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The Discovery of C7-Substituted Norbornyl Bisamides as RXFP1 Small Molecule Agonists C7-取代降冰片基双酰胺类化合物作为RXFP1小分子激动剂的发现 Su, Shun; Myers, Michael C.; Bilder, Donna M.; Clarke, Adam; Friends, Todd; Petrone, Thomas V.; Ryan, Carol; Krause, Carol M.; Chen, Ruihua; Li, Yi-xin; Fronheiser, Matthew; Galella, Michael A.; Rose, Anne V.; Generaux, Claudia N.; Zhao, Lei; Bostwick, Jeff; Li, Jianqing; Mathur, Arvind; Duclos, Franck; Madsen, Cort S.; Wexler, Ruth R.; Lawrence, R. Michael 分享 收藏
Discovery and Optimization of Aryl Piperidinone Ureas as Selective Formyl Peptide Receptor 2 Agonists Wurtz, Nicholas R.; Shirude, Pravin S.; Cheney, Daniel L.; Lupisella, John A.; Chattopadhyay, Amit Kumar; Baligar, Vishweshwaraiah; Seshadri, Balaji; Anjanappa, Prakash; Viet, Andrew; Valente, Meriah N.; Hsu, Mei-Yin; Abousleiman, Mojgan; Sarodaya, Sanket; Tagore, Debarati M.; Dudhgaonkar, Shailesh; Putlur, Sivaprasad; Dierks, Elizabeth A.; Ostrowski, Jacek; Wexler, Ruth R.; Garcia, Ricardo; Kick, Ellen K. 分享 收藏
Discovery of BMS-986308: A Renal Outer Medullary Potassium Channel Inhibitor for the Treatment of Heart Failure Richter, Jeremy M.; Gunaga, Prashantha; Yadav, Navnath; Bora, Rajesh Onkardas; Bhide, Rajeev; Rajugowda, Nagendra; Govindrajulu, Kavitha; Godesi, Sreenivasulu; Akuthota, Nagarjuna; Rao, Prasanna; Sivaraman, Aneesh; Panda, Manoranjan; Kaspady, Mahammed; Gupta, Anuradha; Mathur, Arvind; Levesque, Paul C.; Gulia, Jyoti; Dokania, Manoj; Ramarao, Manjunath; Kole, Prashant; Chacko, Silvi; Lentz, Kimberley A.; Sivaprasad Lvj, Sankara; Thatipamula, Rajendra Prasad; Sridhar, Srikanth; Kamble, Shyam; Govindrajan, Arun; Soleman, Sharif I.; Gordon, David A.; Wexler, Ruth R.; Priestley, E. Scott 分享 收藏
Empowering Voices: Inspiring Women in Medicinal Chemistry Blanco, Maria-Jesus; Bronson, Joanne J.; Dimauro, Erin F.; Dzierba, Carolyn; Eggen, Marijean; Garner, Amanda L.; Georg, Gunda; Giarolla, Jeanine; Goodwin, Nicole C.; Grenier-Davies, Melissa C.; Haskell-Luevano, Carrie; Holzgrabe, Ulrike; Huang, Rong; Lagiakos, H. Rachel; Leftheris, Katerina; Martin, Yvonne; Matos, Maria Joao; May-Dracka, Tricia L.; Muller, Christa E.; Newman, Amy H.; Parmee, Emma; Petter, Jennifer C.; Tamayo, Nuria A.; Wexler, Ruth R.; Bolognesi, Maria Laura; Ripka, Amy; Young, Wendy 分享 收藏
Empowering Voices: Inspiring Women in Medicinal Chemistry Blanco, Maria-Jesus; Bronson, Joanne J.; DiMauro, Erin F.; Dzierba, Carolyn; Eggen, Marijean; Garner, Amanda L.; Georg, Gunda; Giarolla, Jeanine; Goodwin, Nicole C.; Grenier-Davies, Melissa C.; Haskell-Luevano, Carrie; Holzgrabe, Ulrike; Huang, Rong; Lagiakos, H. Rachel; Leftheris, Katerina; Martin, Yvonne; Matos, Maria Joao; May-Dracka, Tricia L.; Muller, Christa E.; Newman, Amy H.; Parmee, Emma; Petter, Jennifer C.; Tamayo, Nuria A.; Wexler, Ruth R.; Bolognesi, Maria Laura; Ripka, Amy; Young, Wendy 分享 收藏
Discovery of Potent and Selective Quinoxaline-Based Protease-Activated Receptor 4 (PAR4) Antagonists for the Prevention of Arterial Thrombosis Zhang, Xiaojun; Jiang, Wen; Richter, Jeremy M.; Bates, J. Alex; Reznik, Samuel K.; Stachura, Sylwia; Rampulla, Richard; Doddalingappa, Dyamanna; Ulaganathan, Sankar; Hua, Ji; Bostwick, Jeffrey S.; Sum, Chi; Posy, Shana; Malmstrom, Sarah; Dickey, Joyce; Harden, David; Lawrence, R. Michael; Guarino, Victor R.; Schumacher, William A.; Wong, Pancras; Yang, Jing; Gordon, David A.; Wexler, Ruth R.; Priestley, Scott 分享 收藏
Discovery of Two Novel Antiplatelet Clinical Candidates (BMS-986120 and BMS-986141) That Antagonize Protease-Activated Receptor 4 Priestley, E. Scott; Banville, Jacques; Deon, Daniel; Dube, Laurence; Gagnon, Marc; Guy, Julia; Lapointe, Philippe; Lavallee, Jean-Francois; Martel, Alain; Plamondon, Serge; Remillard, Roger; Ruediger, Edward; Tremblay, Francois; Posy, Shana L.; Guarino, Victor R.; Richter, Jeremy M.; Li, Jianqing; Gupta, Anuradha; Vetrichelvan, Muthalagu; Balapragalathan, T. J.; Mathur, Arvind; Hua, Ji; Callejo, Mario; Guay, Jocelyne; Sum, Chi Shing; Cvijic, Mary Ellen; Watson, Carol; Wong, Pancras; Yang, Jing; Bouvier, Michel; Gordon, David A.; Wexler, Ruth R.; Marinier, Anne 分享 收藏
Discovery of Heteroaryl Urea Isosteres for Formyl Peptide Receptor 2 Agonists 甲酰基肽受体2激动剂的杂芳基脲等排物的发现 Wurtz, Nicholas R.; Johnson, James A.; Viet, Andrew; Shirude, Pravin S.; Baligar, Vishweshwaraiah; Madduri, Sudhakara; Cheney, Daniel L.; Park, Hyunsoo; Lupisella, John A.; Hsu, Mei-Yin; Abousleiman, Mojgan; Galella, Michael A.; Aulakh, Darpandeep; Dierks, Elizabeth A.; Garcia, Ricardo A.; Ostrowski, Jacek; Kick, Ellen K.; Wexler, Ruth R. 分享 收藏
Milvexian, an orally bioavailable, small-molecule, reversible, direct inhibitor of factor XIa: In vitro studies and in vivo evaluation in experimental thrombosis in rabbits Milvexian，一种口服生物可利用的，小分子的，可逆的，XIa因子的直接抑制剂: 兔实验性血栓形成的体外研究和体内评估 Wong, Pancras C.; Crain, Earl J.; Bozarth, Jeffrey M.; Wu, Yiming; Dilger, Andrew K.; Wexler, Ruth R.; Ewing, William R.; Gordon, David; Luettgen, Joseph M. 分享 收藏
Identification of a Hydroxypyrimidinone Compound (21) as a Potent APJ Receptor Agonist for the Potential Treatment of Heart Failure Meng, Wei; Pi, Zulan; Brigance, Robert; Rossi, Karen A.; Schumacher, William A.; Bostwick, Jeffrey S.; Gargalovic, Peter S.; Onorato, Joelle M.; Luk, Chiuwa E.; Generaux, Claudia N.; Wang, Tao; Wexler, Ruth R.; Finlay, Heather J. 分享 收藏
Identification of 6-Hydroxypyrimidin-4(1H)-one-3-carboxamides as Potent and Orally Active APJ Receptor Agonists Pi, Zulan; Johnson, James A.; Meng, Wei; Phillips, Monique; Schumacher, William A.; Bostwick, Jeffrey S.; Gargalovic, Peter S.; Onorato, Joelle M.; Generaux, Claudia N.; Wang, Tao; He, Yan; Gordon, David A.; Wexler, Ruth R.; Finlay, Heather J. 分享 收藏
Discovery of Milvexian, a High-Affinity, Orally Bioavailable Inhibitor of Factor XIa in Clinical Studies for Antithrombotic Therapy Dilger, Andrew K.; Pabbisetty, Kumar B.; Corte, James R.; De Lucca, Indawati; Fang, Tianan; Yang, Wu; Pinto, Donald J. P.; Wang, Yufeng; Zhu, Yeheng; Mathur, Arvind; Li, Jianqing; Hou, Xiaoping; Smith, Daniel; Sun, Dawn; Zhang, Huiping; Krishnananthan, Subramaniam; Wu, Dauh-Rurng; Myers, Joseph E., Jr.; Sheriff, Steven; Rossi, Karen A.; Chacko, Silvi; Zheng, Joanna J.; Galella, Michael A.; Ziemba, Theresa; Dierks, Elizabeth A.; Bozarth, Jeffrey M.; Wu, Yiming; Crain, Earl; Wong, Pancras C.; Luettgen, Joseph M.; Wexler, Ruth R.; Ewing, William R. 分享 收藏
Selective FPR2 Agonism Promotes a Proresolution Macrophage Phenotype and Improves Cardiac Structure-Function Post Myocardial Infarction 选择性FPR2激动作用可促进重组巨噬细胞表型并改善心肌梗塞后的心脏结构功能 Garcia, Ricardo A.; Lupisella, John A.; Ito, Bruce R.; Hsu, Mei-Yin; Fernando, Gayani; Carson, Nancy L.; Allocco, John J.; Ryan, Carol S.; Zhang, Rongan; Wang, Zhaoqing; Heroux, Madeleine; Carrier, Marilyn; St-Onge, Stephane; Bouvier, Michel; Dudhgaonkar, Shailesh; Nagar, Jignesh; Bustamante-Pozo, Moises M.; Garate-Carrillo, Alejandra; Chen, Jian; Ma, Xiuying; Search, Debra J.; Dierks, Elizabeth A.; Kick, Ellen K.; Wexler, Ruth R.; Gordon, David A.; Ostrowski, Jacek; Wurtz, Nicholas R.; Villarreal, Francisco 分享 收藏
Discovery of a Hydroxypyridinone APJ Receptor Agonist as a Clinical Candidate Johnson, James A.; Kim, Soong-Hoon; Jiang, Ji; Phillips, Monique; Schumacher, William A.; Bostwick, Jeffrey S.; Gargalovic, Peter S.; Onorato, Joelle M.; Luk, Chiuwa E.; Generaux, Claudia; He, Yan; Chen, Xue-Qing; Xu, Carrie; Galella, Michael A.; Wang, Tao; Gordon, David A.; Wexler, Ruth R.; Finlay, Heather J. 分享 收藏
In Vitro and In Vivo Evaluation of a Small-Molecule APJ (Apelin Receptor) Agonist, BMS-986224, as a Potential Treatment for Heart Failure Gargalovic, Peter; Wong, Pancras; Onorato, Joelle; Finlay, Heather; Wang, Tao; Yan, Mujing; Crain, Earl; St-Onge, Stephane; Heroux, Madeleine; Bouvier, Michel; Xu, Carrie; Chen, Xue-Qing; Generaux, Claudia; Lawrence, Michael; Wexler, Ruth; Gordon, David 分享 收藏
Discovery and structure activity relationships of 7-benzyl triazolopyridines as stable, selective, and reversible inhibitors of myeloperoxidase Shaw, Scott A.; Vokits, Benjamin P.; Dilger, Andrew K.; Viet, Andrew; Clark, Charles G.; Abell, Lynn M.; Locke, Gregory A.; Duke, Gerald; Kopcho, Lisa M.; Dongre, Ashok; Gao, Ji; Krishnakumar, Arathi; Jusuf, Sutjano; Khan, Javed; Spronk, Steven A.; Basso, Michael D.; Zhao, Lei; Cantor, Glenn H.; Onorato, Joelle M.; Wexler, Ruth R.; Duclos, Franck; Kick, Ellen K. 分享 收藏
Discovery of a High Affinity, Orally Bioavailable Macrocyclic FXIa Inhibitor with Antithrombotic Activity in Preclinical Species Yang, Wu; Wang, Yufeng; Lai, Amy; Clark, Charles G.; Corte, James R.; Fang, Tianan; Gilligan, Paul J.; Jeon, Yoon; Pabbisetty, Kumar B.; Rampulla, Richard A.; Mathur, Arvind; Kaspady, Mahammed; Neithnadka, Premsai Rai; Arumugam, Arunachalam; Raju, Sivashankaran; Rossi, Karen A.; Myers, Joseph E., Jr.; Sheriff, Steven; Lou, Zhen; Zheng, Joanna J.; Chacko, Silvi A.; Bozarth, Jeffrey M.; Wu, Yiming; Crain, Earl J.; Wong, Pancras C.; Seiffert, Dietmar A.; Luettgen, Joseph M.; Lam, Patrick Y. S.; Wexler, Ruth R.; Ewing, William R. 分享 收藏
Discovery of BMS-986235/LAR-1219: A Potent Formyl Peptide Receptor 2 (FPR2) Selective Agonist for the Prevention of Heart Failure Asahina, Yoshikazu; Wurtz, Nicholas R.; Arakawa, Kazuto; Carson, Nancy; Fujii, Kiyoshi; Fukuchi, Kazunori; Garcia, Ricardo; Hsu, Mei-Yin; Ishiyama, Junichi; Ito, Bruce; Kick, Ellen; Lupisella, John; Matsushima, Shingo; Ohata, Kohei; Ostrowski, Jacek; Saito, Yoshifumi; Tsuda, Kosuke; Villarreal, Francisco; Yamada, Hitomi; Yamaoka, Toshikazu; Wexler, Ruth; Gordon, David; Kohno, Yasushi 分享 收藏
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