Fabienne; Root, David E.; Tiberi, Luca; Kool, Marcel; Schittenhelm, Jens; Bandopadhayay, Pratiti; Segal, Rosalind A.; Tabatabai, Ghazaleh; Merk, Daniel J. 分享 收藏
Comprehensive mutational scanning of EGFR reveals TKI sensitivities of extracellular domain mutants (Vol 15, 2742, 2024) EGFR的综合突变扫描揭示了细胞外结构域突变体的TKI敏感性 (第15卷，2742，2024) Hayes, Tikvah K.; Aquilanti, Elisa; Persky, Nicole S.; Yang, Xiaoping; Kim, Erica E.; Brenan, Lisa; Goodale, Amy B.; Alan, Douglas; Sharpe, Ted; Shue, Robert E.; Westlake, Lindsay; Golomb, Lior; Silverman, Brianna R.; Morris, Myshal D.; Fisher, Ty Running; Beyene, Eden; Li, Yvonne Y.; Cherniack, Andrew D.; Piccioni, Federica; Hicks, J. Kevin; Chi, Andrew S.; Cahill, Daniel P.; Dietrich, Jorg; Batchelor, Tracy T.; Root, David E.; Johannessen, Cory M.; Meyerson, Matthew 分享 收藏
Comprehensive mutational scanning of EGFR reveals TKI sensitivities of extracellular domain mutants EGFR的综合突变扫描揭示了细胞外结构域突变体的TKI敏感性 Hayes, Tikvah K.; Aquilanti, Elisa; Persky, Nicole S.; Yang, Xiaoping; Kim, Erica E.; Brenan, Lisa; Goodale, Amy B.; Alan, Douglas; Sharpe, Ted; Shue, Robert E.; Westlake, Lindsay; Golomb, Lior; Silverman, Brianna R.; Morris, Myshal D.; Fisher, Ty Running; Beyene, Eden; Li, Yvonne Y.; Cherniack, Andrew D.; Piccioni, Federica; Hicks, J. Kevin; Chi, Andrew S.; Cahill, Daniel P.; Dietrich, Jorg; Batchelor, Tracy T.; Root, David E.; Johannessen, Cory M.; Meyerson, Matthew 分享 收藏
Deep mutational scanning of EGFR reveals potential domain-specific TKI sensitivities in lung cancer and glioblastoma Hayes, Tikvah; Aquilanti, Elisa; Kim, Erica; Persky, Nicole; Brenan, Lisa; Goodale, Amy; Sharpe, Ted; Alan, Doug; Shue, Robert; Golomb, Lior; Silverman, Brianna; Li, Yvonne; Westlake, Lindsay; Piccioni, Federica; Cherniack, Andrew; Yang, Xiaoping Yang; Root, David; Hicks, J. Kevin; Chi, Andrew; Dietrich, Jorg; Cahill, Daniel; Johannessen, Cory; Batchelor, Tracy; Meyerson, Matthew 分享 收藏
BAF COMPLEX PERTURBATION AS A NOVEL THERAPEUTIC OPPORTUNITY IN H3K27M PEDIATRIC GLIOMA BAF复杂扰动作为H3K27M小儿神经胶质瘤的新治疗机会 Panditharatna, Eshini; Marques, Joana G.; Wang, Tingjian; Trissal, Maria; Liu, Ilon; Jiang, Li; Beck, Alexander; Groves, Andrew; Dharia, Neekesh; Hoffman, Samantha; Kugener, Guillaume; Shaw, McKenzie; Hack, Olivia; Dempster, Joshua; Lareau, Caleb; Quezada, Michael; Stanton, Ann-Catherine; Wyatt, Meghan; Kalani, Zohra; Goodale, Amy; Vazquez, Francisca; Piccioni, Federica; Doench, John; Root, David; Anastas, Jamie; Jones, Kristen; Conway, Amy; Stopka, Sylwia; Regan, Michael; Liang, Yu; Seo, Hyuk-Soo; Song, Kijun; Bashyal, Puspalata; Mathewson, Nathan; Dhe-Paganon, Sirano; Suva, Mario L.; Carcaboso, Angel M.; Lavarino, Cinzia; Mora, Jaume; Nguyen, Quang-De; Ligon, Keith L.; Shi, Yang; Agnihotri, Sameer; Agar, Nathalie Y. R.; Stegmaier, Kimberly; Stiles, Charles D.; Monje, Michelle; Golub, Todd R.; Qi, Jun; Filbin, Mariella G. 分享 收藏
Genome-wide pooled CRISPR screening in neurospheres Abid, Tanaz; Goodale, Amy B.; Kalani, Zohra; Wyatt, Meghan; Gonzalez, Elizabeth M.; Zhou, Kevin Ning; Qian, Kenin; Novikov, Dana; Condurat, Alexandra-Larisa; Bandopadhayay, Pratiti; Piccioni, Federica; Persky, Nicole S.; Root, David E. 分享 收藏
分享 收藏
Natural variation in gene expression and viral susceptibility revealed by neural progenitor cell villages Wells, Michael F.; Nemesh, James; Ghosh, Sulagna; Mitchell, Jana M.; Salick, Max R.; Mello, Curtis J.; Meyer, Daniel; Pietilainen, Olli; Piccioni, Federica; Guss, Ellen J.; Raghunathan, Kavya; Tegtmeyer, Matthew; Hawes, Derek; Neumann, Anna; Worringer, Kathleen A.; Ho, Daniel; Kommineni, Sravya; Chan, Karrie; Peterson, Brant K.; Raymond, Joseph J.; Gold, John T.; Siekmann, Marco T.; Zuccaro, Emanuela; Nehme, Ralda; Kaykas, Ajamete; Eggan, Kevin; McCarroll, Steven A. 分享 收藏
A Ubiquitination Cascade Regulating the Integrated Stress Response and Survival in Carcinomas Cervia, Lisa D.; Shibue, Tsukasa; Borah, Ashir A.; Gaeta, Benjamin; He, Linh; Leung, Lisa; Li, Naomi; Moyer, Sydney M.; Shim, Brian H.; Dumont, Nancy; Gonzalez, Alfredo; Bick, Nolan R.; Kazachkova, Mariya; Dempster, Joshua M.; Krill-Burger, John Michael; Piccioni, Federica; Udeshi, Namrata D.; Olive, Meagan E.; Carr, Steven A.; Root, David E.; McFarland, James M.; Vazquez, Francisca; Hahn, William C. 分享 收藏
Transcriptional Antagonism by CDK8 Inhibition Improves Therapeutic Efficacy of MEK Inhibitors Malone, Clare F.; Kim, Minjee; Alexe, Gabriela; Engel, Kathleen; Forman, Alexandra B.; Robichaud, Amanda; Conway, Amy Saur; Goodale, Amy; Meyer, Ashleigh; Khalid, Delan; Thayakumar, Allen; Hatcher, John M.; Gray, Nathanael S.; Piccioni, Federica; Stegmaier, Kimberly 分享 收藏
BAF Complex Maintains Glioma Stem Cells in Pediatric H3K27M Glioma Panditharatna, Eshini; Marques, Joana G.; Wang, Tingjian; Trissal, Maria C.; Liu, Ilon; Jiang, Li; Beck, Alexander; Groves, Andrew; Dharia, Neekesh, V; Li, Deyao; Hoffman, Samantha E.; Kugener, Guillaume; Shaw, McKenzie L.; Mire, Hafsa M.; Hack, Olivia A.; Dempster, Joshua M.; Lareau, Caleb; Dai, Lingling; Sigua, Logan H.; Quezada, Michael A.; Stanton, Ann-Catherine J.; Wyatt, Meghan; Kalani, Zohra; Goodale, Amy; Vazquez, Francisca; Piccioni, Federica; Doench, John G.; Root, David E.; Anastas, Jamie N.; Jones, Kristen L.; Conway, Amy Saur; Stopka, Sylwia; Regan, Michael S.; Liang, Yu; Seo, Hyuk-Soo; Song, Kijun; Bashyal, Puspalata; Jerome, William P.; Mathewson, Nathan D.; Dhe-Paganon, Sirano; Suva, Mario L.; Carcaboso, Angel M.; Lavarino, Cinzia; Mora, Jaume; Quang-De Nguyen; Ligon, Keith L.; Shi, Yang; Agnihotri, Sameer; Agar, Nathalie Y. R.; Stegmaier, Kimberly; Stiles, Charles D.; Monje, Michelle; Golub, Todd R.; Qi, Jun; Filbin, Mariella G. 分享 收藏
NSD1 mediates antagonism between SWI/SNF and polycomb complexes and is required for transcriptional activation upon EZH2 inhibition Drosos, Yiannis; Myers, Jacquelyn A.; Xu, Beisi; Mathias, Kaeli M.; Beane, Emma C.; Radko-Juettner, Sandi; Mobley, Robert J.; Larsen, Margaret E.; Piccioni, Federica; Ma, Xiaotu; Low, Jonathan; Hansen, Baranda S.; Peters, Samuel T.; Bhanu, Natarajan, V; Dhanda, Sandeep K.; Chen, Taosheng; Upadhyaya, Santhosh A.; Pruett-Miller, Shondra M.; Root, David E.; Garcia, Benjamin A.; Partridge, Janet F.; Roberts, Charles W. M. 分享 收藏
Allosteric inhibition of PPM1D serine/threonine phosphatase via an altered conformational state Miller, Peter G.; Sathappa, Murugappan; Moroco, Jamie A.; Jiang, Wei; Qian, Yue; Iqbal, Sumaiya; Guo, Qi; Giacomelli, Andrew O.; Shaw, Subrata; Vernier, Camille; Bajrami, Besnik; Yang, Xiaoping; Raffier, Cerise; Sperling, Adam S.; Gibson, Christopher J.; Kahn, Josephine; Jin, Cyrus; Ranaghan, Matthew; Caliman, Alisha; Brousseau, Merissa; Fischer, Eric S.; Lintner, Robert; Piccioni, Federica; Campbell, Arthur J.; Root, David E.; Garvie, Colin W.; Ebert, Benjamin L. 分享 收藏
Phosphate dysregulation via the XPR1-KIDINS220 protein complex is a therapeutic vulnerability in ovarian cancer Bondeson, Daniel P.; Paolella, Brenton R.; Asfaw, Adhana; Rothberg, Michael, V; Skipper, Thomas A.; Langan, Carly; Mesa, Gabriel; Gonzalez, Alfredo; Surface, Lauren E.; Ito, Kentaro; Kazachkova, Mariya; Colgan, William N.; Warren, Allison; Dempster, Joshua M.; Krill-Burger, John M.; Ericsson, Maria; Tang, Andrew A.; Fung, Iris; Chambers, Emily S.; Abdusamad, Mai; Dumont, Nancy; Doench, John G.; Piccioni, Federica; Root, David E.; Boehm, Jesse; Hahn, William C.; Mannstadt, Michael; McFarland, James M.; Vazquez, Francisca; Golub, Todd R. 分享 收藏
.png){kind=icon}
未登录.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
